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Protein

Inhibin alpha chain

Gene
N/A
Organism
Poecilia formosa (Amazon molly) (Limia formosa)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation, HormoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin alpha chainUniRule annotation
OrganismiPoecilia formosa (Amazon molly) (Limia formosa)Imported
Taxonomic identifieri48698 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesPoeciliidaePoeciliinaePoecilia
Proteomesi
  • UP000028760 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500183416024 – 345Inhibin alpha chainSequence analysisAdd BLAST322

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 345TGF_BETA_2InterPro annotationAdd BLAST120

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000005935
OrthoDBiEOG091G0CTF

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR017175 Inhibin_asu
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
PANTHERiPTHR11848 PTHR11848, 1 hit
PTHR11848:SF117 PTHR11848:SF117, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037328 Inhibin_alpha_subunit, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A087Y952-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSWSVLILG TLWIQGLLQV CSTEKLPRGV VVSWFRERVL EGLGLLEPPV
60 70 80 90 100
LAAQRANREG AKPEARQWQA RVPRTSRAVR VSQQRSLGQD RSEVILFPSP
110 120 130 140 150
DPSWILADAE WRGNCSSTPS YRFQPSIPFQ DTVVSSAHFW FYAGPTVNAS
160 170 180 190 200
PLFMLTSGQR RLQAARAPAV LSPDGWTTYD LDESVLAPVV EGPFLLQLQS
210 220 230 240 250
SDQHSLMNPD KTPFLHLHVQ PRVPVRSPRA APVNIPWSPA ALRLLQRPSY
260 270 280 290 300
ERLQLGDCRR EQVEINFQEL GWDSWIVHPK VLTFFYCRGN CSAQGRTAAL
310 320 330 340
LGMAQCCAPV PGTMRSLRIT TTSDGGYSFK YETLPNIMPE ECTCF
Length:345
Mass (Da):38,662
Last modified:November 26, 2014 - v2
Checksum:i1B6730E7C28C5FBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AYCK01011980 Genomic DNA No translation available.
RefSeqiXP_007567651.1, XM_007567589.2

Genome annotation databases

EnsembliENSPFOT00000014577; ENSPFOP00000014555; ENSPFOG00000014537
GeneIDi103148701

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AYCK01011980 Genomic DNA No translation available.
RefSeqiXP_007567651.1, XM_007567589.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPFOT00000014577; ENSPFOP00000014555; ENSPFOG00000014537
GeneIDi103148701

Organism-specific databases

CTDi3623

Phylogenomic databases

GeneTreeiENSGT00390000005935
OrthoDBiEOG091G0CTF

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR017175 Inhibin_asu
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
PANTHERiPTHR11848 PTHR11848, 1 hit
PTHR11848:SF117 PTHR11848:SF117, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037328 Inhibin_alpha_subunit, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A087Y952_POEFO
AccessioniPrimary (citable) accession number: A0A087Y952
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: November 26, 2014
Last modified: March 28, 2018
This is version 25 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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