UniProtKB - A0A087WY22 (A0A087WY22_HUMAN)
Protein
Protein-tyrosine-phosphatase
Gene
PTPRT
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.1.3.48ARBA annotation
GO - Molecular functioni
- protein tyrosine phosphatase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase, Protein phosphataseARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PTPRTImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9682, PTPRT |
VEuPathDBi | HostDB:ENSG00000196090.12 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 365 – 386 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | A0A087WY22 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196090, Expressed in middle temporal gyrus and 108 other tissues |
ExpressionAtlasi | A0A087WY22, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 101 | Fibronectin type-IIIInterPro annotationAdd BLAST | 95 | |
Domaini | 102 – 208 | Fibronectin type-IIIInterPro annotationAdd BLAST | 107 | |
Domaini | 507 – 761 | Tyrosine-protein phosphataseInterPro annotationAdd BLAST | 255 | |
Domaini | 681 – 752 | TYR_PHOSPHATASE_2InterPro annotationAdd BLAST | 72 | |
Domaini | 793 – 1055 | Tyrosine-protein phosphataseInterPro annotationAdd BLAST | 263 | |
Domaini | 969 – 1046 | TYR_PHOSPHATASE_2InterPro annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 408 – 457 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 425 – 457 | PolarSequence analysisAdd BLAST | 33 |
Keywords - Domaini
RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155326 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 2 hits 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR041201, PTPRJ_TM IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00041, fn3, 1 hit PF18861, PTP_tm, 1 hit PF00102, Y_phosphatase, 2 hits |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 2 hits SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF49265, SSF49265, 1 hit SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS00383, TYR_PHOSPHATASE_1, 2 hits PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
A0A087WY22-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
FADPVHGPQN VEIVDIRARQ LTLQWEPFGY AVTRCHSYNL TVQYQYVFNQ
60 70 80 90 100
QQYEAEEVIQ TSSHYTLRGL RPFMTIRLRL LLSNPEGRME SEELVVQTEE
110 120 130 140 150
DVPGAVPLES IQGGPFEEKI YIQWKPPNET NGVITLYEIN YKAVGSLDPS
160 170 180 190 200
ADLSSQRGKV FKLRNETHHL FVGLYPGTTY SFTIKASTAK GFGPPVTTRI
210 220 230 240 250
ATKISAPSMP EYDTDTPLNE TDTTITVMLK PAQSRGAPVS VYQLVVKEER
260 270 280 290 300
LQKSRRAADI IECFSVPVSY RNASSLDSLH YFAAELKPAN LPVTQPFTVG
310 320 330 340 350
DNKTYNGYWN PPLSPLKSYS IYFQALSKAN GETKINCVRL ATKGASTQNS
360 370 380 390 400
NTVEPEKQVD NTVKMAGVIA GLLMFIIILL GVMLTIKRRR NAYSYSYYLK
410 420 430 440 450
LAKKQKETQS GAQREMGPVA SADKPTTKLS ASRNDEGFSS SSQDVNGFTD
460 470 480 490 500
GSRGELSQPT LTIQTHPYRT CDPVEMSYPR DQFQPAIRVA DLLQHITQMK
510 520 530 540 550
RGQGYGFKEE YEALPEGQTA SWDTAKEDEN RNKNRYGNII SYDHSRVRLL
560 570 580 590 600
VLDGDPHSDY INANYIDGYH RPRHYIATQG PMQETVKDFW RMIWQENSAS
610 620 630 640 650
IVMVTNLVEV GRVKCVRYWP DDTEVYGDIK VTLIETEPLA EYVIRTFTVQ
660 670 680 690 700
KKGYHEIREL RLFHFTSWPD HGVPCYATGL LGFVRQVKFL NPPEAGPIVV
710 720 730 740 750
HCSAGAGRTG CFIAIDTMLD MAENEGVVDI FNCVRELRAQ RVNLVQTEEQ
760 770 780 790 800
YVFVHDAILE ACLCGNTAIP VCEFRSLYYN ISRLDPQTNS SQIKDEFQTL
810 820 830 840 850
NIVTPRVRPE DCSIGLLPRN HDKNRSMDVL PLDRCLPFLI SVDGESSNYI
860 870 880 890 900
NAALMDSHKQ PAAFVVTQHP LPNTVADFWR LVFDYNCSSV VMLNEMDTAQ
910 920 930 940 950
FCMQYWPEKT SGCYGPIQVE FVSADIDEDI IHRIFRICNM ARPQDGYRIV
960 970 980 990 1000
QHLQYIGWPA YRDTPPSKRS LLKVVRRLEK WQEQYDGREG RTVVHCLNGG
1010 1020 1030 1040 1050
GRSGTFCAIC SVCEMIQQQN IIDVFHIVKT LRNNKSNMVE TLEQYKFVYE
VALEYLSSF
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO14522 | PTPRT_HUMAN | Receptor-type tyrosine-protein phos... | PTPRT KIAA0283 | 1,441 | Annotation score: | ||
B1AJR9 | B1AJR9_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,451 | Annotation score: | ||
B1AJS0 | B1AJS0_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,431 | Annotation score: | ||
B1AJR8 | B1AJR8_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,450 | Annotation score: | ||
A0A075B6H0 | A0A075B6H0_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,460 | Annotation score: | ||
B1AJR6 | B1AJR6_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,440 | Annotation score: | ||
A0A087X1X2 | A0A087X1X2_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,076 | Annotation score: | ||
A0A087WWD6 | A0A087WWD6_HUMAN | Receptor-type tyrosine-protein phos... | PTPRT | 313 | Annotation score: | ||
A0A087X1J1 | A0A087X1J1_HUMAN | Receptor-type tyrosine-protein phos... | PTPRT | 47 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL022239 Genomic DNA No translation available. AL024473 Genomic DNA No translation available. AL035459 Genomic DNA No translation available. AL049812 Genomic DNA No translation available. AL109826 Genomic DNA No translation available. KF456906 Genomic DNA No translation available. KF456910 Genomic DNA No translation available. Z93942 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000612229; ENSP00000481466; ENSG00000196090 |
UCSCi | uc061xcd.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL022239 Genomic DNA No translation available. AL024473 Genomic DNA No translation available. AL035459 Genomic DNA No translation available. AL049812 Genomic DNA No translation available. AL109826 Genomic DNA No translation available. KF456906 Genomic DNA No translation available. KF456910 Genomic DNA No translation available. Z93942 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A087WY22 |
Protocols and materials databases
Antibodypediai | 2780, 107 antibodies |
Genome annotation databases
Ensembli | ENST00000612229; ENSP00000481466; ENSG00000196090 |
UCSCi | uc061xcd.1, human |
Organism-specific databases
HGNCi | HGNC:9682, PTPRT |
OpenTargetsi | ENSG00000196090 |
VEuPathDBi | HostDB:ENSG00000196090.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155326 |
Miscellaneous databases
ChiTaRSi | PTPRT, human |
Gene expression databases
Bgeei | ENSG00000196090, Expressed in middle temporal gyrus and 108 other tissues |
ExpressionAtlasi | A0A087WY22, baseline and differential |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 2 hits 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR041201, PTPRJ_TM IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00041, fn3, 1 hit PF18861, PTP_tm, 1 hit PF00102, Y_phosphatase, 2 hits |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 2 hits SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF49265, SSF49265, 1 hit SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS00383, TYR_PHOSPHATASE_1, 2 hits PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087WY22_HUMAN | |
Accessioni | A0A087WY22Primary (citable) accession number: A0A087WY22 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | February 10, 2021 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |