UniProtKB - A0A087X2H1 (A0A087X2H1_HUMAN)
Protein
HECT-type E3 ubiquitin transferase
Gene
HECTD1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.26
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 2583 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: InterPro
- ubiquitin-protein transferase activity Source: InterPro
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayPROSITE-ProRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HECTD1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20157, HECTD1 |
VEuPathDBi | HostDB:ENSG00000092148.12 |
PTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
EPDi | A0A087X2H1 |
PeptideAtlasi | A0A087X2H1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000092148, Expressed in gastrocnemius and 214 other tissues |
ExpressionAtlasi | A0A087X2H1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 361 – 483 | ANK_REP_REGIONInterPro annotationAdd BLAST | 123 | |
Repeati | 395 – 427 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 426 – 458 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 1270 – 1342 | MIB/HERC2InterPro annotationAdd BLAST | 73 | |
Domaini | 2155 – 2614 | HECTInterPro annotationAdd BLAST | 460 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 246 – 269 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 489 – 513 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 627 – 657 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 707 – 748 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 1347 – 1410 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 1437 – 1487 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 1500 – 1519 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1596 – 1615 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1678 – 1761 | DisorderedSequence analysisAdd BLAST | 84 | |
Regioni | 1781 – 1801 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 2301 – 2322 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1249 – 1269 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 252 – 269 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 489 – 512 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 733 – 748 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1349 – 1405 | PolarSequence analysisAdd BLAST | 57 | |
Compositional biasi | 1437 – 1461 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1679 – 1704 | AcidicSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1705 – 1725 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1747 – 1761 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationARBA annotation, Coiled coilSequence analysis, RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156572 |
OMAi | AKQWYDL |
Family and domain databases
CDDi | cd00078, HECTc, 1 hit |
Gene3Di | 1.25.10.10, 1 hit 1.25.40.20, 1 hit 2.30.30.920, 1 hit 2.60.120.260, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011989, ARM-like IPR016024, ARM-type_fold IPR041200, FKBP3_BTHB IPR008979, Galactose-bd-like_sf IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR012919, SUN_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF18410, BTHB, 1 hit PF00632, HECT, 1 hit PF06701, MIB_HERC2, 1 hit PF07738, Sad1_UNC, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits SM00119, HECTc, 1 hit |
SUPFAMi | SSF159034, SSF159034, 1 hit SSF48371, SSF48371, 1 hit SSF48403, SSF48403, 1 hit SSF49785, SSF49785, 1 hit SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits PS50237, HECT, 1 hit PS51416, MIB_HERC2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
A0A087X2H1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP
60 70 80 90 100
RTFLPALCKI FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK
110 120 130 140 150
ALCNRLVVVE LNNRTSRDLA EQCVKVLELI CTRESGAVFE AGGLNCVLTF
160 170 180 190 200
IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ DSSLEICVES LSSLLKHEDH
210 220 230 240 250
QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM AAAGGTVSGP
260 270 280 290 300
SSACKPGRST TGAPSTTADS KLSNQVSTIV SLLSTLCRGS PVVTHDLLRS
310 320 330 340 350
ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP
360 370 380 390 400
GLRRLDSSGE RSHRQLIDCI RSKDTDALID AIDTGAFEVN FMDDVGQTLL
410 420 430 440 450
NWASAFGTQE MVEFLCERGA DVNRGQRSSS LHYAACFGRP QVAKTLLRHG
460 470 480 490 500
ANPDLRDEDG KTPLDKARER GHSEVVAILQ SPGDWMCPVN KGDDKKKKDT
510 520 530 540 550
NKDEEECNEP KGDPEMAPIY LKRLLPVFAQ TFQQTMLPSI RKASLALIRK
560 570 580 590 600
MIHFCSEALL KEVCDSDVGH NLPTILVEIT ATVLDQEDDD DGHLLALQII
610 620 630 640 650
RDLVDKGGDI FLDQLARLGV ISKVSTLAGP SSDDENEEES KPEKEDEPQE
660 670 680 690 700
DAKELQQGKP YHWRDWSIIR GRDCLYIWSD AAALELSNGS NGWFRFILDG
710 720 730 740 750
KLATMYSSGS PEGGSDSSES RSEFLEKLQR ARGQVKPSTS SQPILSAPGP
760 770 780 790 800
TKLTVGNWSL TCLKEGEIAI HNSDGQQATI LKEDLPGFVF ESNRGTKHSF
810 820 830 840 850
TAETSLGSEF VTGWTGKRGR KLKSKLEKTK QKVRTMARDL YDDHFKAVES
860 870 880 890 900
MPRGVVVTLR NIATQLESSW ELHTNRQCIE SENTWRDLMK TALENLIVLL
910 920 930 940 950
KDENTISPYE MCSSGLVQAL LTVLNNVSLS SSKEKNTVLK IISTGRKNVF
960 970 980 990 1000
KTAFSENEDD ESRPAVALIR KLIAVLESIE RLPLHLYDTP GSTYNLQILT
1010 1020 1030 1040 1050
RRLRFRLERA PGETALIDRT GRMLKMEPLA TVESLEQYLL KMVAKQWYDF
1060 1070 1080 1090 1100
DRSSFVFVRK LREGQNFIFR HQHDFDENGI IYWIGTNAKT AYEWVNPAAY
1110 1120 1130 1140 1150
GLVVVTSSEG RNLPYGRLED ILSRDNSALN CHSNDDKNAW FAIDLGLWVI
1160 1170 1180 1190 1200
PSAYTLRHAR GYGRSALRNW VFQVSKDGQN WTSLYTHVDD CSLNEPGSTA
1210 1220 1230 1240 1250
TWPLDPPKDE KQGWRHVRIK QMGKNASGQT HYLSLSGFEL YGTVNGVCED
1260 1270 1280 1290 1300
QLGKAAKEAE ANLRRQRRLV RSQVLKYMVP GARVIRGLDW KWRDQDGSPQ
1310 1320 1330 1340 1350
GEGTVTGELH NGWIDVTWDA GGSNSYRMGA EGKFDLKLAP GYDPDTVASP
1360 1370 1380 1390 1400
KPVSSTVSGT TQSWSSLVKN NCPDKTSAAA GSSSRKGSSS SVCSVASSSD
1410 1420 1430 1440 1450
ISLGSTKTER RSEIVMEHSI VSGADVHEPI VVLSSAENVP QTEVGSSSSA
1460 1470 1480 1490 1500
STSTLTAETG SENAERKLGP DSSVRTPGES SAISMGIVSV SSPDVSSVSE
1510 1520 1530 1540 1550
LTNKEAASQR PLSSSASNRL SVSSLLAAGA PMSSSASVPN LSSRETSSLE
1560 1570 1580 1590 1600
SFVRRVANIA RTNATNNMNL SRSSSDNNTN TLGRNVMSTA TSPLMGAQSF
1610 1620 1630 1640 1650
PNLTTPGTTS TVTMSTSSVT SSSNVATATT VLSVGQSLSN TLTTSLTSTS
1660 1670 1680 1690 1700
SESDTGQEAE YSLYDFLDSC RASTLLAELD DDEDLPEPDE EDDENEDDNQ
1710 1720 1730 1740 1750
EDQEYEEVMI LRRPSLQRRA GSRSDVTHHA VTSQLPQVPA GAGSRPIGEQ
1760 1770 1780 1790 1800
EEEEYETKGG RRRTWDDDYV LKRQFSALVP AFDPRPGRTN VQQTTDLEIP
1810 1820 1830 1840 1850
PPGTPHSELL EEVECTPSPR LALTLKVTGL GTTREVELPL TNFRSTIFYY
1860 1870 1880 1890 1900
VQKLLQLSCN GNVKSDKLRR IWEPTYTIMY REMKDSDKEK ENGKMGCWSI
1910 1920 1930 1940 1950
EHVEQYLGTD ELPKNDLITY LQKNADAAFL RHWKLTGTNK SIRKNRNCSQ
1960 1970 1980 1990 2000
LIAAYKDFCE HGTKSGLNQG AISTLQSSDI LNLTKEQPQA KAGNGQNSCG
2010 2020 2030 2040 2050
VEDVLQLLRI LYIVASDPYS RISQEDGDEQ PQFTFPPDEF TSKKITTKIL
2060 2070 2080 2090 2100
QQIEEPLALA SGALPDWCEQ LTSKCPFLIP FETRQLYFTC TAFGASRAIV
2110 2120 2130 2140 2150
WLQNRREATV ERTRTTSSVR RDDPGEFRVG RLKHERVKVP RGESLMEWAE
2160 2170 2180 2190 2200
NVMQIHADRK SVLEVEFLGE EGTGLGPTLE FYALVAAEFQ RTDLGAWLCD
2210 2220 2230 2240 2250
DNFPDDESRH VDLGGGLKPP GYYVQRSCGL FTAPFPQDSD ELERITKLFH
2260 2270 2280 2290 2300
FLGIFLAKCI QDNRLVDLPI SKPFFKLMCM GDIKSNMSKL IYESRGDRDL
2310 2320 2330 2340 2350
HCTESQSEAS TEEGHDSLSV GSFEEDSKSE FILDPPKPKP PAWFNGILTW
2360 2370 2380 2390 2400
EDFELVNPHR ARFLKEIKDL AIKRRQILSN KGLSEDEKNT KLQELVLKNP
2410 2420 2430 2440 2450
SGSGPPLSIE DLGLNFQFCP SSRIYGFTAV DLKPSGEDEM ITMDNAEEYV
2460 2470 2480 2490 2500
DLMFDFCMHT GIQKQMEAFR DGFNKVFPME KLSSFSHEEV QMILCGNQSP
2510 2520 2530 2540 2550
SWAAEDIINY TEPKLGYTRD SPGFLRFVRV LCGMSSDERK AFLQFTTGCS
2560 2570 2580 2590 2600
TLPPGGLANL HPRLTVVRKV DATDASYPSV NTCVHYLKLP EYSSEEIMRE
2610
RLLAATMEKG FHLN
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9ULT8 | HECD1_HUMAN | E3 ubiquitin-protein ligase HECTD1 | HECTD1 KIAA1131 | 2,610 | Annotation score: | ||
H0YJP0 | H0YJP0_HUMAN | HECT-type E3 ubiquitin transferase | HECTD1 | 1,465 | Annotation score: | ||
H0YJV8 | H0YJV8_HUMAN | E3 ubiquitin-protein ligase HECTD1 | HECTD1 | 185 | Annotation score: | ||
H0YJD4 | H0YJD4_HUMAN | E3 ubiquitin-protein ligase HECTD1 | HECTD1 | 976 | Annotation score: | ||
G3V4V5 | G3V4V5_HUMAN | E3 ubiquitin-protein ligase HECTD1 | HECTD1 | 926 | Annotation score: | ||
A0A087WVU6 | A0A087WVU6_HUMAN | E3 ubiquitin-protein ligase HECTD1 | HECTD1 | 212 | Annotation score: | ||
H0YJ72 | H0YJ72_HUMAN | E3 ubiquitin-protein ligase HECTD1 | HECTD1 | 122 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121808 Genomic DNA No translation available. AL136418 Genomic DNA No translation available. KC877516 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000611816; ENSP00000484981; ENSG00000092148 |
UCSCi | uc059anq.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121808 Genomic DNA No translation available. AL136418 Genomic DNA No translation available. KC877516 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A0A087X2H1, 1 interactor |
Proteomic databases
EPDi | A0A087X2H1 |
PeptideAtlasi | A0A087X2H1 |
Protocols and materials databases
Antibodypediai | 5457, 106 antibodies |
Genome annotation databases
Ensembli | ENST00000611816; ENSP00000484981; ENSG00000092148 |
UCSCi | uc059anq.1, human |
Organism-specific databases
HGNCi | HGNC:20157, HECTD1 |
OpenTargetsi | ENSG00000092148 |
VEuPathDBi | HostDB:ENSG00000092148.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156572 |
OMAi | AKQWYDL |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Miscellaneous databases
ChiTaRSi | HECTD1, human |
Gene expression databases
Bgeei | ENSG00000092148, Expressed in gastrocnemius and 214 other tissues |
ExpressionAtlasi | A0A087X2H1, baseline and differential |
Family and domain databases
CDDi | cd00078, HECTc, 1 hit |
Gene3Di | 1.25.10.10, 1 hit 1.25.40.20, 1 hit 2.30.30.920, 1 hit 2.60.120.260, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011989, ARM-like IPR016024, ARM-type_fold IPR041200, FKBP3_BTHB IPR008979, Galactose-bd-like_sf IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR012919, SUN_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF18410, BTHB, 1 hit PF00632, HECT, 1 hit PF06701, MIB_HERC2, 1 hit PF07738, Sad1_UNC, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits SM00119, HECTc, 1 hit |
SUPFAMi | SSF159034, SSF159034, 1 hit SSF48371, SSF48371, 1 hit SSF48403, SSF48403, 1 hit SSF49785, SSF49785, 1 hit SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits PS50237, HECT, 1 hit PS51416, MIB_HERC2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087X2H1_HUMAN | |
Accessioni | A0A087X2H1Primary (citable) accession number: A0A087X2H1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | February 10, 2021 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |