Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 51 (07 Oct 2020)
Sequence version 1 (29 Oct 2014)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Protocadherin Fat 1

Gene

FAT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protocadherin Fat 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAT1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000083857.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3595, FAT1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4184 – 4204HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000083857

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500183197922 – 4590Sequence analysisAdd BLAST4569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3801 ↔ 3818PROSITE-ProRule annotation
Disulfide bondi4042 ↔ 4051PROSITE-ProRule annotation
Disulfide bondi4080 ↔ 4089PROSITE-ProRule annotation
Disulfide bondi4117 ↔ 4126PROSITE-ProRule annotation
Disulfide bondi4155 ↔ 4164PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A0A087WVP1

PeptideAtlas

More...
PeptideAtlasi
A0A087WVP1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000083857, Expressed in epithelium of mammary gland and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A087WVP1, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3792 – 3829EGF-likeInterPro annotationAdd BLAST38
Domaini3831 – 4011LAM_G_DOMAINInterPro annotationAdd BLAST181
Domaini4015 – 4052EGF-likeInterPro annotationAdd BLAST38
Domaini4054 – 4090EGF-likeInterPro annotationAdd BLAST37
Domaini4091 – 4127EGF-likeInterPro annotationAdd BLAST37
Domaini4129 – 4165EGF-likeInterPro annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4257 – 4277DisorderedSequence analysisAdd BLAST21
Regioni4305 – 4329DisorderedSequence analysisAdd BLAST25
Regioni4345 – 4378DisorderedSequence analysisAdd BLAST34
Regioni4437 – 4481DisorderedSequence analysisAdd BLAST45
Regioni4567 – 4590DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4257 – 4275PolarSequence analysisAdd BLAST19
Compositional biasi4358 – 4378PolarSequence analysisAdd BLAST21
Compositional biasi4437 – 4452Pro-richSequence analysisAdd BLAST16

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157733

Identification of Orthologs from Complete Genome Data

More...
OMAi
GRRCEYG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0A087WVP1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028, Cadherin, 29 hits
PF00008, EGF, 2 hits
PF02210, Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112, CA, 34 hits
SM00181, EGF, 5 hits
SM00179, EGF_CA, 4 hits
SM00282, LamG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313, SSF49313, 33 hits
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00232, CADHERIN_1, 13 hits
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 1 hit
PS50025, LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A087WVP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRHLALLLL LLLLFQHFGD SDGSQRLEQT PLQFTHLEYN VTVQENSAAK
60 70 80 90 100
TYVGHPVKMG VYITHPAWEV RYKIVSGDSE NLFKAEEYIL GDFCFLRIRT
110 120 130 140 150
KGGNTAILNR EVKDHYTLIV KALEKNTNVE ARTKVRVQVL DTNDLRPLFS
160 170 180 190 200
PTSYSVSLPE NTAIRTSIAR VSATDADIGT NGEFYYSFKD RTDMFAIHPT
210 220 230 240 250
SGVIVLTGRL DYLETKLYEM EILAADRGMK LYGSSGISSM AKLTVHIEQA
260 270 280 290 300
NECAPVITAV TLSPSELDRD PAYAIVTVDD CDQGANGDIA SLSIVAGDLL
310 320 330 340 350
QQFRTVRSFP GSKEYKVKAI GGIDWDSHPF GYNLTLQAKD KGTPPQFSSV
360 370 380 390 400
KVIHVTSPQF KAGPVKFEKD VYRAEISEFA PPNTPVVMVK AIPAYSHLRY
410 420 430 440 450
VFKSTPGKAK FSLNYNTGLI SILEPVKRQQ AAHFELEVTT SDRKASTKVL
460 470 480 490 500
VKVLGANSNP PEFTQTAYKA AFDENVPIGT TVMSLSAVDP DEGENGYVTY
510 520 530 540 550
SIANLNHVPF AIDHFTGAVS TSENLDYELM PRVYTLRIRA SDWGLPYRRE
560 570 580 590 600
VEVLATITLN NLNDNTPLFE KINCEGTIPR DLGVGEQITT VSAIDADELQ
610 620 630 640 650
LVQYQIEAGN ELDFFSLNPN SGVLSLKRSL MDGLGAKVSF HSLRITATDG
660 670 680 690 700
ENFATPLYIN ITVAASHKLV NLQCEETGVA KMLAEKLLQA NKLHNQGEVE
710 720 730 740 750
DIFFDSHSVN AHIPQFRSTL PTGIQVKENQ PVGSSVIFMN STDLDTGFNG
760 770 780 790 800
KLVYAVSGGN EDSCFMIDME TGMLKILSPL DRETTDKYTL NITVYDLGIP
810 820 830 840 850
QKAAWRLLHV VVVDANDNPP EFLQESYFVE VSEDKEVHSE IIQVEATDKD
860 870 880 890 900
LGPNGHVTYS IVTDTDTFSI DSVTGVVNIA RPLDRELQHE HSLKIEARDQ
910 920 930 940 950
AREEPQLFST VVVKVSLEDV NDNPPTFIPP NYRVKVREDL PEGTVIMWLE
960 970 980 990 1000
AHDPDLGQSG QVRYSLLDHG EGNFDVDKLS GAVRIVQQLD FEKKQVYNLT
1010 1020 1030 1040 1050
VRAKDKGKPV SLSSTCYVEV EVVDVNENLH PPVFSSFVEK GTVKEDAPVG
1060 1070 1080 1090 1100
SLVMTVSAHD EDARRDGEIR YSIRDGSGVG VFKIGEETGV IETSDRLDRE
1110 1120 1130 1140 1150
STSHYWLTVF ATDQGVVPLS SFIEIYIEVE DVNDNAPQTS EPVYYPEIME
1160 1170 1180 1190 1200
NSPKDVSVVQ IEAFDPDSSS NDKLMYKITS GNPQGFFSIH PKTGLITTTS
1210 1220 1230 1240 1250
RKLDREQQDE HILEVTVTDN GSPPKSTIAR VIVKILDEND NKPQFLQKFY
1260 1270 1280 1290 1300
KIRLPEREKP DRERNARREP LYHVIATDKD EGPNAEISYS IEDGNEHGKF
1310 1320 1330 1340 1350
FIEPKTGVVS SKRFSAAGEY DILSIKAVDN GRPQKSSTTR LHIEWISKPK
1360 1370 1380 1390 1400
PSLEPISFEE SFFTFTVMES DPVAHMIGVI SVEPPGIPLW FDITGGNYDS
1410 1420 1430 1440 1450
HFDVDKGTGT IIVAKPLDAE QKSNYNLTVE ATDGTTTILT QVFIKVIDTN
1460 1470 1480 1490 1500
DHRPQFSTSK YEVVIPEDTA PETEILQISA VDQDEKNKLI YTLQSSRDPL
1510 1520 1530 1540 1550
SLKKFRLDPA TGSLYTSEKL DHEAVPAHLT VMVRDQDVPV KRNFARIVVN
1560 1570 1580 1590 1600
VSDTNDHAPW FTASSYKGRV YESAAVGSVV LQVTALDKDK GKNAEVLYSI
1610 1620 1630 1640 1650
ESGTFGNIGN SFMIDPVLGS IKTAKELDRS NQAEYDLMVK ATDKGSPPMS
1660 1670 1680 1690 1700
EITSVRIFVT IADNASPKFT SKEYSVELSE TVSIGSFVGM VTAHSQSSVV
1710 1720 1730 1740 1750
YEIKDGNTGD AFDINPHSGT IITQKALDFE TLPIYTLIIQ GTNMAGLSTN
1760 1770 1780 1790 1800
TTVLVHLQDE NDNAPVFMQA EYTGLISESA SINSVVLTDR NVPLVIRAAD
1810 1820 1830 1840 1850
ADKDSNALLV YHIVEPSVHT YFAIDSSTGA IHTVLSLDYE ETSIFHFTVQ
1860 1870 1880 1890 1900
VHDMGTPRLF AEYAANVTVH VIDINDCPPV FAKPLYEASL LLPTYKGVKV
1910 1920 1930 1940 1950
ITVNATDADS SAFSQLIYSI TEGNIGEKFS MDYKTGALTV QNTTQLRSRY
1960 1970 1980 1990 2000
ELTVRASDGR FAGLTSVKIN VKESKESHLK FTQDVYSAVV KENSTEAETL
2010 2020 2030 2040 2050
AVITAIGNPI NEPLFYHILN PDRRFKISRT SGVLSTTGTP FDREQQEAFD
2060 2070 2080 2090 2100
VVVEVTEEHK PSAVAHVVVK VIVEDQNDNA PVFVNLPYYA VVKVDTEVGH
2110 2120 2130 2140 2150
VIRYVTAVDR DSGRNGEVHY YLKEHHEHFQ IGPLGEISLK KQFELDTLNK
2160 2170 2180 2190 2200
EYLVTVVAKD GGNPAFSAEV IVPITVMNKA MPVFEKPFYS AEIAESIQVH
2210 2220 2230 2240 2250
SPVVHVQANS PEGLKVFYSI TDGDPFSQFT INFNTGVINV IAPLDFEAHP
2260 2270 2280 2290 2300
AYKLSIRATD SLTGAHAEVF VDIIVDDIND NPPVFAQQSY AVTLSEASVI
2310 2320 2330 2340 2350
GTSVVQVRAT DSDSEPNRGI SYQMFGNHSK SHDHFHVDSS TGLISLLRTL
2360 2370 2380 2390 2400
DYEQSRQHTI FVRAVDGGMP TLSSDVIVTV DVTDLNDNPP LFEQQIYEAR
2410 2420 2430 2440 2450
ISEHAPHGHF VTCVKAYDAD SSDIDKLQYS ILSGNDHKHF VIDSATGIIT
2460 2470 2480 2490 2500
LSNLHRHALK PFYSLNLSVS DGVFRSSTQV HVTVIGGNLH SPAFLQNEYE
2510 2520 2530 2540 2550
VELAENAPLH TLVMEVKTTD GDSGIYGHVT YHIVNDFAKD RFYINERGQI
2560 2570 2580 2590 2600
FTLEKLDRET PAEKVISVRL MAKDAGGKVA FCTVNVILTD DNDNAPQFRA
2610 2620 2630 2640 2650
TKYEVNIGSS AAKGTSVVKV LASDADEGSN ADITYAIEAD SESVKENLEI
2660 2670 2680 2690 2700
NKLSGVITTK ESLIGLENEF FTFFVRAVDN GSPSKESVVL VYVKILPPEM
2710 2720 2730 2740 2750
QLPKFSEPFY TFTVSEDVPI GTEIDLIRAE HSGTVLYSLV KGNTPESNRD
2760 2770 2780 2790 2800
ESFVIDRQSG RLKLEKSLDH ETTKWYQFSI LARCTQDDHE MVASVDVSIQ
2810 2820 2830 2840 2850
VKDANDNSPV FESSPYEAFI VENLPGGSRV IQIRASDADS GTNGQVMYSL
2860 2870 2880 2890 2900
DQSQSVEVIE SFAINMETGW ITTLKELDHE KRDNYQIKVV ASDHGEKIQL
2910 2920 2930 2940 2950
SSTAIVDVTV TDVNDSPPRF TAEIYKGTVS EDDPQGGVIA ILSTTDADSE
2960 2970 2980 2990 3000
EINRQVTYFI TGGDPLGQFA VETIQNEWKV YVKKPLDREK RDNYLLTITA
3010 3020 3030 3040 3050
TDGTFSSKAI VEVKVLDAND NSPVCEKTLY SDTIPEDVLP GKLIMQISAT
3060 3070 3080 3090 3100
DADIRSNAEI TYTLLGSGAE KFKLNPDTGE LKTSTPLDRE EQAVYHLLVR
3110 3120 3130 3140 3150
ATDGGGRFCQ ASIVLTLEDV NDNAPEFSAD PYAITVFENT EPGTLLTRVQ
3160 3170 3180 3190 3200
ATDADAGLNR KILYSLIDSA DGQFSINELS GIIQLEKPLD RELQAVYTLS
3210 3220 3230 3240 3250
LKAVDQGLPR RLTATGTVIV SVLDINDNPP VFEYREYGAT VSEDILVGTE
3260 3270 3280 3290 3300
VLQVYAASRD IEANAEITYS IISGNEHGKF SIDSKTGAVF IIENLDYESS
3310 3320 3330 3340 3350
HEYYLTVEAT DGGTPSLSDV ATVNVNVTDI NDNTPVFSQD TYTTVISEDA
3360 3370 3380 3390 3400
VLEQSVITVM ADDADGPSNS HIHYSIIDGN QGSSFTIDPV RGEVKVTKLL
3410 3420 3430 3440 3450
DRETISGYTL TVQASDNGSP PRVNTTTVNI DVSDVNDNAP VFSRGNYSVI
3460 3470 3480 3490 3500
IQENKPVGFS VLQLVVTDED SSHNGPPFFF TIVTGNDEKA FEVNPQGVLL
3510 3520 3530 3540 3550
TSSAIKRKEK DHYLLQVKVA DNGKPQLSSL TYIDIRVIEE SIYPPAILPL
3560 3570 3580 3590 3600
EIFITSSGEE YSGGVIGKIH ATDQDVYDTL TYSLDPQMDN LFSVSSTGGK
3610 3620 3630 3640 3650
LIAHKKLDIG QYLLNVSVTD GKFTTVADIT VHIRQVTQEM LNHTIAIRFA
3660 3670 3680 3690 3700
NLTPEEFVGD YWRNFQRALR NILGVRRNDI QIVSLQSSEP HPHLDVLLFV
3710 3720 3730 3740 3750
EKPGSAQIST KQLLHKINSS VTDIEEIIGV RILNVFQKLC AGLDCPWKFC
3760 3770 3780 3790 3800
DEKVSVDESV MSTHSTARLS FVTPRHHRAA VCLCKEGRCP PVHHGCEDDP
3810 3820 3830 3840 3850
CPEGSECVSD PWEEKHTCVC PSGRFGQCPG SSSMTLTGNS YVKYRLTENE
3860 3870 3880 3890 3900
NKLEMKLTMR LRTYSTHAVV MYARGTDYSI LEIHHGRLQY KFDCGSGPGI
3910 3920 3930 3940 3950
VSVQSIQVND GQWHAVALEV NGNYARLVLD QVHTASGTAP GTLKTLNLDN
3960 3970 3980 3990 4000
YVFFGGHIRQ QGTRHGRSPQ VGNGFRGCMD SIYLNGQELP LNSKPRSYAH
4010 4020 4030 4040 4050
IEESVDVSPG CFLTATEDCA SNPCQNGGVC NPSPAGGYYC KCSALYIGTH
4060 4070 4080 4090 4100
CEISVNPCSS KPCLYGGTCV VDNGGFVCQC RGLYTGQRCQ LSPYCKDEPC
4110 4120 4130 4140 4150
KNGGTCFDSL DGAVCQCDSG FRGERCQSDI DECSGNPCLH GALCENTHGS
4160 4170 4180 4190 4200
YHCNCSHEYR GRHCEDAAPN QYVSTPWNIG LAEGIGIVVF VAGIFLLVVV
4210 4220 4230 4240 4250
FVLCRKMISR KKKHQAEPKD KHLGPATAFL QRPYFDSKLN KNIYSDIPPQ
4260 4270 4280 4290 4300
VPVRPISYTP SIPSDSRNNL DRNSFEGSAI PEHPEFSTFN PESVHGHRKA
4310 4320 4330 4340 4350
VAVCSVAPNL PPPPPSNSPS DSDSIQKPSW DFDYDTKVVD LDPCLSKKPL
4360 4370 4380 4390 4400
EEKPSQPYSA RESLSEVQSL SSFQSESCDD NGYHWDTSDW MPSVPLPDIQ
4410 4420 4430 4440 4450
EFPNYEVIDE QTPLYSADPN AIDTDYYPGG YDIESDFPPP PEDFPAADEL
4460 4470 4480 4490 4500
PPLPPEFSNQ FESIHPPRDM PAAGSLGSSS RNRQRFNLNQ YLPNFYPLDM
4510 4520 4530 4540 4550
SEPQTKGTGE NSTCREPHAP YPPGYQRHFE APAVESMPMS VYASTASCSD
4560 4570 4580 4590
VSACCEVESE VMMSDYESGD DGHFEEVTIP PLDSQQHTEV
Length:4,590
Mass (Da):506,380
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i419289F2225FD5D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q14517FAT1_HUMAN
Protocadherin Fat 1
FAT1 CDHF7, FAT
4,588Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCE4D6RCE4_HUMAN
Protocadherin Fat 1
FAT1
488Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9C8H0Y9C8_HUMAN
Protocadherin Fat 1
FAT1
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9H4H0Y9H4_HUMAN
Protocadherin Fat 1
FAT1
368Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8F5H0Y8F5_HUMAN
Protocadherin Fat 1
FAT1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHE6D6RHE6_HUMAN
Protocadherin Fat 1
FAT1
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC107050 Genomic DNA No translation available.
AC110761 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000614102; ENSP00000479573; ENSG00000083857

UCSC genome browser

More...
UCSCi
uc063bou.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107050 Genomic DNA No translation available.
AC110761 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiA0A087WVP1
PeptideAtlasiA0A087WVP1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
964, 163 antibodies

Genome annotation databases

EnsembliENST00000614102; ENSP00000479573; ENSG00000083857
UCSCiuc063bou.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000083857.13
HGNCiHGNC:3595, FAT1
OpenTargetsiENSG00000083857

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000157733
OMAiGRRCEYG
PhylomeDBiA0A087WVP1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAT1, human

Gene expression databases

BgeeiENSG00000083857, Expressed in epithelium of mammary gland and 236 other tissues
ExpressionAtlasiA0A087WVP1, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR001791, Laminin_G
PfamiView protein in Pfam
PF00028, Cadherin, 29 hits
PF00008, EGF, 2 hits
PF02210, Laminin_G_2, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 34 hits
SM00181, EGF, 5 hits
SM00179, EGF_CA, 4 hits
SM00282, LamG, 1 hit
SUPFAMiSSF49313, SSF49313, 33 hits
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00232, CADHERIN_1, 13 hits
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 1 hit
PS50025, LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087WVP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087WVP1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: October 7, 2020
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again