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Protein

tRNA pseudouridine synthase

Gene

PUS3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation
Biological processtRNA processingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthaseUniRule annotation (EC:5.4.99.-UniRule annotation)
Gene namesi
Name:PUS3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110060.8
HGNCiHGNC:25461 PUS3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110060

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A087WY59

Expressioni

Gene expression databases

BgeeiENSG00000110060
ExpressionAtlasiA0A087WY59 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A087WY59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 122PseudoU_synth_1InterPro annotationAdd BLAST119

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2554 Eukaryota
COG0101 LUCA
GeneTreeiENSGT00510000047444

Family and domain databases

Gene3Di3.30.70.660, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit

Sequencei

Sequence statusi: Complete.

A0A087WY59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYAAQKYVG THDFRNLCKM DVANGVINFQ RTILSAQVQL VGQSPGEGRW
60 70 80 90 100
QEPFQLCQFE VTGQAFLYHQ VRCMMAILFL IGQGMEKPEI IDELLNIEKN
110 120 130 140 150
PQKPQYSMAV EFPLVLYDCK FENVKWIYDQ EAQEFNITHL QQLWANHAVK
160 170 180 190 200
THMLYSMLQG LDTVPVPCGI GPKMDGMTEW GNVKPSVIKQ TSAFVEGVKM
210 220 230 240 250
RTYKPLMDRP KCQGLESRIQ HFVRRGRIEH PHLFHEEETK AKRDCNDTLE
260 270
EENTNLETPT KRVCVDTEIK SII
Length:273
Mass (Da):31,568
Last modified:October 29, 2014 - v1
Checksum:iEABA1C5D1DD83A9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000842 Genomic DNA No translation available.
RefSeqiNP_001258914.1, NM_001271985.1
UniGeneiHs.660922

Genome annotation databases

EnsembliENST00000613398; ENSP00000481536; ENSG00000110060
GeneIDi83480
UCSCiuc031qfe.2 human

Similar proteinsi

Entry informationi

Entry nameiA0A087WY59_HUMAN
AccessioniPrimary (citable) accession number: A0A087WY59
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: May 23, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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