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UniProtKB - A0A087WRB8 (A0A087WRB8_MOUSE)
Protein
Submitted name:
Dystonin
Gene
Dst
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
GO - Biological processi
- intermediate filament cytoskeleton organization Source: InterPro
Keywordsi
Molecular function | Actin-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: DystoninImported |
Gene namesi | Name:DstImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104627, Dst |
VEuPathDBi | HostDB:ENSMUSG00000026131 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- microtubule Source: UniProtKB-KW
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotation, MicrotubuleARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000026131, Expressed in skin of back and 301 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 75 – 178 | Calponin-homology (CH)InterPro annotationAdd BLAST | 104 | |
Domaini | 191 – 295 | Calponin-homology (CH)InterPro annotationAdd BLAST | 105 | |
Domaini | 926 – 983 | SH3InterPro annotationAdd BLAST | 58 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 57 | DisorderedSequence analysisAdd BLAST | 57 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 499 – 519 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 717 – 737 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 781 – 808 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 1148 – 1168 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1247 – 1281 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 35 | Polar residuesSequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the plakin or cytolinker family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155008 |
HOGENOMi | CLU_004168_0_0_1 |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR041615, Desmoplakin_SH3 IPR041573, Desmoplakin_Spectrin-like IPR043197, Plakin IPR030269, Plectin IPR001452, SH3_domain IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat |
PANTHERi | PTHR23169, PTHR23169, 2 hits PTHR23169:SF20, PTHR23169:SF20, 2 hits |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF17902, SH3_10, 1 hit PF00435, Spectrin, 1 hit PF18373, Spectrin_like, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00150, SPEC, 3 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
A0A087WRB8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSGNASYRC SMSSSADFSD EDDFSQKSGS ASPAPGDTLP WNLPKHERSK
60 70 80 90 100
RKIQGGSVLD PAERAVLRIA DERDKVQKKT FTKWINQHLM KVRKHVNDLY
110 120 130 140 150
EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL DYLKRRQVKL
160 170 180 190 200
VNIRNDDITD GNPKLTLGLI WTIILHFQIS DIHVTGESED MSAKERLLLW
210 220 230 240 250
TQQATEGYAG VRCENFTTCW RDGKLFNAII HKYRPDLIDM NTVAVQSNLA
260 270 280 290 300
NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE KSVITYVSSL YDAFPKVPEG
310 320 330 340 350
GEGIGANDVE VKWIEYQNMV NYLIQWIRHH VVTMSERTFP NNPLELKALY
360 370 380 390 400
NQYLQFKEKE IPPKEMEKSK IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK
410 420 430 440 450
EWGKLIIAML EREKALRPEV ERLDMLQQIA TRVQRDSVSC EDKLILARNA
460 470 480 490 500
LQSDSKRLES GVQFQNEAEI AGYILECENL LRQHVIDVQI LIDGKYYQAD
510 520 530 540 550
QLVQRVAKLR DEIMALRNEC SSVYSKGRML TTEQTKLMIS GITQSLNSGF
560 570 580 590 600
AQTLHPSLNS GLTQSLTPSL TSSSVTSGLS SGMTSRLTPS VTPVYAPGFP
610 620 630 640 650
SVVAPNFSLG VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE EEVNMKFVQD
660 670 680 690 700
LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE FESSLKEAKI
710 720 730 740 750
SEIQMTAPLK LSYTDKLHRL ESQYAKLLNT SRNQERHLDT LHNFVTRATN
760 770 780 790 800
ELIWLNEKEE SEVAYDWSER NSSVARKKSY HAELMRELEQ KEESIKAVQE
810 820 830 840 850
IAEQLLLENH PARLTIEAYR AAMQTQWSWI LQLCQCVEQH IQENSAYFEF
860 870 880 890 900
FNDAKEATDY LRNLKDAIQR KYSCDRSSSI HKLEDLVQES MEKEELLQYR
910 920 930 940 950
SVVAGLMGRA KTVVQLKPRN PDNPLKTSIP IKAICDYRQI EITIYKDDEC
960 970 980 990 1000
VLANNSHRAK WKVISPTGNE AMVPSVCFTV PPPNKEAVDF ANRIEQQYQS
1010 1020 1030 1040 1050
VLTLWHESHI NMKSVVSWHY LVNEIDRIRA SNVASIKTML PGEHQQVLSN
1060 1070 1080 1090 1100
LQSRLEDFLE DSQESQIFSG SDISQLEKEV SVCRKYYQEL LKSAEREEQE
1110 1120 1130 1140 1150
ESVYNLYISE VRNIRLRLES CEDRLIRQIR TPLERDDLHE SMLRITEQEK
1160 1170 1180 1190 1200
LKKELDRLKD DLGTITNKCE EFFSQAADSP SVPALRSELS VVIQSLSQIY
1210 1220 1230 1240 1250
SMSSTYIEKL KTVNLVLKNT QAAEALVKLY ETKLCEEEAV IADKNNIENL
1260 1270 1280 1290 1300
MSTLKQWRSE VDEKREVFHA LEDELQKAKA ISDEMFKTHK ERDLDFDWHK
1310 1320 1330 1340 1350
EKADQLVERW QSVHVQIDNR LRDLEGIGKS LKHYRDSYHP LDDWIQHIET
1360 1370 1380 1390 1400
TQRKIQENQP ENSKALALQL NQQKMLVSEI EVKQSKMDEC QKYSEQYSAA
1410 1420 1430 1440 1450
VKDYELQTMT YRAMVESQQK SPVKRRRIQS SADLVIQEFM DLRTRYTALV
1460 1470
TLMTQYIKFA GDSLKRLEEE E
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ91ZU6 | DYST_MOUSE | Dystonin | Dst Bpag1, Macf2 | 7,393 | Annotation score: | ||
S4R1P5 | S4R1P5_MOUSE | Dystonin | Dst | 7,717 | Annotation score: | ||
E9Q9X1 | E9Q9X1_MOUSE | Dystonin | Dst | 7,406 | Annotation score: | ||
A0A087WSP0 | A0A087WSP0_MOUSE | Dystonin | Dst | 5,175 | Annotation score: | ||
S4R1Y6 | S4R1Y6_MOUSE | Dystonin | Dst | 1,638 | Annotation score: | ||
S4R2A8 | S4R2A8_MOUSE | Dystonin | Dst | 262 | Annotation score: | ||
S4R2C6 | S4R2C6_MOUSE | Dystonin | Dst | 259 | Annotation score: | ||
A0A087WPR7 | A0A087WPR7_MOUSE | Dystonin | Dst | 2,987 | Annotation score: | ||
A0A1D5RLZ3 | A0A1D5RLZ3_MOUSE | Dystonin | Dst | 1,674 | Annotation score: | ||
A0A0A6YXR1 | A0A0A6YXR1_MOUSE | Dystonin | Dst | 282 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1471 | Imported | 1 |
Genome annotation databases
Ensembli | ENSMUST00000187486; ENSMUSP00000140560; ENSMUSG00000026131 |
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | A0A087WRB8 |
ModBasei | Search... |
Proteomic databases
ProteomicsDBi | 355784 |
Protocols and materials databases
Antibodypediai | 31066, 184 antibodies from 22 providers |
Genome annotation databases
Ensembli | ENSMUST00000187486; ENSMUSP00000140560; ENSMUSG00000026131 |
Organism-specific databases
MGIi | MGI:104627, Dst |
VEuPathDBi | HostDB:ENSMUSG00000026131 |
Phylogenomic databases
GeneTreei | ENSGT00940000155008 |
HOGENOMi | CLU_004168_0_0_1 |
Miscellaneous databases
ChiTaRSi | Dst, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026131, Expressed in skin of back and 301 other tissues |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR041615, Desmoplakin_SH3 IPR041573, Desmoplakin_Spectrin-like IPR043197, Plakin IPR030269, Plectin IPR001452, SH3_domain IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat |
PANTHERi | PTHR23169, PTHR23169, 2 hits PTHR23169:SF20, PTHR23169:SF20, 2 hits |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF17902, SH3_10, 1 hit PF00435, Spectrin, 1 hit PF18373, Spectrin_like, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00150, SPEC, 3 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A087WRB8_MOUSE | |
Accessioni | A0A087WRB8Primary (citable) accession number: A0A087WRB8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | January 19, 2022 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |