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Protein
Submitted name:

DNA-directed RNA polymerases I, II, and III subunit RPABC1

Gene

POLR2E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
DNA-directed RNA polymerases I, II, and III subunit RPABC1Imported
Gene namesi
Name:POLR2EImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000099817.11
HGNCiHGNC:9192 POLR2E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000099817

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A087WVN5

Expressioni

Gene expression databases

BgeeiENSG00000099817 Expressed in 238 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiA0A087WVN5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A087WVN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3218 Eukaryota
COG2012 LUCA
GeneTreeiENSGT00390000013841

Family and domain databases

Gene3Di3.40.1340.10, 1 hit
InterProiView protein in InterPro
IPR036710 RNA_pol_Rpb5_N_sf
IPR039531 Rpb5-like
PANTHERiPTHR10535 PTHR10535, 1 hit
SUPFAMiSSF53036 SSF53036, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A087WVN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PASASQSARI TEEPKVGIKT IKVYCQRMQE ENITRALIVV QQGMTPSAKQ
60 70 80
SLVDMAPKYI LEQFLQQELL INITEHESLS TSS
Length:83
Mass (Da):9,277
Last modified:October 29, 2014 - v1
Checksum:i997D18C41E8BF7F6
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P19388RPAB1_HUMAN
DNA-directed RNA polymerases I, II,...
POLR2E
210Annotation score:
A0A087WVZ9A0A087WVZ9_HUMAN
DNA-directed RNA polymerases I, II,...
POLR2E
184Annotation score:
A0A087WWX0A0A087WWX0_HUMAN
DNA-directed RNA polymerases I, II,...
POLR2E
134Annotation score:
A0A0A0MQR7A0A0A0MQR7_HUMAN
DNA-directed RNA polymerases I, II,...
POLR2E
204Annotation score:
K7EJ87K7EJ87_HUMAN
DNA-directed RNA polymerases I, II,...
POLR2E
68Annotation score:
K7EQN2K7EQN2_HUMAN
DNA-directed RNA polymerases I, II,...
POLR2E
51Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004151 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000590060; ENSP00000479560; ENSG00000099817
UCSCiuc060qvb.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004151 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A087WVN5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A087WVN5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000590060; ENSP00000479560; ENSG00000099817
UCSCiuc060qvb.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000099817.11
HGNCiHGNC:9192 POLR2E
OpenTargetsiENSG00000099817
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3218 Eukaryota
COG2012 LUCA
GeneTreeiENSGT00390000013841

Miscellaneous databases

ChiTaRSiPOLR2E human

Gene expression databases

BgeeiENSG00000099817 Expressed in 238 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiA0A087WVN5 baseline and differential

Family and domain databases

Gene3Di3.40.1340.10, 1 hit
InterProiView protein in InterPro
IPR036710 RNA_pol_Rpb5_N_sf
IPR039531 Rpb5-like
PANTHERiPTHR10535 PTHR10535, 1 hit
SUPFAMiSSF53036 SSF53036, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A087WVN5_HUMAN
AccessioniPrimary (citable) accession number: A0A087WVN5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: November 7, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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