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Protein
Submitted name:

Cation channel family protein

Gene

Contig9915.g10608

Organism
Stylonychia lemnae (Ciliate)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cation channel family proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Contig9915.g10608Imported
ORF Names:STYLEM_7715Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStylonychia lemnae (Ciliate)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5949 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataSpirotricheaStichotrichiaSporadotrichidaOxytrichidaeStylonychinaeStylonychia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000039865 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei591 – 609HelicalSequence analysisAdd BLAST19
Transmembranei621 – 638HelicalSequence analysisAdd BLAST18
Transmembranei682 – 704HelicalSequence analysisAdd BLAST23
Transmembranei781 – 805HelicalSequence analysisAdd BLAST25
Transmembranei1881 – 1900HelicalSequence analysisAdd BLAST20
Transmembranei1907 – 1926HelicalSequence analysisAdd BLAST20
Transmembranei1974 – 1995HelicalSequence analysisAdd BLAST22
Transmembranei2053 – 2076HelicalSequence analysisAdd BLAST24
Transmembranei2194 – 2217HelicalSequence analysisAdd BLAST24
Transmembranei2323 – 2356HelicalSequence analysisAdd BLAST34
Transmembranei2436 – 2458HelicalSequence analysisAdd BLAST23
Transmembranei2520 – 2540HelicalSequence analysisAdd BLAST21
Transmembranei2555 – 2574HelicalSequence analysisAdd BLAST20
Transmembranei2586 – 2604HelicalSequence analysisAdd BLAST19
Transmembranei2654 – 2676HelicalSequence analysisAdd BLAST23
Transmembranei2738 – 2760HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini552 – 816Ion_transInterPro annotationAdd BLAST265
Domaini1843 – 2083Ion_transInterPro annotationAdd BLAST241
Domaini2202 – 2468Ion_transInterPro annotationAdd BLAST267
Domaini2521 – 2766Ion_transInterPro annotationAdd BLAST246

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili932 – 952Sequence analysisAdd BLAST21
Coiled coili1141 – 1161Sequence analysisAdd BLAST21
Coiled coili1733 – 1765Sequence analysisAdd BLAST33

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A078AA09-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMQLRQVQC PYSPNYLLRS LKFYHNIYQR EDMTDVNAII SDNPKNVSSK
60 70 80 90 100
PPKSPKRDSS LNKQINAGAN GPPSDTQQQE AVPQFSTNPD QNPPTSQINS
110 120 130 140 150
QLPQNSTNSN QGKQPKINNG LVTQYGRQLS GNHDLELNFK KKSKRANEPI
160 170 180 190 200
TQQKISFKAA RMSQGGDSEK ISPLEQKSGT LQKNTTMRIL KNQNNMAPFQ
210 220 230 240 250
SNGFSKFSQQ RTINLNFFDD LQLGFENVDV QNLNYDGVSN SVHNQGKPDQ
260 270 280 290 300
WFQDPNFSVI YKNPKGSEFL DNGDYEDEKM YESRELDTPQ LVDSARNVMM
310 320 330 340 350
PKHINMSITP PAHSNSLRGT PMFIENQNGN LNHQVSIQLN NPSYNSNAQI
360 370 380 390 400
QQNHVFIDDL HNSELDIGAI HHKSQTSKFA DDDYTTQNKD SEENDFIPKF
410 420 430 440 450
SVLNKNQTMQ TDDHLLRPKS KSQKDKKKHP INMDLTKSED QSLMERMKRR
460 470 480 490 500
MEHSIVHIDA DLDNSDIYKR FNYDINEKPQ LDDKRAKAMI MNQFQDYQAK
510 520 530 540 550
GANDDNSFLM IVDKLPIERV DDFEGRCIRF KQILCITRIN INHLAFAIIK
560 570 580 590 600
SKLFEAVSLL VIVANSVSLA IEDPTDNTPK DYQDFMDTLF LALYTIEMAL
610 620 630 640 650
KIIGLGFAFN RGAYLRDAWN IMDFVIVVTA YLPLILQGGS LNLSGLRAFR
660 670 680 690 700
VLRPLKSISS IEGLKVIVSA LLSSLPLLRD TIIVLLFFFF IFAIAGLQLF
710 720 730 740 750
GGYLKKRCVN IETGVAHPDD DFCGYKDCDP GYFCGKRNEN PNFGQTSFDT
760 770 780 790 800
IFYSLIAIFT SVTLEGWTAT MHQIDKSFTN LSFFFFIPLV FIGAFFLMNL
810 820 830 840 850
TLAVIKSKFT KQHEDRKLEK QRGMGNKKAL ANDYVDYDYL DEVAKKIREE
860 870 880 890 900
NELELRKKIL KKWRMILFIK ERIRVRIKQY KEKKINNDTQ TNKNKTTFAS
910 920 930 940 950
TGLENAGNTL GYDYGLLFGT LEQNQEGESQ QNSSAKLELE TQQSQRQLLQ
960 970 980 990 1000
NQSRSNAQQI NLAILGDEKN VKISNNGNKI NIHTLRNFDH EAIAEEDDEY
1010 1020 1030 1040 1050
KTEFSNIIAN NRHFSNKHLQ SSKNVRNGSN GSKSTPKSGT QNDQSEIRRL
1060 1070 1080 1090 1100
SSRGLNFNNQ IQFLNNNKPD GILIESPGKK IKLVGMQSFK KNDKNKRREQ
1110 1120 1130 1140 1150
QQVLDNNILS VRNSRRLSKK VSIDGQFFID FVNHDLDILE KNFSEDQLAD
1160 1170 1180 1190 1200
IARQVEEVEN IANTSQILEM IDDEQFRGQQ FSEISILTDD FLQRNPNFIP
1210 1220 1230 1240 1250
NMRSEEEIND DKNQTPHTQA TGQFAKSGNN YYRQRSKNTN HYFMSQDLSI
1260 1270 1280 1290 1300
SYEYDDNQEQ IHNQIENYQK INESPQTYQS ISNDIINSNE VPINRQITDF
1310 1320 1330 1340 1350
SGSNNNINQR DNPRGYNNNY GGRNGKKTES TATNPQNNLS HSNLTTINQN
1360 1370 1380 1390 1400
GTIQSDANPL IVNQKTRDGK EMRRRTMGSA KIIPYELNSF DPKTADEIIK
1410 1420 1430 1440 1450
IRHGPNTISN QDTIPIDKSV LNSRFLISDY LQKHQKVYIK KEKFDFNFAS
1460 1470 1480 1490 1500
QDIFEQREEI MKEKIKEEKR ITATSYSKNF GLKPYQKKVC YSPKLYTPDE
1510 1520 1530 1540 1550
DQIEYLHYLG LDPSELMTLI QLQYNEPYIT NIHVTGTLSI AIHDKKDIRT
1560 1570 1580 1590 1600
NKTRKIQNIN LKMDDNEEMF NDSFNQSMSV FNGQGTNNSI NAQSPLKRYN
1610 1620 1630 1640 1650
KTTFSGTRKQ NLRILGEADQ FNNDVKTELF MKSTTNVILS KSIKRAKPNV
1660 1670 1680 1690 1700
SLIGEIRKRQ GGQSENNQTV MDSAVKRELL LKKAAAKDPQ LQRRLILSEV
1710 1720 1730 1740 1750
NRDANRSEIF RIIRNKRLNR MTQEEKDNNP KVVAMLKIEK NDDEEEEEEE
1760 1770 1780 1790 1800
EEEDTNSEEE QVNDDFLDWP LECRVEILKA KKKAISSKKN TVQWSGQDVL
1810 1820 1830 1840 1850
TDFDPQHAFK AISQISKVRI WPKWIFGYWK QFQVPLKLFV KGPIFDNLMT
1860 1870 1880 1890 1900
ASVFVNTVAL ALDKYGINST DQQNLSTMNT IFTWIFICEL SFKLIGLGPV
1910 1920 1930 1940 1950
KYFKDKMNYL DCMVVILSIV EMTILSNSGT NLSAFRSIRI FRTFRVLRVA
1960 1970 1980 1990 2000
RLLRSMQSMQ VIISVLIRSM DSFIYLALLL MLFIFIYALL GMQIFGGNFD
2010 2020 2030 2040 2050
FEENFNDPPG VPRTNFNNFN SAFLTTFQIL TLEGWPNLLY DALRSGVSQP
2060 2070 2080 2090 2100
ISILYFISWV FLGNFMLLNL FLAILLDSFT EETPHKSNGE EGDEKAIRKK
2110 2120 2130 2140 2150
HLEELGKKEG QELIEYYQEA KDQSGNDKSK KGLGVKKKKK KKKRDENILD
2160 2170 2180 2190 2200
ESFEFTKEAL TKKVVTKKKK VDFEGVDCNL SFYFMTKKNK LRIFLYRIVT
2210 2220 2230 2240 2250
HTGFETVILI LIILSSIKLV VDTYIYDYPE DDLIQVISAD VDYFFTAIFA
2260 2270 2280 2290 2300
MESVLKSLAF GFIQDKGSYL RETWSQLDFF IVCTSLIDAS FESVNLPIIK
2310 2320 2330 2340 2350
ILRLLRTLRP LRFISHNSGM KTIVVALLGS VSGIFNVLIV VVVVWMMFGI
2360 2370 2380 2390 2400
LAVNFFGGKM QYCSELPYLY HNKVQCLQNR GQWKTQDYNF DNVPQAMITL
2410 2420 2430 2440 2450
FALATLENWP DIMYNTINSQ GVEIGPAINA SPLNGYFFVV YILIGSFLFL
2460 2470 2480 2490 2500
NLFVGVIFKE FQDAQEEEKA SLMLKEQQAK WVDIMKMIIN SNPDLETTNK
2510 2520 2530 2540 2550
PKQLWRAQIH SVMTGACFKY NYVDIFIMTC IVLNMFQMAI NFEGSSLEYN
2560 2570 2580 2590 2600
NMLDYINYFF TGIFALECLF KLLAYGGSYF KTSWNIFDFC VVSASFFDIV
2610 2620 2630 2640 2650
MNQLSTNSLK FLRVGPQLAR VMRVMRVSRL FRLINKYKGL QALIQTITFS
2660 2670 2680 2690 2700
LPSLFNVFSL LMLVYFIFAV LGNFLFRGIT KGQVVDENTN FINFSASMMT
2710 2720 2730 2740 2750
MIRMSTGEDW IYVMYDCMRT EEDNCIPGQN CGINYAPVFF IPYIMITQFI
2760 2770 2780 2790 2800
MLNLFIMVII QQFEIYYLQE DNVLERFKDD LVLFKKNWTR FTADHDCLKL
2810 2820 2830 2840 2850
KDTKLVNYFR AMDPPLGMSD KSDKDIIKDV VLMELQSDED GFVYFHELLY
2860 2870 2880 2890 2900
RTMRRYYGEL HVKNKILVDH ELRTMQKIEA IKMKMKKKSL KNERNQAAQV
2910 2920 2930 2940 2950
NPFMLQMYMN ISFKAWKNQY STNKDKREQE KVYLEQHNQD NFDLLSEDTF
2960 2970 2980 2990 3000
QMNETRKSEQ LQQEWEYVTE EDIECSDEDD DRSSYEDDSE EEEEDEDEDS
3010 3020 3030 3040 3050
SRMLRQRPVN VSHVVANRKK LQSILKSSKA ASRELSKSLH NTSEAEIKIK
3060 3070 3080 3090 3100
QEENASPPSL AVKQDGQVKR LSTRSNLTVE VPKKRISNSQ RPPSNRITNE
3110 3120 3130 3140 3150
NENNSKPSGR SPILLQENVV IPTTHQQFRF DLDKVNGQQH QQIKSPQPFK
3160 3170 3180 3190 3200
IKEQSVVPEI NTQRIQSNSH TAGQQSHRKR DNVIVSSRSG SQGDLRDGDS
3210 3220 3230 3240 3250
VGDDRDQLQD HDPMGRSMKD DENSDQIVLL KINMNANANG QQLINTNVDN

LPNQKHYHK
Length:3,259
Mass (Da):376,208
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADA70E13472637CC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CCKQ01007373 Genomic DNA Translation: CDW78731.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CDW78731; CDW78731; STYLEM_7715

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CCKQ01007373 Genomic DNA Translation: CDW78731.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCDW78731; CDW78731; STYLEM_7715

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A078AA09_STYLE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A078AA09
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: February 28, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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