UniProtKB - A0A087WUL9 (A0A087WUL9_HUMAN)
Protein
26S proteasome non-ATPase regulatory subunit 13
Gene
PSMD13
Organism
Homo sapiens (Human)
Status
Functioni
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.ARBA annotation
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome non-ATPase regulatory subunit 13ARBA annotationAlternative name(s): 26S proteasome regulatory subunit RPN9ARBA annotation 26S proteasome regulatory subunit S11ARBA annotation 26S proteasome regulatory subunit p40.5ARBA annotation |
Gene namesi | Name:PSMD13Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000185627.17 |
HGNCi | HGNC:9558, PSMD13 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185627, Expressed in adenohypophysis and 244 other tissues |
ExpressionAtlasi | A0A087WUL9, baseline and differential |
Interactioni
Subunit structurei
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 171 – 338 | PCIInterPro annotationAdd BLAST | 168 |
Sequence similaritiesi
Belongs to the proteasome subunit S11 family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00390000001802 |
Family and domain databases
InterProi | View protein in InterPro IPR000717, PCI_dom IPR035298, PSMD13 IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10539, PTHR10539, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
A0A087WUL9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDVPGFLQQ SQNSGPGQPA VWHRLEELYT KKLWHQLTLQ VLDFVQDPCF
60 70 80 90 100
AQGDGLIKLY ENFISEFEHR VNPLSLVEII LHVVRQMTDP NVALTFLEKT
110 120 130 140 150
REKVKSSDEA VILCKTAIGA LKLNIGDLQV TKETIEDVEE MLNNLPGVTS
160 170 180 190 200
VHSRFYDLSS KYYQTIGNHA SYYKDALRFL GCVDIKDLPV SEQQERAFTL
210 220 230 240 250
GLAGLLGEGV FNFGELLMHP VLESLRNTDR QWLIDTLYAF NSGNVERFQT
260 270 280 290 300
LKTAWGQQPD LAANEAQLLR KIQLLCLMEM TFTRPANHRQ LTFEEIAKSA
310 320 330 340 350
KITVNEVELL VMKALSVGLV KGSIDEVDKR VHMTWVQPRV LDLQQVMCIK
360 370
EGPPGVLVHG VKSMEMLVEH QAHDILT
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UNM6 | PSD13_HUMAN | 26S proteasome non-ATPase regulator... | PSMD13 | 376 | Annotation score: | ||
H0YD73 | H0YD73_HUMAN | 26S proteasome non-ATPase regulator... | PSMD13 | 221 | Annotation score: | ||
E9PL38 | E9PL38_HUMAN | 26S proteasome non-ATPase regulator... | PSMD13 | 263 | Annotation score: | ||
J3KNQ3 | J3KNQ3_HUMAN | 26S proteasome non-ATPase regulator... | PSMD13 | 349 | Annotation score: | ||
E9PQG3 | E9PQG3_HUMAN | 26S proteasome non-ATPase regulator... | PSMD13 | 113 | Annotation score: | ||
E9PPD2 | E9PPD2_HUMAN | 26S proteasome non-ATPase regulator... | PSMD13 | 70 | Annotation score: | ||
F8W8J6 | F8W8J6_HUMAN | 26S proteasome non-ATPase regulator... | PSMD13 | 72 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC136475 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000621534; ENSP00000478756; ENSG00000185627 |
UCSCi | uc057xdm.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC136475 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A087WUL9 |
Protocols and materials databases
Antibodypediai | 22386, 167 antibodies |
Genome annotation databases
Ensembli | ENST00000621534; ENSP00000478756; ENSG00000185627 |
UCSCi | uc057xdm.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000185627.17 |
HGNCi | HGNC:9558, PSMD13 |
OpenTargetsi | ENSG00000185627 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000001802 |
Miscellaneous databases
ChiTaRSi | PSMD13, human |
Gene expression databases
Bgeei | ENSG00000185627, Expressed in adenohypophysis and 244 other tissues |
ExpressionAtlasi | A0A087WUL9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000717, PCI_dom IPR035298, PSMD13 IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10539, PTHR10539, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087WUL9_HUMAN | |
Accessioni | A0A087WUL9Primary (citable) accession number: A0A087WUL9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | August 12, 2020 | |
This is version 34 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |