Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 39 (07 Oct 2020)
Sequence version 1 (29 Oct 2014)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

CUB and sushi domain-containing protein 2

Gene

CSMD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CUB and sushi domain-containing protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSMD2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000121904.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19290, CSMD2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3515 – 3536HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000121904

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi547 ↔ 574PROSITE-ProRule annotation
Disulfide bondi893 ↔ 920PROSITE-ProRule annotation
Disulfide bondi1271 ↔ 1298PROSITE-ProRule annotation
Disulfide bondi2642 ↔ 2669PROSITE-ProRule annotation
Disulfide bondi2725 ↔ 2752PROSITE-ProRule annotation
Disulfide bondi2783 ↔ 2810PROSITE-ProRule annotation
Disulfide bondi2846 ↔ 2873PROSITE-ProRule annotation
Disulfide bondi2904 ↔ 2931PROSITE-ProRule annotation
Disulfide bondi2965 ↔ 2992PROSITE-ProRule annotation
Disulfide bondi3024 ↔ 3051PROSITE-ProRule annotation
Disulfide bondi3142 ↔ 3169PROSITE-ProRule annotation
Disulfide bondi3200 ↔ 3227PROSITE-ProRule annotation
Disulfide bondi3262 ↔ 3289PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121904, Expressed in neocortex and 154 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A087X0K4, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362479

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 134CUBInterPro annotationAdd BLAST109
Domaini137 – 198SushiInterPro annotationAdd BLAST62
Domaini202 – 306CUBInterPro annotationAdd BLAST105
Domaini341 – 402SushiInterPro annotationAdd BLAST62
Domaini405 – 516CUBInterPro annotationAdd BLAST112
Domaini519 – 576SushiInterPro annotationAdd BLAST58
Domaini578 – 686CUBInterPro annotationAdd BLAST109
Domaini689 – 750SushiInterPro annotationAdd BLAST62
Domaini752 – 860CUBInterPro annotationAdd BLAST109
Domaini865 – 922SushiInterPro annotationAdd BLAST58
Domaini924 – 1034CUBInterPro annotationAdd BLAST111
Domaini1037 – 1096SushiInterPro annotationAdd BLAST60
Domaini1098 – 1206CUBInterPro annotationAdd BLAST109
Domaini1209 – 1269SushiInterPro annotationAdd BLAST61
Domaini1271 – 1380CUBInterPro annotationAdd BLAST110
Domaini1383 – 1443SushiInterPro annotationAdd BLAST61
Domaini1445 – 1553CUBInterPro annotationAdd BLAST109
Domaini1556 – 1617SushiInterPro annotationAdd BLAST62
Domaini1619 – 1727CUBInterPro annotationAdd BLAST109
Domaini1733 – 1794SushiInterPro annotationAdd BLAST62
Domaini1796 – 1904CUBInterPro annotationAdd BLAST109
Domaini1907 – 1966SushiInterPro annotationAdd BLAST60
Domaini1968 – 2076CUBInterPro annotationAdd BLAST109
Domaini2079 – 2138SushiInterPro annotationAdd BLAST60
Domaini2140 – 2251CUBInterPro annotationAdd BLAST112
Domaini2250 – 2311SushiInterPro annotationAdd BLAST62
Domaini2313 – 2424CUBInterPro annotationAdd BLAST112
Domaini2424 – 2486SushiInterPro annotationAdd BLAST63
Domaini2487 – 2548SushiInterPro annotationAdd BLAST62
Domaini2549 – 2613SushiInterPro annotationAdd BLAST65
Domaini2614 – 2671SushiInterPro annotationAdd BLAST58
Domaini2697 – 2754SushiInterPro annotationAdd BLAST58
Domaini2755 – 2812SushiInterPro annotationAdd BLAST58
Domaini2813 – 2875SushiInterPro annotationAdd BLAST63
Domaini2876 – 2933SushiInterPro annotationAdd BLAST58
Domaini2937 – 2994SushiInterPro annotationAdd BLAST58
Domaini2995 – 3053SushiInterPro annotationAdd BLAST59
Domaini3054 – 3113SushiInterPro annotationAdd BLAST60
Domaini3114 – 3171SushiInterPro annotationAdd BLAST58
Domaini3172 – 3229SushiInterPro annotationAdd BLAST58
Domaini3233 – 3291SushiInterPro annotationAdd BLAST59
Domaini3292 – 3351SushiInterPro annotationAdd BLAST60

Keywords - Domaini

SushiPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159768

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 28 hits
cd00041, CUB, 14 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 14 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 14 hits
PF00084, Sushi, 27 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 14 hits
SSF57535, SSF57535, 28 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 14 hits
PS50923, SUSHI, 28 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A087X0K4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLISIAPGP RWQVQSHHPR SAGQNCTFQL HGPNGTVESP GFPYGYPNYA
60 70 80 90 100
NCTWTITAEE QHRIQLVFQS FALEEDFDVL SVFDGPPQPE NLRTRLTGFQ
110 120 130 140 150
LPATIVSAAT TLSLRLISDY AVSAQGFHAT YEVLPSHTCG NPGRLPNGIQ
160 170 180 190 200
QGSTFNLGDK VRYSCNLGFF LEGHAVLTCH AGSENSATWD FPLPSCRADD
210 220 230 240 250
ACGGTLRGQS GIISSPHFPS EYHNNADCTW TILAELGDTI ALVFIDFQLE
260 270 280 290 300
DGYDFLEVTG TEGSSLWFTG ASLPAPVISS KNWLRLHFTS DGNHRQRGFS
310 320 330 340 350
AQYQVKKQIE LKSRGVKLMP SKDNSQKTSV LTQVGVSQGH NMCPDPGIPE
360 370 380 390 400
RGKRLGSDFR LGSSVQFTCN EGYDLQGSKR ITCMKVSDMF AAWSDHRPVC
410 420 430 440 450
RARMCDAHLR GPSGIITSPN FPIQYDNNAH CVWIITALNP SKVIKLAFEE
460 470 480 490 500
FDLERGYDTL TVGDGGQDGD QKTVLYILTG TSVPDLIVST NHQMWLLFQT
510 520 530 540 550
DGSGSSLGFK ASYEEIEQGS CGDPGIPAYG RREGSRFHHG DTLKFECQPA
560 570 580 590 600
FELVGQKAIT CQKNNQWSAK KPGCVFSCFF NFTSPSGVVL SPNYPEDYGN
610 620 630 640 650
HLHCVWLILA RPESRIHLAF NDIDVEPQFD FLVIKDGATA EAPVLGTFSG
660 670 680 690 700
NQLPSSITSS GHVARLEFQT DHSTGKRGFN ITFTTFRHNE CPDPGVPVNG
710 720 730 740 750
KRFGDSLQLG SSISFLCDEG FLGTQGSETI TCVLKEGSVV WNSAVLRCEA
760 770 780 790 800
PCGGHLTSPS GTILSPGWPG FYKDALSCAW VIEAQPGYPI KITFDRFKTE
810 820 830 840 850
VNYDTLEVRD GRTYSAPLIG VYHGTQVPQF LISTSNYLYL LFSTDKSHSD
860 870 880 890 900
IGFQLRYETI TLQSDHCLDP GIPVNGQRHG NDFYVGALVT FSCDSGYTLS
910 920 930 940 950
DGEPLECEPN FQWSRALPSC EALCGGFIQG SSGTILSPGF PDFYPNNLNC
960 970 980 990 1000
TWIIETSHGK GVFFTFHTFH LESGHDYLLI TENGSFTQPL RQLTGSRLPA
1010 1020 1030 1040 1050
PISAGLYGNF TAQVRFISDF SMSYEGFNIT FSEYDLEPCE EPEVPAYSIR
1060 1070 1080 1090 1100
KGLQFGVGDT LTFSCFPGYR LEGTARITCL GGRRRLWSSP LPRCVAECGN
1110 1120 1130 1140 1150
SVTGTQGTLL SPNFPVNYNN NHECIYSIQT QPGKGIQLKA RAFELSEGDV
1160 1170 1180 1190 1200
LKVYDGNNNS ARLLGVFSHS EMMGVTLNST SSSLWLDFIT DAENTSKGFE
1210 1220 1230 1240 1250
LHFSSFELIK CEDPGTPKFG YKVHDEGHFA GSSVSFSCDP GYSLRGSEEL
1260 1270 1280 1290 1300
LCLSGERRTW DRPLPTCVAE CGGTVRGEVS GQVLSPGYPA PYEHNLNCIW
1310 1320 1330 1340 1350
TIEAEAGCTI GLHFLVFDTE EVHDVLRIWD GPVESGVLLK ELSGPALPKD
1360 1370 1380 1390 1400
LHSTFNSVVL QFSTDFFTSK QGFAIQFSVS TATSCNDPGI PQNGSRSGDS
1410 1420 1430 1440 1450
WEAGDSTVFQ CDPGYALQGS AEISCVKIEN RFFWQPSPPT CIAPCGGDLT
1460 1470 1480 1490 1500
GPSGVILSPN YPEPYPPGKE CDWKVTVSPD YVIALVFNIF NLEPGYDFLH
1510 1520 1530 1540 1550
IYDGRDSLSP LIGSFYGSQL PGRIESSSNS LFLAFRSDAS VSNAGFVIDY
1560 1570 1580 1590 1600
TENPRESCFD PGSIKNGTRV GSDLKLGSSV TYYCHGGYEV EGTSTLSCIL
1610 1620 1630 1640 1650
GPDGKPVWNN PRPVCTAPCG GQYVGSDGVV LSPNYPQNYT SGQICLYFVT
1660 1670 1680 1690 1700
VPKDYVVFGQ FAFFHTALND VVEVHDGHSQ HSRLLSSLSG SHTGESLPLA
1710 1720 1730 1740 1750
TSNQVLIKFS AKGLAPARGF HFVYQAVPRT SATQCSSVPE PRYGKRLGSD
1760 1770 1780 1790 1800
FSVGAIVRFE CNSGYALQGS PEIECLPVPG ALAQWNVSAP TCVVPCGGNL
1810 1820 1830 1840 1850
TERRGTILSP GFPEPYLNSL NCVWKIVVPE GAGIQIQVVS FVTEQNWDSL
1860 1870 1880 1890 1900
EVFDGADNTV TMLGSFSGTT VPALLNSTSN QLYLHFYSDI SVSAAGFHLE
1910 1920 1930 1940 1950
YKTVGLSSCP EPAVPSNGVK TGERYLVNDV VSFQCEPGYA LQGHAHISCM
1960 1970 1980 1990 2000
PGTVRRWNYP PPLCIAQCGG TVEEMEGVIL SPGFPGNYPS NMDCSWKIAL
2010 2020 2030 2040 2050
PVGFGAHIQF LNFSTEPNHD YIEIRNGPYE TSRMMGRFSG SELPSSLLST
2060 2070 2080 2090 2100
SHETTVYFHS DHSQNRPGFK LEYQAYELQE CPDPEPFANG IVRGAGYNVG
2110 2120 2130 2140 2150
QSVTFECLPG YQLTGHPVLT CQHGTNRNWD HPLPKCEVPC GGNITSSNGT
2160 2170 2180 2190 2200
VYSPGFPSPY SSSQDCVWLI TVPIGHGVRL NLSLLQTEPS GDFITIWDGP
2210 2220 2230 2240 2250
QQTAPRLGVF TRSMAKKTVQ SSSNQVLLKF HRDAATGGIF AIAFSAYPLT
2260 2270 2280 2290 2300
KCPPPTILPN AEVVTENEEF NIGDIVRYRC LPGFTLVGNE ILTCKLGTYL
2310 2320 2330 2340 2350
QFEGPPPICE VHCPTNELLT DSTGVILSQS YPGSYPQFQT CSWLVRVEPD
2360 2370 2380 2390 2400
YNISLTVEYF LSEKQYDEFE IFDGPSGQSP LLKALSGNYS APLIVTSSSN
2410 2420 2430 2440 2450
SVYLRWSSDH AYNRKGFKIR YSAPYCSLPR APLHGFILGQ TSTQPGGSIH
2460 2470 2480 2490 2500
FGCNAGYRLV GHSMAICTRH PQGYHLWSEA IPLCQALSCG LPEAPKNGMV
2510 2520 2530 2540 2550
FGKEYTVGTK AMYSCSEGYH LQAGAEATAE CLDTGLWSNR NVPPQCVPVT
2560 2570 2580 2590 2600
CPDVSSISVE HGRWRLIFET QYQFQAQLML ICDPGYYYTG QRVIRCQANG
2610 2620 2630 2640 2650
KWSLGDSTPT CRIISCGELP IPPNGHRIGT LSVYGATAIF SCNSGYTLVG
2660 2670 2680 2690 2700
SRVRECMANG LWSGSEVRCL ATQTKLHSIF YKLLFDVLSS PSLTKAGHCG
2710 2720 2730 2740 2750
TPEPIVNGHI NGENYSYRGS VVYQCNAGFR LIGMSVRICQ QDHHWSGKTP
2760 2770 2780 2790 2800
FCVPITCGHP GNPVNGLTQG NQFNLNDVVK FVCNPGYMAE GAARSQCLAS
2810 2820 2830 2840 2850
GQWSDMLPTC RIINCTDPGH QENSVRQVHA SGPHRFSFGT TVSYRCNHGF
2860 2870 2880 2890 2900
YLLGTPVLSC QGDGTWDRPR PQCLLVSCGH PGSPPHSQMS GDSYTVGAVV
2910 2920 2930 2940 2950
RYSCIGKRTL VGNSTRMCGL DGHWTGSLPH CSGTSVGVCG DPGIPAHGIR
2960 2970 2980 2990 3000
LGDSFDPGTV MRFSCEAGHV LRGSSERTCQ ANGSWSGSQP ECGVISCGNP
3010 3020 3030 3040 3050
GTPSNARVVF SDGLVFSSSI VYECREGYYA TGLLSRHCSV NGTWTGSDPE
3060 3070 3080 3090 3100
CLVINCGDPG IPANGLRLGN DFRYNKTVTY QCVPGYMMES HRVSVLSCTK
3110 3120 3130 3140 3150
DRTWNGTKPV CKALMCKPPP LIPNGKVVGS DFMWGSSVTY ACLEGYQLSL
3160 3170 3180 3190 3200
PAVFTCEGNG SWTGELPQCF PVFCGDPGVP SRGRREDRGF SYRSSVSFSC
3210 3220 3230 3240 3250
HPPLVLVGSP RRFCQSDGTW SGTQPSCIDP TLTTCADPGV PQFGIQNNSQ
3260 3270 3280 3290 3300
GYQVGSTVLF RCQKGYLLQG STTRTCLPNL TWSGTPPDCV PHHCRQPETP
3310 3320 3330 3340 3350
THANVGALDL PSMGYTLIYS CQEGFSLKGG SEHRTCKADG SWTGKPPICL
3360 3370 3380 3390 3400
EVRPSGRPIN TAREPPLTQA LIPGDVFAKN SLWKGAYEYQ GKKQPAMLRV
3410 3420 3430 3440 3450
TGFQVANSKV NATMIDHSGV ELHLAGTYKK EDFHLLLQVY QITGPVEIFM
3460 3470 3480 3490 3500
NKFKDDHWAL DGHVSSESSG ATFIYQGSVK GQGFGQFGFQ RLDLRLLESD
3510 3520 3530 3540 3550
PESIGRHFAS NSSSVAAAIL VPFIALIIAG FVLYLYKHRR RPKVPFNGYA
3560 3570 3580 3590
GHENTNVRAT FENPMYDRNI QPTDIMASEA EFTVSTVCTA V
Length:3,591
Mass (Da):391,306
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAA60D8FDED57AEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z408CSMD2_HUMAN
CUB and sushi domain-containing pro...
CSMD2 KIAA1884
3,487Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TAH7Q5TAH7_HUMAN
CUB and Sushi multiple domains 2, i...
CSMD2 hCG_2036650
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T6B5Q5T6B5_HUMAN
CUB and sushi domain-containing pro...
CSMD2
426Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC115285 Genomic DNA No translation available.
AL121980 Genomic DNA No translation available.
AL139140 Genomic DNA No translation available.
AL161643 Genomic DNA No translation available.
AL355178 Genomic DNA No translation available.
KF495903 Genomic DNA No translation available.
KF495911 Genomic DNA No translation available.
KF510204 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000619121; ENSP00000483463; ENSG00000121904

UCSC genome browser

More...
UCSCi
uc057epy.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115285 Genomic DNA No translation available.
AL121980 Genomic DNA No translation available.
AL139140 Genomic DNA No translation available.
AL161643 Genomic DNA No translation available.
AL355178 Genomic DNA No translation available.
KF495903 Genomic DNA No translation available.
KF495911 Genomic DNA No translation available.
KF510204 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000362479

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2390, 69 antibodies

Genome annotation databases

EnsembliENST00000619121; ENSP00000483463; ENSG00000121904
UCSCiuc057epy.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000121904.17
HGNCiHGNC:19290, CSMD2
OpenTargetsiENSG00000121904

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT00940000159768

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CSMD2, human

Gene expression databases

BgeeiENSG00000121904, Expressed in neocortex and 154 other tissues
ExpressionAtlasiA0A087X0K4, baseline and differential

Family and domain databases

CDDicd00033, CCP, 28 hits
cd00041, CUB, 14 hits
Gene3Di2.60.120.290, 14 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431, CUB, 14 hits
PF00084, Sushi, 27 hits
SMARTiView protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 14 hits
SUPFAMiSSF49854, SSF49854, 14 hits
SSF57535, SSF57535, 28 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 14 hits
PS50923, SUSHI, 28 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087X0K4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087X0K4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: October 7, 2020
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again