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UniProtKB - A0A087WYJ0 (A0A087WYJ0_HUMAN)
Protein
Submitted name:
Small conductance calcium-activated potassium channel protein 3
Gene
KCNN3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calmodulin binding Source: InterPro
- small conductance calcium-activated potassium channel activity Source: InterPro
Keywordsi
Biological process | Ion transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Small conductance calcium-activated potassium channel protein 3Imported |
Gene namesi | Name:KCNN3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6292, KCNN3 |
VEuPathDBi | HostDB:ENSG00000143603 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 283 – 302 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 314 – 337 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 454 – 478 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 505 – 526 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 538 – 558 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000143603, Expressed in hypothalamus and 201 other tissues |
ExpressionAtlasi | A0A087WYJ0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 576 – 652 | CaMBDInterPro annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 170 | DisorderedSequence analysisAdd BLAST | 170 | |
Regioni | 239 – 258 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 724 – 746 | DisorderedSequence analysisAdd BLAST | 23 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 657 – 684 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 25 – 39 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 40 – 61 | Pro residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 62 – 100 | Polar residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 107 – 153 | Polar residuesSequence analysisAdd BLAST | 47 |
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00950000182904 |
OMAi | PRRGYDI |
OrthoDBi | 907751at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004178, CaM-bd_dom IPR036122, CaM-bd_dom_sf IPR015449, K_chnl_Ca-activ_SK IPR013099, K_chnl_dom |
PANTHERi | PTHR10153, PTHR10153, 1 hit |
Pfami | View protein in Pfam PF02888, CaMBD, 1 hit PF07885, Ion_trans_2, 1 hit PF03530, SK_channel, 1 hit |
PRINTSi | PR01451, SKCHANNEL |
SMARTi | View protein in SMART SM01053, CaMBD, 1 hit |
SUPFAMi | SSF81327, SSF81327, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0A087WYJ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQQQQQQQ QPPPPAPPAA
60 70 80 90 100
PQQPLGPSLQ PQPPQLQQQQ QQQQQQQQQQ PPHPLSQLAQ LQSQPVHPGL
110 120 130 140 150
LHSSPTAFRA PPSSNSTAIL HPSSRQGSQL NLNDHLLGHS PSSTATSGPG
160 170 180 190 200
GGSRHRQASP LVHRRDSNPF TEIAMSSCKY SGGVMKPLSR LSASRRNLIE
210 220 230 240 250
AETEGQPLQL FSPSNPPEIV ISSREDNHAH QTLLHHPNAT HNHQHAGTTA
260 270 280 290 300
SSTTFPKANK RKNQNIGYKL GHRRALFEKR KRLSDYALIF GMFGIVVMVI
310 320 330 340 350
ETELSWGLYS KDSMFSLALK CLISLSTIIL LGLIIAYHTR EVQLFVIDNG
360 370 380 390 400
ADDWRIAMTY ERILYISLEM LVCAIHPIPG EYKFFWTARL AFSYTPSRAE
410 420 430 440 450
ADVDIILSIP MFLRLYLIAR VMLLHSKLFT DASSRSIGAL NKINFNTRFV
460 470 480 490 500
MKTLMTICPG TVLLVFSISL WIIAAWTVRV CESPESPAQP SGSSLPAWYH
510 520 530 540 550
DQQDVTSNFL GAMWLISITF LSIGYGDMVP HTYCGKGVCL LTGIMGAGCT
560 570 580 590 600
ALVVAVVARK LELTKAEKHV HNFMMDTQLT KRIKNAAANV LRETWLIYKH
610 620 630 640 650
TKLLKKIDHA KVRKHQRKFL QAIHQLRSVK MEQRKLSDQA NTLVDLSKMQ
660 670 680 690 700
NVMYDLITEL NDRSEDLEKQ IGSLESKLEH LTASFNSLPL LIADTLRQQQ
710 720 730 740
QQLLSAIIEA RGVSVAVGTT HTPISDSPIG VSSTSFPTPY TSSSSC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ9UGI6 | KCNN3_HUMAN | Small conductance calcium-activated... | KCNN3 K3 | 731 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL390204 Genomic DNA No translation available. AL606500 Genomic DNA No translation available. AL954342 Genomic DNA No translation available. |
RefSeqi | NP_001191016.1, NM_001204087.1 |
Genome annotation databases
Ensembli | ENST00000618040; ENSP00000481848; ENSG00000143603 |
GeneIDi | 3782 |
UCSCi | uc021pah.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL390204 Genomic DNA No translation available. AL606500 Genomic DNA No translation available. AL954342 Genomic DNA No translation available. |
RefSeqi | NP_001191016.1, NM_001204087.1 |
3D structure databases
SMRi | A0A087WYJ0 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A087WYJ0 |
Protocols and materials databases
Antibodypediai | 20402, 175 antibodies from 28 providers |
DNASUi | 3782 |
Genome annotation databases
Ensembli | ENST00000618040; ENSP00000481848; ENSG00000143603 |
GeneIDi | 3782 |
UCSCi | uc021pah.2, human |
Organism-specific databases
CTDi | 3782 |
HGNCi | HGNC:6292, KCNN3 |
OpenTargetsi | ENSG00000143603 |
VEuPathDBi | HostDB:ENSG00000143603 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182904 |
OMAi | PRRGYDI |
OrthoDBi | 907751at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3782, 5 hits in 1038 CRISPR screens |
ChiTaRSi | KCNN3, human |
GenomeRNAii | 3782 |
Gene expression databases
Bgeei | ENSG00000143603, Expressed in hypothalamus and 201 other tissues |
ExpressionAtlasi | A0A087WYJ0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR004178, CaM-bd_dom IPR036122, CaM-bd_dom_sf IPR015449, K_chnl_Ca-activ_SK IPR013099, K_chnl_dom |
PANTHERi | PTHR10153, PTHR10153, 1 hit |
Pfami | View protein in Pfam PF02888, CaMBD, 1 hit PF07885, Ion_trans_2, 1 hit PF03530, SK_channel, 1 hit |
PRINTSi | PR01451, SKCHANNEL |
SMARTi | View protein in SMART SM01053, CaMBD, 1 hit |
SUPFAMi | SSF81327, SSF81327, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087WYJ0_HUMAN | |
Accessioni | A0A087WYJ0Primary (citable) accession number: A0A087WYJ0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | January 19, 2022 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |