UniProtKB - A0A087WUI7 (A0A087WUI7_HUMAN)
Protein
Submitted name:
Down syndrome cell adhesion molecule
Gene
DSCAM
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- axon guidance Source: InterPro
- cell adhesion Source: InterPro
Keywordsi
Biological process | NeurogenesisARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Down syndrome cell adhesion moleculeImported |
Gene namesi | Name:DSCAMImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3039, DSCAM |
VEuPathDBi | HostDB:ENSG00000171587.14 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1430 – 1451 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000171587, Expressed in endometrium epithelium and 73 other tissues |
ExpressionAtlasi | A0A087WUI7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 140 | Ig-likeInterPro annotationAdd BLAST | 81 | |
Domaini | 148 – 236 | Ig-likeInterPro annotationAdd BLAST | 89 | |
Domaini | 242 – 335 | Ig-likeInterPro annotationAdd BLAST | 94 | |
Domaini | 339 – 427 | Ig-likeInterPro annotationAdd BLAST | 89 | |
Domaini | 431 – 520 | Ig-likeInterPro annotationAdd BLAST | 90 | |
Domaini | 525 – 618 | Ig-likeInterPro annotationAdd BLAST | 94 | |
Domaini | 622 – 718 | Ig-likeInterPro annotationAdd BLAST | 97 | |
Domaini | 720 – 817 | Fibronectin type-IIIInterPro annotationAdd BLAST | 98 | |
Domaini | 822 – 921 | Fibronectin type-IIIInterPro annotationAdd BLAST | 100 | |
Domaini | 926 – 1022 | Fibronectin type-IIIInterPro annotationAdd BLAST | 97 | |
Domaini | 1026 – 1120 | Fibronectin type-IIIInterPro annotationAdd BLAST | 95 | |
Domaini | 1120 – 1212 | Ig-likeInterPro annotationAdd BLAST | 93 | |
Domaini | 1214 – 1308 | Fibronectin type-IIIInterPro annotationAdd BLAST | 95 | |
Domaini | 1309 – 1410 | Fibronectin type-IIIInterPro annotationAdd BLAST | 102 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1553 – 1645 | DisorderedSequence analysisAdd BLAST | 93 | |
Regioni | 1690 – 1718 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1806 – 1847 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1560 – 1602 | PolarSequence analysisAdd BLAST | 43 | |
Compositional biasi | 1617 – 1645 | PolarSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1690 – 1704 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1817 – 1831 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Immunoglobulin domainARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000154678 |
Family and domain databases
CDDi | cd00063, FN3, 6 hits |
Gene3Di | 2.60.40.10, 15 hits |
InterProi | View protein in InterPro IPR043204, Basigin-like IPR033027, DSCAM_metazoan IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
PANTHERi | PTHR10075, PTHR10075, 1 hit PTHR10075:SF51, PTHR10075:SF51, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 5 hits PF07679, I-set, 5 hits |
SMARTi | View protein in SMART SM00060, FN3, 6 hits SM00409, IG, 8 hits SM00408, IGc2, 8 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 8 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 6 hits PS50835, IG_LIKE, 8 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0A087WUI7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SSISGSRFLI TSTGALYIKD VQNEDGLYNY RCITRHRYTG ETRQSNSARL
60 70 80 90 100
FVSDPANSAP SILDGFDHRK AMAGQRVELP CKALGHPEPD YRWLKDNMPL
110 120 130 140 150
ELSGRFQKTV TGLLIENIRP SDSGSYVCEV SNRYGTAKVI GRLYVKQPLK
160 170 180 190 200
ATISPRKVKS SVGSQVSLSC SVTGTEDQEL SWYRNGEILN PGKNVRITGI
210 220 230 240 250
NHENLIMDHM VKSDGGAYQC FVRKDKLSAQ DYVQVVLEDG TPKIISAFSE
260 270 280 290 300
KVVSPAEPVS LMCNVKGTPL PTITWTLDDD PILKGGSHRI SQMITSEGNV
310 320 330 340 350
VSYLNISSSQ VRDGGVYRCT ANNSAGVVLY QARINVRGPA SIRPMKNITA
360 370 380 390 400
IAGRDTYIHC RVIGYPYYSI KWYKNSNLLP FNHRQVAFEN NGTLKLSDVQ
410 420 430 440 450
KEVDEGEYTC NVLVQPQLST SQSVHVTVKV PPFIQPFEFP RFSIGQRVFI
460 470 480 490 500
PCVVVSGDLP ITITWQKDGR PIPGSLGVTI DNIDFTSSLR ISNLSLMHNG
510 520 530 540 550
NYTCIARNEA AAVEHQSQLI VRVPPKFVVQ PRDQDGIYGK AVILNCSAEG
560 570 580 590 600
YPVPTIVWKF SKGAGVPQFQ PIALNGRIQV LSNGSLLIKH VVEEDSGYYL
610 620 630 640 650
CKVSNDVGAD VSKSMYLTVK IPAMITSYPN TTLATQGQKK EMSCTAHGEK
660 670 680 690 700
PIIVRWEKED RIINPEMARY LVSTKEVGEE VISTLQILPT VREDSGFFSC
710 720 730 740 750
HAINSYGEDR GIIQLTVQEP PDPPEIEIKD VKARTITLRW TMGFDGNSPI
760 770 780 790 800
TGYDIECKNK SDSWDSAQRT KDVSPQLNSA TIIDIHPSST YSIRMYAKNR
810 820 830 840 850
IGKSEPSNEL TITADEAAPD GPPQEVHLEP ISSQSIRVTW KAPKKHLQNG
860 870 880 890 900
IIRGYQIGYR EYSTGGNFQF NIISVDTSGD SEVYTLDNLN KFTQYGLVVQ
910 920 930 940 950
ACNRAGTGPS SQEIITTTLE DVPSYPPENV QAIATSPESI SISWSTLSKE
960 970 980 990 1000
ALNGILQGFR VIYWANLMDG ELGEIKNITT TQPSLELDGL EKYTNYSIQV
1010 1020 1030 1040 1050
LAFTRAGDGV RSEQIFTRTK EDVPGPPAGV KAAAASASMV FVSWLPPLKL
1060 1070 1080 1090 1100
NGIIRKYTVF CSHPYPTVIS EFEASPDSFS YRIPNLSRNR QYSVWVVAVT
1110 1120 1130 1140 1150
SAGRGNSSEI ITVEPLAKAP ARILTFSGTV TTPWMKDIVL PCKAVGDPSP
1160 1170 1180 1190 1200
AVKWMKDSNG TPSLVTIDGR RSIFSNGSFI IRTVKAEDSG YYSCIANNNW
1210 1220 1230 1240 1250
GSDEIILNLQ VQVPPDQPRL TVSKTTSSSI TLSWLPGDNG GSSIRGYILQ
1260 1270 1280 1290 1300
YSEDNSEQWG SFPISPSERS YRLENLKCGT WYKFTLTAQN GVGPGRISEI
1310 1320 1330 1340 1350
IEAKTLGKEP QFSKEQELFA SINTTRVRLN LIGWNDGGCP ITSFTLEYRP
1360 1370 1380 1390 1400
FGTTVWTTAQ RTSLSKSYIL YDLQEATWYE LQMRVCNSAG CAEKQANFAT
1410 1420 1430 1440 1450
LNYDGSTIPP LIKSVVQNEE GLTTNEGLKM LVTISCILVG VLLLFVLLLV
1460 1470 1480 1490 1500
VRRRRREQRL KRLRDAKSLA EMLMSKNTRT SDTLSKQQQT LRMHIDIPRA
1510 1520 1530 1540 1550
QLLIEERDTM ETIDDRSTVL LTDADFGEAA KQKSLTVTHT VHYQSVSQAT
1560 1570 1580 1590 1600
GPLVDVSDAR PGTNPTTRRN AKAGPTARNR YASQWTLNRP HPTISAHTLT
1610 1620 1630 1640 1650
TDWRLPTPRA AGSVDKESDS YSVSPSQDTD RARSSMVSTE SASSTYEELA
1660 1670 1680 1690 1700
RAYEHAKMEE QLRHAKFTIT ECFISDTSSE QLTAGTNEYT DSLTSSTPSE
1710 1720 1730 1740 1750
SGICRFTASP PKPQDGGRVM NMAVPKAHRP GDLIHLPPYL RMDFLLNRGG
1760 1770 1780 1790 1800
PGTSRDLSLG QACLEPQKSR TLKRPTVLEP IPMEAASSAS STREGQSWQP
1810 1820 1830 1840
GAVATLPQRE GAELGQAAKM SSSQESLLDS RGHLKGNNPY AKSYTLV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO60469 | DSCAM_HUMAN | Down syndrome cell adhesion molecul... | DSCAM | 2,012 | Annotation score: | ||
Q8WY19 | Q8WY19_HUMAN | Down syndrome cell adhesion molecul... | DSCAM | 1,746 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF042090 Genomic DNA No translation available. AF042091 Genomic DNA No translation available. AF064862 Genomic DNA No translation available. AF064863 Genomic DNA No translation available. AF064865 Genomic DNA No translation available. KF457309 Genomic DNA No translation available. KF457311 Genomic DNA No translation available. KF457321 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000617870; ENSP00000478698; ENSG00000171587 |
UCSCi | uc062agp.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF042090 Genomic DNA No translation available. AF042091 Genomic DNA No translation available. AF064862 Genomic DNA No translation available. AF064863 Genomic DNA No translation available. AF064865 Genomic DNA No translation available. KF457309 Genomic DNA No translation available. KF457311 Genomic DNA No translation available. KF457321 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A087WUI7 |
Protocols and materials databases
Antibodypediai | 23484, 157 antibodies |
Genome annotation databases
Ensembli | ENST00000617870; ENSP00000478698; ENSG00000171587 |
UCSCi | uc062agp.1, human |
Organism-specific databases
HGNCi | HGNC:3039, DSCAM |
OpenTargetsi | ENSG00000171587 |
VEuPathDBi | HostDB:ENSG00000171587.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154678 |
Miscellaneous databases
ChiTaRSi | DSCAM, human |
Gene expression databases
Bgeei | ENSG00000171587, Expressed in endometrium epithelium and 73 other tissues |
ExpressionAtlasi | A0A087WUI7, baseline and differential |
Family and domain databases
CDDi | cd00063, FN3, 6 hits |
Gene3Di | 2.60.40.10, 15 hits |
InterProi | View protein in InterPro IPR043204, Basigin-like IPR033027, DSCAM_metazoan IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
PANTHERi | PTHR10075, PTHR10075, 1 hit PTHR10075:SF51, PTHR10075:SF51, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 5 hits PF07679, I-set, 5 hits |
SMARTi | View protein in SMART SM00060, FN3, 6 hits SM00409, IG, 8 hits SM00408, IGc2, 8 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 8 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 6 hits PS50835, IG_LIKE, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087WUI7_HUMAN | |
Accessioni | A0A087WUI7Primary (citable) accession number: A0A087WUI7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | February 10, 2021 | |
This is version 41 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |