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UniProtKB - A0A087WVF3 (TBC3D_HUMAN)
Protein
TBC1 domain family member 3D
Gene
TBC1D3D
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).
By similarityMiscellaneous
TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor.Curated
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
GO - Biological processi
- activation of GTPase activity Source: GO_Central
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | A0A087WVF3 |
Names & Taxonomyi
Protein namesi | Recommended name: TBC1 domain family member 3DImported |
Gene namesi | Name:TBC1D3DImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28944, TBC1D3D |
neXtProti | NX_A0A087WVF3 |
VEuPathDBi | HostDB:ENSG00000274419 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity
Note: Associated with lipid rafts.By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 101060389 |
OpenTargetsi | ENSG00000274419 |
Miscellaneous databases
Pharosi | A0A087WVF3, Tdark |
Genetic variation databases
BioMutai | TBC1D3D |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000431604 | 1 – 549 | TBC1 domain family member 3DAdd BLAST | 549 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 318 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 325 | S-palmitoyl cysteineBy similarity | 1 |
Post-translational modificationi
Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.By similarity
Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.By similarity
Keywords - PTMi
Lipoprotein, Palmitate, Ubl conjugationProteomic databases
MassIVEi | A0A087WVF3 |
PeptideAtlasi | A0A087WVF3 |
Expressioni
Tissue specificityi
Expressed in pancreas, thymus and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000274419, Expressed in adenohypophysis and 103 other tissues |
Genevisiblei | A0A087WVF3, HS |
Organism-specific databases
HPAi | ENSG00000274419, Low tissue specificity |
Interactioni
Protein-protein interaction databases
IntActi | A0A087WVF3, 1 interactor |
STRINGi | 9606.ENSP00000478426 |
Miscellaneous databases
RNActi | A0A087WVF3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 101 – 293 | Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST | 193 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 350 – 443 | DisorderedSequence analysisAdd BLAST | 94 | |
Regioni | 507 – 526 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 391 – 413 | Pro residuesSequence analysisAdd BLAST | 23 |
Phylogenomic databases
eggNOGi | KOG1102, Eukaryota |
GeneTreei | ENSGT00940000163624 |
HOGENOMi | CLU_005350_10_5_1 |
OMAi | MENSKHA |
OrthoDBi | 976276at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 1 hit |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A087WVF3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG
60 70 80 90 100
IVHETELPPL TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK
110 120 130 140 150
GMPMNIRGPM WSVLLNTEEM KLKNPGRYQI MKEKGKRSSE HIQRIDRDVS
160 170 180 190 200
GTLRKHIFFR DRYGTKQREL LHILLAYEEY NPEVGYCRDL SHIAALFLLY
210 220 230 240 250
LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE HVVATSQPKT
260 270 280 290 300
MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI
310 320 330 340 350
TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL
360 370 380 390 400
TRKQGDLPPP AKPEQGSSAS RPVPASRGGK TLCKGDRQAP PGPPARFPRP
410 420 430 440 450
IWSASPPRAP RSSTPCPGGA VREDTYPVGT QGVPSPALAQ GGPQGSWRFL
460 470 480 490 500
QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV RAISQEDQLA PCWQAEHPAE
510 520 530 540
RVRSAFAAPS TDSDQGTPFR ARDEQQCAPT SGPCLCGLHL ESSQFPPGF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC233968 Genomic DNA No translation available. AC243569 Genomic DNA No translation available. |
CCDSi | CCDS74044.1 |
RefSeqi | NP_001278394.1, NM_001291465.1 |
Genome annotation databases
Ensembli | ENST00000616101.4; ENSP00000478426.1; ENSG00000274419.6 |
GeneIDi | 101060389 |
KEGGi | hsa:101060389 |
UCSCi | uc032fex.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC233968 Genomic DNA No translation available. AC243569 Genomic DNA No translation available. |
CCDSi | CCDS74044.1 |
RefSeqi | NP_001278394.1, NM_001291465.1 |
3D structure databases
AlphaFoldDBi | A0A087WVF3 |
SMRi | A0A087WVF3 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0A087WVF3, 1 interactor |
STRINGi | 9606.ENSP00000478426 |
Genetic variation databases
BioMutai | TBC1D3D |
Proteomic databases
MassIVEi | A0A087WVF3 |
PeptideAtlasi | A0A087WVF3 |
Protocols and materials databases
DNASUi | 101060389 |
Genome annotation databases
Ensembli | ENST00000616101.4; ENSP00000478426.1; ENSG00000274419.6 |
GeneIDi | 101060389 |
KEGGi | hsa:101060389 |
UCSCi | uc032fex.2, human |
Organism-specific databases
CTDi | 101060389 |
DisGeNETi | 101060389 |
GeneCardsi | TBC1D3D |
HGNCi | HGNC:28944, TBC1D3D |
HPAi | ENSG00000274419, Low tissue specificity |
neXtProti | NX_A0A087WVF3 |
OpenTargetsi | ENSG00000274419 |
VEuPathDBi | HostDB:ENSG00000274419 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1102, Eukaryota |
GeneTreei | ENSGT00940000163624 |
HOGENOMi | CLU_005350_10_5_1 |
OMAi | MENSKHA |
OrthoDBi | 976276at2759 |
Enzyme and pathway databases
PathwayCommonsi | A0A087WVF3 |
Miscellaneous databases
BioGRID-ORCSi | 101060389, 5 hits in 58 CRISPR screens |
GenomeRNAii | 101060389 |
Pharosi | A0A087WVF3, Tdark |
PROi | PR:A0A087WVF3 |
RNActi | A0A087WVF3, protein |
Gene expression databases
Bgeei | ENSG00000274419, Expressed in adenohypophysis and 103 other tissues |
Genevisiblei | A0A087WVF3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 1 hit |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TBC3D_HUMAN | |
Accessioni | A0A087WVF3Primary (citable) accession number: A0A087WVF3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 7, 2015 |
Last sequence update: | October 29, 2014 | |
Last modified: | May 25, 2022 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM