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Protein

Autism susceptibility gene 2 protein homolog

Gene

Auts2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation (By similarity). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (PubMed:25533347).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Autism susceptibility gene 2 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Auts2
Synonyms:Kiaa0442Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1919847 Auts2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Brain-specific gene disruption gives rise to no visible phenotype at birth. Mutant mice have normal weight at birth, but then show decreased weight gain over the next few days, decreased milk uptake, impaired motor skills and impaired ultrasonic vocalization after maternal separation.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004418891 – 1261Autism susceptibility gene 2 protein homologAdd BLAST1261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1200PhosphoserineBy similarity1
Modified residuei1235PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A087WPF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain cortex in embryo, neonates and adults (at protein level) (PubMed:19948250, PubMed:25533347, PubMed:25519132). Detected in embryonic and adult Purkinje cells in the cerebellum (PubMed:19948250). Detected in dorsal thalamus and in dopaminergic neurons in substantia nigra (PubMed:19948250).3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in embryonic brain cortex at 15 dpc, and at clearly lower levels in adult brain cortex, hippocampus and in cerebellum Purkinje cells (at protein level) (PubMed:25519132). Very low and barely detectable in embryonic brain at 11 dpc. Detected in the developing brain cortex, thalamus and cerebellum at 12 and 14 dpc. Uniformly expressed all along the preplate at 13 dpc. At 16 dpc, highly expressed in neurons in deep and superficial layers of the frontal cortical region of the preplate, with much lower expression in the caudal region or the preplate. Highly expressed in thalamus at 14 dpc, and at much lower levels in adults. Highly expressed in hippocampus after 13 dpc; expression levels increase subsequently and are high in dentate gyrus and the CA region of the hippocampus at 19 dpc. Expression in dentate gyrus, granule cell layer and the CA region of the hippocampus continues in neonates and into adulthood.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029673 Expressed in 313 organ(s), highest expression level in pituitary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A087WPF7 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 (PubMed:25519132). Within this complex, interacts directly with PCGF5 and CSNK2B (By similarity). Interacts with the histone acetyltransferase EP300/p300 (By similarity). Interacts (via Pro-rich region) with PREX1, DOCK1 and ELMO2 (PubMed:25533347).By similarity1 Publication1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000125349

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni288 – 471Important for regulation of lamellipodia formation1 PublicationAdd BLAST184

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi287 – 645Pro-richPROSITE-ProRule annotationAdd BLAST359
Compositional biasi1124 – 1183His-richPROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Pro-rich region is important for the interaction with RAC guanine nucleotide exchange factors and the subsequent activation of RAC1, which then promotes lamellipodia formation.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AUTS2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGMF Eukaryota
ENOG4111MEB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154823

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG063014

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01SH

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR023246 AUTS2

The PANTHER Classification System

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PANTHERi
PTHR14429 PTHR14429, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF15336 Auts2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR02044 FIBROSIN1LPF

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A0A087WPF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGPTRGHGL RKKRRSRSQR DRERRSRAGL GTGAAGGIGA GRTRAPSLAS
60 70 80 90 100
SSGSDKEDNG KPPSSAPSRP RPPRRKRRES TSAEEDIIDG FAMTSFVTFE
110 120 130 140 150
ALEKDVAVKP QERAEKRQTP LTKKKREALT NGLSFHSKKS RLSHSHHYSS
160 170 180 190 200
DRENDRNLCQ HLGKRKKMPK GLRQLKPGQN SCRDSDSESA SGESKGFQRS
210 220 230 240 250
SSRERLSDSS APSSLGTGYF CDSDSDQEEK ASDASSEKLF NTVLVNKDPE
260 270 280 290 300
LGVGALPEHN QDAGPIVPKI SGLERSQEKS QDCCKEPVFE PVVLKDPHPQ
310 320 330 340 350
LPQLPSQAQA EPQLQIPSPG PDLVPRTEAP PQFPPPSTQP AQGPPEAQLQ
360 370 380 390 400
PAPLPQVQQR PPRPQSPSHL LQQTLPPVQS HPSSQSLSQP LSAYNSSSLS
410 420 430 440 450
LNSLSSRSST PAKTQPAPPH ISHHPSASPF PLSLPNHSPL HSFTPTLQPP
460 470 480 490 500
AHSHHPNMFA PPTALPPPPP LTSGSLQVPG HPAGSTYSEQ DILRQELNTR
510 520 530 540 550
FLASQSADRG ASLGPPPYLR TEFHQHQHQH QHTHQHTHQH TFTPFPHAIP
560 570 580 590 600
PTAIMPTPAP PMFDKYPTKV DPFYRHSLFH SYPPAVSGIP PMIPPTGPFG
610 620 630 640 650
SLQGAFQPKT SNPIDVAARP GTVPHTLLQK DPRLTDPFRP MLRKPGKWCA
660 670 680 690 700
MHVHIAWQIY HHQQKVKKQM QSDPHKLDFG LKPEFLSRPP GPSLFGAIHH
710 720 730 740 750
PHDLARPSTL FSAAGAAHPT GTPFGPPPHH SNFLNPAAHL EPFNRPSTFT
760 770 780 790 800
GLAAVGGNAF GGLGNPSVTP NSVFGHKDSP SVQNFSNPHE PWNRLHRTPP
810 820 830 840 850
SFPTPPPWLK PGELERSASA AAHDRDRDVD KRDSSVSKDD KERESVEKRH
860 870 880 890 900
PSHPSPAPPV PVSALGHNRS STDPTTRGHL NTEAREKDKP KEKERDHSGS
910 920 930 940 950
RKDLTTEEHK AKESHLPERD GHSHEGRAAG EEPKQLSRVP SPYVRTPGVD
960 970 980 990 1000
STRPNSTSSR EAEPRKGEPA YENPKKNAEV KVKEERKEDH DLPTEAPQAH
1010 1020 1030 1040 1050
RTSEAPPPSS SASASVHPGP LASMPMTVGV TGIHAMNSIG SLDRTRMVTP
1060 1070 1080 1090 1100
FMGLSPIPGG ERFPYPSFHW DPMRDPLRDP YRDLDMHRRD PLGRDFLLRN
1110 1120 1130 1140 1150
DPLHRLSTPR LYEADRSFRD REPHDYSHHH HHHHHPLAVD PRREHERGGH
1160 1170 1180 1190 1200
LDERERLHVL REDYEHPRLH PVHPASLDGH LPHPSLLTPG LPSMHYPRIS
1210 1220 1230 1240 1250
PTAGHQNGLL NKTPPTAALS APPPLISTLG GRPGSPRRTT PLSAEIRERP
1260
PSHTLKDIEA R
Length:1,261
Mass (Da):138,920
Last modified:October 25, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E5C161A1211D6FF
GO
Isoform 2 (identifier: A0A087WPF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-258: ASDASSEKLFNTVLVNKDPELGVGALPE → VRRHPLHCKHNPQGSGCTVTCLLVPVPL
     259-1261: Missing.

Show »
Length:258
Mass (Da):28,416
Checksum:i9C1718D3C3B31ED9
GO
Isoform 3 (identifier: A0A087WPF7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-457: Missing.
     563-577: Missing.

Note: No experimental confirmation available.
Show »
Length:789
Mass (Da):87,457
Checksum:i2412FD8614116180
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZ86E9PZ86_MOUSE
Autism susceptibility gene 2 protei...
Auts2
804Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R200S4R200_MOUSE
Autism susceptibility gene 2 protei...
Auts2
142Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QNT9J3QNT9_MOUSE
Autism susceptibility gene 2 protei...
Auts2
103Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CZ47E0CZ47_MOUSE
Autism susceptibility gene 2 protei...
Auts2
119Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WSK2A0A087WSK2_MOUSE
Autism susceptibility gene 2 protei...
Auts2
48Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9F2I4A0A2C9F2I4_MOUSE
Autism susceptibility gene 2 protei...
Auts2
1,013Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0591241 – 457Missing in isoform 3. Add BLAST457
Alternative sequenceiVSP_059125231 – 258ASDAS…GALPE → VRRHPLHCKHNPQGSGCTVT CLLVPVPL in isoform 2. Add BLAST28
Alternative sequenceiVSP_059126259 – 1261Missing in isoform 2. Add BLAST1003
Alternative sequenceiVSP_059127563 – 577Missing in isoform 3. Add BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK052418 mRNA Translation: BAC34980.1
AC102355 Genomic DNA No translation available.
AC103371 Genomic DNA No translation available.
AC104195 Genomic DNA No translation available.
AC113203 Genomic DNA No translation available.
AC113510 Genomic DNA No translation available.
AC117622 Genomic DNA No translation available.
AC118932 Genomic DNA No translation available.
AC121298 Genomic DNA No translation available.
AC121500 Genomic DNA No translation available.
AC157928 Genomic DNA No translation available.
AC164607 Genomic DNA No translation available.
BC151031 mRNA Translation: AAI51032.1
BC151047 mRNA Translation: AAI51048.1
AK129144 mRNA Translation: BAC97954.1

NCBI Reference Sequences

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RefSeqi
NP_796021.2, NM_177047.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.409595
Mm.428892
Mm.488992

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000161374; ENSMUSP00000124730; ENSMUSG00000029673 [A0A087WPF7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
319974

UCSC genome browser

More...
UCSCi
uc008zuv.1 mouse [A0A087WPF7-1]
uc008zuw.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052418 mRNA Translation: BAC34980.1
AC102355 Genomic DNA No translation available.
AC103371 Genomic DNA No translation available.
AC104195 Genomic DNA No translation available.
AC113203 Genomic DNA No translation available.
AC113510 Genomic DNA No translation available.
AC117622 Genomic DNA No translation available.
AC118932 Genomic DNA No translation available.
AC121298 Genomic DNA No translation available.
AC121500 Genomic DNA No translation available.
AC157928 Genomic DNA No translation available.
AC164607 Genomic DNA No translation available.
BC151031 mRNA Translation: AAI51032.1
BC151047 mRNA Translation: AAI51048.1
AK129144 mRNA Translation: BAC97954.1
RefSeqiNP_796021.2, NM_177047.3
UniGeneiMm.409595
Mm.428892
Mm.488992

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125349

Proteomic databases

PaxDbiA0A087WPF7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161374; ENSMUSP00000124730; ENSMUSG00000029673 [A0A087WPF7-3]
GeneIDi319974
UCSCiuc008zuv.1 mouse [A0A087WPF7-1]
uc008zuw.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26053
MGIiMGI:1919847 Auts2

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG410IGMF Eukaryota
ENOG4111MEB LUCA
GeneTreeiENSGT00940000154823
HOVERGENiHBG063014
OrthoDBiEOG091G01SH

Enzyme and pathway databases

ReactomeiR-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Auts2 mouse

Protein Ontology

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PROi
PR:A0A087WPF7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000029673 Expressed in 313 organ(s), highest expression level in pituitary gland
ExpressionAtlasiA0A087WPF7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR023246 AUTS2
PANTHERiPTHR14429 PTHR14429, 1 hit
PfamiView protein in Pfam
PF15336 Auts2, 1 hit
PRINTSiPR02044 FIBROSIN1LPF

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAUTS2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087WPF7
Secondary accession number(s): E9PWJ4, Q6ZQB3, Q8BWI6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
Last sequence update: October 25, 2017
Last modified: December 5, 2018
This is version 28 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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