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Entry version 31 (13 Feb 2019)
Sequence version 1 (29 Oct 2014)
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Protein
Submitted name:

Uncharacterized protein

Gene

LOC725993

Organism
Apis mellifera (Honeybee)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi801 – 808ATPPROSITE-ProRule annotation8
Nucleotide bindingi1418 – 1425ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC725993Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiApis mellifera (Honeybee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7460 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005203 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Linkage group 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei41 – 60HelicalSequence analysisAdd BLAST20
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei226 – 247HelicalSequence analysisAdd BLAST22
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Transmembranei456 – 475HelicalSequence analysisAdd BLAST20
Transmembranei531 – 555HelicalSequence analysisAdd BLAST25
Transmembranei561 – 580HelicalSequence analysisAdd BLAST20
Transmembranei645 – 667HelicalSequence analysisAdd BLAST23
Transmembranei687 – 706HelicalSequence analysisAdd BLAST20
Transmembranei1038 – 1058HelicalSequence analysisAdd BLAST21
Transmembranei1105 – 1133HelicalSequence analysisAdd BLAST29
Transmembranei1180 – 1199HelicalSequence analysisAdd BLAST20
Transmembranei1205 – 1224HelicalSequence analysisAdd BLAST20
Transmembranei1290 – 1310HelicalSequence analysisAdd BLAST21
Transmembranei1322 – 1344HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A087ZZ50

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7460.GB15227-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini424 – 703ABC transmembrane type-1InterPro annotationAdd BLAST280
Domaini769 – 992ABC transporterInterPro annotationAdd BLAST224
Domaini1051 – 1349ABC transmembrane type-1InterPro annotationAdd BLAST299
Domaini1384 – 1617ABC transporterInterPro annotationAdd BLAST234

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili375 – 395Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

KEGG Orthology (KO)

More...
KOi
K05674

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0A087ZZ50

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A087ZZ50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNWLINNDE QMWKWNWTEL CGYHGGIKPL NTNTHDLDVC FQQLCLQIPV
60 70 80 90 100
LTCIAIISAY HCGKRNVYSI RHYGSNYFIN LRIIITICLV ILPILRAYII
110 120 130 140 150
VTNTVLDPSS DNSIQKYIMT STKKPELLSM NSSNILHQIQ DEWNHTIDIA
160 170 180 190 200
KSILFPKNSI QNTTQSSVIT TAQEYNPIFT TIKNKITSAK PIDYLVAGTE
210 220 230 240 250
GLAWVVHLCF ILSLKKGRDF NPRGPVSIRA LILLLIVISS LLLRSHIKYN
260 270 280 290 300
PQNDVLPNLS LGFSIIVVTL LILYALTLIP GHNSLRDMRS SQYNEIGERT
310 320 330 340 350
ALLSSPNSSY VRFPEEQDPI YLGTAMEDAT ATSKLIFHWV NSLMEKGVHG
360 370 380 390 400
LLNHSDDLFD LPEYISTNTI NQKINKHLQN MADDTTNTLE NSESTLGTHV
410 420 430 440 450
HIITNKITLF KLLHKCFGWE FYSVGILKFI ADSTSFMGPL LLNKLIGFIE
460 470 480 490 500
DKNEPIMYGY LYASLIFVSA LIGAFCNTHF TFWMSVVGLK IRSTVVTLLY
510 520 530 540 550
RKILHSSNVQ LKQQFNFGEI VNFMTTDNDR VVNSCASFHA FWSIPLQLII
560 570 580 590 600
TLYLLNKQIG VSFLAGIIFA IVLIPINKVI ANQIGKFSTK LMECKDQRVR
610 620 630 640 650
LIGEILRGIT TIKLNVWEDH FLRNISKLRE NEIKYLRGRK YLDALCVYFW
660 670 680 690 700
ATTPVLISIL TFATYVLLGN KLDAKTVFTS MALLNMLIAP LNAFPWVLNG
710 720 730 740 750
LTEAWVSLKR IQRMLDLPDA DMSSYYSESP SGIDLMLQNV IFSINSNSNI
760 770 780 790 800
EQNGLNVPKG VLSPSGSSES KKTISFENND IFNLYDINIS IPKGHLVGIM
810 820 830 840 850
GEVGSGKSLL LNGILGEIIK VHGTIGVNDI EKGFAYVKQN PWLQRGTIRD
860 870 880 890 900
NILFGKSYDY NRYKNILKAC ALSADLNSLP KKDLTLIGEA GNTLSGGQKT
910 920 930 940 950
RISLARAIYA DKDIYLLDDV LATLDPKVAS YIFKHVILGL LNTKTRLLCT
960 970 980 990 1000
HQTRYLMYAN LVIEMSKGKI INQGKPSEVL SDLEDYLLSS DSIESELNTI
1010 1020 1030 1040 1050
SISDLPKEMY QANKDERDPL LDEEYKEKGK VRFGVYNCYI KAIGYYLAIS
1060 1070 1080 1090 1100
IILSMFLMQS SKNVTDLWLS YWVTHANTTV TNITDSTKTL RLEYFFDDYN
1110 1120 1130 1140 1150
MSTNYYLTVY TVLAVFNTLF TLMRAFMFAY GGIQAAISIH KQLLKIIVRA
1160 1170 1180 1190 1200
KAVFFDIQPF GRILNRFSSD IYTIDDSLPF IANILFAQLF GLIATIIIIA
1210 1220 1230 1240 1250
YGLPWILLVL APLIPVYHWI QNHYRLTSRE LKRLSSAALS PLYANFNETL
1260 1270 1280 1290 1300
YGLSTIRAFR TVARFKQENE LLLEISQKTQ FASFAVSQWL ALRLQLIGVA
1310 1320 1330 1340 1350
LLAGVSNIAV LQHQYNIADP GLIGLVITYT LSVTGLLSGV VNAFTETERE
1360 1370 1380 1390 1400
MIAVERVKQY LENVPIETIK GDNPPYAWPS QGVIEFRDVV LKYREHLVPS
1410 1420 1430 1440 1450
LNSVSFVTRP AEKIGIVGRT GAGKSSLFNS LFRLTEINSG SILIDNVNIQ
1460 1470 1480 1490 1500
SLQLNAIRSR LAIIPQNPFL FSGTIRENLD PLNQYPDLLI YKALEKCKIH
1510 1520 1530 1540 1550
SLVYRLGGLG ASLDENGSNL SAGQRQLFCL VRAILHNAKI VCIDEATANV
1560 1570 1580 1590 1600
DQETDKFIQA TIKSSFQTAT VLTIAHRIRT IMYCDRVLVM GDGEVLEFEE
1610 1620
PNLLIQNIDS YFYHLVLSQE FSDNE
Length:1,625
Mass (Da):183,339
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A64B699E1384158
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_001121775.1, XM_001121775.4
XP_016767210.1, XM_016911721.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Ame.8669

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
GB44193-RA; GB44193-PA; GB44193

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
725993

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ame:725993

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_001121775.1, XM_001121775.4
XP_016767210.1, XM_016911721.1
UniGeneiAme.8669

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7460.GB15227-PA

Proteomic databases

PaxDbiA0A087ZZ50

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiGB44193-RA; GB44193-PA; GB44193
GeneIDi725993
KEGGiame:725993

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
KOiK05674
OrthoDBi138195at2759
PhylomeDBiA0A087ZZ50

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087ZZ50_APIME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087ZZ50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: February 13, 2019
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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