UniProtKB - A0A087X0W8 (A0A087X0W8_HUMAN)
Protein
Submitted name:
Transcription factor p65
Gene
RELA
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- positive regulation of NF-kappaB transcription factor activity Source: InterPro
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor p65Imported |
Gene namesi | Name:RELAImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9955, RELA |
VEuPathDBi | HostDB:ENSG00000173039.18 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173039, Expressed in tibial artery and 238 other tissues |
ExpressionAtlasi | A0A087X0W8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 190 | RHDInterPro annotationAdd BLAST | 175 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 309 – 348 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 379 – 429 | DisorderedSequence analysisAdd BLAST | 51 |
Phylogenomic databases
GeneTreei | ENSGT00940000159867 |
HOGENOMi | CLU_004343_5_1_1 |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR030495, RelA IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 2 hits PTHR24169:SF1, PTHR24169:SF1, 2 hits |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All
A0A087X0W8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER
60 70 80 90 100
STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY
110 120 130 140 150
EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG
160 170 180 190 200
DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS HPIFDNRAPN TAELKICRVN
210 220 230 240 250
RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI
260 270 280 290 300
VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE
310 320 330 340 350
KRKRTYETFK SIMKKSPFSG PTDPRPPPRR IAVPSRSSAS VPKPAPQPYP
360 370 380 390 400
FTSSLSTINY DEFPTMVFPS GQISQASALA PAPPQVLPQA PAPAPAPAMV
410 420 430 440
SALAQRPPDP APAPLGAPGL PNGLLSGDED FSSIADMDFS ALLSQISS
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ04206 | TF65_HUMAN | Transcription factor p65 | RELA NFKB3 | 551 | Annotation score: | ||
Q2TAM5 | Q2TAM5_HUMAN | RELA protein | RELA | 377 | Annotation score: | ||
E9PKH5 | E9PKH5_HUMAN | Transcription factor p65 | RELA | 418 | Annotation score: | ||
E9PI38 | E9PI38_HUMAN | Transcription factor p65 | RELA | 185 | Annotation score: | ||
E9PMD5 | E9PMD5_HUMAN | Transcription factor p65 | RELA | 161 | Annotation score: | ||
E9PNK5 | E9PNK5_HUMAN | Transcription factor p65 | RELA | 85 | Annotation score: | ||
E9PJR1 | E9PJR1_HUMAN | Transcription factor p65 | RELA | 89 | Annotation score: | ||
E9PN69 | E9PN69_HUMAN | Transcription factor p65 | RELA | 134 | Annotation score: | ||
E9PNV4 | E9PNV4_HUMAN | Transcription factor p65 | RELA | 153 | Annotation score: | ||
E9PRX2 | E9PRX2_HUMAN | Transcription factor p65 | RELA | 95 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP001362 Genomic DNA No translation available. |
RefSeqi | NP_001230914.1, NM_001243985.1 |
Genome annotation databases
Ensembli | ENST00000612991; ENSP00000483705; ENSG00000173039 |
GeneIDi | 5970 |
UCSCi | uc001off.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP001362 Genomic DNA No translation available. |
RefSeqi | NP_001230914.1, NM_001243985.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A087X0W8 |
Protocols and materials databases
Antibodypediai | 3557, 3731 antibodies |
DNASUi | 5970 |
Genome annotation databases
Ensembli | ENST00000612991; ENSP00000483705; ENSG00000173039 |
GeneIDi | 5970 |
UCSCi | uc001off.4, human |
Organism-specific databases
CTDi | 5970 |
HGNCi | HGNC:9955, RELA |
OpenTargetsi | ENSG00000173039 |
VEuPathDBi | HostDB:ENSG00000173039.18 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159867 |
HOGENOMi | CLU_004343_5_1_1 |
Miscellaneous databases
BioGRID-ORCSi | 5970, 124 hits in 1019 CRISPR screens |
ChiTaRSi | RELA, human |
GenomeRNAii | 5970 |
Gene expression databases
Bgeei | ENSG00000173039, Expressed in tibial artery and 238 other tissues |
ExpressionAtlasi | A0A087X0W8, baseline and differential |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR030495, RelA IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 2 hits PTHR24169:SF1, PTHR24169:SF1, 2 hits |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087X0W8_HUMAN | |
Accessioni | A0A087X0W8Primary (citable) accession number: A0A087X0W8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | April 7, 2021 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |