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Protein

Neuroblastoma breakpoint family member 19

Gene

NBPF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.Curated

Caution

Could be the product of a pseudogene.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 19Imported
Gene namesi
Name:NBPF19Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000271383.6
HGNCiHGNC:31999 NBPF19
MIMi614006 gene
neXtProtiNX_A0A087WUL8

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000271383

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004354221 – 3843Neuroblastoma breakpoint family member 19Add BLAST3843

Proteomic databases

PRIDEiA0A087WUL8

PTM databases

iPTMnetiA0A087WUL8
PhosphoSitePlusiA0A087WUL8

Expressioni

Gene expression databases

BgeeiENSG00000271383 Expressed in 91 organ(s), highest expression level in leukocyte
ExpressionAtlasiA0A087WUL8 baseline and differential

Organism-specific databases

HPAiHPA042595
HPA043105
HPA043692
HPA044023
HPA046971
HPA058050

Structurei

3D structure databases

ProteinModelPortaliA0A087WUL8
SMRiA0A087WUL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 257NBPF 1PROSITE-ProRule annotationAdd BLAST93
Domaini258 – 329NBPF 2PROSITE-ProRule annotationAdd BLAST72
Domaini330 – 421NBPF 3PROSITE-ProRule annotationAdd BLAST92
Domaini424 – 479NBPF 4PROSITE-ProRule annotationAdd BLAST56
Domaini480 – 572NBPF 5PROSITE-ProRule annotationAdd BLAST93
Domaini573 – 665NBPF 6PROSITE-ProRule annotationAdd BLAST93
Domaini668 – 723NBPF 7PROSITE-ProRule annotationAdd BLAST56
Domaini724 – 816NBPF 8PROSITE-ProRule annotationAdd BLAST93
Domaini817 – 909NBPF 9PROSITE-ProRule annotationAdd BLAST93
Domaini912 – 967NBPF 10PROSITE-ProRule annotationAdd BLAST56
Domaini968 – 1060NBPF 11PROSITE-ProRule annotationAdd BLAST93
Domaini1061 – 1153NBPF 12PROSITE-ProRule annotationAdd BLAST93
Domaini1156 – 1211NBPF 13PROSITE-ProRule annotationAdd BLAST56
Domaini1212 – 1304NBPF 14PROSITE-ProRule annotationAdd BLAST93
Domaini1305 – 1397NBPF 15PROSITE-ProRule annotationAdd BLAST93
Domaini1400 – 1455NBPF 16PROSITE-ProRule annotationAdd BLAST56
Domaini1456 – 1548NBPF 17PROSITE-ProRule annotationAdd BLAST93
Domaini1549 – 1641NBPF 18PROSITE-ProRule annotationAdd BLAST93
Domaini1644 – 1699NBPF 19PROSITE-ProRule annotationAdd BLAST56
Domaini1700 – 1792NBPF 20PROSITE-ProRule annotationAdd BLAST93
Domaini1793 – 1885NBPF 21PROSITE-ProRule annotationAdd BLAST93
Domaini1888 – 1943NBPF 22PROSITE-ProRule annotationAdd BLAST56
Domaini1944 – 2036NBPF 23PROSITE-ProRule annotationAdd BLAST93
Domaini2037 – 2129NBPF 24PROSITE-ProRule annotationAdd BLAST93
Domaini2132 – 2187NBPF 25PROSITE-ProRule annotationAdd BLAST56
Domaini2188 – 2280NBPF 26PROSITE-ProRule annotationAdd BLAST93
Domaini2281 – 2373NBPF 27PROSITE-ProRule annotationAdd BLAST93
Domaini2376 – 2431NBPF 28PROSITE-ProRule annotationAdd BLAST56
Domaini2432 – 2524NBPF 29PROSITE-ProRule annotationAdd BLAST93
Domaini2525 – 2617NBPF 30PROSITE-ProRule annotationAdd BLAST93
Domaini2620 – 2675NBPF 31PROSITE-ProRule annotationAdd BLAST56
Domaini2676 – 2768NBPF 32PROSITE-ProRule annotationAdd BLAST93
Domaini2769 – 2861NBPF 33PROSITE-ProRule annotationAdd BLAST93
Domaini2864 – 2919NBPF 34PROSITE-ProRule annotationAdd BLAST56
Domaini2920 – 3012NBPF 35PROSITE-ProRule annotationAdd BLAST93
Domaini3013 – 3105NBPF 36PROSITE-ProRule annotationAdd BLAST93
Domaini3108 – 3163NBPF 37PROSITE-ProRule annotationAdd BLAST56
Domaini3164 – 3256NBPF 38PROSITE-ProRule annotationAdd BLAST93
Domaini3257 – 3349NBPF 39PROSITE-ProRule annotationAdd BLAST93
Domaini3352 – 3407NBPF 40PROSITE-ProRule annotationAdd BLAST56
Domaini3408 – 3500NBPF 41PROSITE-ProRule annotationAdd BLAST93
Domaini3501 – 3593NBPF 42PROSITE-ProRule annotationAdd BLAST93
Domaini3596 – 3651NBPF 43PROSITE-ProRule annotationAdd BLAST56
Domaini3652 – 3744NBPF 44PROSITE-ProRule annotationAdd BLAST93
Domaini3745 – 3843NBPF 45PROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili70 – 130Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi248 – 292Glu-richPROSITE-ProRule annotationAdd BLAST45

Sequence similaritiesi

Belongs to the NBPF family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00420000029746
OrthoDBiEOG091G03WI

Family and domain databases

InterProiView protein in InterPro
IPR010630 NBPF_dom
PfamiView protein in Pfam
PF06758 DUF1220, 45 hits
SMARTiView protein in SMART
SM01148 DUF1220, 45 hits
PROSITEiView protein in PROSITE
PS51316 NBPF, 45 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A087WUL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVSAGPWSS EKAEMNILEI NETLRPQLAE KKQQFRNLKE KCFLTQLAGF
60 70 80 90 100
LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLFH
110 120 130 140 150
SQERELTQLR EKLREGRDAS RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE
160 170 180 190 200
GCRLAQHLVQ KLSPENDNDD DEDVQVEVAE KVQKSSAPRE MQKAEEKEVP
210 220 230 240 250
EDSLEECAIT YSNSHGPYDS NQPHRKTKIT FEEDKVDSTL IGSSSHVEWE
260 270 280 290 300
DAVHIIPENE SDDEEEEEKG PVSPRNLQES EEEEVPQESW DEGYSTLSIP
310 320 330 340 350
PEMLASYQSY SSTFHSLEEQ QVCMAVDIGR HRWDQVKKED QEATGPRLSR
360 370 380 390 400
ELLDEKGPEV LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA
410 420 430 440 450
IDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL DRCYSIPSGY
460 470 480 490 500
LELPDLGQPY SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QDPPCPRLSR
510 520 530 540 550
ELVEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS
560 570 580 590 600
LDVGEIEKKG KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLSRELLDEK
610 620 630 640 650
GPEVLQDSLD RCYSTPSGCL ELTDSCQPYR SAFYILEQQC VGLAVDMDEI
660 670 680 690 700
EKYQEVEEDQ DPSCPRLSRE LLDEKEPEVL QDSLDRCYSI PSGYLELPDL
710 720 730 740 750
GQPYSSAVYS LEEQYLGLAL DVDRIKKDQE EEEDQDPPCP RLSRELVEVV
760 770 780 790 800
EPEVLQDSLD RCYSTPSSCL EQPDSCQPYG SSFYALEEKH VGFSLDVGEI
810 820 830 840 850
EKKGKGKKRR GRRSKKERRR GRKEGEEDQN PPCPRLSREL LDEKGPEVLQ
860 870 880 890 900
DSLDRCYSTP SGCLELTDSC QPYRSAFYIL EQQCVGLAID MDEIEKYQEV
910 920 930 940 950
EEDQDPSCPR LSRELLDEKE PEVLQDSLDR CYSIPSGYLE LPDLGQPYSS
960 970 980 990 1000
AVYSLEEQYL GLALDVDRIK KDQEEEEDQD PPCPRLSREL VEVVEPEVLQ
1010 1020 1030 1040 1050
DSLDRCYSTP SSCLEQPDSC QPYGSSFYAL EEKHVGFSLD VGEIEKKGKG
1060 1070 1080 1090 1100
KKRRGRRSKK ERRRGRKEGE EDQNPPCPRL SRELLDEKGP EVLQDSLDRC
1110 1120 1130 1140 1150
YSTPSGCLEL TDSCQPYRSA FYILEQQCVG LAVDMDEIEK YQEVEEDQDP
1160 1170 1180 1190 1200
SCPRLSRELL DEKEPEVLQD SLDRCYSIPS GYLELPDLGQ PYSSAVYSLE
1210 1220 1230 1240 1250
EQYLGLALDV DRIKKDQEEE EDQDPPCPRL SRELVEVVEP EVLQDSLDRC
1260 1270 1280 1290 1300
YSTPSSCLEQ PDSCQPYGSS FYALEEKHVG FSLDVGEIEK KGKGKKRRGR
1310 1320 1330 1340 1350
RSKKERRRGR KEGEEDQNPP CPRLSRELLD EKGPEVLQDS LDRCYSTPSG
1360 1370 1380 1390 1400
CLELTDSCQP YRSAFYILEQ QCVGLAVDMD EIEKYQEVEE DQDPSCPRLS
1410 1420 1430 1440 1450
RELLDEKEPE VLQDSLDRCY SIPSGYLELP DLGQPYSSAV YSLEEQYLGL
1460 1470 1480 1490 1500
ALDVDRIKKD QEEEEDQDPP CPRLSRELVE VVEPEVLQDS LDRCYSTPSS
1510 1520 1530 1540 1550
CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKK RRGRRSKKER
1560 1570 1580 1590 1600
RRGRKEGEED QNPPCPRLSR ELLDEKGPEV LQDSLDRCYS TPSGCLELTD
1610 1620 1630 1640 1650
SCQPYRSAFY ILEQQCVGLA VDMDEIEKYQ EVEEDQDPSC PRLSRELLDE
1660 1670 1680 1690 1700
KEPEVLQDSL DRCYSIPSGY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR
1710 1720 1730 1740 1750
IKKDQEEEED QDPPCPRLSR ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD
1760 1770 1780 1790 1800
SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKERRRGRKE
1810 1820 1830 1840 1850
GEEDQNPPCP RLSRELLDEK GPEVLQDSLD RCYSTPSGCL ELTDSCQPYR
1860 1870 1880 1890 1900
SAFYILEQQC VGLAVDMDEI EKYQEVEEDQ DPSCPRLSRE LLDEKEPEVL
1910 1920 1930 1940 1950
QDSLDRCYST PSGYLELPDL GQPYSSAVYS LEEQYLGLAL DVDRIKKDQE
1960 1970 1980 1990 2000
EEEDQGPPCP RLSRELLEVV EPEVLQDSLD RCYSTPSSCL EQPDSCQPYG
2010 2020 2030 2040 2050
SSFYALEEKH VGFSLDVGEI EKKGKGKKRR GRRSKKERRR GRKEGEEDQN
2060 2070 2080 2090 2100
PPCPRLSREL LDEKGPEVLQ DSLDRCYSTP SGCLELTDSC QPYRSAFYIL
2110 2120 2130 2140 2150
EQQCVGLAVD MDEIEKYQEV EEDQDPSCPR LSRELLDEKE PEVLQDSLDR
2160 2170 2180 2190 2200
CYSTPSGYLE LPDLGQPYSS AVYSLEEQYL GLALDVDRIK KDQEEEEDQG
2210 2220 2230 2240 2250
PPCPRLSREL LEVVEPEVLQ DSLDRCYSTP SSCLEQPDSC QPYGSSFYAL
2260 2270 2280 2290 2300
EEKHVGFSLD VGEIEKKGKG KKRRGRRSKK ERRRGRKEGE EDQNPPCPRL
2310 2320 2330 2340 2350
SRELLDEKGP EVLQDSLDRC YSTPSGCLEL TDSCQPYRSA FYILEQQCVG
2360 2370 2380 2390 2400
LAVDMDEIEK YQEVEEDQDP SCPRLSRELL DEKEPEVLQD SLDRCYSTPS
2410 2420 2430 2440 2450
GYLELPDLGQ PYSSAVYSLE EQYLGLALDV DRIKKDQEEE EDQGPPCPRL
2460 2470 2480 2490 2500
SRELLEVVEP EVLQDSLDRC YSTPSSCLEQ PDSCQPYGSS FYALEEKHVG
2510 2520 2530 2540 2550
FSLDVGEIEK KGKGKKRRGR RSKKERRRGR KEGEEDQNPP CPRLSRELLD
2560 2570 2580 2590 2600
EKGPEVLQDS LDRCYSTPSG CLELTDSCQP YRSAFYILEQ QCVGLAVDMD
2610 2620 2630 2640 2650
EIEKYQEVEE DQDPSCPRLS RELLDEKEPE VLQDSLDRCY STPSGYLELP
2660 2670 2680 2690 2700
DLGQPYSSAV YSLEEQYLGL ALDVDRIKKD QEEEEDQGPP CPRLSRELLE
2710 2720 2730 2740 2750
VVEPEVLQDS LDRCYSTPSS CLEQPDSCQP YGSSFYALEE KHVGFSLDVG
2760 2770 2780 2790 2800
EIEKKGKGKK RRGRRSKKER RRGRKEGEED QNPPCPRLSR ELLDEKGPEV
2810 2820 2830 2840 2850
LQDSLDRCYS TPSGCLELTD SCQPYRSAFY ILEQQCVGLA VDMDEIEKYQ
2860 2870 2880 2890 2900
EVEEDQDPSC PRLSRELLDE KEPEVLQDSL DRCYSTPSGY LELPDLGQPY
2910 2920 2930 2940 2950
SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QGPPCPRLSR ELLEVVEPEV
2960 2970 2980 2990 3000
LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG
3010 3020 3030 3040 3050
KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLSRELLDEK GPEVLQDSLD
3060 3070 3080 3090 3100
RCYSTPSGCL ELTDSCQPYR SAFYILEQQC VGLAVDMDEI EKYQEVEEDQ
3110 3120 3130 3140 3150
DPSCPRLSRE LLAEKEPEVL QDPLDRCYST PSGYLELPDL GQPYSSAVYS
3160 3170 3180 3190 3200
LEEQYLGLAL DVDRIKKDQE EEEDQGPPCP RLSRELLEVV EPEVLQDSLD
3210 3220 3230 3240 3250
RCYSTPSSCL EQPDSCQPYG SSFYALEEKH VGFSLDVGEI EKKGKGKKRR
3260 3270 3280 3290 3300
GRRSKKERRR GRKEGEEDQN PPCPRLSREL LDEKGPEVLQ DSLDRCYSTP
3310 3320 3330 3340 3350
SGCLELTDSC QPYRSAFYIL EQQCVGLAVD MDEIEKYQEV EEDQDPSCPR
3360 3370 3380 3390 3400
LSRELLAEKE PEVLQDPLDR CYSTPSGYLE LPDLGQPYSS AVYSLEEQYL
3410 3420 3430 3440 3450
GLALDVDRIK KDQEEEEDQG PPCPRLSREL LEVVEPEVLQ DSLDRCYSTP
3460 3470 3480 3490 3500
SSCLEQPDSC QPYGSSFYAL EEKHVGFSLD VGEIEKKGKG KKRRGRRSKK
3510 3520 3530 3540 3550
ERRRGRKEGE EDQNPPCPRL SRELLDEKGP EVLQDSLDRC YSTPSGCLEL
3560 3570 3580 3590 3600
TDSCQPYRSA FYILEQQCVG LAVDMDEIEK YQEVEEDQDP SCPRLSRELL
3610 3620 3630 3640 3650
AEKEPEVLQD PLDRCYSTPS GYLELPDLGQ PYSSAVYSLE EQYLGLALDV
3660 3670 3680 3690 3700
DRIKKDQEEE EDQGPPCPRL SRELLEVVEP EVLQDSLDRC YSTPSSCLEQ
3710 3720 3730 3740 3750
PDSCQPYGSS FYALEEKHVG FSLDVGEIEK KGKGKKRRGR RSKKERRRGR
3760 3770 3780 3790 3800
KEGEEDQNPP CPRLNSVLME VEEPEVLQDS LDGCYSTPSM YFELPDSFQH
3810 3820 3830 3840
YRSVFYSFEE EHISFALYLD NRFFTLTVTS LHLVFQMLVI FPQ
Length:3,843
Mass (Da):440,408
Last modified:October 29, 2014 - v1
Checksum:i24A59AA23097CB90
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B6G5A0A075B6G5_HUMAN
Neuroblastoma breakpoint family mem...
NBPF19
921Annotation score:
A0A087X230A0A087X230_HUMAN
Neuroblastoma breakpoint family mem...
NBPF19
299Annotation score:
A0A087X288A0A087X288_HUMAN
Neuroblastoma breakpoint family mem...
NBPF19
235Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC242842 Genomic DNA No translation available.
AC242843 Genomic DNA No translation available.
CCDSiCCDS86016.1
UniGeneiHs.445080
Hs.534675

Genome annotation databases

EnsembliENST00000621744; ENSP00000478752; ENSG00000271383
UCSCiuc031uxc.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC242842 Genomic DNA No translation available.
AC242843 Genomic DNA No translation available.
CCDSiCCDS86016.1
UniGeneiHs.445080
Hs.534675

3D structure databases

ProteinModelPortaliA0A087WUL8
SMRiA0A087WUL8
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA0A087WUL8
PhosphoSitePlusiA0A087WUL8

Proteomic databases

PRIDEiA0A087WUL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000621744; ENSP00000478752; ENSG00000271383
UCSCiuc031uxc.2 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000271383.6
GeneCardsiNBPF19
HGNCiHGNC:31999 NBPF19
HPAiHPA042595
HPA043105
HPA043692
HPA044023
HPA046971
HPA058050
MIMi614006 gene
neXtProtiNX_A0A087WUL8
OpenTargetsiENSG00000271383
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00420000029746
OrthoDBiEOG091G03WI

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSG00000271383 Expressed in 91 organ(s), highest expression level in leukocyte
ExpressionAtlasiA0A087WUL8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR010630 NBPF_dom
PfamiView protein in Pfam
PF06758 DUF1220, 45 hits
SMARTiView protein in SMART
SM01148 DUF1220, 45 hits
PROSITEiView protein in PROSITE
PS51316 NBPF, 45 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNBPFJ_HUMAN
AccessioniPrimary (citable) accession number: A0A087WUL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 17, 2016
Last sequence update: October 29, 2014
Last modified: September 12, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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