UniProtKB - A0A087X1S6 (A0A087X1S6_HUMAN)
Protein
Phosphatidylinositol-four-phosphate adapter protein 2
Gene
PLEKHA8
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol-four-phosphate adapter protein 2ARBA annotationAlternative name(s): Pleckstrin homology domain-containing family A member 8ARBA annotation |
Gene namesi | Name:PLEKHA8Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000106086.18 |
HGNCi | HGNC:30037, PLEKHA8 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane ARBA annotation
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Golgi apparatusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000106086, Expressed in placenta and 196 other tissues |
ExpressionAtlasi | A0A087X1S6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 93 | PHInterPro annotationAdd BLAST | 93 |
Phylogenomic databases
GeneTreei | ENSGT00940000157288 |
Family and domain databases
Gene3Di | 1.10.3520.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR036497, GLTP_sf IPR014830, Glycolipid_transfer_prot_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF08718, GLTP, 1 hit PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF110004, SSF110004, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A0A087X1S6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGVLYKWTN YLSGWQPRWF LLCGGILSYY DSPEDAWKGC KGSIQMAVCE
60 70 80 90 100
IQVHSVDNTR MDLIIPGEQY FYLKARSVAE RQRWLVALGS AKACLTDSRT
110 120 130 140 150
QKEKEFAENT ENLKTKMSEL RLYCDLLVQQ VDKTKEVTTT GVSNSEEGID
160 170 180 190 200
VGTLLKSTCN TFLKTLEECM QIANAAFTSE LLYRTPPGSP QLAMLKSSKM
210 220 230 240 250
KHPIIPIHNS LERQMELSTC ENGSLNMEIN GEEEILMKNK NSLYLKSAEI
260 270 280 290 300
DCSISSEENT DDNITVQGEI RKEDGMENLK NHDNNLTQSG SDSSCSPECL
310 320 330 340 350
WEEGKEVIPT FFSTMNTSFS DIELLEDSGI PTEAFLASCY AVVPVLDKLG
360 370 380 390 400
PTVFAPVKMD LVGNIKKVNQ KYITNKEEFT TLQKIVLHEV EADVAQVRNS
410 420 430 440 450
ATEALLWLKR GLKFLKGFLT EVKNGEKDIQ TALNNAYGKT LRQHHGWVVR
GVFAGHTNV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ96JA3 | PKHA8_HUMAN | Pleckstrin homology domain-containi... | PLEKHA8 FAPP2 | 519 | Annotation score: | ||
B5MDU3 | B5MDU3_HUMAN | Phosphatidylinositol-four-phosphate... | PLEKHA8 | 439 | Annotation score: | ||
A0A3B3IST3 | A0A3B3IST3_HUMAN | Pleckstrin homology domain-containi... | PLEKHA8 | 71 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007036 Genomic DNA No translation available. AC007285 Genomic DNA No translation available. |
RefSeqi | NP_001183956.1, NM_001197027.1 |
Genome annotation databases
Ensembli | ENST00000622102; ENSP00000484427; ENSG00000106086 |
GeneIDi | 84725 |
UCSCi | uc022aba.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007036 Genomic DNA No translation available. AC007285 Genomic DNA No translation available. |
RefSeqi | NP_001183956.1, NM_001197027.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | A0A087X1S6 |
PeptideAtlasi | A0A087X1S6 |
Protocols and materials databases
Antibodypediai | 26151, 163 antibodies |
Genome annotation databases
Ensembli | ENST00000622102; ENSP00000484427; ENSG00000106086 |
GeneIDi | 84725 |
UCSCi | uc022aba.1, human |
Organism-specific databases
CTDi | 84725 |
EuPathDBi | HostDB:ENSG00000106086.18 |
HGNCi | HGNC:30037, PLEKHA8 |
OpenTargetsi | ENSG00000106086 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157288 |
Miscellaneous databases
BioGRID-ORCSi | 84725, 7 hits in 821 CRISPR screens |
ChiTaRSi | PLEKHA8, human |
GenomeRNAii | 84725 |
Gene expression databases
Bgeei | ENSG00000106086, Expressed in placenta and 196 other tissues |
ExpressionAtlasi | A0A087X1S6, baseline and differential |
Family and domain databases
Gene3Di | 1.10.3520.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR036497, GLTP_sf IPR014830, Glycolipid_transfer_prot_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF08718, GLTP, 1 hit PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF110004, SSF110004, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087X1S6_HUMAN | |
Accessioni | A0A087X1S6Primary (citable) accession number: A0A087X1S6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | December 2, 2020 | |
This is version 43 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |