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Protein

Cardiolipin synthase A

Gene

cls

Organism
Edwardsiella anguillarum ET080813
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotationSAAS annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224UniRule annotation1
Active sitei226UniRule annotation1
Active sitei231UniRule annotation1
Active sitei404UniRule annotation1
Active sitei406UniRule annotation1
Active sitei411UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesisUniRule annotationSAAS annotation, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotationSAAS annotation (EC:2.7.8.-UniRule annotationSAAS annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsImported
Synonyms:clsAUniRule annotation
ORF Names:ETEE_3520Imported
OrganismiEdwardsiella anguillarum ET080813Imported
Taxonomic identifieri667120 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesHafniaceaeEdwardsiella
Proteomesi
  • UP000028681 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalUniRule annotationAdd BLAST20
Transmembranei37 – 58HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 246PLD phosphodiesteraseInterPro annotationAdd BLAST28
Domaini399 – 426PLD phosphodiesteraseInterPro annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

KOiK06131

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

A0A076LPU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTFYTVISW LAIFGYWLLI ASVTLRILMK RRAVPSAMAW LLIIYILPLV
60 70 80 90 100
GIIAYLSFGE LHLGKRRAER ARAMWPSTAR WLADLRSCRS IFATHNSEVA
110 120 130 140 150
APLFQLCERR QGIAGVKGNQ LQLLTSTDDT LNALIRDIEL AHNSIEMMFY
160 170 180 190 200
IWQPGGLADR VAEAMMAAAR RGVHCRLMLD SAGSVAFFRS PYPAIMREAG
210 220 230 240 250
IEVVEALQVN LLRVFLRRMD LRQHRKVVLI DNFIAYTGSM NLVDPRYFKQ
260 270 280 290 300
DAGVGQWIDV MARMEGPVAT TMGIYYAFDW EMETGKRILP PEPVCNILPF
310 320 330 340 350
EKESGHTIQV IASGPGFPEE LIHQSLLTAV YSARQQLVMT TPYFVPSDDL
360 370 380 390 400
LHAICTAAQR GVDVSIIVPK KNDSMMVGWA SRAFFTEMLA AGVKIYQFEG
410 420 430 440 450
GLLHTKSVLV DGQLSLVGTV NLDMRSLWLN FEITLVIDDD GFGSDLACVQ
460 470 480
EDYIARSSLL DPLAWLKRPL WQRVVERLFY FFSPLL
Length:486
Mass (Da):54,826
Last modified:October 29, 2014 - v1
Checksum:iC263D9ACB13CEBFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006664 Genomic DNA Translation: AIJ09941.1
RefSeqiWP_034165126.1, NZ_CP006664.1

Genome annotation databases

EnsemblBacteriaiAIJ09941; AIJ09941; ETEE_3520
GeneIDi33940951
KEGGiete:ETEE_3520

Similar proteinsi

Entry informationi

Entry nameiA0A076LPU8_9GAMM
AccessioniPrimary (citable) accession number: A0A076LPU8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: November 22, 2017
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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