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Entry version 43 (29 Sep 2021)
Sequence version 1 (29 Oct 2014)
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Protein
Submitted name:

Partitioning defective 3 homolog B

Gene

PARD3B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Partitioning defective 3 homolog BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARD3BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14446, PARD3B

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000116117

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000116117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A087WYL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116117, Expressed in sural nerve and 182 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A087WYL6, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A087WYL6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini127 – 215PDZInterPro annotationAdd BLAST89
Domaini309 – 382PDZInterPro annotationAdd BLAST74
Domaini424 – 499PDZInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni63 – 91DisorderedSequence analysisAdd BLAST29
Regioni244 – 300DisorderedSequence analysisAdd BLAST57
Regioni634 – 778DisorderedSequence analysisAdd BLAST145
Regioni968 – 1062DisorderedSequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi255 – 279Polar residuesSequence analysisAdd BLAST25
Compositional biasi654 – 680Polar residuesSequence analysisAdd BLAST27
Compositional biasi693 – 708Basic residuesSequence analysisAdd BLAST16
Compositional biasi709 – 778Basic and acidic residuesSequence analysisAdd BLAST70
Compositional biasi997 – 1024Pro residuesSequence analysisAdd BLAST28
Compositional biasi1045 – 1062Polar residuesSequence analysisAdd BLAST18

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183214

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A087WYL6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LIAVFEEQEP LHKIESPSGN PADRQSPDAF ETEVAAQLAA FKPIGGEIEV
60 70 80 90 100
TPSALKLGTP LLVRRSSDPV PGPPADTQPS ASHPGGQSLK LVVPDSTQNL
110 120 130 140 150
EDREVLNGVQ TELLTSPRTK DTLSDMTRTV EISGEGGPLG IHVVPFFSSL
160 170 180 190 200
SGRILGLFIR GIEDNSRSKR EGLFHENECI VKINNVDLVD KTFAQAQDVF
210 220 230 240 250
RQAMKSPSVL LHVLPPQNRE QYEKSVIGSL NIFGNNDGVL KTKVPPPVHG
260 270 280 290 300
KSGLKTANLT GTDSPETDAS ASLQQNKSPR VPRLGGKPSS PSLSPLMGFG
310 320 330 340 350
SNKNAKKIKI DLKKGPEGLG FTVVTRDSSI HGPGPIFVKN ILPKGAAIKD
360 370 380 390 400
GRLQSGDRIL EVNGRDVTGR TQEELVAMLR STKQGETASL VIARQEGHFL
410 420 430 440 450
PRELKGEPDC CALSLETSEQ LTFEIPLNDS GSAGLGVSLK GNKSRETGTD
460 470 480 490 500
LGIFIKSIIH GGAAFKDGRL RMNDQLIAVN GESLLGKSNH EAMETLRRSM
510 520 530 540 550
SMEGNIRGMI QLVILRRPER PMEDPAECGA FSKPCFENCQ NAVTTSRRND
560 570 580 590 600
NSILHPLGTC SPQDKQKGLL LPNDGWAESE VPPSPTPHSA LGLGLEDYSH
610 620 630 640 650
SSGVDSAVYF PDQHINFRSV TPARQPESIN LKASKSMDLV PDESKVHSLA
660 670 680 690 700
GQKSDGLSDK SSHSGQGALN CESAPQGNSE LEDMENKARK VKKTKEKEKK
710 720 730 740 750
KEKGKLKVKE KKRKEENEDP ERKIKKKGFG AMLRFGKKKE DKGGKAEQKG
760 770 780 790 800
TLKHGGLREE ELEKMKEERE RIGAKHQELR EKQARGLLDY ATGAIGSVYD
810 820 830 840 850
MDDDEMDPNY ARVNHFREPC TSANVFRSPS PPRAGPFGYP RDGHPLSPER
860 870 880 890 900
DHLEGLYAKV NKPYHPLVPA DSGRPTGGST DRIQKLRKEY YQARREGFPL
910 920 930 940 950
YEDDEGRARP SEYDLLWVPG RGPDGNAHNL RFEGMERQYA SLPRGGPADP
960 970 980 990 1000
VDYLPAAPRG LYKERELPYY PGAHPMHPPK GSYPRPTELR VADLRYPQHY
1010 1020 1030 1040 1050
PPPPAPQHKG PFRQDVPPSP PQHQRMPAYQ ETGRPGPRGG SPDQYPYRTQ
1060
DSRQKNPMTA AV
Length:1,062
Mass (Da):116,531
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1818D84EF8BBC501
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8TEW8PAR3L_HUMAN
Partitioning defective 3 homolog B
PARD3B ALS2CR19, PAR3B, PAR3L
1,205Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN62R4GN62_HUMAN
Partitioning defective 3 homolog B
PARD3B
935Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1S9A0A087X1S9_HUMAN
Partitioning defective 3 homolog B
PARD3B
1,069Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZG6A0A087WZG6_HUMAN
Partitioning defective 3 homolog B
PARD3B
1,030Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC007465 Genomic DNA No translation available.
AC007736 Genomic DNA No translation available.
AC008168 Genomic DNA No translation available.
AC008171 Genomic DNA No translation available.
AC009316 Genomic DNA No translation available.
AC011750 Genomic DNA No translation available.
AC016903 Genomic DNA No translation available.
AC108468 Genomic DNA No translation available.
KF510215 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000614500; ENSP00000481918; ENSG00000116117

UCSC genome browser

More...
UCSCi
uc061rri.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007465 Genomic DNA No translation available.
AC007736 Genomic DNA No translation available.
AC008168 Genomic DNA No translation available.
AC008171 Genomic DNA No translation available.
AC009316 Genomic DNA No translation available.
AC011750 Genomic DNA No translation available.
AC016903 Genomic DNA No translation available.
AC108468 Genomic DNA No translation available.
KF510215 Genomic DNA No translation available.

3D structure databases

SMRiA0A087WYL6
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA0A087WYL6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34169, 40 antibodies

Genome annotation databases

EnsembliENST00000614500; ENSP00000481918; ENSG00000116117
UCSCiuc061rri.1, human

Organism-specific databases

HGNCiHGNC:14446, PARD3B
OpenTargetsiENSG00000116117
VEuPathDBiHostDB:ENSG00000116117

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00950000183214

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PARD3B, human

Gene expression databases

BgeeiENSG00000116117, Expressed in sural nerve and 182 other tissues
ExpressionAtlasiA0A087WYL6, baseline and differential

Family and domain databases

Gene3Di2.30.42.10, 3 hits
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF00595, PDZ, 2 hits
SMARTiView protein in SMART
SM00228, PDZ, 3 hits
SUPFAMiSSF50156, SSF50156, 3 hits
PROSITEiView protein in PROSITE
PS50106, PDZ, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087WYL6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087WYL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: September 29, 2021
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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