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Protein

Highly reducing polyketide synthase ATR6

Gene

ATR6

Organism
Stachybotrys chlorohalonata (strain IBT 40285)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Highly reducing polyketide synthase; part of the core atranone cluster (CAC) which products are predicted to catalyze most or all steps of mycotoxin atranone synthesis, starting from geranylgeranyl pyrophosphate (GGPP) (PubMed:25015739). The initial cyclization of GGPP to dolabellane is probably performed by the terpene cyclase ATR13 (PubMed:25015739). The Baeyer-Villiger oxidation near the end of the atranone synthesis, which converts atranones D and E to atranones F and G is predicted to be catalyzed by the monooxygenase ATR8 (PubMed:25015739). Of the CAC's other predicted gene products, the reducing PKS ATR6 might synthesize a polyketide chain (PubMed:25015739). This polyketide is probably transferred onto the atranone backbone by the polyketide transferase ATR5 (By similarity). Other predicted CAC products include 4 oxygenases (ATR2, ATR3, ATR4, and ATR14), 3 short-chain reductases (ATR7, ATR9, and ATR10), and a methyltransferase (ATR12) (PubMed:25015739). These may all be involved in the various steps of atranone biosynthesis, although their specific roles must await experimental determination (PubMed:25015739).By similarity1 Publication

Pathwayi: Mycotoxin biosynthesis

This protein is involved in Mycotoxin biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Mycotoxin biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei192For beta-ketoacyl synthase activityBy similarity1
Active sitei682For malonyltransferase activityBy similarity1
Active sitei1011For beta-hydroxyacyl dehydratase activityBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMultifunctional enzyme, Oxidoreductase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Highly reducing polyketide synthase ATR61 Publication (EC:2.3.1.-1 Publication)
Alternative name(s):
Core atranone cluster (CAC) protein 61 Publication
Gene namesi
Name:ATR61 Publication
ORF Names:S40285_03331
OrganismiStachybotrys chlorohalonata (strain IBT 40285)
Taxonomic identifieri1283841 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesStachybotryaceaeStachybotrys
Proteomesi
  • UP000028524 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004424001 – 2435Highly reducing polyketide synthase ATR6Add BLAST2435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2389O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2353 – 2429CarrierPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 453Ketosynthase (KS) domainSequence analysisAdd BLAST433
Regioni586 – 883Malonyl-CoA:ACP transacylase (MAT) domainSequence analysisAdd BLAST298
Regioni979 – 1291Dehydratase (DH) domainSequence analysisAdd BLAST313
Regioni1724 – 2037Enoylreductase (ER) domainSequence analysisAdd BLAST314
Regioni2062 – 2301Catalytic ketoreductase (KRc) domainSequence analysisAdd BLAST240

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH_C
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00107 ADH_zinc_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 2 hits
SSF53901 SSF53901, 2 hits
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS50075 CARRIER, 1 hit

Sequencei

Sequence statusi: Complete.

A0A084R1H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSEAPTPTS SSFALPYAEP IAIVSAACRL PGHIQNPHQL WQFLQAGGIA
60 70 80 90 100
TSDVVPESRY NVAGHFDGSG RPGTLKTPGG MFIEDIDLGA FDAPFFHIGK
110 120 130 140 150
SDAVSMDPQQ RQLLEVVYEC LENGGITMQG IDGDQIGCFV ASYSADWHEM
160 170 180 190 200
QSRHPASRAP GTTAGTSRAI LSNRISHFFN IKGSSWTIDT ACSGGLVGVD
210 220 230 240 250
AACQYLRAGK LNGAIVAAAQ LWMSPEYNEE LGTMRAAASS TGRCHSFDAK
260 270 280 290 300
ADGYCRSEAV NAVYLKRLSD ALRDGDPVRA VIRGTANNSD GRTPGLHSPN
310 320 330 340 350
SDAQAAAIRA AYADAGIDST QYTKTAFMEC HATGTPAGDP SEVRGSASVL
360 370 380 390 400
ASMRPPSDPL IIGTIKSNLG HAEPGAGISG LMKAMMAVEK GIIPGNPTFI
410 420 430 440 450
TPNPNIDFAG LRVRASQRNM RWPQSTKDYR RASVASSGFG GSNAHVVLDN
460 470 480 490 500
AEHYMQHHFL SVQPQFRTYV SSYAETGDVL SMLSGFGLGA ANSSDKLAPL
510 520 530 540 550
PNVLVFSAHD ADSLKRQMGA LSAHLVDPRV AIKLSDLSYT LSERRSRHFH
560 570 580 590 600
RSFIVCRPNK GGNIETLPTD LAKYAMKPTS PVRIGFVFTG QGAQWSGMGA
610 620 630 640 650
DLIRLFPKTA KAVVDELDAA LQELPADVRP SWSLLAELTE PRSSEHLREP
660 670 680 690 700
EFSQPLVTAL QLALLAVLKS WNVTADAVVG HSSGEIAAAC SAGLLTPGQA
710 720 730 740 750
ILTAYFRGQA AKQVVMEGSM GMLAVGLGSA GVQKYLEDTS RAGKVVIACY
760 770 780 790 800
NSPASVTLSG PTSLLSELAQ VIQTDGHFAR LLQVNLPYHS HYMSAIGDRY
810 820 830 840 850
EKLLLDHGRL DEIQGETATR KIPMISSVST IVLEGSKSCS AAYWKSNMVS
860 870 880 890 900
AVQFDGACKR IVADQDLSAN LLIEIGPSAA LGGPIGQIIK QAGIDNVTYT
910 920 930 940 950
SAAQRGTDSI LALFGVAGQL FLHDCPVSLD HVNTDETALT EPKPAVIIDL
960 970 980 990 1000
PNYRWNHSTR YWHESLASKD WRFRNFPEHD LLGGKVLGTA WESPSWTKTL
1010 1020 1030 1040 1050
RLEDVPWLRD HKIGSEILFP ASGYIAMAVE AARQATISTA RSQNKAAPSA
1060 1070 1080 1090 1100
HAYHYVLRDV HFERGLVLED ETDTTLMLSL APVARLGVKW WVFKVMSLAS
1110 1120 1130 1140 1150
GGSSSSSDSW IEHSNGLVRL ALNASEPLPR VTPDNYSLPL QYPTPARFWY
1160 1170 1180 1190 1200
KAFENAGYGY GPGFQKQSYI ECTEGSFSAR STIMLNPPLS KWEPQPNYPL
1210 1220 1230 1240 1250
HPASMESCIQ ATLTSMYRGD RAGINNVLVP NAIDRIILSG DTWRSNEAVS
1260 1270 1280 1290 1300
VTTSESSSGI TSKPLSNASL FDPTNGVLII DLRGISMTSV GLQGNVCSFS
1310 1320 1330 1340 1350
TYTRVEWKPD ICHLDSDTKI RRAILDLTDG TGDFVQEVLD LAAHKKPNMR
1360 1370 1380 1390 1400
VLEVDLTGGQ PRSLWLSGNE TSRITRAATS EFNYASDRPE SVLSAQDLYS
1410 1420 1430 1440 1450
DMSSGYTSRF TLLPITSQSF VAPPELCRSD LVLIRTSQLP SMETASILTR
1460 1470 1480 1490 1500
NARCLLTEGG TIVLHVLDVS KYSKVGQESL REALSRGKFS KIRQAADGLF
1510 1520 1530 1540 1550
VAEATDADTA YSQGKSLVVL HFSTSPVFSW SSAVITSLID KGWPITELTL
1560 1570 1580 1590 1600
EEGCRLTELP AKATILVMDE VNRPLFASME EYQLEAIQSI VQRDCSLLWV
1610 1620 1630 1640 1650
TQGSQMHVSS PLKAICHGVF RSVRSMDPNA RIVTLDVDSA AEDQLAKMAD
1660 1670 1680 1690 1700
ILHTVLLQVR VTPESLPADF EFVERGGLLY ISRLRPAQVD NESRSDGDKD
1710 1720 1730 1740 1750
GLQPVPVDLH STESTIGLVS GRPGILDTLH FAELGPGRLL VLGPEDIEVE
1760 1770 1780 1790 1800
IFAASVDDGD YALAKNLDPE DSTRLGYGGA GIVTRTGDSI TDIRAGQRVA
1810 1820 1830 1840 1850
LFHGGCVANR IVVARQVVFS VPDTMTFEDA ATLPTAFVPA IYSIYHLAQL
1860 1870 1880 1890 1900
RQGQRVLIHS AANAVGIACV QLCQGLSCKP YVTVDSDEER KFLAEEVGVS
1910 1920 1930 1940 1950
SDHILLLNSE NFAREMQDSA QNHGFDVIIN TSQHHLPDQG WGVVSPGGVH
1960 1970 1980 1990 2000
VALGQTINDR SLLPMDYFTN NRSFCSLDIR TLPLDKLASP RACSQLSDLI
2010 2020 2030 2040 2050
YGSSIKHMLP KAVFPCHGVQ AALQSCHDHN RLRNVVISTG PDKDVRILVK
2060 2070 2080 2090 2100
PEKQQPRCTF APEQTYLLVG KLKGVSGSLA LHLARCGAKY LVIMSPKNSE
2110 2120 2130 2140 2150
NSENISRSIR AMGCSLRFFE GDAASIDDMR RCYGQISGPI GGIVHGAAAQ
2160 2170 2180 2190 2200
SFRLMSHETY QATLARSVLS AWNLHTVSLE RDDSVPFFIM LSSTAGVVGD
2210 2220 2230 2240 2250
EKQPHHAGSD VFHNALATYR CGLGLPSTSI NLGPINDDAL LPDSEKTFKT
2260 2270 2280 2290 2300
LSSGVWFGVN EAVFRRIIDH SLSREHHGAQ RHFELASQAQ IITGIAVPQP
2310 2320 2330 2340 2350
GSSDILHDVR LLGLKLAQSG NSSSAASGRD DSQNREMQTF LLCARSTNPD
2360 2370 2380 2390 2400
PAVLLSSAVG VLQAQFTKML RLNELMDPAY PLNTYGMDSL AAAEPRSWVR
2410 2420 2430
TAFGVQLTTL DVVNAASLVV LCQKIISRMG LGKEV
Length:2,435
Mass (Da):263,256
Last modified:October 29, 2014 - v1
Checksum:iB5250B5AB0363780
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KL659308 Genomic DNA Translation: KFA70061.1

Genome annotation databases

EnsemblFungiiKFA70061; KFA70061; S40285_03331

Similar proteinsi

Entry informationi

Entry nameiATR6_STAC4
AccessioniPrimary (citable) accession number: A0A084R1H6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: October 29, 2014
Last modified: February 28, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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