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Entry version 50 (02 Dec 2020)
Sequence version 1 (29 Oct 2014)
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Protein
Submitted name:

Alstrom syndrome protein 1

Gene

ALMS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alstrom syndrome protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALMS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000116127.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:428, ALMS1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000116127

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A087WTU9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116127, Expressed in amniotic fluid and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A087WTU9, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3990 – 4122ALMS_motifInterPro annotationAdd BLAST133

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 74DisorderedSequence analysisAdd BLAST74
Regioni516 – 537DisorderedSequence analysisAdd BLAST22
Regioni564 – 583DisorderedSequence analysisAdd BLAST20
Regioni657 – 676DisorderedSequence analysisAdd BLAST20
Regioni693 – 727DisorderedSequence analysisAdd BLAST35
Regioni799 – 823DisorderedSequence analysisAdd BLAST25
Regioni904 – 927DisorderedSequence analysisAdd BLAST24
Regioni941 – 965DisorderedSequence analysisAdd BLAST25
Regioni985 – 1013DisorderedSequence analysisAdd BLAST29
Regioni1179 – 1199DisorderedSequence analysisAdd BLAST21
Regioni1744 – 1764DisorderedSequence analysisAdd BLAST21
Regioni2414 – 2435DisorderedSequence analysisAdd BLAST22
Regioni2558 – 2579DisorderedSequence analysisAdd BLAST22
Regioni2711 – 2786DisorderedSequence analysisAdd BLAST76
Regioni2850 – 2870DisorderedSequence analysisAdd BLAST21
Regioni3241 – 3268DisorderedSequence analysisAdd BLAST28
Regioni3347 – 3384DisorderedSequence analysisAdd BLAST38
Regioni3523 – 3552DisorderedSequence analysisAdd BLAST30
Regioni3601 – 3662DisorderedSequence analysisAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili384 – 404Sequence analysisAdd BLAST21
Coiled coili2444 – 2471Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 32AcidicSequence analysisAdd BLAST32
Compositional biasi52 – 66PolyampholyteSequence analysisAdd BLAST15
Compositional biasi523 – 537PolarSequence analysisAdd BLAST15
Compositional biasi566 – 583PolarSequence analysisAdd BLAST18
Compositional biasi659 – 673PolarSequence analysisAdd BLAST15
Compositional biasi713 – 727PolarSequence analysisAdd BLAST15
Compositional biasi806 – 823PolarSequence analysisAdd BLAST18
Compositional biasi904 – 926PolarSequence analysisAdd BLAST23
Compositional biasi946 – 965PolarSequence analysisAdd BLAST20
Compositional biasi999 – 1013PolarSequence analysisAdd BLAST15
Compositional biasi1184 – 1199PolarSequence analysisAdd BLAST16
Compositional biasi1750 – 1764PolarSequence analysisAdd BLAST15
Compositional biasi2722 – 2743PolarSequence analysisAdd BLAST22
Compositional biasi2744 – 2775PolyampholyteSequence analysisAdd BLAST32
Compositional biasi2850 – 2866PolyampholyteSequence analysisAdd BLAST17
Compositional biasi3244 – 3264PolarSequence analysisAdd BLAST21
Compositional biasi3538 – 3552PolarSequence analysisAdd BLAST15
Compositional biasi3606 – 3627PolyampholyteSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153123

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000177_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028781, ALMS1
IPR029299, ALMS_motif
IPR040972, ALMS_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR21553:SF22, PTHR21553:SF22, 13 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15309, ALMS_motif, 1 hit
PF18727, ALMS_repeat, 35 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A087WTU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPEDLPWPG ELEEEEEEEE EEEEEEEEAA AAAAANVDDV VVVEEVEEEA
60 70 80 90 100
GRELDSDSHY GPQHLESIDD EEDEEAKAWL QAHPGRILPP LSPPQHRYSE
110 120 130 140 150
GERTSLEKKT ESWHCLPQEM DSSQTLDTSQ TRFNVRTEDT EVTDFPSLEE
160 170 180 190 200
GILTQSENQV KEPNRDLFCS PLLVIQDSFA SPDLPLLTCL TQDQEFAPDS
210 220 230 240 250
LFHQSELSFA PLRGIPDKSE DTEWSSRPSE VSEALFQATA EVASDLASSR
260 270 280 290 300
FSVSQHPLIG STAVGSQCPF LPSEQGNNEE TISSVDELKI PKDCDRYDDL
310 320 330 340 350
CSYMSWKTRK DTQWPENNLA DKDQVSVATS FDITDENIAT KRSDHFDAAR
360 370 380 390 400
SYGQYWTQED SSKQAETYLT KGLQGKVESD VITLDGLNEN AVVCSERVAE
410 420 430 440 450
LQRKPTRESE YHSSDLRMLR MSPDTVPKAP KHLKAGDTSK GGIAKVTQSN
460 470 480 490 500
LKSGITTTPV DSDIGSHLSL SLEDLSQLAV SSPLETTTGQ HTDTLNQKTL
510 520 530 540 550
ADTHLTEETL KVTAIPEPAD QKTATPTVLS SSHSHRGKPS IFYQQGLPDS
560 570 580 590 600
HLTEEALKVS AAPGLADQTT GMSTLTSTSY SHREKPGTFY QQELPESNLT
610 620 630 640 650
EEPLEVSAAP GPVEQKTGIP TVSSTSHSHV EDLLFFYRQT LPDGHLTDQA
660 670 680 690 700
LKVSAVSGPA DQKTGTATVL STPHSHREKP GIFYQQEFAD SHQTEETLTK
710 720 730 740 750
VSATPGPADQ KTEIPAVQSS SYSQREKPSI LYPQDLADSH LPEEGLKVSA
760 770 780 790 800
VAGPADQKTG LPTVPSSAYS HREKLLVFYQ QALLDSHLPE EALKVSAVSG
810 820 830 840 850
PADGKTGTPA VTSTSSASSS LGEKPSAFYQ QTLPNSHLTE EALKVSIVPG
860 870 880 890 900
PGDQKTGIPS APSSFYSHRE KPIIFSQQTL PDFLFPEEAL KVSAVSVLAA
910 920 930 940 950
QKTGTPTVSS NSHSHSEKSS VFYQQELPDS DLPRESLKMS AIPGLTDQKT
960 970 980 990 1000
VPTPTVPSGS FSHREKPSIF YQQEWPDSYA TEKALKVSTG PGPADQKTEI
1010 1020 1030 1040 1050
PAVQSSSYPQ REKPSVLYPQ VLSDSHLPEE SLKVSAFPGP ADQMTDTPAV
1060 1070 1080 1090 1100
PSTFYSQREK PGIFYQQTLP ESHLPKEALK ISVAPGLADQ KTGTPTVTST
1110 1120 1130 1140 1150
SYSQHREKPS IFHQQALPGT HIPEEAQKVS AVTGPGNQKT WIPRVLSTFY
1160 1170 1180 1190 1200
SQREKPGIFY QQTLPGSHIP EEAQKVSPVL GPADQKTGTP TPTSASYSHT
1210 1220 1230 1240 1250
EKPGIFYQQV LPDNHPTEEA LKISVASEPV DQTTGTPAVT STSYSQYREK
1260 1270 1280 1290 1300
PSIFYQQSLP SSHLTEEAKN VSAVPGPADQ KTVIPILPST FYSHTEKPGV
1310 1320 1330 1340 1350
FYQQVLPHSH PTEEALKISV ASEPVDQTTG TPTVTSTSYS QHTEKPSIFY
1360 1370 1380 1390 1400
QQSLPGSHLT EEAKNVSAVP GPGDRKTGIP TLPSTFYSHT EKPGSFYQQV
1410 1420 1430 1440 1450
LPHSHLPEEA LEVSVAPGPV DQTIGTPTVT SPSSSFGEKP IVIYKQAFPE
1460 1470 1480 1490 1500
GHLPEESLKV SVAPGPVGQT TGAPTITSPS YSQHRAKSGS FYQLALLGSQ
1510 1520 1530 1540 1550
IPEEALRVSS APGPADQTTG IPTITSTSYS FGEKPIVNYK QAFPDGHLPE
1560 1570 1580 1590 1600
EALKVSIVSG PTEKKTDIPA GPLGSSALGE KPITFYRQAL LDSPLNKEVV
1610 1620 1630 1640 1650
KVSAAPGPAD QKTETLPVHS TSYSNRGKPV IFYQQTLSDS HLPEEALKVP
1660 1670 1680 1690 1700
PVPGPDAQKT ETPSVSSSLY SYREKPIVFY QQALPDSELT QEALKVSAVP
1710 1720 1730 1740 1750
QPADQKTGLS TVTSSFYSHT EKPNISYQQE LPDSHLTEEA LKVSNVPGPA
1760 1770 1780 1790 1800
DQKTGVSTVT STSYSHREKP IVSYQRELPH FTEAGLKILR VPGPADQKTG
1810 1820 1830 1840 1850
INILPSNSYP QREHSVISYE QELPDLTEVT LKAIGVPGPA DQKTGIQIAS
1860 1870 1880 1890 1900
SSSYSNREKA SIFHQQELPD VTEEALNVFV VPGQGDRKTE IPTVPLSYYS
1910 1920 1930 1940 1950
RREKPSVISQ QELPDSHLTE EALKVSPVSI PAEQKTGIPI GLSSSYSHSH
1960 1970 1980 1990 2000
KEKLKISTVH IPDDQKTEFP AATLSSYSQI EKPKISTVIG PNDQKTPSQT
2010 2020 2030 2040 2050
AFHSSYSQTV KPNILFQQQL PDRDQSKGIL KISAVPELTD VNTGKPVSLS
2060 2070 2080 2090 2100
SSYFHREKSN IFSPQELPGS HVTEDVLKVS TIPGPAGQKT VLPTALPSSF
2110 2120 2130 2140 2150
SHREKPDIFY QKDLPDRHLT EDALKISSAL GQADQITGLQ TVPSGTYSHG
2160 2170 2180 2190 2200
ENHKLVSEHV QRLIDNLNSS DSSVSSNNVL LNSQADDRVV INKPESAGFR
2210 2220 2230 2240 2250
DVGSEEIQDA ENSAKTLKEI RTLLMEAENM ALKRCNFPAP LARFRDISDI
2260 2270 2280 2290 2300
SFIQSKKVVC FKEPSSTGVS NGDLLHRQPF TEESPSSRCI QKDIGTQTNL
2310 2320 2330 2340 2350
KCRRGIENWE FISSTTVRSP LQEAESKVSM ALEETLRQYQ AAKSVMRSEP
2360 2370 2380 2390 2400
EGCSGTIGNK IIIPMMTVIK SDSSSDASDG NGSCSWDSNL PESLESVSDV
2410 2420 2430 2440 2450
LLNFFPYVSP KTSITDSREE EGVSESEDGG GSSVDSLAAH VKNLLQCESS
2460 2470 2480 2490 2500
LNHAKEILRN AEEEESRVRA HAWNMKFNLA HDCGYSISEL NEDDRRKVEE
2510 2520 2530 2540 2550
IKAELFGHGR TTDLSKGLQS PRGMGCKPEA VCSHIIIESH EKGCFRTLTS
2560 2570 2580 2590 2600
EHPQLDRHPC AFRSAGPSEM TRGRQNPSSC RAKHVNLSAS LDQNNSHFKV
2610 2620 2630 2640 2650
WNSLQLKSHS PFQNFIPDEF KISKGLRMPF DEKMDPWLSE LVEPAFVPPK
2660 2670 2680 2690 2700
EVDFHSSSQM PSPEPMKKFT TSITFSSHRH SKCISNSSVV KVGVTEGSQC
2710 2720 2730 2740 2750
TGASVGVFNS HFTEEQNPPR DLKQKTSSPS SFKMHSNSQD KEVTILAEGR
2760 2770 2780 2790 2800
RQSQKLPVDF ERSFQEEKPL ERSDFTGSHS EPSTRANCSN FKEIQISDNH
2810 2820 2830 2840 2850
TLISMGRPSS TLGVNRSSSR LGVKEKNVTI TPDLPSCIFL EQRELFEQSK
2860 2870 2880 2890 2900
APRADDHVRK HHSPSPQHQD YVAPDLPSCI FLEQRELFEQ CKAPYVDHQM
2910 2920 2930 2940 2950
RENHSPLPQG QDSIASDLPS PISLEQCQSK APGVDDQMNK HHFPLPQGQD
2960 2970 2980 2990 3000
CVVEKNNQHK PKSHISNINV EAKFNTVVSQ SAPNHCTLAA SASTPPSNRK
3010 3020 3030 3040 3050
ALSCVHITLC PKTSSKLDSG TLDERFHSLD AASKARMNSE FNFDLHTVSS
3060 3070 3080 3090 3100
RSLEPTSKLL TSKPVAQDQE SLGFLGPKSS LDFQVVQPSL PDSNTITQDL
3110 3120 3130 3140 3150
KTIPSQNSQI VTSRQIQVNI SDFEGHSNPE GTPVFADRLP EKMKTPLSAF
3160 3170 3180 3190 3200
SEKLSSDAVT QITTESPEKT LFSSEIFINA EDRGHEIIEP GNQKLRKAPV
3210 3220 3230 3240 3250
KFASSSSVQQ VTFSRGTDGQ PLLLPYKPSG STKMYYVPQL RQIPPSPDSK
3260 3270 3280 3290 3300
SDTTVESSHS GSNDAIAPDF PAQVLGTRDD DLSATVNIKH KEGIYSKRVV
3310 3320 3330 3340 3350
TKASLPVGEK PLQNENADAS VQVLITGDEN LSDKKQQEIH STRAVTEAAQ
3360 3370 3380 3390 3400
AKEKESLQKD TADSSAAAAA EHSAQVGDPE MKNLPDTKAI TQKEEIHRKK
3410 3420 3430 3440 3450
TVPEEAWPNN KESLQINIEE SECHSEFENT TRSVFRSAKF YIHHPVHLPS
3460 3470 3480 3490 3500
DQDICHESLG KSVFMRHSWK DFFQHHPDKH REHMCLPLPY QNMDKTKTDY
3510 3520 3530 3540 3550
TRIKSLSINV NLGNKEVMDT TKSQVRDYPK HNGQISDPQR DQKVTPEQTT
3560 3570 3580 3590 3600
QHTVSLNELW NKYRERQRQQ RQPELGDRKE LSLVDRLDRL AKILQNPITH
3610 3620 3630 3640 3650
SLQVSESTHD DSRGERSVKE WSGRQQQRNK LQKKKRFKSL EKSHKNTGEL
3660 3670 3680 3690 3700
KKSKVLSHHR AGRSNQIKIE QIKFDKYILS KQPGFNYISN TSSDCRPSEE
3710 3720 3730 3740 3750
SELLTDTTTN ILSGTTSTVE SDILTQTDRE VALHERSSSV STIDTARLIQ
3760 3770 3780 3790 3800
AFGHERVCLS PRRIKLYSSI TNQQRRYLEK RSKHSKKVLN TGHPLVTSEH
3810 3820 3830 3840 3850
TRRRHIQVAN HVISSDSISS SASSFLSSNS TFCNKQNVHM LNKGIQAGNL
3860 3870 3880 3890 3900
EIVNGAKKHT RDVGITFPTP SSSEAKLEEN SDVTSWSEEK REEKMLFTGY
3910 3920 3930 3940 3950
PEDRKLKKNK KNSHEGVSWF VPVENVESRS KKENVPNTCG PGISWFEPIT
3960 3970 3980 3990 4000
KTRPWREPLR EQNCQGQHLD GRGYLAGPGR EAGRDLLRPF VRATLQESLQ
4010 4020 4030 4040 4050
FHRPDFISRS GERIKRLKLI VQERKLQSML QTERDALFNI DRERQGHQNR
4060 4070 4080 4090 4100
MCPLPKRVFL AIQKNKPISK KEMIQRSKRI YEQLPEVQKK REEEKRKSEY
4110 4120
KSYRLRAQLY KKRVTNQLLG RKVPWD
Length:4,126
Mass (Da):456,418
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B1C45C54EA8127F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8TCU4ALMS1_HUMAN
Alstrom syndrome protein 1
ALMS1 KIAA0328
4,168Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV20A0A087WV20_HUMAN
Alstrom syndrome protein 1
ALMS1
3,859Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0F1A0A494C0F1_HUMAN
Alstrom syndrome protein 1
ALMS1
886Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1D9H7C1D9_HUMAN
Alstrom syndrome protein 1
ALMS1
1,023Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7Z9A0A2R8Y7Z9_HUMAN
Alstrom syndrome protein 1
ALMS1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZW1A0A494BZW1_HUMAN
Alstrom syndrome protein 1
ALMS1
312Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C003A0A494C003_HUMAN
Alstrom syndrome protein 1
ALMS1
428Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1N9A0A494C1N9_HUMAN
Alstrom syndrome protein 1
ALMS1
901Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC074008 Genomic DNA No translation available.
AC092653 Genomic DNA No translation available.
AC096546 Genomic DNA No translation available.
KF573641 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000484298; ENSP00000478155; ENSG00000116127

UCSC genome browser

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UCSCi
uc032nre.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC074008 Genomic DNA No translation available.
AC092653 Genomic DNA No translation available.
AC096546 Genomic DNA No translation available.
KF573641 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0A087WTU9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
8144, 113 antibodies

Genome annotation databases

EnsembliENST00000484298; ENSP00000478155; ENSG00000116127
UCSCiuc032nre.2, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000116127.17
HGNCiHGNC:428, ALMS1
OpenTargetsiENSG00000116127

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000153123
HOGENOMiCLU_000177_0_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ALMS1, human

Gene expression databases

BgeeiENSG00000116127, Expressed in amniotic fluid and 237 other tissues
ExpressionAtlasiA0A087WTU9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR028781, ALMS1
IPR029299, ALMS_motif
IPR040972, ALMS_repeat
PANTHERiPTHR21553:SF22, PTHR21553:SF22, 13 hits
PfamiView protein in Pfam
PF15309, ALMS_motif, 1 hit
PF18727, ALMS_repeat, 35 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087WTU9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087WTU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: December 2, 2020
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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