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UniProtKB - A0A087WXB8 (A0A087WXB8_HUMAN)
Protein
Submitted name:
ST3 beta-galactoside alpha-2,3-sialyltransferase 6, isoform CRA_b
Gene
ST3GAL6
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- sialyltransferase activity Source: InterPro
GO - Biological processi
- protein glycosylation Source: InterPro
Keywordsi
Molecular function | GlycosyltransferaseImportedARBA annotation, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: ST3 beta-galactoside alpha-2,3-sialyltransferase 6, isoform CRA_bImportedSubmitted name: Type 2 lactosamine alpha-2,3-sialyltransferaseImported |
Gene namesi | Name:ST3GAL6Imported ORF Names:hCG_18894Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18080, ST3GAL6 |
VEuPathDBi | HostDB:ENSG00000064225 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Golgi apparatus
- Golgi apparatus Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 57 – 85 | HelicalSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
Golgi apparatusARBA annotation, MembranePTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 171 ↔ 324 | UniRule annotation |
Expressioni
Gene expression databases
Bgeei | ENSG00000064225, Expressed in testis and 225 other tissues |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the glycosyltransferase 29 family.ARBA annotation
Keywords - Domaini
Signal-anchorARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000161415 |
OrthoDBi | 891104at2759 |
Family and domain databases
Gene3Di | 3.90.1480.20, 1 hit |
InterProi | View protein in InterPro IPR001675, Glyco_trans_29 IPR038578, GT29-like_sf IPR012163, Sialyl_trans |
Pfami | View protein in Pfam PF00777, Glyco_transf_29, 1 hit |
PIRSFi | PIRSF005557, Sialyl_trans, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
A0A087WXB8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWQAPRERQQ PAGAAAPQVS EPGAPLRSSL LGLGGSLLPA GFAAGLHCPG
60 70 80 90 100
EPAMRGYLVA IFLSAVFLYY VLHCILWGTN VYWVAPVEMK RRNKIQPCLS
110 120 130 140 150
KPAFASLLRF HQFHPFLCAA DFRKIASLYG SDKFDLPYGM RTSAEYFRLA
160 170 180 190 200
LSKLQSCDLF DEFDNIPCKK CVVVGNGGVL KNKTLGEKID SYDVIIRMNN
210 220 230 240 250
GPVLGHEEEV GRRTTFRLFY PESVFSDPIH NDPNTTVILT AFKPHDLRWL
260 270 280 290 300
LELLMGDKIN TNGFWKKPAL NLIYKPYQIR ILDPFIIRTA AYELLHFPKV
310 320 330 340 350
FPKNQKPKHP TTGIIAITLA FYICHEVHLA GFKYNFSDLK SPLHYYGNAT
360 370 380
MSLMNKNAYH NVTAEQLFLK DIIEKNLVIN LTQD
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9Y274 | SIA10_HUMAN | Type 2 lactosamine alpha-2,3-sialyl... | ST3GAL6 SIAT10 | 331 | Annotation score: | ||
C9J0E2 | C9J0E2_HUMAN | Type 2 lactosamine alpha-2,3-sialyl... | ST3GAL6 | 231 | Annotation score: | ||
C9J9Y4 | C9J9Y4_HUMAN | Type 2 lactosamine alpha-2,3-sialyl... | ST3GAL6 | 165 | Annotation score: | ||
C9IZL6 | C9IZL6_HUMAN | Type 2 lactosamine alpha-2,3-sialyl... | ST3GAL6 | 218 | Annotation score: | ||
C9JWJ3 | C9JWJ3_HUMAN | Type 2 lactosamine alpha-2,3-sialyl... | ST3GAL6 | 157 | Annotation score: | ||
C9J480 | C9J480_HUMAN | Type 2 lactosamine alpha-2,3-sialyl... | ST3GAL6 | 239 | Annotation score: | ||
C9JMW7 | C9JMW7_HUMAN | Type 2 lactosamine alpha-2,3-sialyl... | ST3GAL6 | 146 | Annotation score: | ||
C9JWI9 | C9JWI9_HUMAN | Type 2 lactosamine alpha-2,3-sialyl... | ST3GAL6 | 101 | Annotation score: | ||
F2Z2F4 | F2Z2F4_HUMAN | Type 2 lactosamine alpha-2,3-sialyl... | ST3GAL6 | 90 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC106728 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79851.1 |
RefSeqi | NP_001258074.1, NM_001271145.1 |
Genome annotation databases
Ensembli | ENST00000613264; ENSP00000480884; ENSG00000064225 |
GeneIDi | 10402 |
UCSCi | uc010hpd.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC106728 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79851.1 |
RefSeqi | NP_001258074.1, NM_001271145.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 35151, 59 antibodies from 23 providers |
DNASUi | 10402 |
Genome annotation databases
Ensembli | ENST00000613264; ENSP00000480884; ENSG00000064225 |
GeneIDi | 10402 |
UCSCi | uc010hpd.4, human |
Organism-specific databases
CTDi | 10402 |
HGNCi | HGNC:18080, ST3GAL6 |
OpenTargetsi | ENSG00000064225 |
VEuPathDBi | HostDB:ENSG00000064225 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161415 |
OrthoDBi | 891104at2759 |
Miscellaneous databases
BioGRID-ORCSi | 10402, 38 hits in 1070 CRISPR screens |
ChiTaRSi | ST3GAL6, human |
GenomeRNAii | 10402 |
Gene expression databases
Bgeei | ENSG00000064225, Expressed in testis and 225 other tissues |
Family and domain databases
Gene3Di | 3.90.1480.20, 1 hit |
InterProi | View protein in InterPro IPR001675, Glyco_trans_29 IPR038578, GT29-like_sf IPR012163, Sialyl_trans |
Pfami | View protein in Pfam PF00777, Glyco_transf_29, 1 hit |
PIRSFi | PIRSF005557, Sialyl_trans, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087WXB8_HUMAN | |
Accessioni | A0A087WXB8Primary (citable) accession number: A0A087WXB8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | May 25, 2022 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |