Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 38 (29 Sep 2021)
Sequence version 1 (29 Oct 2014)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Kielin/chordin-like protein

Gene

KCP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Kielin/chordin-like proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17585, KCP

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000135253

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000135253

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500183221124 – 1504Sequence analysisAdd BLAST1481

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A087X1L3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135253, Expressed in cortex of kidney and 130 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A087X1L3, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A087X1L3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini136 – 193VWFCInterPro annotationAdd BLAST58
Domaini194 – 251VWFCInterPro annotationAdd BLAST58
Domaini251 – 309VWFCInterPro annotationAdd BLAST59
Domaini365 – 424VWFCInterPro annotationAdd BLAST60
Domaini424 – 483VWFCInterPro annotationAdd BLAST60
Domaini483 – 541VWFCInterPro annotationAdd BLAST59
Domaini541 – 600VWFCInterPro annotationAdd BLAST60
Domaini603 – 661VWFCInterPro annotationAdd BLAST59
Domaini661 – 718VWFCInterPro annotationAdd BLAST58
Domaini718 – 777VWFCInterPro annotationAdd BLAST60
Domaini836 – 895VWFCInterPro annotationAdd BLAST60
Domaini895 – 953VWFCInterPro annotationAdd BLAST59
Domaini953 – 1021VWFCInterPro annotationAdd BLAST69
Domaini1018 – 1081VWFCInterPro annotationAdd BLAST64
Domaini1085 – 1145VWFCInterPro annotationAdd BLAST61
Domaini1150 – 1362VWFDInterPro annotationAdd BLAST213

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 49DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili60 – 87Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi35 – 49Polar residuesSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160243

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000367_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036084, Ser_inhib-like_sf
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00093, VWC, 8 hits
PF00094, VWD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832, C8, 1 hit
SM00214, VWC, 18 hits
SM00215, VWC_out, 7 hits
SM00216, VWD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567, SSF57567, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01208, VWFC_1, 8 hits
PS50184, VWFC_2, 15 hits
PS51233, VWFD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A087X1L3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGVGAAALS LLLHLGALAL AAGAEGGAVP REPPGQQTTA HSSVLAGNSQ
60 70 80 90 100
EQWHPLREWL GRLEAAVMEL REQNKDLQTR VRQLESCECH PASPQCWGLG
110 120 130 140 150
RAWPEGARWE PDACTACVCQ DGAAHCGPQA HLPHCRGCSQ NGQTYGNGET
160 170 180 190 200
FSPDACTTCR CLTGAVQCQG PSCSELNCLE SCTPPGECCP ICRCTEGGSH
210 220 230 240 250
WEHGQEWTTP GDPCRICRCL EGHIQCRQRE CASLCPYPAR PLPGTCCPVC
260 270 280 290 300
DGCFLNGREH RSGEPVGSGD PCSHCRCANG SVQCEPLPCP PVPCRHPGKI
310 320 330 340 350
PGQCCPVCDG CEYQGHQYQS QETFRLQERG LCVRCSCQAG EVSCEEQECP
360 370 380 390 400
VTPCALPASG RQLCPACELD GEEFAEGVQW EPDGRPCTAC VCQDGVPKCG
410 420 430 440 450
AVLCPPAPCQ HPTQPPGACC PSCDSCTYHS QVYANGQNFT DADSPCHACH
460 470 480 490 500
CQDGTVTCSL VDCPPTTCAR PQSGPGQCCP RCPDCILEEE VFVDGESFSH
510 520 530 540 550
PRDPCQECRC QEGHAHCQPR PCPRAPCAHP LPGTCCPNDC SGCAFGGKEY
560 570 580 590 600
PSGADFPHPS DPCRLCRCLS GNVQCLARRC VPLPCPEPVL LPGECCPQCP
610 620 630 640 650
APAGCPRPGA AHARHQEYFS PPGDPCRRCL CLDGSVSCQR LPCPPAPCAH
660 670 680 690 700
PRQGPCCPSC DGCLYQGKEF ASGERFPSPT AACHLCLCWE GSVSCEPKAC
710 720 730 740 750
APALCPFPAR GDCCPDCDGC EYLGESYLSN QEFPDPREPC NLCTCLGGFV
760 770 780 790 800
TCGRRPCEPP GCSHPLIPSG HCCPTCQGCR YHGVTTASGE TLPDPLDPTC
810 820 830 840 850
SLCTCQEGSM RCQKKPCPPA LCPHPSPGPC FCPVCHSCLS QGREHQDGEE
860 870 880 890 900
FEGPAGSCEW CRCQAGQVSC VRLQCPPLPC KLQVTERGSC CPRCRGCLAH
910 920 930 940 950
GEEHPEGSRW VPPDSACSSC VCHEGVVTCA RIQCISSCAQ PRQGPHDCCP
960 970 980 990 1000
QCSDCEHEGR KYEPGESFQP GADPCEVCIC EPQPEGPPSL RCHRRQCPSL
1010 1020 1030 1040 1050
VGCPPSQLLP PGPQHCCPTC AEALSNCSEG LLGSELAPPD PCYTCQCQDL
1060 1070 1080 1090 1100
TWLCIHQACP ELSCPLSERH TPPGSCCPVC RAPTQSCVHQ GREVASGERW
1110 1120 1130 1140 1150
TVDTCTSCSC MAGTVRCQSQ RCSPLSCGPD KAPALSPGSC CPRCLPRPAS
1160 1170 1180 1190 1200
CMAFGDPHYR TFDGRLLHFQ GSCSYVLAKD CHSGDFSVHV TNDDRGRSGV
1210 1220 1230 1240 1250
AWTQEVAVLL GDMAVRLLQD GAVTVDGHPV ALPFLQEPLL YVELRGHTVI
1260 1270 1280 1290 1300
LHAQPGLQVL WDGQSQVEVS VPGSYQGRTC GLCGNFNGFA QDDLQGPEGL
1310 1320 1330 1340 1350
LLPSEAAFGN SWQVSEGLWP GRPCSAGREV DPCRAAGYRA RREANARCGV
1360 1370 1380 1390 1400
LKSSPFSRCH AVVPPEPFFA ACVYDLCACG PGSSADACLC DALEAYASHC
1410 1420 1430 1440 1450
RQAGVTPTWR GPTLCVVGCP LERGFVFDEC GPPCPRTCFN QHIPLGELAA
1460 1470 1480 1490 1500
HCVRPCVPGC QCPAGLVEHE AHCIPPEACP QVLLTGDQPL GARPSPSREP

QETP
Length:1,504
Mass (Da):160,094
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD23912909F8DE494
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6ZWJ8KCP_HUMAN
Kielin/chordin-like protein
KCP CRIM2, KCP1
1,568Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVT8A0A087WVT8_HUMAN
Kielin/chordin-like protein
KCP
1,628Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXB2A0A087WXB2_HUMAN
Kielin/chordin-like protein
KCP
1,275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V446A0A7I2V446_HUMAN
Kielin/chordin-like protein
KCP
308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC025594 Genomic DNA No translation available.
KF495713 Genomic DNA No translation available.
KF510975 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000620378; ENSP00000484293; ENSG00000135253

UCSC genome browser

More...
UCSCi
uc064hwc.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025594 Genomic DNA No translation available.
KF495713 Genomic DNA No translation available.
KF510975 Genomic DNA No translation available.

3D structure databases

SMRiA0A087X1L3
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA0A087X1L3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
73205, 25 antibodies

Genome annotation databases

EnsembliENST00000620378; ENSP00000484293; ENSG00000135253
UCSCiuc064hwc.1, human

Organism-specific databases

HGNCiHGNC:17585, KCP
OpenTargetsiENSG00000135253
VEuPathDBiHostDB:ENSG00000135253

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000160243
HOGENOMiCLU_000367_0_0_1

Gene expression databases

BgeeiENSG00000135253, Expressed in cortex of kidney and 130 other tissues
ExpressionAtlasiA0A087X1L3, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036084, Ser_inhib-like_sf
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
PfamiView protein in Pfam
PF00093, VWC, 8 hits
PF00094, VWD, 1 hit
SMARTiView protein in SMART
SM00832, C8, 1 hit
SM00214, VWC, 18 hits
SM00215, VWC_out, 7 hits
SM00216, VWD, 1 hit
SUPFAMiSSF57567, SSF57567, 1 hit
PROSITEiView protein in PROSITE
PS01208, VWFC_1, 8 hits
PS50184, VWFC_2, 15 hits
PS51233, VWFD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087X1L3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087X1L3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: September 29, 2021
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again