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Protein
Submitted name:

SH3 and multiple ankyrin repeat domains protein 2

Gene

SHANK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
SH3 and multiple ankyrin repeat domains protein 2Imported
Gene namesi
Name:SHANK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000162105.16
HGNCiHGNC:14295 SHANK2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162105

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A087WZC6

Expressioni

Gene expression databases

BgeeiENSG00000162105 Expressed in 180 organ(s), highest expression level in dorsolateral prefrontal cortex
ExpressionAtlasiA0A087WZC6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A087WZC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 98ANK_REP_REGIONInterPro annotationAdd BLAST98
Repeati12 – 44ANKPROSITE-ProRule annotationAdd BLAST33
Repeati45 – 77ANKPROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00510000046474

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All

A0A087WZC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XEHATVCCKD ENGWHEIHQA CRYGHVQHLE HLLFYGADMS AQNASGNTAL
60 70 80 90 100
HICALYNQDS CARVLLFRGG NKELKNYNSQ TPFQVAIIAG NFELAEYIKN

HKETDIGE
Length:108
Mass (Da):12,174
Last modified:October 29, 2014 - v1
Checksum:iA1095DE7EB21351F
GO

Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UPX8SHAN2_HUMAN
SH3 and multiple ankyrin repeat dom...
SHANK2 CORTBP1, KIAA1022, PROSAP1
1,470Annotation score:
A6NHU9A6NHU9_HUMAN
SH3 and multiple ankyrin repeat dom...
SHANK2
1,261Annotation score:
H7BZP8H7BZP8_HUMAN
SH3 and multiple ankyrin repeat dom...
SHANK2
212Annotation score:
H7C1X5H7C1X5_HUMAN
SH3 and multiple ankyrin repeat dom...
SHANK2
1,128Annotation score:
E7EX50E7EX50_HUMAN
SH3 and multiple ankyrin repeat dom...
SHANK2
244Annotation score:
E7EUA2E7EUA2_HUMAN
SH3 and multiple ankyrin repeat dom...
SHANK2
1,253Annotation score:
H0Y7S5H0Y7S5_HUMAN
SH3 and multiple ankyrin repeat dom...
SHANK2
257Annotation score:
H7BZV1H7BZV1_HUMAN
SH3 and multiple ankyrin repeat dom...
SHANK2
153Annotation score:
A0A0A0MSQ6A0A0A0MSQ6_HUMAN
SH3 and multiple ankyrin repeat dom...
SHANK2
1,261Annotation score:
B7ZKU9B7ZKU9_HUMAN
SH3 and multiple ankyrin repeat dom...
SHANK2
271Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC234421 Genomic DNA No translation available.
AP000590 Genomic DNA No translation available.
AP001271 Genomic DNA No translation available.
AP001648 Genomic DNA No translation available.
AP003783 Genomic DNA No translation available.
AP003967 Genomic DNA No translation available.
AP004370 Genomic DNA No translation available.
AP005401 Genomic DNA No translation available.
KF455409 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000618363; ENSP00000482553; ENSG00000162105
UCSCiuc058eue.1 human

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC234421 Genomic DNA No translation available.
AP000590 Genomic DNA No translation available.
AP001271 Genomic DNA No translation available.
AP001648 Genomic DNA No translation available.
AP003783 Genomic DNA No translation available.
AP003967 Genomic DNA No translation available.
AP004370 Genomic DNA No translation available.
AP005401 Genomic DNA No translation available.
KF455409 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A087WZC6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A087WZC6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000618363; ENSP00000482553; ENSG00000162105
UCSCiuc058eue.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000162105.16
HGNCiHGNC:14295 SHANK2
OpenTargetsiENSG00000162105
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00510000046474

Miscellaneous databases

ChiTaRSiSHANK2 human

Gene expression databases

BgeeiENSG00000162105 Expressed in 180 organ(s), highest expression level in dorsolateral prefrontal cortex
ExpressionAtlasiA0A087WZC6 baseline and differential

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A087WZC6_HUMAN
AccessioniPrimary (citable) accession number: A0A087WZC6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: September 12, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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