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Entry version 46 (02 Jun 2021)
Sequence version 1 (29 Oct 2014)
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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Bifidobacterium longum subsp. longum
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in the pathway UMP biosynthesis via de novo pathway, which is part of Pyrimidine metabolism.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotationARBA annotation This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseUniRule annotationARBA annotation
Biological processPyrimidine biosynthesisUniRule annotationARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00070
UPA00070;UER00116

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pyrBUniRule annotationImported
ORF Names:BBL306_0833Imported, BL1206_0905Imported, BLGA_08570Imported, BLOI2_0564Imported, MCC10002_0949Imported, MCC10003_0970Imported, MCC10004_1130Imported, MCC10007_0939Imported, MCC10008_0940Imported, MCC10009_0944Imported, MCC10012_0982Imported, MCC10015_1014Imported, MCC10040_0884Imported, MCC10043_0925Imported, MCC10044_0830Imported, MCC10070_1112Imported, MCC10075_0942Imported, MCC10076_1073Imported, MCC10080_0885Imported, MCC10094_1234Imported, MCC10096_0914Imported, MCC10102_0929Imported, MCC10103_0902Imported, MCC10113_0981Imported, MCC10114_0914Imported, MCC10115_0952Imported, MCC10116_1056Imported, MCC10120_0971Imported, MCC10123_0883Imported, MCC10126_0918Imported, MCC10128_0997Imported, MCC10212_0871Imported, NL89_09770Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBifidobacterium longum subsp. longumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1679 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000291299 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000292787 Componenti: Unassembled WGS sequence
  • UP000292966 Componenti: Unassembled WGS sequence
  • UP000291881 Componenti: Unassembled WGS sequence
  • UP000292097 Componenti: Unassembled WGS sequence
  • UP000293475 Componenti: Unassembled WGS sequence
  • UP000095109 Componenti: Chromosome
  • UP000293683 Componenti: Unassembled WGS sequence
  • UP000594099 Componenti: Chromosome
  • UP000293247 Componenti: Unassembled WGS sequence
  • UP000291214 Componenti: Unassembled WGS sequence
  • UP000030357 Componenti: Unassembled WGS sequence
  • UP000293441 Componenti: Unassembled WGS sequence
  • UP000292478 Componenti: Unassembled WGS sequence
  • UP000292751 Componenti: Unassembled WGS sequence
  • UP000293701 Componenti: Unassembled WGS sequence
  • UP000292260 Componenti: Unassembled WGS sequence
  • UP000291602 Componenti: Unassembled WGS sequence
  • UP000037245 Componenti: Unassembled WGS sequence
  • UP000292692 Componenti: Unassembled WGS sequence
  • UP000292528 Componenti: Unassembled WGS sequence
  • UP000293591 Componenti: Unassembled WGS sequence
  • UP000291713 Componenti: Unassembled WGS sequence
  • UP000292770 Componenti: Unassembled WGS sequence
  • UP000292023 Componenti: Unassembled WGS sequence
  • UP000291814 Componenti: Unassembled WGS sequence
  • UP000293461 Componenti: Unassembled WGS sequence
  • UP000294075 Componenti: Unassembled WGS sequence
  • UP000065375 Componenti: Chromosome
  • UP000293319 Componenti: Unassembled WGS sequence
  • UP000292932 Componenti: Unassembled WGS sequence
  • UP000291501 Componenti: Unassembled WGS sequence
  • UP000292241 Componenti: Unassembled WGS sequence

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 143OTCace_NInterPro annotationAdd BLAST140
Domaini151 – 298OTCaceInterPro annotationAdd BLAST148

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aspartate/ornithine carbamoyltransferase superfamily.UniRule annotation
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.UniRule annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1370, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_00001, Asp_carb_tr, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006132, Asp/Orn_carbamoyltranf_P-bd
IPR006130, Asp/Orn_carbamoylTrfase
IPR036901, Asp/Orn_carbamoylTrfase_sf
IPR002082, Asp_carbamoyltransf
IPR006131, Asp_carbamoyltransf_Asp/Orn-bd

The PANTHER Classification System

More...
PANTHERi
PTHR11405:SF16, PTHR11405:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00185, OTCace, 1 hit
PF02729, OTCace_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00100, AOTCASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53671, SSF53671, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00670, asp_carb_tr, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00097, CARBAMOYLTRANSFERASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A087AZ14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGKSVVTLD GLSTNQILDL LHKAEYIDSH RKEIAHTCDG RVLATLFYEP
60 70 80 90 100
STRTRLSFET AMLRLGGKVI GFAGAQLASV TKGESIADTL KTVSNYVDVV
110 120 130 140 150
AIRHPKEGAA LVASRAASVP VINAGDGGHM HPTQTLADLA TLQSRFGRIT
160 170 180 190 200
DLTVGLCGDL TFGRTVHSLI ETLCRFGNVR FVLISPDELK TPQYVIDRIN
210 220 230 240 250
ATDSCSYVEV RDLASVIGDL DVLYMTRVQK ERFFNEDDYL RLRDTYILDE
260 270 280 290 300
EKLQLAKPSM AVLHPLPRVN EIAVDVDDDP RAAYFEQVKN GMLVRMALES
310 320
TVVGDELPGY EPLNPKEVQA
Length:320
Mass (Da):35,264
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEC328C7F9EFA0DC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP011965 Genomic DNA Translation: ALO74362.1
CP016019 Genomic DNA Translation: AOP00946.1
AP022379 Genomic DNA Translation: BBV23446.1
JRWN01000020 Genomic DNA Translation: KHD94278.1
LFDU01000005 Genomic DNA Translation: KOP63051.1
SHPM01000018 Genomic DNA Translation: TCD74449.1
SHPN01000024 Genomic DNA Translation: TCD74597.1
SHPO01000020 Genomic DNA Translation: TCD77986.1
SHPQ01000019 Genomic DNA Translation: TCD81763.1
SHPR01000022 Genomic DNA Translation: TCD83889.1
SHPS01000019 Genomic DNA Translation: TCD85958.1
SHPV01000031 Genomic DNA Translation: TCD92703.1
SHPX01000018 Genomic DNA Translation: TCD97716.1
SHQR01000014 Genomic DNA Translation: TCE36748.1
SHQU01000019 Genomic DNA Translation: TCE41181.1
SHQV01000012 Genomic DNA Translation: TCE44670.1
SHRR01000016 Genomic DNA Translation: TCE85939.1
SHRW01000018 Genomic DNA Translation: TCE96764.1
SHRX01000015 Genomic DNA Translation: TCE98557.1
SHSB01000016 Genomic DNA Translation: TCF05000.1
SHSN01000009 Genomic DNA Translation: TCF27823.1
SHSP01000009 Genomic DNA Translation: TCF32495.1
SHSW01000007 Genomic DNA Translation: TCF45542.1
SHSV01000014 Genomic DNA Translation: TCF46271.1
SHTC01000013 Genomic DNA Translation: TCF58636.1
SHTD01000023 Genomic DNA Translation: TCF60779.1
SHTE01000020 Genomic DNA Translation: TCF64073.1
SHTF01000013 Genomic DNA Translation: TCF64480.1
SHTK01000011 Genomic DNA Translation: TCF76437.1
SHTN01000016 Genomic DNA Translation: TCF83773.1
SHTO01000013 Genomic DNA Translation: TCF84000.1
SHTQ01000006 Genomic DNA Translation: TCF87591.1
SHTU01000017 Genomic DNA Translation: TCF95261.1

NCBI Reference Sequences

More...
RefSeqi
WP_007054218.1, NZ_SZNG01000020.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ALO74362; ALO74362; BBL306_0833
AOP00946; AOP00946; BL1206_0905
KHD94278; KHD94278; NL89_09770
KOP63051; KOP63051; BLOI2_0564

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1679.10.peg.903

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011965 Genomic DNA Translation: ALO74362.1
CP016019 Genomic DNA Translation: AOP00946.1
AP022379 Genomic DNA Translation: BBV23446.1
JRWN01000020 Genomic DNA Translation: KHD94278.1
LFDU01000005 Genomic DNA Translation: KOP63051.1
SHPM01000018 Genomic DNA Translation: TCD74449.1
SHPN01000024 Genomic DNA Translation: TCD74597.1
SHPO01000020 Genomic DNA Translation: TCD77986.1
SHPQ01000019 Genomic DNA Translation: TCD81763.1
SHPR01000022 Genomic DNA Translation: TCD83889.1
SHPS01000019 Genomic DNA Translation: TCD85958.1
SHPV01000031 Genomic DNA Translation: TCD92703.1
SHPX01000018 Genomic DNA Translation: TCD97716.1
SHQR01000014 Genomic DNA Translation: TCE36748.1
SHQU01000019 Genomic DNA Translation: TCE41181.1
SHQV01000012 Genomic DNA Translation: TCE44670.1
SHRR01000016 Genomic DNA Translation: TCE85939.1
SHRW01000018 Genomic DNA Translation: TCE96764.1
SHRX01000015 Genomic DNA Translation: TCE98557.1
SHSB01000016 Genomic DNA Translation: TCF05000.1
SHSN01000009 Genomic DNA Translation: TCF27823.1
SHSP01000009 Genomic DNA Translation: TCF32495.1
SHSW01000007 Genomic DNA Translation: TCF45542.1
SHSV01000014 Genomic DNA Translation: TCF46271.1
SHTC01000013 Genomic DNA Translation: TCF58636.1
SHTD01000023 Genomic DNA Translation: TCF60779.1
SHTE01000020 Genomic DNA Translation: TCF64073.1
SHTF01000013 Genomic DNA Translation: TCF64480.1
SHTK01000011 Genomic DNA Translation: TCF76437.1
SHTN01000016 Genomic DNA Translation: TCF83773.1
SHTO01000013 Genomic DNA Translation: TCF84000.1
SHTQ01000006 Genomic DNA Translation: TCF87591.1
SHTU01000017 Genomic DNA Translation: TCF95261.1
RefSeqiWP_007054218.1, NZ_SZNG01000020.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiALO74362; ALO74362; BBL306_0833
AOP00946; AOP00946; BL1206_0905
KHD94278; KHD94278; NL89_09770
KOP63051; KOP63051; BLOI2_0564
PATRICifig|1679.10.peg.903

Enzyme and pathway databases

UniPathwayiUPA00070
UPA00070;UER00116

Family and domain databases

Gene3Di3.40.50.1370, 2 hits
HAMAPiMF_00001, Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132, Asp/Orn_carbamoyltranf_P-bd
IPR006130, Asp/Orn_carbamoylTrfase
IPR036901, Asp/Orn_carbamoylTrfase_sf
IPR002082, Asp_carbamoyltransf
IPR006131, Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16, PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185, OTCace, 1 hit
PF02729, OTCace_N, 1 hit
PRINTSiPR00100, AOTCASE
SUPFAMiSSF53671, SSF53671, 1 hit
TIGRFAMsiTIGR00670, asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097, CARBAMOYLTRANSFERASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A087AZ14_BIFLN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A087AZ14
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: June 2, 2021
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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