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Entry version 29 (12 Aug 2020)
Sequence version 1 (29 Oct 2014)
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Protein
Submitted name:

IgGFc-binding protein

Gene

FCGBP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
IgGFc-binding proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FCGBPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000275395.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13572, FCGBP

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000275395

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A087WUZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000275395, Expressed in mucosa of sigmoid colon and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A087WUZ2, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini116 – 342VWFDInterPro annotationAdd BLAST227
Domaini537 – 760VWFDInterPro annotationAdd BLAST224
Domaini936 – 1147VWFDInterPro annotationAdd BLAST212
Domaini1317 – 1543VWFDInterPro annotationAdd BLAST227

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183155

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001167_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR025615, TILa_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742, C8, 4 hits
PF01826, TIL, 5 hits
PF12714, TILa, 4 hits
PF00094, VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832, C8, 4 hits
SM00214, VWC, 3 hits
SM00215, VWC_out, 4 hits
SM00216, VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567, SSF57567, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51233, VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A087WUZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CPPHSHYEAC SYGCPLSCGD LPVPEGCESA CREGCVCDAG FVLSGDTCVP
60 70 80 90 100
VGQCGCLHDD RYYPLGQTFY PGPGCDSLCR CREGGEVSCE PSSCGPHETC
110 120 130 140 150
RPSGGSLGCV AVGSTTCQAS GDPHYTTFDG HRFDFMGTCV YVLAQTCGTR
160 170 180 190 200
PGLHRFAVLQ ENVAWGNGRV SVTRVITVQV ANFTLRLEQR QWKVTVNGVD
210 220 230 240 250
MKLPVVLANG QIRASQHGSD VVIETDFGLR VAYDLVYYVR VTVPGNYYQL
260 270 280 290 300
MCGLCGNYNG DPKDDFQKPN GSQAGNANEF GNSWEEVVSD SPCLPPPTCP
310 320 330 340 350
PGSEGCIPSE ECPPELEKKY QKEEFCGLLS SPTGPLSSCH KLVDPQGPLK
360 370 380 390 400
DCIFDLCLGG GNLSILCSNI HAYVSACQVA GGHVEPWRNE TFCPMECPQN
410 420 430 440 450
SHYELCADTC SLGCSALSAP LQCPDGCAEG CQCDSGFLYN GQACVPIQQC
460 470 480 490 500
GCYHNGAYYE PEQTVLIDNC RQQCTCHAGK VVVCQEHSCK PGQVCQPSGG
510 520 530 540 550
ILSCVTKDPC HGVTCRPQET CKEQGGQGVC LPNYEATCWL WGDPHYHSFD
560 570 580 590 600
GRKFDFQGTC NYVLATTGCP GVSTQGLTPF TVTTKNQNRG NPAVSYVRVV
610 620 630 640 650
TVAALGTNIS IHKDEIGKVR VNGVLTALPV SVADGRISVT QGASKALLVA
660 670 680 690 700
DFGLQVSYDW NWRVDVTLPS SYHGAVCGLC GNMDRNPNND QVFPNGTLAP
710 720 730 740 750
SIPIWGGSWR APGWDPLCWD ECRGSCPTCP EDRLEQYEGP GFCGPLAPGT
760 770 780 790 800
GGPFTTCHAH VPPESFFKGC VLDVCMGGGD RDILCKALAS YVAACQAAGV
810 820 830 840 850
VIEDWRAQVG CEITCPENSH YEVCGPPCPA SCPSPAPLTT PAVCEGPCVE
860 870 880 890 900
GCQCDAGFVL SADRCVPLNN GCGCWANGTY HEAGSEFWAD GTCSQWCRCG
910 920 930 940 950
PGGGSLVCTP ASCGLGEVCG LLPSGQHGCQ PVSTAECQAW GDPHYVTLDG
960 970 980 990 1000
HRFDFQGTCE YLLSAPCHGP PLGAENFTVT VANEHRGSQA VSYTRSVTLQ
1010 1020 1030 1040 1050
IYNHSLTLSA RWPRKLQVDG VFVTLPFQLD SLLHAHLSGA DVVVTTTSGL
1060 1070 1080 1090 1100
SLAFDGDSFV RLRVPAAYAG SLCGLCGNYN QDPADDLKAV GGKPAGWQVG
1110 1120 1130 1140 1150
GAQGCGECVS KPCPSPCTPE QQESFGGPDA CGVISATDGP LAPCHGLVPP
1160 1170 1180 1190 1200
AQYFQGCLLD ACQVQGHPGG LCPAVATYVA ACQAAGAQLR EWRRPDFCPF
1210 1220 1230 1240 1250
QCPAHSHYEL CGDSCPGSCP SLSAPEGCES ACREGCVCDA GFVLSGDTCV
1260 1270 1280 1290 1300
PVGQCGCLHD DRYYPLGQTF YPGPGCDSLC RCREGGEVSC EPSSCGPHET
1310 1320 1330 1340 1350
CRPSGGSLGC VAVGSTTCQA SGDPHYTTFD GHRFDFMGTC VYVLAQTCGT
1360 1370 1380 1390 1400
RPGLHRFAVL QENVAWGNGR VSVTRVITVQ VANFTLRLEQ RQWKVTVNGV
1410 1420 1430 1440 1450
DMKLPVVLAN GQIRASQHGS DVVIETDFGL RVAYDLVYYV RVTVPGNYYQ
1460 1470 1480 1490 1500
LMCGLCGNYN GDPKDDFQKP NGSQAGNANE FGNSWEEVVP DSPCLPPPTC
1510 1520 1530 1540 1550
PPGSAGCIPS DKCPPELEKK YQKEEFCGLL SSPTGPLSSC HKLVDPQGPL
1560 1570 1580 1590 1600
KDCIFDLCLG GGNLSILCSN IHAYVSACQA AGGHVEPWRN ETFCPMECPQ
1610 1620 1630 1640
NSHYELCADT CSLGCSALSA PLQCPDGCAE GCQCDSGFLY NG
Length:1,642
Mass (Da):174,119
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3CAD6867E49CD87
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Y6R7FCGBP_HUMAN
IgGFc-binding protein
FCGBP
5,405Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXI2A0A087WXI2_HUMAN
IgGFc-binding protein
FCGBP
4,204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006950 Genomic DNA No translation available.
AC007842 Genomic DNA No translation available.
AC011536 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000620799; ENSP00000479036; ENSG00000275395

UCSC genome browser

More...
UCSCi
uc060ynv.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006950 Genomic DNA No translation available.
AC007842 Genomic DNA No translation available.
AC011536 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0A087WUZ2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
77945, 49 antibodies

Genome annotation databases

EnsembliENST00000620799; ENSP00000479036; ENSG00000275395
UCSCiuc060ynv.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000275395.4
HGNCiHGNC:13572, FCGBP
OpenTargetsiENSG00000275395

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00950000183155
HOGENOMiCLU_001167_0_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FCGBP, human

Gene expression databases

BgeeiENSG00000275395, Expressed in mucosa of sigmoid colon and 213 other tissues
ExpressionAtlasiA0A087WUZ2, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR025615, TILa_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
PfamiView protein in Pfam
PF08742, C8, 4 hits
PF01826, TIL, 5 hits
PF12714, TILa, 4 hits
PF00094, VWD, 4 hits
SMARTiView protein in SMART
SM00832, C8, 4 hits
SM00214, VWC, 3 hits
SM00215, VWC_out, 4 hits
SM00216, VWD, 4 hits
SUPFAMiSSF57567, SSF57567, 5 hits
PROSITEiView protein in PROSITE
PS51233, VWFD, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087WUZ2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087WUZ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: August 12, 2020
This is version 29 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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