Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 42 (12 Aug 2020)
Sequence version 1 (29 Oct 2014)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Collagen alpha-1(XV) chain

Gene

COL15A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen alpha-1(XV) chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL15A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204291.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2192, COL15A1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000204291

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A0A087X0K0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204291, Expressed in placenta and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A087X0K0, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 214LAM_G_DOMAINInterPro annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni209 – 236DisorderedSequence analysisAdd BLAST28
Regioni252 – 287DisorderedSequence analysisAdd BLAST36
Regioni359 – 781DisorderedSequence analysisAdd BLAST423
Regioni813 – 850DisorderedSequence analysisAdd BLAST38
Regioni974 – 1002DisorderedSequence analysisAdd BLAST29
Regioni1015 – 1119DisorderedSequence analysisAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi361 – 383PolarSequence analysisAdd BLAST23
Compositional biasi429 – 454PolarSequence analysisAdd BLAST26
Compositional biasi514 – 528Pro-richSequence analysisAdd BLAST15
Compositional biasi605 – 619Pro-richSequence analysisAdd BLAST15
Compositional biasi636 – 650Pro-richSequence analysisAdd BLAST15
Compositional biasi701 – 718Pro-richSequence analysisAdd BLAST18
Compositional biasi727 – 741PolarSequence analysisAdd BLAST15
Compositional biasi1063 – 1096Pro-richSequence analysisAdd BLAST34

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

CollagenARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158302

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00247, Endostatin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR039070, COL15A1
IPR008160, Collagen
IPR010515, Collagenase_NC10/endostatin
IPR013320, ConA-like_dom_sf
IPR016187, CTDL_fold
IPR001791, Laminin_G

The PANTHER Classification System

More...
PANTHERi
PTHR24023:SF912, PTHR24023:SF912, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391, Collagen, 4 hits
PF06482, Endostatin, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00210, TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit
SSF56436, SSF56436, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A087X0K0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLSVSTPLP AVTQTRGATE TASQGHLDLT QLIGVPLPSS VSFVTGYGGF
60 70 80 90 100
PAYSFGPGAN VGRPARTLIP STFFRDFAIS VVVKPSSTRG GVLFAITDAF
110 120 130 140 150
QKVIYLGLRL SGVEDGHQRI ILYYTEPGSH VSQEAAAFSV PVMTHRWNRF
160 170 180 190 200
AMIVQGEEVT LLVNCEEHSR IPFQRSSQAL AFESSAGIFM GNAGATGLER
210 220 230 240 250
FTGSLQQLTV HPDPRTPEEL CDPEESSASG ETSGLQEADG VAEILEAVTY
260 270 280 290 300
TQASPKEAKV EPINTPPTPS SPFEDMELSG EPVPEGTLET TNMSIIQHSS
310 320 330 340 350
PKQGKGAILN DTLEGVHSVD GDPITDSGSG AGAFLDIAEE KNLAATAAGL
360 370 380 390 400
AEVPISTAGE AEASSVPTGG PTLSMSTENP EEGVTPGPDN EERLAATAAG
410 420 430 440 450
EAEALASMPG EVEASGVAPG ELDLSMSAQS LGEEATVGPS SEDSLTTAAA
460 470 480 490 500
ATEVSLSTFE DEEASGVPTD GLAPLTATMA PERAVTSGPG DEEDLAAATT
510 520 530 540 550
EEPLITAGGE ESGSPPPDGP PLPLPTVAPE RWITPAQREH VGMKGQAGPK
560 570 580 590 600
GEKGDAGEEL PGPPEPSGPV GPTAGAEAEG SGLGWGSDVG SGSGDLVGSE
610 620 630 640 650
QLLRGPPGPP GPPGLPGIPG KPGTDVFMGP PGSPGEDGPA GEPGPPGPEG
660 670 680 690 700
QPGVDGATGL PGMKGEKGAR GPNGSVGEKG DPGNRGLPGP PGKKGQAGPP
710 720 730 740 750
GVMGPPGPPG PPGPPGPGCT MGLGFEDTEG SGSTQLLNEP KLSRPTAAIG
760 770 780 790 800
LKGEKGDRGP KGERGMDGAS IVGPPGPRGP PGHIKVLSNS LINITHGFMN
810 820 830 840 850
FSDIPELVGP PGPDGLPGLP GFPGPRGPKG DTGLPGFPGL KGEQGEKGEP
860 870 880 890 900
GAILTEDIPL ERLMGKKGEP GMHGAPGPMG PKGPPGHKGE FGLPGRPGRP
910 920 930 940 950
GLNGLKGTKG DPGVIMQGPP GLPGPPGPPG PPGAVINIKG AIFPIPVRPH
960 970 980 990 1000
CKMPVDTAHP GSPELITFHG VKGEKGSWGL PGSKGEKGDQ GAQGPPGPPL
1010 1020 1030 1040 1050
DLAYLRHFLN NLKGENGDKG FKGEKGEKGD INGSFLMSGP PGLPGNPGPA
1060 1070 1080 1090 1100
GQKGETVVGP QGPPGAPGLP GPPGFGRPGD PGPPGPPGPP GPPAILGAAV
1110 1120 1130 1140 1150
ALPGPPGPPG QPGLPGSRNL VTAFSNMDDM LQKAHLVIEG TFIYLRDSTE
1160 1170 1180 1190 1200
FFIRVRDGWK KLQLGELIPI PADSPPPPAL SSNPHQLLPP PNPISSANYE
1210 1220 1230 1240 1250
KPALHLAALN MPFSGDIRAD FQCFKQARAA GLLSTYRAFL SSHLQDLSTI
1260 1270 1280 1290 1300
VRKAERYSLP IVNLKGQVLF NNWDSIFSGH GGQFNMHIPI YSFDGRDIMT
1310 1320 1330 1340 1350
DPSWPQKVIW HGSSPHGVRL VDNYCEAWRT ADTAVTGLAS PLSTGKILDQ
1360 1370
KAYSCANRLI VLCIENSFMT DARK
Length:1,374
Mass (Da):140,059
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5643A781AFB0369A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P39059COFA1_HUMAN
Collagen alpha-1(XV) chain
COL15A1
1,388Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136084 Genomic DNA No translation available.
AL354923 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000610452; ENSP00000483455; ENSG00000204291

UCSC genome browser

More...
UCSCi
uc064uti.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136084 Genomic DNA No translation available.
AL354923 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiA0A087X0K0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
14522, 134 antibodies

Genome annotation databases

EnsembliENST00000610452; ENSP00000483455; ENSG00000204291
UCSCiuc064uti.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000204291.10
HGNCiHGNC:2192, COL15A1
OpenTargetsiENSG00000204291

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000158302

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COL15A1, human

Gene expression databases

BgeeiENSG00000204291, Expressed in placenta and 212 other tissues
ExpressionAtlasiA0A087X0K0, baseline and differential

Family and domain databases

CDDicd00247, Endostatin-like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR039070, COL15A1
IPR008160, Collagen
IPR010515, Collagenase_NC10/endostatin
IPR013320, ConA-like_dom_sf
IPR016187, CTDL_fold
IPR001791, Laminin_G
PANTHERiPTHR24023:SF912, PTHR24023:SF912, 2 hits
PfamiView protein in Pfam
PF01391, Collagen, 4 hits
PF06482, Endostatin, 2 hits
SMARTiView protein in SMART
SM00210, TSPN, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
SSF56436, SSF56436, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087X0K0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087X0K0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: August 12, 2020
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again