UniProtKB - A0A087WRL3 (A0A087WRL3_MOUSE)
Protein
Ubiquitinyl hydrolase 1
Gene
Uchl5
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ARBA annotation EC:3.4.19.12
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
- proteasome binding Source: InterPro
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
GO - Biological processi
- protein deubiquitination Source: InterPro
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Biological process | Ubl conjugation pathwayARBA annotation |
Protein family/group databases
MEROPSi | C12.005 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Uchl5Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914848, Uchl5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000018189, Expressed in epiblast (generic) and 316 other tissues |
Family & Domainsi
Phylogenomic databases
GeneTreei | ENSGT00940000155195 |
HOGENOMi | CLU_018316_0_2_1 |
Family and domain databases
CDDi | cd02255, Peptidase_C12, 1 hit |
Gene3Di | 3.40.532.10, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001578, Peptidase_C12_UCH IPR036959, Peptidase_C12_UCH_sf IPR033837, UCH37 IPR041507, UCH_C |
PANTHERi | PTHR10589, PTHR10589, 1 hit |
Pfami | View protein in Pfam PF01088, Peptidase_C12, 1 hit PF18031, UCH_C, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0A087WRL3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
KEEDAFHFVS YVPVNGRLYE LDGLREGPID LGACNQDDWI TAVRPVIEKR
60 70 80 90 100
IQKYSEGEIR FNLMAIVSDR KMIYEQKIAE LQRQLAEEEP MDTDQGSTVL
110 120 130 140 150
SAIQSEVARN QMLIEEEVQK LKRYKIENIR RKHNYLPFIM ELLKTLAEHQ
160
QLIPLVEKIF SCRGKNL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9WUP7 | UCHL5_MOUSE | Ubiquitin carboxyl-terminal hydrola... | Uchl5 Uch37 | 329 | Annotation score: | ||
A0A087WP81 | A0A087WP81_MOUSE | Ubiquitinyl hydrolase 1 | Uchl5 | 225 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL592403 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000185539; ENSMUSP00000140681; ENSMUSG00000018189 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL592403 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A087WRL3 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | C12.005 |
Proteomic databases
ProteomicsDBi | 334501 |
Protocols and materials databases
Antibodypediai | 1573, 321 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000185539; ENSMUSP00000140681; ENSMUSG00000018189 |
Organism-specific databases
MGIi | MGI:1914848, Uchl5 |
Phylogenomic databases
GeneTreei | ENSGT00940000155195 |
HOGENOMi | CLU_018316_0_2_1 |
Miscellaneous databases
ChiTaRSi | Uchl5, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018189, Expressed in epiblast (generic) and 316 other tissues |
Family and domain databases
CDDi | cd02255, Peptidase_C12, 1 hit |
Gene3Di | 3.40.532.10, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001578, Peptidase_C12_UCH IPR036959, Peptidase_C12_UCH_sf IPR033837, UCH37 IPR041507, UCH_C |
PANTHERi | PTHR10589, PTHR10589, 1 hit |
Pfami | View protein in Pfam PF01088, Peptidase_C12, 1 hit PF18031, UCH_C, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087WRL3_MOUSE | |
Accessioni | A0A087WRL3Primary (citable) accession number: A0A087WRL3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | April 7, 2021 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |