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Protein
Submitted name:

Regulator of G-protein-signaling 6

Gene

RGS6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Regulator of G-protein-signaling 6Imported
Gene namesi
Name:RGS6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000182732.16
HGNCiHGNC:10002 RGS6

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182732

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A087WTW9

Expressioni

Gene expression databases

BgeeiENSG00000182732 Expressed in 127 organ(s), highest expression level in frontal cortex
ExpressionAtlasiA0A087WTW9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A087WTW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 80DEPInterPro annotationAdd BLAST76
Domaini301 – 416RGSInterPro annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142

Family and domain databases

CDDicd00068 GGL, 1 hit
cd08737 RGS_RGS6, 1 hit
Gene3Di1.10.10.10, 1 hit
1.10.196.10, 2 hits
4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR037956 RGS6_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A087WTW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQDDKTGGVP IRTVKSFLSK IPSVVTGTDI VQWLMKNLSI EDPVEAIHLG
60 70 80 90 100
SLIAAQGYIF PISDHVLTMK DDGTFYRFQA PYFWPSNCWE PENTDYAIYL
110 120 130 140 150
CKRTMQNKAR LELADYEAEN LARLQRAFAR KWEFIFMQAE AQVKIDRKKD
160 170 180 190 200
KTERKILDSQ ERAFWDVHRP VPGCVNTTEM DIRKCRRLKN PQKVKKSVYG
210 220 230 240 250
VTEESQAQSP VHVLSQPIRK TTKEDIRKQI TFLNAQIDRH CLKMSKVAES
260 270 280 290 300
LIAYTEQYVE YDPLITPAEP SNPWISDDVA LWDIEMSKEP SQQRVKRWGF
310 320 330 340 350
SFDEILKDQV GRDQFLRFLE SEFSSENLRF WLAVQDLKKQ PLQDVAKRVE
360 370 380 390 400
EIWQEFLAPG APSAINLDSH SYEITSQNVK DGGRYTFEDA QEHIYKLMKS
410 420 430 440 450
DSYARFLRSN AYQDLLLAKK KPESEQGRRT SLEKFTRSVG KSLAGKRLTG

LMQSS
Length:455
Mass (Da):52,777
Last modified:October 29, 2014 - v1
Checksum:iFEC5E4CD918B68FD
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P49758RGS6_HUMAN
Regulator of G-protein signaling 6
RGS6
472Annotation score:
B7Z2N1B7Z2N1_HUMAN
Regulator of G-protein-signaling 6
RGS6
437Annotation score:
B7Z7N5B7Z7N5_HUMAN
Regulator of G-protein-signaling 6
RGS6
539Annotation score:
A0A0A0MRA9A0A0A0MRA9_HUMAN
Regulator of G-protein-signaling 6
RGS6
418Annotation score:
A0A2R8Y8A2A0A2R8Y8A2_HUMAN
Regulator of G-protein-signaling 6
RGS6
97Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004828 Genomic DNA No translation available.
AC005157 Genomic DNA No translation available.
AC005226 Genomic DNA No translation available.
AC005227 Genomic DNA No translation available.
AC005477 Genomic DNA No translation available.
AC005533 Genomic DNA No translation available.
AC005993 Genomic DNA No translation available.
KF455935 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000622468; ENSP00000478186; ENSG00000182732
UCSCiuc059czg.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004828 Genomic DNA No translation available.
AC005157 Genomic DNA No translation available.
AC005226 Genomic DNA No translation available.
AC005227 Genomic DNA No translation available.
AC005477 Genomic DNA No translation available.
AC005533 Genomic DNA No translation available.
AC005993 Genomic DNA No translation available.
KF455935 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A087WTW9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A087WTW9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000622468; ENSP00000478186; ENSG00000182732
UCSCiuc059czg.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000182732.16
HGNCiHGNC:10002 RGS6
OpenTargetsiENSG00000182732
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142

Miscellaneous databases

ChiTaRSiRGS6 human

Gene expression databases

BgeeiENSG00000182732 Expressed in 127 organ(s), highest expression level in frontal cortex
ExpressionAtlasiA0A087WTW9 baseline and differential

Family and domain databases

CDDicd00068 GGL, 1 hit
cd08737 RGS_RGS6, 1 hit
Gene3Di1.10.10.10, 1 hit
1.10.196.10, 2 hits
4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR037956 RGS6_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A087WTW9_HUMAN
AccessioniPrimary (citable) accession number: A0A087WTW9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: November 7, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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