UniProtKB - A0A087WTU9 (A0A087WTU9_HUMAN)
Protein
Submitted name:
Alstrom syndrome protein 1
Gene
ALMS1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- endosomal transport Source: InterPro
- regulation of stress fiber assembly Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Alstrom syndrome protein 1Imported |
Gene namesi | Name:ALMS1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000116127.17 |
HGNCi | HGNC:428, ALMS1 |
Subcellular locationi
Cytoskeleton
- centrosome ARBA annotation
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Keywords - Cellular componenti
Cytoplasm, CytoskeletonARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000116127, Expressed in amniotic fluid and 237 other tissues |
ExpressionAtlasi | A0A087WTU9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3990 – 4122 | ALMS_motifInterPro annotationAdd BLAST | 133 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 74 | DisorderedSequence analysisAdd BLAST | 74 | |
Regioni | 516 – 537 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 564 – 583 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 657 – 676 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 693 – 727 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 799 – 823 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 904 – 927 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 941 – 965 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 985 – 1013 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1179 – 1199 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1744 – 1764 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 2414 – 2435 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 2558 – 2579 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 2711 – 2786 | DisorderedSequence analysisAdd BLAST | 76 | |
Regioni | 2850 – 2870 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 3241 – 3268 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 3347 – 3384 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 3523 – 3552 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 3601 – 3662 | DisorderedSequence analysisAdd BLAST | 62 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 384 – 404 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 2444 – 2471 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 32 | AcidicSequence analysisAdd BLAST | 32 | |
Compositional biasi | 52 – 66 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 523 – 537 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 566 – 583 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 659 – 673 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 713 – 727 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 806 – 823 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 904 – 926 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 946 – 965 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 999 – 1013 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1184 – 1199 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1750 – 1764 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2722 – 2743 | PolarSequence analysisAdd BLAST | 22 | |
Compositional biasi | 2744 – 2775 | PolyampholyteSequence analysisAdd BLAST | 32 | |
Compositional biasi | 2850 – 2866 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 3244 – 3264 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 3538 – 3552 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 3606 – 3627 | PolyampholyteSequence analysisAdd BLAST | 22 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000153123 |
HOGENOMi | CLU_000177_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR028781, ALMS1 IPR029299, ALMS_motif IPR040972, ALMS_repeat |
PANTHERi | PTHR21553:SF22, PTHR21553:SF22, 13 hits |
Pfami | View protein in Pfam PF15309, ALMS_motif, 1 hit PF18727, ALMS_repeat, 35 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
A0A087WTU9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPEDLPWPG ELEEEEEEEE EEEEEEEEAA AAAAANVDDV VVVEEVEEEA
60 70 80 90 100
GRELDSDSHY GPQHLESIDD EEDEEAKAWL QAHPGRILPP LSPPQHRYSE
110 120 130 140 150
GERTSLEKKT ESWHCLPQEM DSSQTLDTSQ TRFNVRTEDT EVTDFPSLEE
160 170 180 190 200
GILTQSENQV KEPNRDLFCS PLLVIQDSFA SPDLPLLTCL TQDQEFAPDS
210 220 230 240 250
LFHQSELSFA PLRGIPDKSE DTEWSSRPSE VSEALFQATA EVASDLASSR
260 270 280 290 300
FSVSQHPLIG STAVGSQCPF LPSEQGNNEE TISSVDELKI PKDCDRYDDL
310 320 330 340 350
CSYMSWKTRK DTQWPENNLA DKDQVSVATS FDITDENIAT KRSDHFDAAR
360 370 380 390 400
SYGQYWTQED SSKQAETYLT KGLQGKVESD VITLDGLNEN AVVCSERVAE
410 420 430 440 450
LQRKPTRESE YHSSDLRMLR MSPDTVPKAP KHLKAGDTSK GGIAKVTQSN
460 470 480 490 500
LKSGITTTPV DSDIGSHLSL SLEDLSQLAV SSPLETTTGQ HTDTLNQKTL
510 520 530 540 550
ADTHLTEETL KVTAIPEPAD QKTATPTVLS SSHSHRGKPS IFYQQGLPDS
560 570 580 590 600
HLTEEALKVS AAPGLADQTT GMSTLTSTSY SHREKPGTFY QQELPESNLT
610 620 630 640 650
EEPLEVSAAP GPVEQKTGIP TVSSTSHSHV EDLLFFYRQT LPDGHLTDQA
660 670 680 690 700
LKVSAVSGPA DQKTGTATVL STPHSHREKP GIFYQQEFAD SHQTEETLTK
710 720 730 740 750
VSATPGPADQ KTEIPAVQSS SYSQREKPSI LYPQDLADSH LPEEGLKVSA
760 770 780 790 800
VAGPADQKTG LPTVPSSAYS HREKLLVFYQ QALLDSHLPE EALKVSAVSG
810 820 830 840 850
PADGKTGTPA VTSTSSASSS LGEKPSAFYQ QTLPNSHLTE EALKVSIVPG
860 870 880 890 900
PGDQKTGIPS APSSFYSHRE KPIIFSQQTL PDFLFPEEAL KVSAVSVLAA
910 920 930 940 950
QKTGTPTVSS NSHSHSEKSS VFYQQELPDS DLPRESLKMS AIPGLTDQKT
960 970 980 990 1000
VPTPTVPSGS FSHREKPSIF YQQEWPDSYA TEKALKVSTG PGPADQKTEI
1010 1020 1030 1040 1050
PAVQSSSYPQ REKPSVLYPQ VLSDSHLPEE SLKVSAFPGP ADQMTDTPAV
1060 1070 1080 1090 1100
PSTFYSQREK PGIFYQQTLP ESHLPKEALK ISVAPGLADQ KTGTPTVTST
1110 1120 1130 1140 1150
SYSQHREKPS IFHQQALPGT HIPEEAQKVS AVTGPGNQKT WIPRVLSTFY
1160 1170 1180 1190 1200
SQREKPGIFY QQTLPGSHIP EEAQKVSPVL GPADQKTGTP TPTSASYSHT
1210 1220 1230 1240 1250
EKPGIFYQQV LPDNHPTEEA LKISVASEPV DQTTGTPAVT STSYSQYREK
1260 1270 1280 1290 1300
PSIFYQQSLP SSHLTEEAKN VSAVPGPADQ KTVIPILPST FYSHTEKPGV
1310 1320 1330 1340 1350
FYQQVLPHSH PTEEALKISV ASEPVDQTTG TPTVTSTSYS QHTEKPSIFY
1360 1370 1380 1390 1400
QQSLPGSHLT EEAKNVSAVP GPGDRKTGIP TLPSTFYSHT EKPGSFYQQV
1410 1420 1430 1440 1450
LPHSHLPEEA LEVSVAPGPV DQTIGTPTVT SPSSSFGEKP IVIYKQAFPE
1460 1470 1480 1490 1500
GHLPEESLKV SVAPGPVGQT TGAPTITSPS YSQHRAKSGS FYQLALLGSQ
1510 1520 1530 1540 1550
IPEEALRVSS APGPADQTTG IPTITSTSYS FGEKPIVNYK QAFPDGHLPE
1560 1570 1580 1590 1600
EALKVSIVSG PTEKKTDIPA GPLGSSALGE KPITFYRQAL LDSPLNKEVV
1610 1620 1630 1640 1650
KVSAAPGPAD QKTETLPVHS TSYSNRGKPV IFYQQTLSDS HLPEEALKVP
1660 1670 1680 1690 1700
PVPGPDAQKT ETPSVSSSLY SYREKPIVFY QQALPDSELT QEALKVSAVP
1710 1720 1730 1740 1750
QPADQKTGLS TVTSSFYSHT EKPNISYQQE LPDSHLTEEA LKVSNVPGPA
1760 1770 1780 1790 1800
DQKTGVSTVT STSYSHREKP IVSYQRELPH FTEAGLKILR VPGPADQKTG
1810 1820 1830 1840 1850
INILPSNSYP QREHSVISYE QELPDLTEVT LKAIGVPGPA DQKTGIQIAS
1860 1870 1880 1890 1900
SSSYSNREKA SIFHQQELPD VTEEALNVFV VPGQGDRKTE IPTVPLSYYS
1910 1920 1930 1940 1950
RREKPSVISQ QELPDSHLTE EALKVSPVSI PAEQKTGIPI GLSSSYSHSH
1960 1970 1980 1990 2000
KEKLKISTVH IPDDQKTEFP AATLSSYSQI EKPKISTVIG PNDQKTPSQT
2010 2020 2030 2040 2050
AFHSSYSQTV KPNILFQQQL PDRDQSKGIL KISAVPELTD VNTGKPVSLS
2060 2070 2080 2090 2100
SSYFHREKSN IFSPQELPGS HVTEDVLKVS TIPGPAGQKT VLPTALPSSF
2110 2120 2130 2140 2150
SHREKPDIFY QKDLPDRHLT EDALKISSAL GQADQITGLQ TVPSGTYSHG
2160 2170 2180 2190 2200
ENHKLVSEHV QRLIDNLNSS DSSVSSNNVL LNSQADDRVV INKPESAGFR
2210 2220 2230 2240 2250
DVGSEEIQDA ENSAKTLKEI RTLLMEAENM ALKRCNFPAP LARFRDISDI
2260 2270 2280 2290 2300
SFIQSKKVVC FKEPSSTGVS NGDLLHRQPF TEESPSSRCI QKDIGTQTNL
2310 2320 2330 2340 2350
KCRRGIENWE FISSTTVRSP LQEAESKVSM ALEETLRQYQ AAKSVMRSEP
2360 2370 2380 2390 2400
EGCSGTIGNK IIIPMMTVIK SDSSSDASDG NGSCSWDSNL PESLESVSDV
2410 2420 2430 2440 2450
LLNFFPYVSP KTSITDSREE EGVSESEDGG GSSVDSLAAH VKNLLQCESS
2460 2470 2480 2490 2500
LNHAKEILRN AEEEESRVRA HAWNMKFNLA HDCGYSISEL NEDDRRKVEE
2510 2520 2530 2540 2550
IKAELFGHGR TTDLSKGLQS PRGMGCKPEA VCSHIIIESH EKGCFRTLTS
2560 2570 2580 2590 2600
EHPQLDRHPC AFRSAGPSEM TRGRQNPSSC RAKHVNLSAS LDQNNSHFKV
2610 2620 2630 2640 2650
WNSLQLKSHS PFQNFIPDEF KISKGLRMPF DEKMDPWLSE LVEPAFVPPK
2660 2670 2680 2690 2700
EVDFHSSSQM PSPEPMKKFT TSITFSSHRH SKCISNSSVV KVGVTEGSQC
2710 2720 2730 2740 2750
TGASVGVFNS HFTEEQNPPR DLKQKTSSPS SFKMHSNSQD KEVTILAEGR
2760 2770 2780 2790 2800
RQSQKLPVDF ERSFQEEKPL ERSDFTGSHS EPSTRANCSN FKEIQISDNH
2810 2820 2830 2840 2850
TLISMGRPSS TLGVNRSSSR LGVKEKNVTI TPDLPSCIFL EQRELFEQSK
2860 2870 2880 2890 2900
APRADDHVRK HHSPSPQHQD YVAPDLPSCI FLEQRELFEQ CKAPYVDHQM
2910 2920 2930 2940 2950
RENHSPLPQG QDSIASDLPS PISLEQCQSK APGVDDQMNK HHFPLPQGQD
2960 2970 2980 2990 3000
CVVEKNNQHK PKSHISNINV EAKFNTVVSQ SAPNHCTLAA SASTPPSNRK
3010 3020 3030 3040 3050
ALSCVHITLC PKTSSKLDSG TLDERFHSLD AASKARMNSE FNFDLHTVSS
3060 3070 3080 3090 3100
RSLEPTSKLL TSKPVAQDQE SLGFLGPKSS LDFQVVQPSL PDSNTITQDL
3110 3120 3130 3140 3150
KTIPSQNSQI VTSRQIQVNI SDFEGHSNPE GTPVFADRLP EKMKTPLSAF
3160 3170 3180 3190 3200
SEKLSSDAVT QITTESPEKT LFSSEIFINA EDRGHEIIEP GNQKLRKAPV
3210 3220 3230 3240 3250
KFASSSSVQQ VTFSRGTDGQ PLLLPYKPSG STKMYYVPQL RQIPPSPDSK
3260 3270 3280 3290 3300
SDTTVESSHS GSNDAIAPDF PAQVLGTRDD DLSATVNIKH KEGIYSKRVV
3310 3320 3330 3340 3350
TKASLPVGEK PLQNENADAS VQVLITGDEN LSDKKQQEIH STRAVTEAAQ
3360 3370 3380 3390 3400
AKEKESLQKD TADSSAAAAA EHSAQVGDPE MKNLPDTKAI TQKEEIHRKK
3410 3420 3430 3440 3450
TVPEEAWPNN KESLQINIEE SECHSEFENT TRSVFRSAKF YIHHPVHLPS
3460 3470 3480 3490 3500
DQDICHESLG KSVFMRHSWK DFFQHHPDKH REHMCLPLPY QNMDKTKTDY
3510 3520 3530 3540 3550
TRIKSLSINV NLGNKEVMDT TKSQVRDYPK HNGQISDPQR DQKVTPEQTT
3560 3570 3580 3590 3600
QHTVSLNELW NKYRERQRQQ RQPELGDRKE LSLVDRLDRL AKILQNPITH
3610 3620 3630 3640 3650
SLQVSESTHD DSRGERSVKE WSGRQQQRNK LQKKKRFKSL EKSHKNTGEL
3660 3670 3680 3690 3700
KKSKVLSHHR AGRSNQIKIE QIKFDKYILS KQPGFNYISN TSSDCRPSEE
3710 3720 3730 3740 3750
SELLTDTTTN ILSGTTSTVE SDILTQTDRE VALHERSSSV STIDTARLIQ
3760 3770 3780 3790 3800
AFGHERVCLS PRRIKLYSSI TNQQRRYLEK RSKHSKKVLN TGHPLVTSEH
3810 3820 3830 3840 3850
TRRRHIQVAN HVISSDSISS SASSFLSSNS TFCNKQNVHM LNKGIQAGNL
3860 3870 3880 3890 3900
EIVNGAKKHT RDVGITFPTP SSSEAKLEEN SDVTSWSEEK REEKMLFTGY
3910 3920 3930 3940 3950
PEDRKLKKNK KNSHEGVSWF VPVENVESRS KKENVPNTCG PGISWFEPIT
3960 3970 3980 3990 4000
KTRPWREPLR EQNCQGQHLD GRGYLAGPGR EAGRDLLRPF VRATLQESLQ
4010 4020 4030 4040 4050
FHRPDFISRS GERIKRLKLI VQERKLQSML QTERDALFNI DRERQGHQNR
4060 4070 4080 4090 4100
MCPLPKRVFL AIQKNKPISK KEMIQRSKRI YEQLPEVQKK REEEKRKSEY
4110 4120
KSYRLRAQLY KKRVTNQLLG RKVPWD
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8TCU4 | ALMS1_HUMAN | Alstrom syndrome protein 1 | ALMS1 KIAA0328 | 4,168 | Annotation score: | ||
A0A087WV20 | A0A087WV20_HUMAN | Alstrom syndrome protein 1 | ALMS1 | 3,859 | Annotation score: | ||
A0A494C0F1 | A0A494C0F1_HUMAN | Alstrom syndrome protein 1 | ALMS1 | 886 | Annotation score: | ||
H7C1D9 | H7C1D9_HUMAN | Alstrom syndrome protein 1 | ALMS1 | 1,023 | Annotation score: | ||
A0A2R8Y7Z9 | A0A2R8Y7Z9_HUMAN | Alstrom syndrome protein 1 | ALMS1 | 50 | Annotation score: | ||
A0A494BZW1 | A0A494BZW1_HUMAN | Alstrom syndrome protein 1 | ALMS1 | 312 | Annotation score: | ||
A0A494C003 | A0A494C003_HUMAN | Alstrom syndrome protein 1 | ALMS1 | 428 | Annotation score: | ||
A0A494C1N9 | A0A494C1N9_HUMAN | Alstrom syndrome protein 1 | ALMS1 | 901 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC074008 Genomic DNA No translation available. AC092653 Genomic DNA No translation available. AC096546 Genomic DNA No translation available. KF573641 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000484298; ENSP00000478155; ENSG00000116127 |
UCSCi | uc032nre.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC074008 Genomic DNA No translation available. AC092653 Genomic DNA No translation available. AC096546 Genomic DNA No translation available. KF573641 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A087WTU9 |
Protocols and materials databases
Antibodypediai | 8144, 113 antibodies |
Genome annotation databases
Ensembli | ENST00000484298; ENSP00000478155; ENSG00000116127 |
UCSCi | uc032nre.2, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000116127.17 |
HGNCi | HGNC:428, ALMS1 |
OpenTargetsi | ENSG00000116127 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153123 |
HOGENOMi | CLU_000177_0_0_1 |
Miscellaneous databases
ChiTaRSi | ALMS1, human |
Gene expression databases
Bgeei | ENSG00000116127, Expressed in amniotic fluid and 237 other tissues |
ExpressionAtlasi | A0A087WTU9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR028781, ALMS1 IPR029299, ALMS_motif IPR040972, ALMS_repeat |
PANTHERi | PTHR21553:SF22, PTHR21553:SF22, 13 hits |
Pfami | View protein in Pfam PF15309, ALMS_motif, 1 hit PF18727, ALMS_repeat, 35 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087WTU9_HUMAN | |
Accessioni | A0A087WTU9Primary (citable) accession number: A0A087WTU9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |