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Entry version 49 (22 Apr 2020)
Sequence version 1 (29 Oct 2014)
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Protein
Submitted name:

Laminin subunit alpha-2

Gene

LAMA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Laminin subunit alpha-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMA2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196569.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6482 LAMA2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000196569

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500183203823 – 3118Sequence analysisAdd BLAST3096

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi309 ↔ 318PROSITE-ProRule annotation
Disulfide bondi381 ↔ 390PROSITE-ProRule annotation
Disulfide bondi414 ↔ 426PROSITE-ProRule annotation
Disulfide bondi444 ↔ 453PROSITE-ProRule annotation
Disulfide bondi488 ↔ 497PROSITE-ProRule annotation
Disulfide bondi776 ↔ 785PROSITE-ProRule annotation
Disulfide bondi835 ↔ 844PROSITE-ProRule annotation
Disulfide bondi889 ↔ 898PROSITE-ProRule annotation
Disulfide bondi901 ↔ 915PROSITE-ProRule annotation
Disulfide bondi918 ↔ 930PROSITE-ProRule annotation
Disulfide bondi920 ↔ 937PROSITE-ProRule annotation
Disulfide bondi939 ↔ 948PROSITE-ProRule annotation
Disulfide bondi967 ↔ 979PROSITE-ProRule annotation
Disulfide bondi987 ↔ 996PROSITE-ProRule annotation
Disulfide bondi1032 ↔ 1041PROSITE-ProRule annotation
Disulfide bondi1060 ↔ 1072PROSITE-ProRule annotation
Disulfide bondi1062 ↔ 1079PROSITE-ProRule annotation
Disulfide bondi1081 ↔ 1090PROSITE-ProRule annotation
Disulfide bondi1106 ↔ 1118PROSITE-ProRule annotation
Disulfide bondi1136 ↔ 1145PROSITE-ProRule annotation
Disulfide bondi1439 ↔ 1448PROSITE-ProRule annotation
Disulfide bondi1497 ↔ 1506PROSITE-ProRule annotation
Disulfide bondi1527 ↔ 1539PROSITE-ProRule annotation
Disulfide bondi1529 ↔ 1546PROSITE-ProRule annotation
Disulfide bondi1548 ↔ 1557PROSITE-ProRule annotation
Disulfide bondi2679 ↔ 2706PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A087WYF1

PeptideAtlas

More...
PeptideAtlasi
A0A087WYF1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196569 Expressed in esophagus and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A087WYF1 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 286Laminin N-terminalInterPro annotationAdd BLAST252
Domaini287 – 343Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini344 – 413Laminin EGF-likeInterPro annotationAdd BLAST70
Domaini414 – 468Laminin EGF-likeInterPro annotationAdd BLAST55
Domaini469 – 517Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini538 – 723Laminin IV type AInterPro annotationAdd BLAST186
Domaini757 – 806Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini807 – 864Laminin EGF-likeInterPro annotationAdd BLAST58
Domaini865 – 917Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini918 – 966Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini967 – 1013Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini1014 – 1059Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1060 – 1105Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1106 – 1165Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini1180 – 1379Laminin IV type AInterPro annotationAdd BLAST200
Domaini1420 – 1468Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini1469 – 1526Laminin EGF-likeInterPro annotationAdd BLAST58
Domaini1527 – 1573Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini2145 – 2328LAM_G_DOMAINInterPro annotationAdd BLAST184
Domaini2340 – 2517LAM_G_DOMAINInterPro annotationAdd BLAST178
Domaini2522 – 2706LAM_G_DOMAINInterPro annotationAdd BLAST185
Domaini2759 – 2930LAM_G_DOMAINInterPro annotationAdd BLAST172
Domaini2935 – 3115LAM_G_DOMAINInterPro annotationAdd BLAST181

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3039 – 3059DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1633 – 1653Sequence analysisAdd BLAST21
Coiled coili1682 – 1702Sequence analysisAdd BLAST21
Coiled coili1707 – 1757Sequence analysisAdd BLAST51
Coiled coili1762 – 1785Sequence analysisAdd BLAST24
Coiled coili1811 – 1845Sequence analysisAdd BLAST35
Coiled coili1867 – 1887Sequence analysisAdd BLAST21
Coiled coili1931 – 1955Sequence analysisAdd BLAST25
Coiled coili1981 – 2008Sequence analysisAdd BLAST28
Coiled coili2034 – 2075Sequence analysisAdd BLAST42
Coiled coili2092 – 2140Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3039 – 3058PolarSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1836 Eukaryota
ENOG410XRDC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155362

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000301_0_0_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 2 hits
PF00053 Laminin_EGF, 16 hits
PF00054 Laminin_G_1, 4 hits
PF02210 Laminin_G_2, 1 hit
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 16 hits
SM00281 LamB, 2 hits
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 5 hits
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01248 EGF_LAM_1, 6 hits
PS50027 EGF_LAM_2, 15 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 2 hits
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A087WYF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGAAGVLLL LLLSGGLGGV QAQRPQQQRQ SQAHQQRGLF PAVLNLASNA
60 70 80 90 100
LITTNATCGE KGPEMYCKLV EHVPGQPVRN PQCRICNQNS SNPNQRHPIT
110 120 130 140 150
NAIDGKNTWW QSPSIKNGIE YHYVTITLDL QQVFQIAYVI VKAANSPRPG
160 170 180 190 200
NWILERSLDD VEYKPWQYHA VTDTECLTLY NIYPRTGPPS YAKDDEVICT
210 220 230 240 250
SFYSKIHPLE NGEIHISLIN GRPSADDPSP ELLEFTSARY IRLRFQRIRT
260 270 280 290 300
LNADLMMFAH KDPREIDPIV TRRYYYSVKD ISVGGMCICY GHARACPLDP
310 320 330 340 350
ATNKSRCECE HNTCGDSCDQ CCPGFHQKPW RAGTFLTKTE CEACNCHGKA
360 370 380 390 400
EECYYDENVA RRNLSLNIRG KYIGGGVCIN CTQNTAGINC ETCTDGFFRP
410 420 430 440 450
KGVSPNYPRP CQPCHCDPIG SLNEVCVKDE KHARRGLAPG SCHCKTGFGG
460 470 480 490 500
VSCDRCARGY TGYPDCKACN CSGLGSKNED PCFGPCICKE NVEGGDCSRC
510 520 530 540 550
KSGFFNLQED NWKGCDECFC SGVSNRCQSS YWTYGKIQDM SGWYLTDLPG
560 570 580 590 600
RIRVAPQQDD LDSPQQISIS NAEARQALPH SYYWSAPAPY LGNKLPAVGG
610 620 630 640 650
QLTFTISYDL EEEEEDTERV LQLMIILEGN DLSISTAQDE VYLHPSEEHT
660 670 680 690 700
NVLLLKEESF TIHGTHFPVR RKEFMTVLAN LKRVLLQITY SFGMDAIFRL
710 720 730 740 750
SSVNLESAVS YPTDGSIAAA VEVCQCPPGY TGSSCESCWP RHRRVNGTIF
760 770 780 790 800
GGICEPCQCF GHAESCDDVT GECLNCKDHT GGPYCDKCLP GFYGEPTKGT
810 820 830 840 850
SEDCQPCACP LNIPSNNFSP TCHLDRSLGL ICDGCPVGYT GPRCERCAEG
860 870 880 890 900
YFGQPSVPGG SCQPCQCNDN LDFSIPGSCD SLSGSCLICK PGTTGRYCEL
910 920 930 940 950
CADGYFGDAV DAKNCQPCRC NAGGSFSEVC HSQTGQCECR ANVQGQRCDK
960 970 980 990 1000
CKAGTFGLQS ARGCVPCNCN SFGSKSFDCE ESGQCWCQPG VTGKKCDRCA
1010 1020 1030 1040 1050
HGYFNFQEGG CTACECSHLG NNCDPKTGRC ICPPNTIGEK CSKCAPNTWG
1060 1070 1080 1090 1100
HSITTGCKAC NCSTVGSLDF QCNVNTGQCN CHPKFSGAKC TECSRGHWNY
1110 1120 1130 1140 1150
PRCNLCDCFL PGTDATTCDS ETKKCSCSDQ TGQCTCKVNV EGIHCDRCRP
1160 1170 1180 1190 1200
GKFGLDAKNP LGCSSCYCFG TTTQCSEAKG LIRTWVTLKA EQTILPLVDE
1210 1220 1230 1240 1250
ALQHTTTKGI VFQHPEIVAH MDLMREDLHL EPFYWKLPEQ FEGKKLMAYG
1260 1270 1280 1290 1300
GKLKYAIYFE AREETGFSTY NPQVIIRGGT PTHARIIVRH MAAPLIGQLT
1310 1320 1330 1340 1350
RHEIEMTEKE WKYYGDDPRV HRTVTREDFL DILYDIHYIL IKATYGNFMR
1360 1370 1380 1390 1400
QSRISEISME VAEQGRGTTM TPPADLIEKC DCPLGYSGLS CEACLPGFYR
1410 1420 1430 1440 1450
LRSQPGGRTP GPTLGTCVPC QCNGHSSLCD PETSICQNCQ HHTAGDFCER
1460 1470 1480 1490 1500
CALGYYGIVK GLPNDCQQCA CPLISSSNNF SPSCVAEGLD DYRCTACPRG
1510 1520 1530 1540 1550
YEGQYCERCA PGYTGSPGNP GGSCQECECD PYGSLPVPCD PVTGFCTCRP
1560 1570 1580 1590 1600
GATGRKCDGC KHWHAREGWE CVFCGDECTG LLLGDLARLE QMVMSINLTG
1610 1620 1630 1640 1650
PLPAPYKMLY GLENMTQELK HLLSPQRAPE RLIQLAEGNL NTLVTEMNEL
1660 1670 1680 1690 1700
LTRATKVTAD GEQTGQDAER TNTRAKSLGE FIKELARDAE AVNEKAIKLN
1710 1720 1730 1740 1750
ETLGTRDEAF ERNLEGLQKE IDQMIKELRR KNLETQKEIA EDELVAAEAL
1760 1770 1780 1790 1800
LKKVKKLFGE SRGENEEMEK DLREKLADYK NKVDDAWDLL REATDKIREA
1810 1820 1830 1840 1850
NRLFAVNQKN MTALEKKKEA VESGKRQIEN TLKEGNDILD EANRLADEIN
1860 1870 1880 1890 1900
SIIDYVEDIQ TKLPPMSEEL NDKIDDLSQE IKDRKLAEKV SQAESHAAQL
1910 1920 1930 1940 1950
NDSSAVLDGI LDEAKNISFN ATAAFKAYSN IKDYIDEAEK VAKEAKDLAH
1960 1970 1980 1990 2000
EATKLATGPR GLLKEDAKGC LQKSFRILNE AKKLANDVKE NEDHLNGLKT
2010 2020 2030 2040 2050
RIENADARNG DLLRTLNDTL GKLSAIPNDT AAKLQAVKDK ARQANDTAKD
2060 2070 2080 2090 2100
VLAQITELHQ NLDGLKKNYN KLADSVAKTN AVVKDPSKNN AVADADATVK
2110 2120 2130 2140 2150
NLEQEADRLI DKLKPIKELE DNLKKNISEI KELINQARKQ ANSIKVSVSS
2160 2170 2180 2190 2200
GGDCIRTYKP EIKKGSYNNI VVNVKTAVAD NLLFYLGSAK FIDFLAIEMR
2210 2220 2230 2240 2250
KGKVSFLWDV GSGVGRVEYP DLTIDDSYWY RIVASRTGRN GTISVRALDG
2260 2270 2280 2290 2300
PKASIVPSTH HSTSPPGYTI LDVDANAMLF VGGLTGKLKK ADAVRVITFT
2310 2320 2330 2340 2350
GCMGETYFDN KPIGLWNFRE KEGDCKGCTV SPQVEDSEGT IQFDGEGYAL
2360 2370 2380 2390 2400
VSRPIRWYPN ISTVMFKFRT FSSSALLMYL ATRDLRDFMS VELTDGHIKV
2410 2420 2430 2440 2450
SYDLGSGMAS VVSNQNHNDG KWKSFTLSRI QKQANISIVD IDTNQEENIA
2460 2470 2480 2490 2500
TSSSGNNFGL DLKADDKIYF GGLPTLRNLR PEVNLKKYSG CLKDIEISRT
2510 2520 2530 2540 2550
PYNILSSPDY VGVTKGCSLE NVYTVSFPKP GFVELSPVPI DVGTEINLSF
2560 2570 2580 2590 2600
STKNESGIIL LGSGGTPAPP RRKRRQTGQA YYAILLNRGR LEVHLSTGAR
2610 2620 2630 2640 2650
TMRKIVIRPE PNLFHDGREH SVHVERTRGI FTVQVDENRR YMQNLTVEQP
2660 2670 2680 2690 2700
IEVKKLFVGG APPEFQPSPL RNIPPFEGCI WNLVINSVPM DFARPVSFKN
2710 2720 2730 2740 2750
ADIGRCAHQK LREDEDGAAP AEIVIQPEPV PTPAFPTPTP VLTHGPCAAE
2760 2770 2780 2790 2800
SEPALLIGSK QFGLSRNSHI AIAFDDTKVK NRLTIELEVR TEAESGLLFY
2810 2820 2830 2840 2850
MARINHADFA TVQLRNGLPY FSYDLGSGDT HTMIPTKIND GQWHKIKIMR
2860 2870 2880 2890 2900
SKQEGILYVD GASNRTISPK KADILDVVGM LYVGGLPINY TTRRIGPVTY
2910 2920 2930 2940 2950
SIDGCVRNLH MAEAPADLEQ PTSSFHVGTC FANAQRGTYF DGTGFAKAVG
2960 2970 2980 2990 3000
GFKVGLDLLV EFEFRTTTTT GVLLGISSQK MDGMGIEMID EKLMFHVDNG
3010 3020 3030 3040 3050
AGRFTAVYDA GVPGHLCDGQ WHKVTANKIK HRIELTVDGN QVEAQSPNPA
3060 3070 3080 3090 3100
STSADTNDPV FVGGFPDDLK QFGLTTSIPF RGCIRSLKLT KGTGKPLEVN
3110
FAKALELRGV QPVSCPAN
Length:3,118
Mass (Da):343,418
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF02D0A799681B275
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P24043LAMA2_HUMAN
Laminin subunit alpha-2
LAMA2 LAMM
3,122Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX80A0A087WX80_HUMAN
Laminin subunit alpha-2
LAMA2
3,121Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDM5A0A2R8YDM5_HUMAN
Laminin subunit alpha-2
LAMA2
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL356124 Genomic DNA No translation available.
AL445439 Genomic DNA No translation available.
AL513527 Genomic DNA No translation available.
AL583853 Genomic DNA No translation available.
AL589927 Genomic DNA No translation available.
AL590613 Genomic DNA No translation available.
AL669984 Genomic DNA No translation available.
KF458292 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000617695; ENSP00000481744; ENSG00000196569

UCSC genome browser

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UCSCi
uc063rgw.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356124 Genomic DNA No translation available.
AL445439 Genomic DNA No translation available.
AL513527 Genomic DNA No translation available.
AL583853 Genomic DNA No translation available.
AL589927 Genomic DNA No translation available.
AL590613 Genomic DNA No translation available.
AL669984 Genomic DNA No translation available.
KF458292 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

jPOSTiA0A087WYF1
PeptideAtlasiA0A087WYF1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
763 195 antibodies

Genome annotation databases

EnsembliENST00000617695; ENSP00000481744; ENSG00000196569
UCSCiuc063rgw.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000196569.11
HGNCiHGNC:6482 LAMA2
OpenTargetsiENSG00000196569

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1836 Eukaryota
ENOG410XRDC LUCA
GeneTreeiENSGT00940000155362
HOGENOMiCLU_000301_0_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LAMA2 human

Gene expression databases

BgeeiENSG00000196569 Expressed in esophagus and 220 other tissues
ExpressionAtlasiA0A087WYF1 baseline and differential

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 2 hits
PF00053 Laminin_EGF, 16 hits
PF00054 Laminin_G_1, 4 hits
PF02210 Laminin_G_2, 1 hit
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 16 hits
SM00281 LamB, 2 hits
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit
SUPFAMiSSF49899 SSF49899, 5 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 6 hits
PS50027 EGF_LAM_2, 15 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 2 hits
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087WYF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087WYF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: April 22, 2020
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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