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Entry version 33 (11 Dec 2019)
Sequence version 1 (29 Oct 2014)
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Protein

Neuroblastoma breakpoint family member 19

Gene

NBPF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein uncertaini <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.Curated

Caution

Could be the product of a pseudogene.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NBPF19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000271383.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:31999 NBPF19

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614006 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A0A087WUL8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000271383

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A0A087WUL8 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NBPF19

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004354221 – 3843Neuroblastoma breakpoint family member 19Add BLAST3843

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A087WUL8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A0A087WUL8

PRoteomics IDEntifications database

More...
PRIDEi
A0A087WUL8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A0A087WUL8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A0A087WUL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000271383 Expressed in 91 organ(s), highest expression level in leukocyte

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042595
HPA043105
HPA043692
HPA044023
HPA046971
HPA058050

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478752

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A0A087WUL8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A087WUL8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 257NBPF 1PROSITE-ProRule annotationAdd BLAST93
Domaini258 – 329NBPF 2PROSITE-ProRule annotationAdd BLAST72
Domaini330 – 421NBPF 3PROSITE-ProRule annotationAdd BLAST92
Domaini424 – 479NBPF 4PROSITE-ProRule annotationAdd BLAST56
Domaini480 – 572NBPF 5PROSITE-ProRule annotationAdd BLAST93
Domaini573 – 665NBPF 6PROSITE-ProRule annotationAdd BLAST93
Domaini668 – 723NBPF 7PROSITE-ProRule annotationAdd BLAST56
Domaini724 – 816NBPF 8PROSITE-ProRule annotationAdd BLAST93
Domaini817 – 909NBPF 9PROSITE-ProRule annotationAdd BLAST93
Domaini912 – 967NBPF 10PROSITE-ProRule annotationAdd BLAST56
Domaini968 – 1060NBPF 11PROSITE-ProRule annotationAdd BLAST93
Domaini1061 – 1153NBPF 12PROSITE-ProRule annotationAdd BLAST93
Domaini1156 – 1211NBPF 13PROSITE-ProRule annotationAdd BLAST56
Domaini1212 – 1304NBPF 14PROSITE-ProRule annotationAdd BLAST93
Domaini1305 – 1397NBPF 15PROSITE-ProRule annotationAdd BLAST93
Domaini1400 – 1455NBPF 16PROSITE-ProRule annotationAdd BLAST56
Domaini1456 – 1548NBPF 17PROSITE-ProRule annotationAdd BLAST93
Domaini1549 – 1641NBPF 18PROSITE-ProRule annotationAdd BLAST93
Domaini1644 – 1699NBPF 19PROSITE-ProRule annotationAdd BLAST56
Domaini1700 – 1792NBPF 20PROSITE-ProRule annotationAdd BLAST93
Domaini1793 – 1885NBPF 21PROSITE-ProRule annotationAdd BLAST93
Domaini1888 – 1943NBPF 22PROSITE-ProRule annotationAdd BLAST56
Domaini1944 – 2036NBPF 23PROSITE-ProRule annotationAdd BLAST93
Domaini2037 – 2129NBPF 24PROSITE-ProRule annotationAdd BLAST93
Domaini2132 – 2187NBPF 25PROSITE-ProRule annotationAdd BLAST56
Domaini2188 – 2280NBPF 26PROSITE-ProRule annotationAdd BLAST93
Domaini2281 – 2373NBPF 27PROSITE-ProRule annotationAdd BLAST93
Domaini2376 – 2431NBPF 28PROSITE-ProRule annotationAdd BLAST56
Domaini2432 – 2524NBPF 29PROSITE-ProRule annotationAdd BLAST93
Domaini2525 – 2617NBPF 30PROSITE-ProRule annotationAdd BLAST93
Domaini2620 – 2675NBPF 31PROSITE-ProRule annotationAdd BLAST56
Domaini2676 – 2768NBPF 32PROSITE-ProRule annotationAdd BLAST93
Domaini2769 – 2861NBPF 33PROSITE-ProRule annotationAdd BLAST93
Domaini2864 – 2919NBPF 34PROSITE-ProRule annotationAdd BLAST56
Domaini2920 – 3012NBPF 35PROSITE-ProRule annotationAdd BLAST93
Domaini3013 – 3105NBPF 36PROSITE-ProRule annotationAdd BLAST93
Domaini3108 – 3163NBPF 37PROSITE-ProRule annotationAdd BLAST56
Domaini3164 – 3256NBPF 38PROSITE-ProRule annotationAdd BLAST93
Domaini3257 – 3349NBPF 39PROSITE-ProRule annotationAdd BLAST93
Domaini3352 – 3407NBPF 40PROSITE-ProRule annotationAdd BLAST56
Domaini3408 – 3500NBPF 41PROSITE-ProRule annotationAdd BLAST93
Domaini3501 – 3593NBPF 42PROSITE-ProRule annotationAdd BLAST93
Domaini3596 – 3651NBPF 43PROSITE-ProRule annotationAdd BLAST56
Domaini3652 – 3744NBPF 44PROSITE-ProRule annotationAdd BLAST93
Domaini3745 – 3843NBPF 45PROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili70 – 130Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi248 – 292Glu-richPROSITE-ProRule annotationAdd BLAST45

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NBPF family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00420000029746

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010630 Olduvai_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06758 Olduvai, 45 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01148 DUF1220, 45 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51316 NBPF, 45 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A087WUL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVSAGPWSS EKAEMNILEI NETLRPQLAE KKQQFRNLKE KCFLTQLAGF
60 70 80 90 100
LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLFH
110 120 130 140 150
SQERELTQLR EKLREGRDAS RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE
160 170 180 190 200
GCRLAQHLVQ KLSPENDNDD DEDVQVEVAE KVQKSSAPRE MQKAEEKEVP
210 220 230 240 250
EDSLEECAIT YSNSHGPYDS NQPHRKTKIT FEEDKVDSTL IGSSSHVEWE
260 270 280 290 300
DAVHIIPENE SDDEEEEEKG PVSPRNLQES EEEEVPQESW DEGYSTLSIP
310 320 330 340 350
PEMLASYQSY SSTFHSLEEQ QVCMAVDIGR HRWDQVKKED QEATGPRLSR
360 370 380 390 400
ELLDEKGPEV LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA
410 420 430 440 450
IDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL DRCYSIPSGY
460 470 480 490 500
LELPDLGQPY SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QDPPCPRLSR
510 520 530 540 550
ELVEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS
560 570 580 590 600
LDVGEIEKKG KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLSRELLDEK
610 620 630 640 650
GPEVLQDSLD RCYSTPSGCL ELTDSCQPYR SAFYILEQQC VGLAVDMDEI
660 670 680 690 700
EKYQEVEEDQ DPSCPRLSRE LLDEKEPEVL QDSLDRCYSI PSGYLELPDL
710 720 730 740 750
GQPYSSAVYS LEEQYLGLAL DVDRIKKDQE EEEDQDPPCP RLSRELVEVV
760 770 780 790 800
EPEVLQDSLD RCYSTPSSCL EQPDSCQPYG SSFYALEEKH VGFSLDVGEI
810 820 830 840 850
EKKGKGKKRR GRRSKKERRR GRKEGEEDQN PPCPRLSREL LDEKGPEVLQ
860 870 880 890 900
DSLDRCYSTP SGCLELTDSC QPYRSAFYIL EQQCVGLAID MDEIEKYQEV
910 920 930 940 950
EEDQDPSCPR LSRELLDEKE PEVLQDSLDR CYSIPSGYLE LPDLGQPYSS
960 970 980 990 1000
AVYSLEEQYL GLALDVDRIK KDQEEEEDQD PPCPRLSREL VEVVEPEVLQ
1010 1020 1030 1040 1050
DSLDRCYSTP SSCLEQPDSC QPYGSSFYAL EEKHVGFSLD VGEIEKKGKG
1060 1070 1080 1090 1100
KKRRGRRSKK ERRRGRKEGE EDQNPPCPRL SRELLDEKGP EVLQDSLDRC
1110 1120 1130 1140 1150
YSTPSGCLEL TDSCQPYRSA FYILEQQCVG LAVDMDEIEK YQEVEEDQDP
1160 1170 1180 1190 1200
SCPRLSRELL DEKEPEVLQD SLDRCYSIPS GYLELPDLGQ PYSSAVYSLE
1210 1220 1230 1240 1250
EQYLGLALDV DRIKKDQEEE EDQDPPCPRL SRELVEVVEP EVLQDSLDRC
1260 1270 1280 1290 1300
YSTPSSCLEQ PDSCQPYGSS FYALEEKHVG FSLDVGEIEK KGKGKKRRGR
1310 1320 1330 1340 1350
RSKKERRRGR KEGEEDQNPP CPRLSRELLD EKGPEVLQDS LDRCYSTPSG
1360 1370 1380 1390 1400
CLELTDSCQP YRSAFYILEQ QCVGLAVDMD EIEKYQEVEE DQDPSCPRLS
1410 1420 1430 1440 1450
RELLDEKEPE VLQDSLDRCY SIPSGYLELP DLGQPYSSAV YSLEEQYLGL
1460 1470 1480 1490 1500
ALDVDRIKKD QEEEEDQDPP CPRLSRELVE VVEPEVLQDS LDRCYSTPSS
1510 1520 1530 1540 1550
CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKK RRGRRSKKER
1560 1570 1580 1590 1600
RRGRKEGEED QNPPCPRLSR ELLDEKGPEV LQDSLDRCYS TPSGCLELTD
1610 1620 1630 1640 1650
SCQPYRSAFY ILEQQCVGLA VDMDEIEKYQ EVEEDQDPSC PRLSRELLDE
1660 1670 1680 1690 1700
KEPEVLQDSL DRCYSIPSGY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR
1710 1720 1730 1740 1750
IKKDQEEEED QDPPCPRLSR ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD
1760 1770 1780 1790 1800
SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKERRRGRKE
1810 1820 1830 1840 1850
GEEDQNPPCP RLSRELLDEK GPEVLQDSLD RCYSTPSGCL ELTDSCQPYR
1860 1870 1880 1890 1900
SAFYILEQQC VGLAVDMDEI EKYQEVEEDQ DPSCPRLSRE LLDEKEPEVL
1910 1920 1930 1940 1950
QDSLDRCYST PSGYLELPDL GQPYSSAVYS LEEQYLGLAL DVDRIKKDQE
1960 1970 1980 1990 2000
EEEDQGPPCP RLSRELLEVV EPEVLQDSLD RCYSTPSSCL EQPDSCQPYG
2010 2020 2030 2040 2050
SSFYALEEKH VGFSLDVGEI EKKGKGKKRR GRRSKKERRR GRKEGEEDQN
2060 2070 2080 2090 2100
PPCPRLSREL LDEKGPEVLQ DSLDRCYSTP SGCLELTDSC QPYRSAFYIL
2110 2120 2130 2140 2150
EQQCVGLAVD MDEIEKYQEV EEDQDPSCPR LSRELLDEKE PEVLQDSLDR
2160 2170 2180 2190 2200
CYSTPSGYLE LPDLGQPYSS AVYSLEEQYL GLALDVDRIK KDQEEEEDQG
2210 2220 2230 2240 2250
PPCPRLSREL LEVVEPEVLQ DSLDRCYSTP SSCLEQPDSC QPYGSSFYAL
2260 2270 2280 2290 2300
EEKHVGFSLD VGEIEKKGKG KKRRGRRSKK ERRRGRKEGE EDQNPPCPRL
2310 2320 2330 2340 2350
SRELLDEKGP EVLQDSLDRC YSTPSGCLEL TDSCQPYRSA FYILEQQCVG
2360 2370 2380 2390 2400
LAVDMDEIEK YQEVEEDQDP SCPRLSRELL DEKEPEVLQD SLDRCYSTPS
2410 2420 2430 2440 2450
GYLELPDLGQ PYSSAVYSLE EQYLGLALDV DRIKKDQEEE EDQGPPCPRL
2460 2470 2480 2490 2500
SRELLEVVEP EVLQDSLDRC YSTPSSCLEQ PDSCQPYGSS FYALEEKHVG
2510 2520 2530 2540 2550
FSLDVGEIEK KGKGKKRRGR RSKKERRRGR KEGEEDQNPP CPRLSRELLD
2560 2570 2580 2590 2600
EKGPEVLQDS LDRCYSTPSG CLELTDSCQP YRSAFYILEQ QCVGLAVDMD
2610 2620 2630 2640 2650
EIEKYQEVEE DQDPSCPRLS RELLDEKEPE VLQDSLDRCY STPSGYLELP
2660 2670 2680 2690 2700
DLGQPYSSAV YSLEEQYLGL ALDVDRIKKD QEEEEDQGPP CPRLSRELLE
2710 2720 2730 2740 2750
VVEPEVLQDS LDRCYSTPSS CLEQPDSCQP YGSSFYALEE KHVGFSLDVG
2760 2770 2780 2790 2800
EIEKKGKGKK RRGRRSKKER RRGRKEGEED QNPPCPRLSR ELLDEKGPEV
2810 2820 2830 2840 2850
LQDSLDRCYS TPSGCLELTD SCQPYRSAFY ILEQQCVGLA VDMDEIEKYQ
2860 2870 2880 2890 2900
EVEEDQDPSC PRLSRELLDE KEPEVLQDSL DRCYSTPSGY LELPDLGQPY
2910 2920 2930 2940 2950
SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QGPPCPRLSR ELLEVVEPEV
2960 2970 2980 2990 3000
LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG
3010 3020 3030 3040 3050
KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLSRELLDEK GPEVLQDSLD
3060 3070 3080 3090 3100
RCYSTPSGCL ELTDSCQPYR SAFYILEQQC VGLAVDMDEI EKYQEVEEDQ
3110 3120 3130 3140 3150
DPSCPRLSRE LLAEKEPEVL QDPLDRCYST PSGYLELPDL GQPYSSAVYS
3160 3170 3180 3190 3200
LEEQYLGLAL DVDRIKKDQE EEEDQGPPCP RLSRELLEVV EPEVLQDSLD
3210 3220 3230 3240 3250
RCYSTPSSCL EQPDSCQPYG SSFYALEEKH VGFSLDVGEI EKKGKGKKRR
3260 3270 3280 3290 3300
GRRSKKERRR GRKEGEEDQN PPCPRLSREL LDEKGPEVLQ DSLDRCYSTP
3310 3320 3330 3340 3350
SGCLELTDSC QPYRSAFYIL EQQCVGLAVD MDEIEKYQEV EEDQDPSCPR
3360 3370 3380 3390 3400
LSRELLAEKE PEVLQDPLDR CYSTPSGYLE LPDLGQPYSS AVYSLEEQYL
3410 3420 3430 3440 3450
GLALDVDRIK KDQEEEEDQG PPCPRLSREL LEVVEPEVLQ DSLDRCYSTP
3460 3470 3480 3490 3500
SSCLEQPDSC QPYGSSFYAL EEKHVGFSLD VGEIEKKGKG KKRRGRRSKK
3510 3520 3530 3540 3550
ERRRGRKEGE EDQNPPCPRL SRELLDEKGP EVLQDSLDRC YSTPSGCLEL
3560 3570 3580 3590 3600
TDSCQPYRSA FYILEQQCVG LAVDMDEIEK YQEVEEDQDP SCPRLSRELL
3610 3620 3630 3640 3650
AEKEPEVLQD PLDRCYSTPS GYLELPDLGQ PYSSAVYSLE EQYLGLALDV
3660 3670 3680 3690 3700
DRIKKDQEEE EDQGPPCPRL SRELLEVVEP EVLQDSLDRC YSTPSSCLEQ
3710 3720 3730 3740 3750
PDSCQPYGSS FYALEEKHVG FSLDVGEIEK KGKGKKRRGR RSKKERRRGR
3760 3770 3780 3790 3800
KEGEEDQNPP CPRLNSVLME VEEPEVLQDS LDGCYSTPSM YFELPDSFQH
3810 3820 3830 3840
YRSVFYSFEE EHISFALYLD NRFFTLTVTS LHLVFQMLVI FPQ
Length:3,843
Mass (Da):440,408
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24A59AA23097CB90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X230A0A087X230_HUMAN
Neuroblastoma breakpoint family mem...
NBPF19
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B6G5A0A075B6G5_HUMAN
Neuroblastoma breakpoint family mem...
NBPF19
921Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X288A0A087X288_HUMAN
Neuroblastoma breakpoint family mem...
NBPF19
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC242842 Genomic DNA No translation available.
AC242843 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS86016.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000651566; ENSP00000498781; ENSG00000271383

UCSC genome browser

More...
UCSCi
uc031uxc.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC242842 Genomic DNA No translation available.
AC242843 Genomic DNA No translation available.
CCDSiCCDS86016.1

3D structure databases

SMRiA0A087WUL8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000478752

PTM databases

iPTMnetiA0A087WUL8
PhosphoSitePlusiA0A087WUL8

Polymorphism and mutation databases

BioMutaiNBPF19

Proteomic databases

jPOSTiA0A087WUL8
MassIVEiA0A087WUL8
PRIDEiA0A087WUL8

Genome annotation databases

EnsembliENST00000651566; ENSP00000498781; ENSG00000271383
UCSCiuc031uxc.2 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000271383.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ENSG00000286185
NBPF19
HGNCiHGNC:31999 NBPF19
HPAiHPA042595
HPA043105
HPA043692
HPA044023
HPA046971
HPA058050
MIMi614006 gene
neXtProtiNX_A0A087WUL8
OpenTargetsiENSG00000271383

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00420000029746

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NBPF19 human
PharosiA0A087WUL8 Tdark
RNActiA0A087WUL8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000271383 Expressed in 91 organ(s), highest expression level in leukocyte

Family and domain databases

InterProiView protein in InterPro
IPR010630 Olduvai_dom
PfamiView protein in Pfam
PF06758 Olduvai, 45 hits
SMARTiView protein in SMART
SM01148 DUF1220, 45 hits
PROSITEiView protein in PROSITE
PS51316 NBPF, 45 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNBPFJ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087WUL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 17, 2016
Last sequence update: October 29, 2014
Last modified: December 11, 2019
This is version 33 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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