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UniProtKB - A0A087X0D5 (A0A087X0D5_HUMAN)
Protein
Submitted name:
Pro-cathepsin H
Gene
CTSH
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Pro-cathepsin HImported |
Gene namesi | Name:CTSHImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2535, CTSH |
VEuPathDBi | HostDB:ENSG00000103811 |
Subcellular locationi
Lysosome
- Lysosome ARBA annotation
Cytosol
- cytosol Source: HPA
Lysosome
- lysosome Source: UniProtKB-SubCell
Other locations
- cytoplasmic ribonucleoprotein granule Source: HPA
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
LysosomeARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5029850880 | 23 – 358 | Sequence analysisAdd BLAST | 336 |
Keywords - PTMi
ZymogenARBA annotationProteomic databases
PeptideAtlasi | A0A087X0D5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000103811, Expressed in right lung and 241 other tissues |
ExpressionAtlasi | A0A087X0D5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 90 | Inhibitor_I29InterPro annotationAdd BLAST | 56 | |
Domaini | 116 – 355 | Pept_C1InterPro annotationAdd BLAST | 240 |
Sequence similaritiesi
Belongs to the peptidase C1 family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000160227 |
HOGENOMi | CLU_012184_1_1_1 |
OMAi | WMAQYNK |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 26 potential isoforms that are computationally mapped.Show allAlign All
A0A087X0D5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWATLPLLCA GAWLLGVPVC GAAELCVNSL EKFHFKSWMS KHRKTYSTEE
60 70 80 90 100
YHHRLQTFAS NWRKINAHNN GNHTFKMALN QFSDMSFAEI KHKYLWSEPQ
110 120 130 140 150
NCSATKSNYL RGTGPYPPSV DWRKKGNFVS PVKNQGACGS CWTFSTTGAL
160 170 180 190 200
ESAIAIATGK MLSLAEQQLV DCAQDFNNHG CQGGLPSQAF EYILYNKGIM
210 220 230 240 250
GEDTYPYQGK DGYCKFQPGK AIGFVKDVAN ITIQLSASCR RGYEHVLDTA
260 270 280 290 300
CVKLRRYDEE AMVEAVALYN PVSFAFEVTQ DFMMYRTGIY SSTSCHKTPD
310 320 330 340 350
KVNHAVLAVG YGEKNGIPYW IVKNSWGPQW GMNGYFLIER GKNMCGLAAC
ASYPIPLV
Computationally mapped potential isoform sequencesi
There are 26 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP09668 | CATH_HUMAN | Pro-cathepsin H | CTSH CPSB | 335 | Annotation score: | ||
A0A3B3IRM7 | A0A3B3IRM7_HUMAN | Pro-cathepsin H | CTSH | 169 | Annotation score: | ||
A0A7I2V2L7 | A0A7I2V2L7_HUMAN | Pro-cathepsin H | CTSH | 311 | Annotation score: | ||
A0A7I2V4X5 | A0A7I2V4X5_HUMAN | Pro-cathepsin H | CTSH | 367 | Annotation score: | ||
A0A7I2V2E4 | A0A7I2V2E4_HUMAN | Pro-cathepsin H | CTSH | 238 | Annotation score: | ||
A0A7I2V314 | A0A7I2V314_HUMAN | Pro-cathepsin H | CTSH | 260 | Annotation score: | ||
A0A7I2V3T9 | A0A7I2V3T9_HUMAN | Pro-cathepsin H | CTSH | 293 | Annotation score: | ||
A0A7I2V439 | A0A7I2V439_HUMAN | Pro-cathepsin H | CTSH | 240 | Annotation score: | ||
A0A7I2YQH4 | A0A7I2YQH4_HUMAN | Pro-cathepsin H | CTSH | 345 | Annotation score: | ||
A0A7I2YQE6 | A0A7I2YQE6_HUMAN | Pro-cathepsin H | CTSH | 170 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011944 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000615999; ENSP00000483303; ENSG00000103811 |
UCSCi | uc059mgn.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011944 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A087X0D5 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A087X0D5 |
Protocols and materials databases
Antibodypediai | 1041, 405 antibodies from 35 providers |
Genome annotation databases
Ensembli | ENST00000615999; ENSP00000483303; ENSG00000103811 |
UCSCi | uc059mgn.1, human |
Organism-specific databases
HGNCi | HGNC:2535, CTSH |
OpenTargetsi | ENSG00000103811 |
VEuPathDBi | HostDB:ENSG00000103811 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160227 |
HOGENOMi | CLU_012184_1_1_1 |
OMAi | WMAQYNK |
Miscellaneous databases
ChiTaRSi | CTSH, human |
Gene expression databases
Bgeei | ENSG00000103811, Expressed in right lung and 241 other tissues |
ExpressionAtlasi | A0A087X0D5, baseline and differential |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087X0D5_HUMAN | |
Accessioni | A0A087X0D5Primary (citable) accession number: A0A087X0D5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | April 7, 2021 | |
Last modified: | January 19, 2022 | |
This is version 46 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |