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UniProtKB - A0A087WTU9 (A0A087WTU9_HUMAN)

Entry version 50 (02 Dec 2020)
Sequence version 1 (29 Oct 2014)
Previous versions | rss
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Protein
Submitted name:

Alstrom syndrome protein 1

Gene

ALMS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alstrom syndrome protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALMS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000116127.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:428, ALMS1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000116127

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		A0A087WTU9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116127, Expressed in amniotic fluid and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A087WTU9, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3990 – 4122ALMS_motifInterPro annotationAdd BLAST133

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 74DisorderedSequence analysisAdd BLAST74
Regioni516 – 537DisorderedSequence analysisAdd BLAST22
Regioni564 – 583DisorderedSequence analysisAdd BLAST20
Regioni657 – 676DisorderedSequence analysisAdd BLAST20
Regioni693 – 727DisorderedSequence analysisAdd BLAST35
Regioni799 – 823DisorderedSequence analysisAdd BLAST25
Regioni904 – 927DisorderedSequence analysisAdd BLAST24
Regioni941 – 965DisorderedSequence analysisAdd BLAST25
Regioni985 – 1013DisorderedSequence analysisAdd BLAST29
Regioni1179 – 1199DisorderedSequence analysisAdd BLAST21
Regioni1744 – 1764DisorderedSequence analysisAdd BLAST21
Regioni2414 – 2435DisorderedSequence analysisAdd BLAST22
Regioni2558 – 2579DisorderedSequence analysisAdd BLAST22
Regioni2711 – 2786DisorderedSequence analysisAdd BLAST76
Regioni2850 – 2870DisorderedSequence analysisAdd BLAST21
Regioni3241 – 3268DisorderedSequence analysisAdd BLAST28
Regioni3347 – 3384DisorderedSequence analysisAdd BLAST38
Regioni3523 – 3552DisorderedSequence analysisAdd BLAST30
Regioni3601 – 3662DisorderedSequence analysisAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili384 – 404Sequence analysisAdd BLAST21
Coiled coili2444 – 2471Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 32AcidicSequence analysisAdd BLAST32
Compositional biasi52 – 66PolyampholyteSequence analysisAdd BLAST15
Compositional biasi523 – 537PolarSequence analysisAdd BLAST15
Compositional biasi566 – 583PolarSequence analysisAdd BLAST18
Compositional biasi659 – 673PolarSequence analysisAdd BLAST15
Compositional biasi713 – 727PolarSequence analysisAdd BLAST15
Compositional biasi806 – 823PolarSequence analysisAdd BLAST18
Compositional biasi904 – 926PolarSequence analysisAdd BLAST23
Compositional biasi946 – 965PolarSequence analysisAdd BLAST20
Compositional biasi999 – 1013PolarSequence analysisAdd BLAST15
Compositional biasi1184 – 1199PolarSequence analysisAdd BLAST16
Compositional biasi1750 – 1764PolarSequence analysisAdd BLAST15
Compositional biasi2722 – 2743PolarSequence analysisAdd BLAST22
Compositional biasi2744 – 2775PolyampholyteSequence analysisAdd BLAST32
Compositional biasi2850 – 2866PolyampholyteSequence analysisAdd BLAST17
Compositional biasi3244 – 3264PolarSequence analysisAdd BLAST21
Compositional biasi3538 – 3552PolarSequence analysisAdd BLAST15
Compositional biasi3606 – 3627PolyampholyteSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153123

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000177_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028781, ALMS1
IPR029299, ALMS_motif
IPR040972, ALMS_repeat

The PANTHER Classification System

More...PANTHERi		PTHR21553:SF22, PTHR21553:SF22, 13 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15309, ALMS_motif, 1 hit
PF18727, ALMS_repeat, 35 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A087WTU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPEDLPWPG ELEEEEEEEE EEEEEEEEAA AAAAANVDDV VVVEEVEEEA 
        60         70         80         90        100
GRELDSDSHY GPQHLESIDD EEDEEAKAWL QAHPGRILPP LSPPQHRYSE 
       110        120        130        140        150
GERTSLEKKT ESWHCLPQEM DSSQTLDTSQ TRFNVRTEDT EVTDFPSLEE 
       160        170        180        190        200
GILTQSENQV KEPNRDLFCS PLLVIQDSFA SPDLPLLTCL TQDQEFAPDS 
       210        220        230        240        250
LFHQSELSFA PLRGIPDKSE DTEWSSRPSE VSEALFQATA EVASDLASSR 
       260        270        280        290        300
FSVSQHPLIG STAVGSQCPF LPSEQGNNEE TISSVDELKI PKDCDRYDDL 
       310        320        330        340        350
CSYMSWKTRK DTQWPENNLA DKDQVSVATS FDITDENIAT KRSDHFDAAR 
       360        370        380        390        400
SYGQYWTQED SSKQAETYLT KGLQGKVESD VITLDGLNEN AVVCSERVAE 
       410        420        430        440        450
LQRKPTRESE YHSSDLRMLR MSPDTVPKAP KHLKAGDTSK GGIAKVTQSN 
       460        470        480        490        500
LKSGITTTPV DSDIGSHLSL SLEDLSQLAV SSPLETTTGQ HTDTLNQKTL 
       510        520        530        540        550
ADTHLTEETL KVTAIPEPAD QKTATPTVLS SSHSHRGKPS IFYQQGLPDS 
       560        570        580        590        600
HLTEEALKVS AAPGLADQTT GMSTLTSTSY SHREKPGTFY QQELPESNLT 
       610        620        630        640        650
EEPLEVSAAP GPVEQKTGIP TVSSTSHSHV EDLLFFYRQT LPDGHLTDQA 
       660        670        680        690        700
LKVSAVSGPA DQKTGTATVL STPHSHREKP GIFYQQEFAD SHQTEETLTK 
       710        720        730        740        750
VSATPGPADQ KTEIPAVQSS SYSQREKPSI LYPQDLADSH LPEEGLKVSA 
       760        770        780        790        800
VAGPADQKTG LPTVPSSAYS HREKLLVFYQ QALLDSHLPE EALKVSAVSG 
       810        820        830        840        850
PADGKTGTPA VTSTSSASSS LGEKPSAFYQ QTLPNSHLTE EALKVSIVPG 
       860        870        880        890        900
PGDQKTGIPS APSSFYSHRE KPIIFSQQTL PDFLFPEEAL KVSAVSVLAA 
       910        920        930        940        950
QKTGTPTVSS NSHSHSEKSS VFYQQELPDS DLPRESLKMS AIPGLTDQKT 
       960        970        980        990       1000
VPTPTVPSGS FSHREKPSIF YQQEWPDSYA TEKALKVSTG PGPADQKTEI 
      1010       1020       1030       1040       1050
PAVQSSSYPQ REKPSVLYPQ VLSDSHLPEE SLKVSAFPGP ADQMTDTPAV 
      1060       1070       1080       1090       1100
PSTFYSQREK PGIFYQQTLP ESHLPKEALK ISVAPGLADQ KTGTPTVTST 
      1110       1120       1130       1140       1150
SYSQHREKPS IFHQQALPGT HIPEEAQKVS AVTGPGNQKT WIPRVLSTFY 
      1160       1170       1180       1190       1200
SQREKPGIFY QQTLPGSHIP EEAQKVSPVL GPADQKTGTP TPTSASYSHT 
      1210       1220       1230       1240       1250
EKPGIFYQQV LPDNHPTEEA LKISVASEPV DQTTGTPAVT STSYSQYREK 
      1260       1270       1280       1290       1300
PSIFYQQSLP SSHLTEEAKN VSAVPGPADQ KTVIPILPST FYSHTEKPGV 
      1310       1320       1330       1340       1350
FYQQVLPHSH PTEEALKISV ASEPVDQTTG TPTVTSTSYS QHTEKPSIFY 
      1360       1370       1380       1390       1400
QQSLPGSHLT EEAKNVSAVP GPGDRKTGIP TLPSTFYSHT EKPGSFYQQV 
      1410       1420       1430       1440       1450
LPHSHLPEEA LEVSVAPGPV DQTIGTPTVT SPSSSFGEKP IVIYKQAFPE 
      1460       1470       1480       1490       1500
GHLPEESLKV SVAPGPVGQT TGAPTITSPS YSQHRAKSGS FYQLALLGSQ 
      1510       1520       1530       1540       1550
IPEEALRVSS APGPADQTTG IPTITSTSYS FGEKPIVNYK QAFPDGHLPE 
      1560       1570       1580       1590       1600
EALKVSIVSG PTEKKTDIPA GPLGSSALGE KPITFYRQAL LDSPLNKEVV 
      1610       1620       1630       1640       1650
KVSAAPGPAD QKTETLPVHS TSYSNRGKPV IFYQQTLSDS HLPEEALKVP 
      1660       1670       1680       1690       1700
PVPGPDAQKT ETPSVSSSLY SYREKPIVFY QQALPDSELT QEALKVSAVP 
      1710       1720       1730       1740       1750
QPADQKTGLS TVTSSFYSHT EKPNISYQQE LPDSHLTEEA LKVSNVPGPA 
      1760       1770       1780       1790       1800
DQKTGVSTVT STSYSHREKP IVSYQRELPH FTEAGLKILR VPGPADQKTG 
      1810       1820       1830       1840       1850
INILPSNSYP QREHSVISYE QELPDLTEVT LKAIGVPGPA DQKTGIQIAS 
      1860       1870       1880       1890       1900
SSSYSNREKA SIFHQQELPD VTEEALNVFV VPGQGDRKTE IPTVPLSYYS 
      1910       1920       1930       1940       1950
RREKPSVISQ QELPDSHLTE EALKVSPVSI PAEQKTGIPI GLSSSYSHSH 
      1960       1970       1980       1990       2000
KEKLKISTVH IPDDQKTEFP AATLSSYSQI EKPKISTVIG PNDQKTPSQT 
      2010       2020       2030       2040       2050
AFHSSYSQTV KPNILFQQQL PDRDQSKGIL KISAVPELTD VNTGKPVSLS 
      2060       2070       2080       2090       2100
SSYFHREKSN IFSPQELPGS HVTEDVLKVS TIPGPAGQKT VLPTALPSSF 
      2110       2120       2130       2140       2150
SHREKPDIFY QKDLPDRHLT EDALKISSAL GQADQITGLQ TVPSGTYSHG 
      2160       2170       2180       2190       2200
ENHKLVSEHV QRLIDNLNSS DSSVSSNNVL LNSQADDRVV INKPESAGFR 
      2210       2220       2230       2240       2250
DVGSEEIQDA ENSAKTLKEI RTLLMEAENM ALKRCNFPAP LARFRDISDI 
      2260       2270       2280       2290       2300
SFIQSKKVVC FKEPSSTGVS NGDLLHRQPF TEESPSSRCI QKDIGTQTNL 
      2310       2320       2330       2340       2350
KCRRGIENWE FISSTTVRSP LQEAESKVSM ALEETLRQYQ AAKSVMRSEP 
      2360       2370       2380       2390       2400
EGCSGTIGNK IIIPMMTVIK SDSSSDASDG NGSCSWDSNL PESLESVSDV 
      2410       2420       2430       2440       2450
LLNFFPYVSP KTSITDSREE EGVSESEDGG GSSVDSLAAH VKNLLQCESS 
      2460       2470       2480       2490       2500
LNHAKEILRN AEEEESRVRA HAWNMKFNLA HDCGYSISEL NEDDRRKVEE 
      2510       2520       2530       2540       2550
IKAELFGHGR TTDLSKGLQS PRGMGCKPEA VCSHIIIESH EKGCFRTLTS 
      2560       2570       2580       2590       2600
EHPQLDRHPC AFRSAGPSEM TRGRQNPSSC RAKHVNLSAS LDQNNSHFKV 
      2610       2620       2630       2640       2650
WNSLQLKSHS PFQNFIPDEF KISKGLRMPF DEKMDPWLSE LVEPAFVPPK 
      2660       2670       2680       2690       2700
EVDFHSSSQM PSPEPMKKFT TSITFSSHRH SKCISNSSVV KVGVTEGSQC 
      2710       2720       2730       2740       2750
TGASVGVFNS HFTEEQNPPR DLKQKTSSPS SFKMHSNSQD KEVTILAEGR 
      2760       2770       2780       2790       2800
RQSQKLPVDF ERSFQEEKPL ERSDFTGSHS EPSTRANCSN FKEIQISDNH 
      2810       2820       2830       2840       2850
TLISMGRPSS TLGVNRSSSR LGVKEKNVTI TPDLPSCIFL EQRELFEQSK 
      2860       2870       2880       2890       2900
APRADDHVRK HHSPSPQHQD YVAPDLPSCI FLEQRELFEQ CKAPYVDHQM 
      2910       2920       2930       2940       2950
RENHSPLPQG QDSIASDLPS PISLEQCQSK APGVDDQMNK HHFPLPQGQD 
      2960       2970       2980       2990       3000
CVVEKNNQHK PKSHISNINV EAKFNTVVSQ SAPNHCTLAA SASTPPSNRK 
      3010       3020       3030       3040       3050
ALSCVHITLC PKTSSKLDSG TLDERFHSLD AASKARMNSE FNFDLHTVSS 
      3060       3070       3080       3090       3100
RSLEPTSKLL TSKPVAQDQE SLGFLGPKSS LDFQVVQPSL PDSNTITQDL 
      3110       3120       3130       3140       3150
KTIPSQNSQI VTSRQIQVNI SDFEGHSNPE GTPVFADRLP EKMKTPLSAF 
      3160       3170       3180       3190       3200
SEKLSSDAVT QITTESPEKT LFSSEIFINA EDRGHEIIEP GNQKLRKAPV 
      3210       3220       3230       3240       3250
KFASSSSVQQ VTFSRGTDGQ PLLLPYKPSG STKMYYVPQL RQIPPSPDSK 
      3260       3270       3280       3290       3300
SDTTVESSHS GSNDAIAPDF PAQVLGTRDD DLSATVNIKH KEGIYSKRVV 
      3310       3320       3330       3340       3350
TKASLPVGEK PLQNENADAS VQVLITGDEN LSDKKQQEIH STRAVTEAAQ 
      3360       3370       3380       3390       3400
AKEKESLQKD TADSSAAAAA EHSAQVGDPE MKNLPDTKAI TQKEEIHRKK 
      3410       3420       3430       3440       3450
TVPEEAWPNN KESLQINIEE SECHSEFENT TRSVFRSAKF YIHHPVHLPS 
      3460       3470       3480       3490       3500
DQDICHESLG KSVFMRHSWK DFFQHHPDKH REHMCLPLPY QNMDKTKTDY 
      3510       3520       3530       3540       3550
TRIKSLSINV NLGNKEVMDT TKSQVRDYPK HNGQISDPQR DQKVTPEQTT 
      3560       3570       3580       3590       3600
QHTVSLNELW NKYRERQRQQ RQPELGDRKE LSLVDRLDRL AKILQNPITH 
      3610       3620       3630       3640       3650
SLQVSESTHD DSRGERSVKE WSGRQQQRNK LQKKKRFKSL EKSHKNTGEL 
      3660       3670       3680       3690       3700
KKSKVLSHHR AGRSNQIKIE QIKFDKYILS KQPGFNYISN TSSDCRPSEE 
      3710       3720       3730       3740       3750
SELLTDTTTN ILSGTTSTVE SDILTQTDRE VALHERSSSV STIDTARLIQ 
      3760       3770       3780       3790       3800
AFGHERVCLS PRRIKLYSSI TNQQRRYLEK RSKHSKKVLN TGHPLVTSEH 
      3810       3820       3830       3840       3850
TRRRHIQVAN HVISSDSISS SASSFLSSNS TFCNKQNVHM LNKGIQAGNL 
      3860       3870       3880       3890       3900
EIVNGAKKHT RDVGITFPTP SSSEAKLEEN SDVTSWSEEK REEKMLFTGY 
      3910       3920       3930       3940       3950
PEDRKLKKNK KNSHEGVSWF VPVENVESRS KKENVPNTCG PGISWFEPIT 
      3960       3970       3980       3990       4000
KTRPWREPLR EQNCQGQHLD GRGYLAGPGR EAGRDLLRPF VRATLQESLQ 
      4010       4020       4030       4040       4050
FHRPDFISRS GERIKRLKLI VQERKLQSML QTERDALFNI DRERQGHQNR 
      4060       4070       4080       4090       4100
MCPLPKRVFL AIQKNKPISK KEMIQRSKRI YEQLPEVQKK REEEKRKSEY 
      4110       4120 
KSYRLRAQLY KKRVTNQLLG RKVPWD
Length:4,126
Mass (Da):456,418
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B1C45C54EA8127F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8TCU4ALMS1_HUMAN
Alstrom syndrome protein 1
ALMS1 KIAA0328
4,168Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV20A0A087WV20_HUMAN
Alstrom syndrome protein 1
ALMS1
3,859Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0F1A0A494C0F1_HUMAN
Alstrom syndrome protein 1
ALMS1
886Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1D9H7C1D9_HUMAN
Alstrom syndrome protein 1
ALMS1
1,023Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7Z9A0A2R8Y7Z9_HUMAN
Alstrom syndrome protein 1
ALMS1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZW1A0A494BZW1_HUMAN
Alstrom syndrome protein 1
ALMS1
312Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C003A0A494C003_HUMAN
Alstrom syndrome protein 1
ALMS1
428Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1N9A0A494C1N9_HUMAN
Alstrom syndrome protein 1
ALMS1
901Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC074008 Genomic DNA No translation available.
AC092653 Genomic DNA No translation available.
AC096546 Genomic DNA No translation available.
KF573641 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000484298; ENSP00000478155; ENSG00000116127

UCSC genome browser

More...UCSCi		uc032nre.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC074008 Genomic DNA No translation available.
AC092653 Genomic DNA No translation available.
AC096546 Genomic DNA No translation available.
KF573641 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0A087WTU9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		8144, 113 antibodies

Genome annotation databases

EnsembliENST00000484298; ENSP00000478155; ENSG00000116127
UCSCiuc032nre.2, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000116127.17
HGNCiHGNC:428, ALMS1
OpenTargetsiENSG00000116127

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000153123
HOGENOMiCLU_000177_0_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ALMS1, human

Gene expression databases

BgeeiENSG00000116127, Expressed in amniotic fluid and 237 other tissues
ExpressionAtlasiA0A087WTU9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR028781, ALMS1
IPR029299, ALMS_motif
IPR040972, ALMS_repeat
PANTHERiPTHR21553:SF22, PTHR21553:SF22, 13 hits
PfamiView protein in Pfam
PF15309, ALMS_motif, 1 hit
PF18727, ALMS_repeat, 35 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087WTU9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087WTU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: December 2, 2020
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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