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Entry version 34 (02 Jun 2021)
Sequence version 1 (29 Oct 2014)
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Protein

Genome polyprotein

Gene
N/A
Organism
Norovirus Hu/GII/10116/2009/VNM
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation.

PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.PROSITE-ProRule annotation EC:3.4.22.66

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1011For 3CLpro activityPROSITE-ProRule annotation1
Active sitei1035For 3CLpro activityPROSITE-ProRule annotation1
Active sitei1120For 3CLpro activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseARBA annotation, Thiol proteasePROSITE-ProRule annotationARBA annotation, Transferase
Biological processViral RNA replicationARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C37.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyproteinARBA annotation (EC:2.7.7.48ARBA annotation, EC:3.4.22.66ARBA annotation, EC:3.6.1.15ARBA annotation)
Alternative name(s):
NTPaseARBA annotation
VPgARBA annotation
Viral genome-linked proteinARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNorovirus Hu/GII/10116/2009/VNMImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1526944 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesPicornaviralesCaliciviridaeNorovirus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins. 3CLpro is first autocatalytically cleaved, then processes the whole polyprotein.PROSITE-ProRule annotation

Keywords - PTMi

Covalent protein-RNA linkageARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini438 – 605SF3 helicaseInterPro annotationAdd BLAST168
Domaini982 – 1162Peptidase C37InterPro annotationAdd BLAST181
Domaini1398 – 1519RdRp catalyticInterPro annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 50DisorderedSequence analysisAdd BLAST50
Regioni71 – 92DisorderedSequence analysisAdd BLAST22
Regioni819 – 868DisorderedSequence analysisAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili434 – 454Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 49Pro residuesSequence analysisAdd BLAST31
Compositional biasi71 – 86Polar residuesSequence analysisAdd BLAST16
Compositional biasi820 – 852Basic and acidic residuesSequence analysisAdd BLAST33

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
3.30.70.270, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR001665, Norovirus_pept_C37
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR013614, Viral_PP_Calicivir_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08405, Calici_PP_N, 1 hit
PF05416, Peptidase_C37, 1 hit
PF00680, RdRP_1, 1 hit
PF00910, RNA_helicase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00917, SRSVCYSPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51537, NV_3CL_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A076EGG6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSNMAVTFK RALGARPKQP PPREIPQRPP RPPTPELVKK IPPPPPNGED
60 70 80 90 100
EIVVSYSAKD GVSGLPELST VRQPEETNTA FSVPPLNQRE NRDAKEPLTG
110 120 130 140 150
TILEMWDGEI YHYGLYVERG LVLGVHKPPA AISLAKVELT PLSLFWRPVY
160 170 180 190 200
TPQYLISPDT LKKLHGETFP YTAFDNNCYA FCCWVLDLND SWLSRRMIQR
210 220 230 240 250
TTGFFRPYQD WNRKPLPTMD DSKLKKVANI FLCALSSLFT RPIKDIIGKL
260 270 280 290 300
RPLNIINILA SCDWTFAGIV ESLILLAELF GVFWTPPDVS AMIAPLLGDF
310 320 330 340 350
ELQGPEDLVV ELVPVVMGGI GLVLGFTKEK IGKMLSSAAS TLRACKDLGA
360 370 380 390 400
YGLEILKLVM KWFFPKKEEA NELAMVRSIE DAVLDLEAIE NNHMTTLLKD
410 420 430 440 450
KDSLATYMRT LDLEEEKARK LSTKSASPDI VGTINALLAR IAAARSLVHR
460 470 480 490 500
AKEELSSRPR PVVLMISGRP GIGKTHLARE VAKRIAASLT GDQRVGLIPR
510 520 530 540 550
NGVDHWDAYK GERVVLWDDY GMSNPIHDAL RLQELADTCP LTLNCDRIEN
560 570 580 590 600
KGKVFDSDVI IITTNLANPA PLDYVNFEAC SRRIDFLVYA EAPEVEKAKR
610 620 630 640 650
DFPGQPDMWK NAFSSDFSHI KLALAPQGGF DKNGNTPHGK GVMKTLTTGS
660 670 680 690 700
LIARASGLLH ERLDEFELQG PALTTFNFDR NKVLAFRQLA AENKYGLIDT
710 720 730 740 750
MKVGRQLKDV KTMPELKQAL KNISIKKCQI VYSGCTYTLE SDGKGNVKVD
760 770 780 790 800
RIQSTSVQTN NELAGALHHL RCARIRYYVK CVQEALYSII QIAGAAFVTT
810 820 830 840 850
RIIKRVNIQD LWSKPQVENT EEATNRDGCP KPKDDGEFVI SSDDIKTEGK
860 870 880 890 900
KGKNKTGRGK KHTAFSSKGL SDEEYDEYKR IREERNGRYS IEEYLQDRDK
910 920 930 940 950
YYEEVAIARA TEEDFCEEEE AKIRQRIFRP TRKQRKEERA SLGLVTGSEI
960 970 980 990 1000
RKRNPDDFKP KGKLWADDDR SVDYNEKLSF EAPPSIWSRI VNFGSGWGFW
1010 1020 1030 1040 1050
VSPSLFITST HVIPQGAKEF FGVPIKQIQV HKSGEFCRLR FPKPIRTDVT
1060 1070 1080 1090 1100
GMILEEGAPE GTVVTLLIKR STGELMPLAA RMGTHATMKI QGRTVGGQMG
1110 1120 1130 1140 1150
MLLTGSNAKS MDLGTTPGDC GCPYIYKRGN DYVVIGVHTA AARGGNTVIC
1160 1170 1180 1190 1200
ATQGGEGEAT LEGGDSKGTY CGAPILGPGS APKLSTKTKF WRSSTAPLPP
1210 1220 1230 1240 1250
GTYEPAYLGG KDPRVKGGPS LQQVMRDQLK PFTEPRGKPP KPSVLEAAKK
1260 1270 1280 1290 1300
TIINVLEQTI DPPEKWSFAQ ACASLDKTTS SGHPHHMRKN DCWNGESFTG
1310 1320 1330 1340 1350
KLADQASKAN LMFEEGKNMT PVYTGALKDE LVKTDKIYGK IKKRLLWGSD
1360 1370 1380 1390 1400
LATMIRCARA FGGLMDELKA HCVTLPIRVG MNMNEDGPII FEKHSRYRYH
1410 1420 1430 1440 1450
YDADYSRWDS TQQRAVLAAA LEIMVKFSSE PHLAQVVAED LLSPSVVDVG
1460 1470 1480 1490 1500
DFTISINEGL PSGVPCTSQW NSIAHWLLTL CALSEVTNLS PDIIQANSLF
1510 1520 1530 1540 1550
SFYGDDEIVS TDIKLDPEKL TAKLKEYGLK PTRPDKTEGP LVISEDLDGL
1560 1570 1580 1590 1600
TFLRRTVTRD PAGWFGKLEQ SSILRQMYWT RGPNHEDPSE SMIPHSQRPI
1610 1620 1630 1640 1650
QLMSLLGEAA LHGPTFYSKI SKLVIAELKE GGMDFYVPRQ EPMFRWMRFS
1660 1670
DLSTWEGDRN LAPSFVNEDG VE
Length:1,672
Mass (Da):186,409
Last modified:October 29, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BF51633ECA8D871
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KM198480 Genomic RNA Translation: AII02568.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM198480 Genomic RNA Translation: AII02568.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC37.001

Family and domain databases

Gene3Di2.40.10.10, 2 hits
3.30.70.270, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR001665, Norovirus_pept_C37
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR013614, Viral_PP_Calicivir_N
PfamiView protein in Pfam
PF08405, Calici_PP_N, 1 hit
PF05416, Peptidase_C37, 1 hit
PF00680, RdRP_1, 1 hit
PF00910, RNA_helicase, 1 hit
PRINTSiPR00917, SRSVCYSPTASE
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51537, NV_3CL_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A076EGG6_9CALI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A076EGG6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: June 2, 2021
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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