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Entry version 50 (29 Sep 2021)
Sequence version 1 (29 Oct 2014)
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Protein
Submitted name:

Dystonin

Gene

Dst

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi4801 – 4812PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi4837 – 4848PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandCalciumPROSITE-ProRule annotation, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DystoninImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DstImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:104627, Dst

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000026131

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, CytoskeletonPROSITE-ProRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A087WSP0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
351350

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026131, Expressed in skin of back and 301 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A087WSP0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini560 – 617SH3InterPro annotationAdd BLAST58
Domaini4788 – 4823EF-handInterPro annotationAdd BLAST36
Domaini4824 – 4859EF-handInterPro annotationAdd BLAST36
Domaini4864 – 4942GARInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni4966 – 5009DisorderedSequence analysisAdd BLAST44
Regioni5085 – 5175DisorderedSequence analysisAdd BLAST91

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili133 – 153Sequence analysisAdd BLAST21
Coiled coili351 – 371Sequence analysisAdd BLAST21
Coiled coili415 – 442Sequence analysisAdd BLAST28
Coiled coili782 – 802Sequence analysisAdd BLAST21
Coiled coili881 – 915Sequence analysisAdd BLAST35
Coiled coili1091 – 1121Sequence analysisAdd BLAST31
Coiled coili1265 – 1292Sequence analysisAdd BLAST28
Coiled coili1309 – 1343Sequence analysisAdd BLAST35
Coiled coili1358 – 1378Sequence analysisAdd BLAST21
Coiled coili1476 – 1496Sequence analysisAdd BLAST21
Coiled coili1525 – 1552Sequence analysisAdd BLAST28
Coiled coili1824 – 1865Sequence analysisAdd BLAST42
Coiled coili1937 – 1964Sequence analysisAdd BLAST28
Coiled coili2092 – 2112Sequence analysisAdd BLAST21
Coiled coili2149 – 2176Sequence analysisAdd BLAST28
Coiled coili2367 – 2387Sequence analysisAdd BLAST21
Coiled coili2404 – 2424Sequence analysisAdd BLAST21
Coiled coili2534 – 2554Sequence analysisAdd BLAST21
Coiled coili2620 – 2640Sequence analysisAdd BLAST21
Coiled coili2655 – 2675Sequence analysisAdd BLAST21
Coiled coili2695 – 2722Sequence analysisAdd BLAST28
Coiled coili2839 – 2866Sequence analysisAdd BLAST28
Coiled coili2874 – 2894Sequence analysisAdd BLAST21
Coiled coili3128 – 3148Sequence analysisAdd BLAST21
Coiled coili3785 – 3812Sequence analysisAdd BLAST28
Coiled coili3891 – 3935Sequence analysisAdd BLAST45
Coiled coili4164 – 4184Sequence analysisAdd BLAST21
Coiled coili4546 – 4573Sequence analysisAdd BLAST28
Coiled coili4754 – 4774Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4978 – 4996Polar residuesSequence analysisAdd BLAST19
Compositional biasi5120 – 5134Polar residuesSequence analysisAdd BLAST15
Compositional biasi5152 – 5166Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155008

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 6 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 19 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 33 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All

A0A087WSP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSSSYSYRS SDSVFSNTTS TRTSLDSNEN LLSVHCGPTL INSCISFSNE
60 70 80 90 100
SLDGHRLDML QQIATRVQRD SVSCEDKLIL ARNALQSDSK RLESGVQFQN
110 120 130 140 150
EAEIAGYILE CENLLRQHVI DVQILIDGKY YQADQLVQRV AKLRDEIMAL
160 170 180 190 200
RNECSSVYSK GRMLTTEQTK LMISGITQSL NSGFAQTLHP SLNSGLTQSL
210 220 230 240 250
TPSLTSSSVT SGLSSGMTSR LTPSVTPVYA PGFPSVVAPN FSLGVEPNSL
260 270 280 290 300
QTLKLMQIRK PLLKSSLLDQ NLTEEEVNMK FVQDLLNWVD EMQVQLDRTE
310 320 330 340 350
WGSDLPSVES HLENHKNVHR AIEEFESSLK EAKISEIQMT APLKLSYTDK
360 370 380 390 400
LHRLESQYAK LLNTSRNQER HLDTLHNFVT RATNELIWLN EKEESEVAYD
410 420 430 440 450
WSERNSSVAR KKSYHAELMR ELEQKEESIK AVQEIAEQLL LENHPARLTI
460 470 480 490 500
EAYRAAMQTQ WSWILQLCQC VEQHIQENSA YFEFFNDAKE ATDYLRNLKD
510 520 530 540 550
AIQRKYSCDR SSSIHKLEDL VQESMEKEEL LQYRSVVAGL MGRAKTVVQL
560 570 580 590 600
KPRNPDNPLK TSIPIKAICD YRQIEITIYK DDECVLANNS HRAKWKVISP
610 620 630 640 650
TGNEAMVPSV CFTVPPPNKE AVDFANRIEQ QYQSVLTLWH ESHINMKSVV
660 670 680 690 700
SWHYLVNEID RIRASNVASI KTMLPGEHQQ VLSNLQSRLE DFLEDSQESQ
710 720 730 740 750
IFSGSDISQL EKEVSVCRKY YQELLKSAER EEQEESVYNL YISEVRNIRL
760 770 780 790 800
RLESCEDRLI RQIRTPLERD DLHESMLRIT EQEKLKKELD RLKDDLGTIT
810 820 830 840 850
NKCEEFFSQA ADSPSVPALR SELSVVIQSL SQIYSMSSTY IEKLKTVNLV
860 870 880 890 900
LKNTQAAEAL VKLYETKLCE EEAVIADKNN IENLMSTLKQ WRSEVDEKRE
910 920 930 940 950
VFHALEDELQ KAKAISDEMF KTHKERDLDF DWHKEKADQL VERWQSVHVQ
960 970 980 990 1000
IDNRLRDLEG IGKSLKHYRD SYHPLDDWIQ HIETTQRKIQ ENQPENSKAL
1010 1020 1030 1040 1050
ALQLNQQKML VSEIEVKQSK MDECQKYSEQ YSAAVKDYEL QTMTYRAMVE
1060 1070 1080 1090 1100
SQQKSPVKRR RIQSSADLVI QEFMDLRTRY TALVTLMTQY IKFAGDSLKR
1110 1120 1130 1140 1150
LEEEEKSLDE EKKQHIEKAK ELQKWVSNIS KTLGDGEKAG KPLFSKQQMS
1160 1170 1180 1190 1200
SKEISTKKEQ FSEALQTTQI FLAKHGDKLT EEERSDLEKQ VKTLQEGYNL
1210 1220 1230 1240 1250
LFSESLKQQE LQPSGESKVP EKVVAERQQE YREKLQGLCD LLTQTENRLI
1260 1270 1280 1290 1300
SNQEAFVIGD GTVELQKYQS KQEELQRDMQ GSTQAMEEIV RNTELFLKES
1310 1320 1330 1340 1350
GDELSQADRA LIEQKLNEVK MKCAQLNLKA EQSRKELDKA VTTALKEETE
1360 1370 1380 1390 1400
KVAAVRQLEE SKTKIENLLN WLSNVEEDSE GVWTKHTQPM EQNGTYLHEG
1410 1420 1430 1440 1450
DSKLGAGEED EVNGNLLETD AEGHSEATKG NLNQQYEKVK AQHGKIMAQH
1460 1470 1480 1490 1500
QAVLLATQSA QVLLEKQGHY LSPEEKEKLQ KNTQELKVHY EKVLAECEKK
1510 1520 1530 1540 1550
VKLTHSLQEE LEKFDTDYSE FEHWLQQSEQ ELANLEAGAD DLSGLMDKLT
1560 1570 1580 1590 1600
RQKSFSEDVI SHKGDLRYIT ISGNRVIDAA KSCSKRDSDR IGKDSVETSA
1610 1620 1630 1640 1650
THREVQTKLD QVTDRFRSLY SKCSVLGNNL KDLVDQYQQY EDASCGLLSG
1660 1670 1680 1690 1700
LQACEAKASK HLREPIALDP KNLQRQLEET KALQGQISSQ QVAVEKLKKT
1710 1720 1730 1740 1750
AEVLLDAKGS LLPAKNDIQK TLDDIVGRYD DLSKCVNERN EKLQITLTRS
1760 1770 1780 1790 1800
LSVQDALDEM LDWMGSVESS LVKPGQVPLN STALQDLISK DTMLEQDITG
1810 1820 1830 1840 1850
RQSSINAMNE KVKTFIETTD PSTASSLQAK MKDLSARFSE ASQKHKEKLA
1860 1870 1880 1890 1900
KMVELKAKVE QFEKLSDKLQ TFLETQSQAL TEVAMPGKDV PELSQHMQES
1910 1920 1930 1940 1950
TAKFLEHRKD LEALHSLLKE ISSHGLPGDK ALVFEKTNNL SRKFKEMEDT
1960 1970 1980 1990 2000
IQEKKDALSS CQEQLSAFQT LAQSLKTWIK ETTKQVPVVK PSLGTEDLRK
2010 2020 2030 2040 2050
SLEETKKLQE KWNLKAPEIH KANNSGVSLC NLLSALISPA KAIAAAKSGG
2060 2070 2080 2090 2100
VILNGEGTDT NTQDFLANKG LTSIKKDMTD ISHSYEDLGL LLKDKIVELN
2110 2120 2130 2140 2150
TKLSKLQKAQ EESSAMMQWL EKMNKTASRW RQTPTPADTE SVKLQVEQNK
2160 2170 2180 2190 2200
SFEAELKQNV NKVQELKDKL SELLEENPEA PEAQSWKQAL AEMDTKWQEL
2210 2220 2230 2240 2250
NQLTMDRQQK LEESSNNLTQ FQTTEAQLKQ WLMEKELMVS VLGPLSIDPN
2260 2270 2280 2290 2300
MLNTQKQQVQ ILLQEFDTRK PQYEQLTAAG QGILSRPGED PSLHGIVNEQ
2310 2320 2330 2340 2350
LEAVTQKWDN LTGQLRDRCD WIDQAIVKST QYQSLLRSLS GTLTELDDKL
2360 2370 2380 2390 2400
SSGLTSGALP DAVNQQLEAA QRLKQEIEQQ APKIKEAQEV CEDLSALVKE
2410 2420 2430 2440 2450
EYLKAELSRQ LEGILKSFKD IEQKTENHVQ HLQSACASSH QFQQMSKDFQ
2460 2470 2480 2490 2500
AWLDAKKEEQ RDSPPISAKL DVLESLLNSQ KDFGKTFTEQ SNIYEKTISE
2510 2520 2530 2540 2550
GENLLLKTQG AEKAALQLQL NTMKTDWDRF RKQVKEREEK LKDSLEKALK
2560 2570 2580 2590 2600
YREQVETLRP WIDRCQHSLD GVTFSLDPTE SESSIAELKS LQKEMDHHFG
2610 2620 2630 2640 2650
MLELLNNTAN SLLSVCEVDK EAVTEENQSL MEKVNRVTEQ LQSKTVSLEN
2660 2670 2680 2690 2700
MAQKFKEFQE VSRDTQRQLQ DTKEQLEVHH SLGPQAYSNK HLSVLQAQQK
2710 2720 2730 2740 2750
SLQTLKQQVD EAKRLAQDLV VEAADSKGTS DVLLQAETLA EEHSELSQQV
2760 2770 2780 2790 2800
DEKCSFLETK LQGLGHFQNT IREMFSQFTE CDDELDGMAP VGRDAETLRK
2810 2820 2830 2840 2850
QKACMQTFLK KLEALMASND SANRTCKMML ATEETSPDLI GVKRDLEALS
2860 2870 2880 2890 2900
KQCNKLLDRA KTREEQVDGA TEKLEEFHRK LEEFSTLLQK AEEHEESQGP
2910 2920 2930 2940 2950
VGTETETINQ QLDVFKVFQK EEIEPLQVKQ QDVNWLGQGL IQSAAANTCT
2960 2970 2980 2990 3000
QGLEHDLDSV NSRWKTLNKK VAQRTSQLQE ALLHCGRFQD ALESLLSWMA
3010 3020 3030 3040 3050
DTEELVANQK PPSAEFKVVK AQIQEQKLLQ RLLEDRKSTV EVIKREGEKI
3060 3070 3080 3090 3100
AASAEPADRV KLTRQLSLLD SRWEALLSRA EARNRQLEGI SVVAQEFHET
3110 3120 3130 3140 3150
LEPLNEWLTA VEKKLANSEP IGTQAPKLEE QISQHKVLED DITNHSKQLH
3160 3170 3180 3190 3200
QAVSIGQSLK VLSSREDKDL VQSKLDSLQV WYFEIQEKSH SRSELLQQAL
3210 3220 3230 3240 3250
CNAKIFGEDE VELMNWLNEV HGKLSKLSVQ DHSPEALWRQ RAELRALQED
3260 3270 3280 3290 3300
ILLRKQSVDQ ALLNGLELLK QTTGDEVLII QDKLEAIKAR YKDITKLSAD
3310 3320 3330 3340 3350
VAKTLEHALQ LAGQLQSMHK ELCNWLDKVE VELLSYETQG LKGEAASQVQ
3360 3370 3380 3390 3400
ERQKELKNEV RSNKALVDSL NEVSSALLEL VPWRAREGLE KTIAEDNERY
3410 3420 3430 3440 3450
RLVSDTITQK VEEIDAAILR SQQFEQAADA ELSWITETQK KLMSLGDIRL
3460 3470 3480 3490 3500
EQDQTSAQLQ VQKAFTMDIL RHKDIIDELV TSGHKIMTTS SEEEKQSMKK
3510 3520 3530 3540 3550
KLDKVLKKYD AVCQINSERH LQLERAQSLV SQFWETYEEL WPWLTETQRI
3560 3570 3580 3590 3600
ISQLPAPALE YETLRRQQEE HRQLRELIAE HKPHIDKMNK TGPQLLELSP
3610 3620 3630 3640 3650
KEGIYIQEKY VAADTLYSQI KEDVKKRAVV LDEAISQSTQ FHDKIDQILE
3660 3670 3680 3690 3700
SLERIAERLR QPPSISAEVE KIKEQIGENK SVSVDMEKLQ PLYETLRQRG
3710 3720 3730 3740 3750
EEMIARSEGT EKDVSARAVQ DKLDQMVFIW GSIHTLVEER EAKLLDVMEL
3760 3770 3780 3790 3800
AEKFWCDHMS LVVTIKDTQD FIRDLEDPGI DPSVVKQQQE AAEAIREEID
3810 3820 3830 3840 3850
GLQEELDMVI TLGSELIAAC GEPDKPIVKK SIDELNSAWD SLNKAWKDRV
3860 3870 3880 3890 3900
DRLEEAMQAA VQYQDGLQGI FDWVDIAGNK LATMSPIGTD LETVKQQIEE
3910 3920 3930 3940 3950
LKQFKSEAYQ QQIEMERLNH QAELLLKKVT EEADKHTVQD PLMELKLIWD
3960 3970 3980 3990 4000
SLDERIVSRQ HKLEGALLAL GQFQHALDEL LAWLTHTKGL LSEQKPVGGD
4010 4020 4030 4040 4050
PKAIEIELAK HHVLQNDVLA HQSTVEAVNK AGNDLIESSE GEEASNLQYK
4060 4070 4080 4090 4100
LRILNQRWQD ILEKTDQRKQ QLDSALRQAK GFHGEIEDLQ QWLTDTERHL
4110 4120 4130 4140 4150
LASKPLGGLP ETAKEQLNAH MEVCTAFAIK EETYKSLMLR GQQMLARCPR
4160 4170 4180 4190 4200
SAETNIDQDI TNLKEKWESV KSKLNEKKTK LEEALHLAMN FHNSLQDFIN
4210 4220 4230 4240 4250
WLTQAEQTLN VASRPSLILD TILFQIDEHK VFANEVNSHR EQIIELDKTG
4260 4270 4280 4290 4300
THLKYFSQKQ DVVLIKNLLI SVQSRWEKVV QRLVERGRSL DEARKRAKQF
4310 4320 4330 4340 4350
HEAWSKLMEW LEESEKSLDS ELEIANDPDK IKAQLVQHKE FQKSLGGKHS
4360 4370 4380 4390 4400
VYDTTNRTGR SLKEKTSLAD DNLKLDNMLS ELRDKWDTIC GKSVERQNKL
4410 4420 4430 4440 4450
EEALLFSGQF TDALQALIDW LYRVEPQLAE DQPVHGDIDL VMNLIDNHKV
4460 4470 4480 4490 4500
FQKELGKRTS SVQALKRSAR ELIEGSRDDS SWVRVQMQEL STRWETVCAL
4510 4520 4530 4540 4550
SISKQTRLES ALQQAEEFHS VVHTLLEWLA EAEQTLRFHG ALPDDEDALR
4560 4570 4580 4590 4600
TLIEQHKEFM KRLEEKRAEL SKATGMGDAL LAVCHPDSIT TIKHWITIIQ
4610 4620 4630 4640 4650
ARFEEVLAWA KQHQQRLAGA LAGLIAKQEL LETLLAWLQW AETTLTEKDK
4660 4670 4680 4690 4700
EVIPQEIEEV KTLIAEHQTF MEEMTRKQPD VDKVTKTYKR RATDPPSLQS
4710 4720 4730 4740 4750
HIPVLDKGRA GRKRFPASGF YPSGSQTQIE TKNPRVNLLV SKWQQVWLLA
4760 4770 4780 4790 4800
LERRRKLNDA LDRLEELREF ANFDFDIWRK KYMRWMNHKK SRVMDFFRRI
4810 4820 4830 4840 4850
DKDQDGKITR QEFIDGILSS KFPTSRLEMS AVADIFDRDG DGYIDYYEFV
4860 4870 4880 4890 4900
AALHPNKDAY KPITDADKIE DEVTRQVAKC KCAKRFQVEQ IGDNKYRFFL
4910 4920 4930 4940 4950
GNQFGDSQQL RLVRILRSTV MVRVGGGWMA LDEFLVKNDP CRAKGRTNME
4960 4970 4980 4990 5000
LREKFILADG ASQGMAAFRP RGRRSRPSSR GASPNRSTSA SSHACQAASP
5010 5020 5030 5040 5050
PVPAAASTPK ILHPLTRNYG KPWLANSKMS TPCKAAECPD FPVSSAEGTP
5060 5070 5080 5090 5100
IQGSKLRLPG YLSGKGFHSG EDSALITTAA ARVRTQFAES RKTPSRPGSR
5110 5120 5130 5140 5150
AGSKAGSRAS SRRGSDASDF DISEIQSVCS DVETVPQTHR PVPRAGSRPS
5160 5170
TAKPSKIPTP QRRSPASKLD KSSKR
Length:5,175
Mass (Da):590,439
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i713FBB4DCFF38E5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q91ZU6DYST_MOUSE
Dystonin
Dst Bpag1, Macf2
7,393Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1P5S4R1P5_MOUSE
Dystonin
Dst
7,717Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9X1E9Q9X1_MOUSE
Dystonin
Dst
7,406Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1Y6S4R1Y6_MOUSE
Dystonin
Dst
1,638Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WRB8A0A087WRB8_MOUSE
Dystonin
Dst
1,471Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2A8S4R2A8_MOUSE
Dystonin
Dst
262Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2C6S4R2C6_MOUSE
Dystonin
Dst
259Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WPR7A0A087WPR7_MOUSE
Dystonin
Dst
2,987Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RLZ3A0A1D5RLZ3_MOUSE
Dystonin
Dst
1,674Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YXR1A0A0A6YXR1_MOUSE
Dystonin
Dst
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000185269; ENSMUSP00000141127; ENSMUSG00000026131

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiA0A087WSP0
ModBaseiSearch...

Proteomic databases

jPOSTiA0A087WSP0
ProteomicsDBi351350

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31066, 184 antibodies

Genome annotation databases

EnsembliENSMUST00000185269; ENSMUSP00000141127; ENSMUSG00000026131

Organism-specific databases

MGIiMGI:104627, Dst
VEuPathDBiHostDB:ENSMUSG00000026131

Phylogenomic databases

GeneTreeiENSGT00940000155008

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dst, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026131, Expressed in skin of back and 301 other tissues

Family and domain databases

CDDicd00051, EFh, 1 hit
Gene3Di3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 6 hits
PfamiView protein in Pfam
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 19 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 33 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087WSP0_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087WSP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: September 29, 2021
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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