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Entry version 28 (16 Oct 2019)
Sequence version 1 (29 Oct 2014)
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Protein
Submitted name:

Vitellogenin

Gene
N/A
Organism
Apis mellifera (Honeybee)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
VitellogeninImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiApis mellifera (Honeybee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7460 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005203 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Linkage group 4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500183566517 – 1770Sequence analysisAdd BLAST1754

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 809VitellogeninInterPro annotationAdd BLAST788
Domaini1442 – 1670VWFDInterPro annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni373 – 394DisorderedSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKR4 Eukaryota
ENOG4110M1Q LUCA

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHCHHRV

Database of Orthologous Groups

More...
OrthoDBi
36651at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0A088ADL8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.20, 1 hit
2.30.230.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht
IPR001846 VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit
PF00094 VWD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit
SM00216 VWD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51211 VITELLOGENIN, 1 hit
PS51233 VWFD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A088ADL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLLLTLLLF AGTVSADFQH NWQVGNEYTY LVRSRTLTSL GDLSDVHTGI
60 70 80 90 100
LIKALLTVQA KDSNVLAAKV WNGQYARVQQ SMPDGWETEI SDQMLELRDL
110 120 130 140 150
PISGKPFQIR MKHGLIRDLI VDRDVPTWEV NILKSIVGQL QVDTQGENAV
160 170 180 190 200
KVNSVQVPTD DEPYASFKAM EDSVGGKCEV LYDIAPLSDF VIHRSPELVP
210 220 230 240 250
MPTLKGDGRH MEVIKIKNFD NCDQRINYHF GMTDNSRLEP GTNKNGKFFS
260 270 280 290 300
RSSTSRIVIS GSLKHFTIQS SVTTSKMMVS PRLYDRQNGL VLSRMNLTLA
310 320 330 340 350
KMEKTSKPLP TVNNPESTGN LVYIYNNPFS DVEERRVSKT AMNSNQIVSD
360 370 380 390 400
NSLSSSEEKL KQDILNLRTD ISSSSSSISS SEENDFWQPK PTLEDAPQNS
410 420 430 440 450
LLPNFVGYKG KHIGKSGKVD VINAAKELIF QIANELEDAS NIPVHATLEK
460 470 480 490 500
FMILCNLMRT MNRKQISELE SNMQISPNEL KPNDKSQVVK QNTWTVFRDA
510 520 530 540 550
ITQTGTGPAF LTIKEWIERG TTKSMEAANI MSKLPKTVRT PTDSYIRSFF
560 570 580 590 600
ELLQNPKVSN EQFLNTAATL SFCEMIHNAQ VNKRSIHNNY PVHTFGRLTS
610 620 630 640 650
KHDNSLYDEY IPFLERELRK AHQEKDSPRI QTYIMALGMI GEPKILSVFE
660 670 680 690 700
PYLEGKQQMT VFQRTLMVGS LGKLTETNPK LARSVLYKIY LNTMESHEVR
710 720 730 740 750
CTAVFLLMKT NPPLSMLQRM AEFTKLDTNR QVNSAVKSTI QSLMKLKSPE
760 770 780 790 800
WKDLAKKARS VNHLLTHHEY DYELSRGYID EKILENQNII THMILNYVGS
810 820 830 840 850
EDSVIPRILY LTWYSSNGDI KVPSTKVLAM ISSVKSFMEL SLRSVKDRET
860 870 880 890 900
IISAAEKIAE ELKIVPEELV PLEGNLMINN KYALKFFPFD KHILDKLPTL
910 920 930 940 950
ISNYIEAVKE GKFMNVNMLD TYESVHSFPT ETGLPFVYTF NVIKLTKTSG
960 970 980 990 1000
TVQAQINPDF AFIANSNLRL TFSKNVQGRV GFVTPFEHRH FISGIDSNLH
1010 1020 1030 1040 1050
VYAPLKISLD VNTPKGNMQW KIWPMKGEEK SRLFHYSVVP FVSNHDILNL
1060 1070 1080 1090 1100
RPLSMEKGTR PMIPDDNTSL ALPKNEGPFR LNVETAKTNE EMWELIDTEK
1110 1120 1130 1140 1150
LTDRLPYPWS MDNERYVKVD MYMNLEGEQK DPVIFSTSFD SKVMTRPDTD
1160 1170 1180 1190 1200
SENWTPKMMA VEPTDKQANS KTRRQEMMRE AGRGIESAKS YVVDVRVHVP
1210 1220 1230 1240 1250
GESESETVLT LAWSESNVEN KGRLLGFWRV EMPRSNADYE VCIGSQIMVS
1260 1270 1280 1290 1300
PETLLSYDEK MDQKPKMDFN VDIRYGKNCG KGERIDMNGK LRQSPRLKEL
1310 1320 1330 1340 1350
VGATSIIKDC VEDMKRGNKI LRTCQKAVVL SMLLDEVDIS MEVPSDALIA
1360 1370 1380 1390 1400
LYSQGLFSLS EIDNLDVSLD VSNPKNAGKK KIDVRAKLNE YLDKADVIVN
1410 1420 1430 1440 1450
TPIMDAHFKD VKLSDFGFST EDILDTADED LLINNVFYED ETSCMLDKTR
1460 1470 1480 1490 1500
VQTFDGKDYP LRLGPCWHAV MTTYPRINPD NHNEKLHIPK DKSVSVLSRE
1510 1520 1530 1540 1550
NEAGQKEVKV LLGSDKIKFV PGTTSQPEVF VNGEKIVVSR NKAYQKVEEN
1560 1570 1580 1590 1600
EIIFEIYKMG DRFIGLTSDK FDVSLALDGE RVMLKASEDY RYSVRGLCGN
1610 1620 1630 1640 1650
FDHDSTNDFV GPKNCLFRKP EHFVASYALI SNQCEGDSLN VAKSLQDHDC
1660 1670 1680 1690 1700
IRQERTQQRN VISDSESGRL DTEMSTWGYH HNVNKHCMIH RTQVKETDDK
1710 1720 1730 1740 1750
ICFTMRPVVS CASGCTAVET KSKPYKFHCM EKNEAAMKLK KRIEKGANPD
1760 1770
LSQKPVSTTE ELTVPLVCKA
Length:1,770
Mass (Da):200,956
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E39C9C3D6F70683
GO

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
GB49544-RA; GB49544-PA; GB49544

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiGB49544-RA; GB49544-PA; GB49544

Phylogenomic databases

eggNOGiENOG410IKR4 Eukaryota
ENOG4110M1Q LUCA
OMAiGHCHHRV
OrthoDBi36651at2759
PhylomeDBiA0A088ADL8

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit
PF00094 VWD, 1 hit
SMARTiView protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit
SM00216 VWD, 1 hit
SUPFAMiSSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit
PS51233 VWFD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A088ADL8_APIME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A088ADL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: October 16, 2019
This is version 28 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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