UniProtKB - A0A087WWU8 (A0A087WWU8_HUMAN)
Protein
Submitted name:
Tropomyosin alpha-3 chain
Gene
TPM3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Keywordsi
Molecular function | Actin-bindingARBA annotation, Muscle proteinARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Tropomyosin alpha-3 chainImported |
Gene namesi | Name:TPM3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12012, TPM3 |
VEuPathDBi | HostDB:ENSG00000143549.19 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Expressioni
Gene expression databases
Bgeei | ENSG00000143549, Expressed in muscle of leg and 163 other tissues |
ExpressionAtlasi | A0A087WWU8, baseline and differential |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 7 – 97 | Sequence analysisAdd BLAST | 91 | |
Coiled coili | 105 – 209 | Sequence analysisAdd BLAST | 105 |
Sequence similaritiesi
Belongs to the tropomyosin family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT01010000222381 |
Family and domain databases
InterProi | View protein in InterPro IPR000533, Tropomyosin |
Pfami | View protein in Pfam PF00261, Tropomyosin, 1 hit |
PRINTSi | PR00194, TROPOMYOSIN |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
A0A087WWU8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGITTIEAV KRKIQVLQQQ ADDAEERAER LQREVEGERR AREQAEAEVA
60 70 80 90 100
SLNRRIQLVE EELDRAQERL ATALQKLEEA EKAADESERG MKVIENRALK
110 120 130 140 150
DEEKMELQEI QLKEAKHIAE EADRKYEEVA RKLVIIEGDL ERTEERAELA
160 170 180 190 200
ESRCREMDEQ IRLMDQNLKC LSAAEEKAET RAEFAERSVA KLEKTIDDLE
210 220
DKLKCTKEEH LCTQRMLDQT LLDLNEM
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP06753 | TPM3_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 285 | Annotation score: | ||
J3KN67 | J3KN67_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 285 | Annotation score: | ||
A0A2R2Y2Q3 | A0A2R2Y2Q3_HUMAN | Tropomyosin 3 nu | TPM3 TPM3nu | 285 | Annotation score: | ||
A0A494C0P6 | A0A494C0P6_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 214 | Annotation score: | ||
Q5VU61 | Q5VU61_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 49 | Annotation score: | ||
A0A494C034 | A0A494C034_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 97 | Annotation score: | ||
A0A494C0G0 | A0A494C0G0_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 87 | Annotation score: | ||
D6R904 | D6R904_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 95 | Annotation score: | ||
D6RGJ6 | D6RGJ6_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 75 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590431 Genomic DNA No translation available. |
RefSeqi | NP_001265119.1, NM_001278190.1 |
Genome annotation databases
Ensembli | ENST00000611659; ENSP00000480520; ENSG00000143549 |
GeneIDi | 7170 |
UCSCi | uc031ppo.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590431 Genomic DNA No translation available. |
RefSeqi | NP_001265119.1, NM_001278190.1 |
3D structure databases
SMRi | A0A087WWU8 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A087WWU8 |
Protocols and materials databases
Antibodypediai | 1682, 223 antibodies |
Genome annotation databases
Ensembli | ENST00000611659; ENSP00000480520; ENSG00000143549 |
GeneIDi | 7170 |
UCSCi | uc031ppo.1, human |
Organism-specific databases
CTDi | 7170 |
HGNCi | HGNC:12012, TPM3 |
OpenTargetsi | ENSG00000143549 |
VEuPathDBi | HostDB:ENSG00000143549.19 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01010000222381 |
Miscellaneous databases
BioGRID-ORCSi | 7170, 4 hits in 872 CRISPR screens |
ChiTaRSi | TPM3, human |
GenomeRNAii | 7170 |
Gene expression databases
Bgeei | ENSG00000143549, Expressed in muscle of leg and 163 other tissues |
ExpressionAtlasi | A0A087WWU8, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000533, Tropomyosin |
Pfami | View protein in Pfam PF00261, Tropomyosin, 1 hit |
PRINTSi | PR00194, TROPOMYOSIN |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087WWU8_HUMAN | |
Accessioni | A0A087WWU8Primary (citable) accession number: A0A087WWU8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | February 10, 2021 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |