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UniProtKB - A0A087X2H1 (A0A087X2H1_HUMAN)

Entry version 56 (10 Feb 2021)
Sequence version 1 (29 Oct 2014)
Previous versions | rss
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Protein

HECT-type E3 ubiquitin transferase

Gene

HECTD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2583Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseARBA annotation
Biological processUbl conjugation pathwayPROSITE-ProRule annotationARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HECT-type E3 ubiquitin transferaseARBA annotation (EC:2.3.2.26ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HECTD1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20157, HECTD1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000092148.12

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000092148

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A0A087X2H1

PeptideAtlas

More...PeptideAtlasi		A0A087X2H1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000092148, Expressed in gastrocnemius and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A087X2H1, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A0A087X2H1, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini361 – 483ANK_REP_REGIONInterPro annotationAdd BLAST123
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati395 – 427ANKPROSITE-ProRule annotationAdd BLAST33
Repeati426 – 458ANKPROSITE-ProRule annotationAdd BLAST33
Domaini1270 – 1342MIB/HERC2InterPro annotationAdd BLAST73
Domaini2155 – 2614HECTInterPro annotationAdd BLAST460

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni246 – 269DisorderedSequence analysisAdd BLAST24
Regioni489 – 513DisorderedSequence analysisAdd BLAST25
Regioni627 – 657DisorderedSequence analysisAdd BLAST31
Regioni707 – 748DisorderedSequence analysisAdd BLAST42
Regioni1347 – 1410DisorderedSequence analysisAdd BLAST64
Regioni1437 – 1487DisorderedSequence analysisAdd BLAST51
Regioni1500 – 1519DisorderedSequence analysisAdd BLAST20
Regioni1596 – 1615DisorderedSequence analysisAdd BLAST20
Regioni1678 – 1761DisorderedSequence analysisAdd BLAST84
Regioni1781 – 1801DisorderedSequence analysisAdd BLAST21
Regioni2301 – 2322DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1249 – 1269Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi252 – 269PolarSequence analysisAdd BLAST18
Compositional biasi489 – 512PolyampholyteSequence analysisAdd BLAST24
Compositional biasi733 – 748PolarSequence analysisAdd BLAST16
Compositional biasi1349 – 1405PolarSequence analysisAdd BLAST57
Compositional biasi1437 – 1461PolarSequence analysisAdd BLAST25
Compositional biasi1679 – 1704AcidicSequence analysisAdd BLAST26
Compositional biasi1705 – 1725PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1747 – 1761PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPL family. K-HECT subfamily.ARBA annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156572

Identification of Orthologs from Complete Genome Data

More...OMAi		AKQWYDL

Family and domain databases

Conserved Domains Database

More...CDDi		cd00078, HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit
1.25.40.20, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR041200, FKBP3_BTHB
IPR008979, Galactose-bd-like_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR012919, SUN_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 1 hit
PF18410, BTHB, 1 hit
PF00632, HECT, 1 hit
PF06701, MIB_HERC2, 1 hit
PF07738, Sad1_UNC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 3 hits
SM00119, HECTc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF159034, SSF159034, 1 hit
SSF48371, SSF48371, 1 hit
SSF48403, SSF48403, 1 hit
SSF49785, SSF49785, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50237, HECT, 1 hit
PS51416, MIB_HERC2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

A0A087X2H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP 
        60         70         80         90        100
RTFLPALCKI FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK 
       110        120        130        140        150
ALCNRLVVVE LNNRTSRDLA EQCVKVLELI CTRESGAVFE AGGLNCVLTF 
       160        170        180        190        200
IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ DSSLEICVES LSSLLKHEDH 
       210        220        230        240        250
QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM AAAGGTVSGP 
       260        270        280        290        300
SSACKPGRST TGAPSTTADS KLSNQVSTIV SLLSTLCRGS PVVTHDLLRS 
       310        320        330        340        350
ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP 
       360        370        380        390        400
GLRRLDSSGE RSHRQLIDCI RSKDTDALID AIDTGAFEVN FMDDVGQTLL 
       410        420        430        440        450
NWASAFGTQE MVEFLCERGA DVNRGQRSSS LHYAACFGRP QVAKTLLRHG 
       460        470        480        490        500
ANPDLRDEDG KTPLDKARER GHSEVVAILQ SPGDWMCPVN KGDDKKKKDT 
       510        520        530        540        550
NKDEEECNEP KGDPEMAPIY LKRLLPVFAQ TFQQTMLPSI RKASLALIRK 
       560        570        580        590        600
MIHFCSEALL KEVCDSDVGH NLPTILVEIT ATVLDQEDDD DGHLLALQII 
       610        620        630        640        650
RDLVDKGGDI FLDQLARLGV ISKVSTLAGP SSDDENEEES KPEKEDEPQE 
       660        670        680        690        700
DAKELQQGKP YHWRDWSIIR GRDCLYIWSD AAALELSNGS NGWFRFILDG 
       710        720        730        740        750
KLATMYSSGS PEGGSDSSES RSEFLEKLQR ARGQVKPSTS SQPILSAPGP 
       760        770        780        790        800
TKLTVGNWSL TCLKEGEIAI HNSDGQQATI LKEDLPGFVF ESNRGTKHSF 
       810        820        830        840        850
TAETSLGSEF VTGWTGKRGR KLKSKLEKTK QKVRTMARDL YDDHFKAVES 
       860        870        880        890        900
MPRGVVVTLR NIATQLESSW ELHTNRQCIE SENTWRDLMK TALENLIVLL 
       910        920        930        940        950
KDENTISPYE MCSSGLVQAL LTVLNNVSLS SSKEKNTVLK IISTGRKNVF 
       960        970        980        990       1000
KTAFSENEDD ESRPAVALIR KLIAVLESIE RLPLHLYDTP GSTYNLQILT 
      1010       1020       1030       1040       1050
RRLRFRLERA PGETALIDRT GRMLKMEPLA TVESLEQYLL KMVAKQWYDF 
      1060       1070       1080       1090       1100
DRSSFVFVRK LREGQNFIFR HQHDFDENGI IYWIGTNAKT AYEWVNPAAY 
      1110       1120       1130       1140       1150
GLVVVTSSEG RNLPYGRLED ILSRDNSALN CHSNDDKNAW FAIDLGLWVI 
      1160       1170       1180       1190       1200
PSAYTLRHAR GYGRSALRNW VFQVSKDGQN WTSLYTHVDD CSLNEPGSTA 
      1210       1220       1230       1240       1250
TWPLDPPKDE KQGWRHVRIK QMGKNASGQT HYLSLSGFEL YGTVNGVCED 
      1260       1270       1280       1290       1300
QLGKAAKEAE ANLRRQRRLV RSQVLKYMVP GARVIRGLDW KWRDQDGSPQ 
      1310       1320       1330       1340       1350
GEGTVTGELH NGWIDVTWDA GGSNSYRMGA EGKFDLKLAP GYDPDTVASP 
      1360       1370       1380       1390       1400
KPVSSTVSGT TQSWSSLVKN NCPDKTSAAA GSSSRKGSSS SVCSVASSSD 
      1410       1420       1430       1440       1450
ISLGSTKTER RSEIVMEHSI VSGADVHEPI VVLSSAENVP QTEVGSSSSA 
      1460       1470       1480       1490       1500
STSTLTAETG SENAERKLGP DSSVRTPGES SAISMGIVSV SSPDVSSVSE 
      1510       1520       1530       1540       1550
LTNKEAASQR PLSSSASNRL SVSSLLAAGA PMSSSASVPN LSSRETSSLE 
      1560       1570       1580       1590       1600
SFVRRVANIA RTNATNNMNL SRSSSDNNTN TLGRNVMSTA TSPLMGAQSF 
      1610       1620       1630       1640       1650
PNLTTPGTTS TVTMSTSSVT SSSNVATATT VLSVGQSLSN TLTTSLTSTS 
      1660       1670       1680       1690       1700
SESDTGQEAE YSLYDFLDSC RASTLLAELD DDEDLPEPDE EDDENEDDNQ 
      1710       1720       1730       1740       1750
EDQEYEEVMI LRRPSLQRRA GSRSDVTHHA VTSQLPQVPA GAGSRPIGEQ 
      1760       1770       1780       1790       1800
EEEEYETKGG RRRTWDDDYV LKRQFSALVP AFDPRPGRTN VQQTTDLEIP 
      1810       1820       1830       1840       1850
PPGTPHSELL EEVECTPSPR LALTLKVTGL GTTREVELPL TNFRSTIFYY 
      1860       1870       1880       1890       1900
VQKLLQLSCN GNVKSDKLRR IWEPTYTIMY REMKDSDKEK ENGKMGCWSI 
      1910       1920       1930       1940       1950
EHVEQYLGTD ELPKNDLITY LQKNADAAFL RHWKLTGTNK SIRKNRNCSQ 
      1960       1970       1980       1990       2000
LIAAYKDFCE HGTKSGLNQG AISTLQSSDI LNLTKEQPQA KAGNGQNSCG 
      2010       2020       2030       2040       2050
VEDVLQLLRI LYIVASDPYS RISQEDGDEQ PQFTFPPDEF TSKKITTKIL 
      2060       2070       2080       2090       2100
QQIEEPLALA SGALPDWCEQ LTSKCPFLIP FETRQLYFTC TAFGASRAIV 
      2110       2120       2130       2140       2150
WLQNRREATV ERTRTTSSVR RDDPGEFRVG RLKHERVKVP RGESLMEWAE 
      2160       2170       2180       2190       2200
NVMQIHADRK SVLEVEFLGE EGTGLGPTLE FYALVAAEFQ RTDLGAWLCD 
      2210       2220       2230       2240       2250
DNFPDDESRH VDLGGGLKPP GYYVQRSCGL FTAPFPQDSD ELERITKLFH 
      2260       2270       2280       2290       2300
FLGIFLAKCI QDNRLVDLPI SKPFFKLMCM GDIKSNMSKL IYESRGDRDL 
      2310       2320       2330       2340       2350
HCTESQSEAS TEEGHDSLSV GSFEEDSKSE FILDPPKPKP PAWFNGILTW 
      2360       2370       2380       2390       2400
EDFELVNPHR ARFLKEIKDL AIKRRQILSN KGLSEDEKNT KLQELVLKNP 
      2410       2420       2430       2440       2450
SGSGPPLSIE DLGLNFQFCP SSRIYGFTAV DLKPSGEDEM ITMDNAEEYV 
      2460       2470       2480       2490       2500
DLMFDFCMHT GIQKQMEAFR DGFNKVFPME KLSSFSHEEV QMILCGNQSP 
      2510       2520       2530       2540       2550
SWAAEDIINY TEPKLGYTRD SPGFLRFVRV LCGMSSDERK AFLQFTTGCS 
      2560       2570       2580       2590       2600
TLPPGGLANL HPRLTVVRKV DATDASYPSV NTCVHYLKLP EYSSEEIMRE 
      2610 
RLLAATMEKG FHLN
Length:2,614
Mass (Da):289,633
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD277899CF3D4FAB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9ULT8HECD1_HUMAN
E3 ubiquitin-protein ligase HECTD1
HECTD1 KIAA1131
2,610Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJP0H0YJP0_HUMAN
HECT-type E3 ubiquitin transferase
HECTD1
1,465Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJV8H0YJV8_HUMAN
E3 ubiquitin-protein ligase HECTD1
HECTD1
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJD4H0YJD4_HUMAN
E3 ubiquitin-protein ligase HECTD1
HECTD1
976Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4V5G3V4V5_HUMAN
E3 ubiquitin-protein ligase HECTD1
HECTD1
926Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVU6A0A087WVU6_HUMAN
E3 ubiquitin-protein ligase HECTD1
HECTD1
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ72H0YJ72_HUMAN
E3 ubiquitin-protein ligase HECTD1
HECTD1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL121808 Genomic DNA No translation available.
AL136418 Genomic DNA No translation available.
KC877516 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000611816; ENSP00000484981; ENSG00000092148

UCSC genome browser

More...UCSCi		uc059anq.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121808 Genomic DNA No translation available.
AL136418 Genomic DNA No translation available.
KC877516 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiA0A087X2H1, 1 interactor

Proteomic databases

EPDiA0A087X2H1
PeptideAtlasiA0A087X2H1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		5457, 106 antibodies

Genome annotation databases

EnsembliENST00000611816; ENSP00000484981; ENSG00000092148
UCSCiuc059anq.1, human

Organism-specific databases

HGNCiHGNC:20157, HECTD1
OpenTargetsiENSG00000092148
VEuPathDBiHostDB:ENSG00000092148.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000156572
OMAiAKQWYDL

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HECTD1, human

Gene expression databases

BgeeiENSG00000092148, Expressed in gastrocnemius and 214 other tissues
ExpressionAtlasiA0A087X2H1, baseline and differential

Family and domain databases

CDDicd00078, HECTc, 1 hit
Gene3Di1.25.10.10, 1 hit
1.25.40.20, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR041200, FKBP3_BTHB
IPR008979, Galactose-bd-like_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR012919, SUN_dom
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF18410, BTHB, 1 hit
PF00632, HECT, 1 hit
PF06701, MIB_HERC2, 1 hit
PF07738, Sad1_UNC, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 3 hits
SM00119, HECTc, 1 hit
SUPFAMiSSF159034, SSF159034, 1 hit
SSF48371, SSF48371, 1 hit
SSF48403, SSF48403, 1 hit
SSF49785, SSF49785, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50237, HECT, 1 hit
PS51416, MIB_HERC2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087X2H1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087X2H1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: February 10, 2021
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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