UniProtKB - A0A087X295 (A0A087X295_HUMAN)
Protein
Submitted name:
WD repeat-containing protein 6
Gene
WDR6
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: WD repeat-containing protein 6Imported |
Gene namesi | Name:WDR6Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12758, WDR6 |
VEuPathDBi | HostDB:ENSG00000178252.17 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- protein-containing complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000178252, Expressed in oviduct epithelium and 237 other tissues |
ExpressionAtlasi | A0A087X295, baseline and differential |
Interactioni
GO - Molecular functioni
- insulin receptor substrate binding Source: Ensembl
Protein-protein interaction databases
IntActi | A0A087X295, 1 interactor |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 235 – 365 | WD_REPEATS_REGIONInterPro annotationAdd BLAST | 131 | |
Repeati | 235 – 268 | WDPROSITE-ProRule annotationAdd BLAST | 34 |
Keywords - Domaini
WD repeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00420000029923 |
OMAi | HFFTGHE |
OrthoDBi | 555109at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 4 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 3 hits |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
A0A087X295-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSAARWEGS FSREFSSLLS RGCLSTSRID MDALEDYVWP RATSELILLP
60 70 80 90 100
VTGLECVGDR LLAGEGPDVL VYSLDFGGHL RMIKRVQNLL GHYLIHGFRV
110 120 130 140 150
RPEPNGDLDL EAMVAVFGSK GLRVVKISWG QGHFWELWRS GLWNMSDWIW
160 170 180 190 200
DARWLEGNIA LALGHNSVVL YDPVVGCILQ EVPCTDRCTL SSACLIGDAW
210 220 230 240 250
KELTIVAGAV SNQLLVWYPA TALADNKPVA PDRRISGHVG IIFSMSYLES
260 270 280 290 300
KGLLATASED RSVRIWKVGD LRVPGGRVQN IGHCFGHSAR VWQVKLLENY
310 320 330 340 350
LISAGEDCVC LVWSHEGEIL QAFRGHQGRG IRAIAAHERQ AWVITGGDDS
360 370 380 390 400
GIRLWHLVGR GYRGLGVSAL CFKSRSRPGT LKAVTLAGSW RLLAVTDTGA
410 420 430 440 450
LYLYDVEVKC WEQLLEDKHF QSYCLLEAAP GPEGFGLCAM ANGEGRVKVV
460 470 480 490 500
PINTPTAAVD QTLFPGKVHS LSWALRGYEE LLLLASGPGG VVACLEISAA
510 520 530 540 550
PSGKAIFVKE RCRYLLPPSK QRWHTCSAFL PPGDFLVCGD RRGSVLLFPS
560 570 580 590 600
RPGLLKDPGV GGKARAGAGA PVVGSGSSGG GNAFTGLGPV STLPSLHGKQ
610 620 630 640 650
GVTSVTCHGG YVYTTGRDGA YYQLFVRDGQ LQPVLRQKSC RGMNWLAGLR
660 670 680 690 700
IVPDGSMVIL GFHANEFVVW NPRSHEKLHI VNCGGGHRSW AFSDTEAAMA
710 720 730 740 750
FAYLKDGDVM LYRALGGCTR PHVILREGLH GREITCVKRV GTITLGPEYG
760 770 780 790 800
VPSFMQPDDL EPGSEGPDLT DIVITCSEDT TVCVLALPTT TGSAHALTAV
810 820 830 840 850
CNHISSVRAV AVWGIGTPGG PQDPQPGLTA HVVSAGGRAE MHCFSIMVTP
860 870 880 890 900
DPSTPSRLAC HVMHLSSHRL DEYWDRQRNR HRMVKVDPET RYMSLAVCEL
910 920 930 940 950
DQPGLGPLVA AACSDGAVRL FLLQDSGRIL QLLAETFHHK RCVLKVHSFT
960 970 980 990 1000
HEAPNQRRRL LLCSAATDGS LAFWDLTTML DHDSTVLEPP VDPGLPYRLG
1010 1020 1030 1040 1050
TPSLTLQAHS CGINSLHTLP TREGHHLVAS GSEDGSLHVF VLAVEMLQLE
1060 1070 1080 1090 1100
EAVGEAGLVP QLRVLEEYSV PCAHAAHVTG LKILSPSIMV SASIDQRLTF
1110 1120 1130 1140 1150
WRLGHGEPTF MNSTVFHVPD VADMDCWPVS PEFGHRCALG GQGLEVYNWY
D
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9NNW5 | WDR6_HUMAN | WD repeat-containing protein 6 | WDR6 | 1,121 | Annotation score: | ||
E9PDU5 | E9PDU5_HUMAN | WD repeat-containing protein 6 | WDR6 | 1,070 | Annotation score: | ||
C9K020 | C9K020_HUMAN | WD repeat-containing protein 6 | WDR6 | 271 | Annotation score: | ||
V9GYU1 | V9GYU1_HUMAN | WD repeat-containing protein 6 | WDR6 | 125 | Annotation score: | ||
E9PBK6 | E9PBK6_HUMAN | WD repeat-containing protein 6 | WDR6 | 569 | Annotation score: | ||
Q6PKC6 | Q6PKC6_HUMAN | WD repeat-containing protein 6 | WDR6 | 289 | Annotation score: | ||
C9JFP6 | C9JFP6_HUMAN | WD repeat-containing protein 6 | WDR6 | 99 | Annotation score: | ||
F8WE36 | F8WE36_HUMAN | WD repeat-containing protein 6 | WDR6 | 68 | Annotation score: | ||
E5RFX3 | E5RFX3_HUMAN | WD repeat-containing protein 6 | WDR6 | 61 | Annotation score: | ||
V9GZ48 | V9GZ48_HUMAN | WD repeat-containing protein 6 | WDR6 | 31 | Annotation score: | ||
There is more potential isoformShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC137630 Genomic DNA No translation available. |
RefSeqi | NP_060501.3, NM_018031.4 |
Genome annotation databases
Ensembli | ENST00000395474; ENSP00000378857; ENSG00000178252 ENST00000610967; ENSP00000484799; ENSG00000178252 |
GeneIDi | 11180 |
KEGGi | hsa:11180 |
UCSCi | uc003cvj.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC137630 Genomic DNA No translation available. |
RefSeqi | NP_060501.3, NM_018031.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A0A087X295, 1 interactor |
Protocols and materials databases
Antibodypediai | 13436, 91 antibodies |
Genome annotation databases
Ensembli | ENST00000395474; ENSP00000378857; ENSG00000178252 ENST00000610967; ENSP00000484799; ENSG00000178252 |
GeneIDi | 11180 |
KEGGi | hsa:11180 |
UCSCi | uc003cvj.2, human |
Organism-specific databases
CTDi | 11180 |
HGNCi | HGNC:12758, WDR6 |
OpenTargetsi | ENSG00000178252 |
VEuPathDBi | HostDB:ENSG00000178252.17 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00420000029923 |
OMAi | HFFTGHE |
OrthoDBi | 555109at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11180, 14 hits in 884 CRISPR screens |
ChiTaRSi | WDR6, human |
GenomeRNAii | 11180 |
Gene expression databases
Bgeei | ENSG00000178252, Expressed in oviduct epithelium and 237 other tissues |
ExpressionAtlasi | A0A087X295, baseline and differential |
Family and domain databases
Gene3Di | 2.130.10.10, 4 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 3 hits |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087X295_HUMAN | |
Accessioni | A0A087X295Primary (citable) accession number: A0A087X295 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | February 10, 2021 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |