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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:COIImported
Encoded oniMitochondrionImported
OrganismiArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)Imported
Taxonomic identifieri6661 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 54HelicalSequence analysisAdd BLAST22
Transmembranei117 – 142HelicalSequence analysisAdd BLAST26
Transmembranei154 – 181HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 187COX1InterPro annotationAdd BLAST187

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A075D7P7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GTSLSMLIRA ELGQPGSLIG DEQVYNVIVT AHAFIMIFFM VMPILIGGFG
60 70 80 90 100
NWLVPIMLGA PDMAFPRLNN LSFWMLPPSL TLLLASSMVE SGAGTGWTVY
110 120 130 140 150
PPLSSAIAHA GPSVDLAIFS LHLAGVSSIL GAVNFITTII NMRPQSMSID
160 170 180
RMPLFVWAVG ITAVLLLLSL PVLAGAITML LTDRNLN
Length:187
Mass (Da):19,909
Last modified:October 29, 2014 - v1
Checksum:i2886E6482425E91D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei187Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF691154 Genomic DNA Translation: AHH82089.1
KF691155 Genomic DNA Translation: AHH82090.1
KF691156 Genomic DNA Translation: AHH82091.1
KF691160 Genomic DNA Translation: AHH82095.1
KF691161 Genomic DNA Translation: AHH82096.1
KF691163 Genomic DNA Translation: AHH82098.1
KF691164 Genomic DNA Translation: AHH82099.1
KF691165 Genomic DNA Translation: AHH82100.1
KF691173 Genomic DNA Translation: AHH82108.1
KF691174 Genomic DNA Translation: AHH82109.1
KF691175 Genomic DNA Translation: AHH82110.1
KF691176 Genomic DNA Translation: AHH82111.1
KF691177 Genomic DNA Translation: AHH82112.1
KF691178 Genomic DNA Translation: AHH82113.1
KF691179 Genomic DNA Translation: AHH82114.1
KF691180 Genomic DNA Translation: AHH82115.1
KF691181 Genomic DNA Translation: AHH82116.1
KF691182 Genomic DNA Translation: AHH82117.1
KF691184 Genomic DNA Translation: AHH82119.1
KF691185 Genomic DNA Translation: AHH82120.1
KF691186 Genomic DNA Translation: AHH82121.1
KF691190 Genomic DNA Translation: AHH82125.1
KF691191 Genomic DNA Translation: AHH82126.1
KF691192 Genomic DNA Translation: AHH82127.1
KF691193 Genomic DNA Translation: AHH82128.1
KF691195 Genomic DNA Translation: AHH82130.1
KF691196 Genomic DNA Translation: AHH82131.1
KF691197 Genomic DNA Translation: AHH82132.1
KF691198 Genomic DNA Translation: AHH82133.1
KF691205 Genomic DNA Translation: AHH82140.1
KF691206 Genomic DNA Translation: AHH82141.1
KF691207 Genomic DNA Translation: AHH82142.1
KF691219 Genomic DNA Translation: AHH82154.1
KF691220 Genomic DNA Translation: AHH82155.1
KF691221 Genomic DNA Translation: AHH82156.1
KF691222 Genomic DNA Translation: AHH82157.1
KF691223 Genomic DNA Translation: AHH82158.1
KF691227 Genomic DNA Translation: AHH82162.1
KF691228 Genomic DNA Translation: AHH82163.1
KF691229 Genomic DNA Translation: AHH82164.1
KF691230 Genomic DNA Translation: AHH82165.1
KF691231 Genomic DNA Translation: AHH82166.1
KF691232 Genomic DNA Translation: AHH82167.1
KF691237 Genomic DNA Translation: AHH82172.1
KF691239 Genomic DNA Translation: AHH82174.1
KF691240 Genomic DNA Translation: AHH82175.1
KF691241 Genomic DNA Translation: AHH82176.1
KF691242 Genomic DNA Translation: AHH82177.1
KF691243 Genomic DNA Translation: AHH82178.1
KF691244 Genomic DNA Translation: AHH82179.1
KF691250 Genomic DNA Translation: AHH82185.1
KF691251 Genomic DNA Translation: AHH82186.1
KF691252 Genomic DNA Translation: AHH82187.1
KF691253 Genomic DNA Translation: AHH82188.1
KF691254 Genomic DNA Translation: AHH82189.1
KF691255 Genomic DNA Translation: AHH82190.1
KF691256 Genomic DNA Translation: AHH82191.1
KF691258 Genomic DNA Translation: AHH82193.1
KF691259 Genomic DNA Translation: AHH82194.1
KF691260 Genomic DNA Translation: AHH82195.1
KF691261 Genomic DNA Translation: AHH82196.1
KF691262 Genomic DNA Translation: AHH82197.1
KF691263 Genomic DNA Translation: AHH82198.1
KF691264 Genomic DNA Translation: AHH82199.1
KF691266 Genomic DNA Translation: AHH82201.1
KF691267 Genomic DNA Translation: AHH82202.1
KF691278 Genomic DNA Translation: AHH82213.1
KF691279 Genomic DNA Translation: AHH82214.1
KF691280 Genomic DNA Translation: AHH82215.1
KF691281 Genomic DNA Translation: AHH82216.1
KF691282 Genomic DNA Translation: AHH82217.1
KF691283 Genomic DNA Translation: AHH82218.1
KF691284 Genomic DNA Translation: AHH82219.1
KF691285 Genomic DNA Translation: AHH82220.1
KF691286 Genomic DNA Translation: AHH82221.1
KF691291 Genomic DNA Translation: AHH82226.1
KF691292 Genomic DNA Translation: AHH82227.1
KF691293 Genomic DNA Translation: AHH82228.1
KF691294 Genomic DNA Translation: AHH82229.1
KF691295 Genomic DNA Translation: AHH82230.1
KF691296 Genomic DNA Translation: AHH82231.1
KF691297 Genomic DNA Translation: AHH82232.1
KF691303 Genomic DNA Translation: AHH82238.1
KF691304 Genomic DNA Translation: AHH82239.1
KF691305 Genomic DNA Translation: AHH82240.1
KF691306 Genomic DNA Translation: AHH82241.1
KF691307 Genomic DNA Translation: AHH82242.1
KF691308 Genomic DNA Translation: AHH82243.1
KF691309 Genomic DNA Translation: AHH82244.1
KF691310 Genomic DNA Translation: AHH82245.1
KF691311 Genomic DNA Translation: AHH82246.1
KF691312 Genomic DNA Translation: AHH82247.1
KF691313 Genomic DNA Translation: AHH82248.1
KF691314 Genomic DNA Translation: AHH82249.1
KF691315 Genomic DNA Translation: AHH82250.1
KF691324 Genomic DNA Translation: AHH82259.1
KF691325 Genomic DNA Translation: AHH82260.1
KF691326 Genomic DNA Translation: AHH82261.1
KF691327 Genomic DNA Translation: AHH82262.1
KF691328 Genomic DNA Translation: AHH82263.1
KF691329 Genomic DNA Translation: AHH82264.1
KF691330 Genomic DNA Translation: AHH82265.1
KF691331 Genomic DNA Translation: AHH82266.1
KF691332 Genomic DNA Translation: AHH82267.1
KF691347 Genomic DNA Translation: AHH82282.1
KF691349 Genomic DNA Translation: AHH82284.1
KF691351 Genomic DNA Translation: AHH82286.1
KF691352 Genomic DNA Translation: AHH82287.1
KF691353 Genomic DNA Translation: AHH82288.1
KF691354 Genomic DNA Translation: AHH82289.1
KF691355 Genomic DNA Translation: AHH82290.1
KF691356 Genomic DNA Translation: AHH82291.1
KF691362 Genomic DNA Translation: AHH82297.1
KF691363 Genomic DNA Translation: AHH82298.1
KF691364 Genomic DNA Translation: AHH82299.1
KF691365 Genomic DNA Translation: AHH82300.1
KF691366 Genomic DNA Translation: AHH82301.1
KF691376 Genomic DNA Translation: AHH82311.1
KF691377 Genomic DNA Translation: AHH82312.1
KF691378 Genomic DNA Translation: AHH82313.1
KF691379 Genomic DNA Translation: AHH82314.1
KF691380 Genomic DNA Translation: AHH82315.1
KF691381 Genomic DNA Translation: AHH82316.1
KF691382 Genomic DNA Translation: AHH82317.1
KF691383 Genomic DNA Translation: AHH82318.1
KF691439 Genomic DNA Translation: AHH82374.1
KF691440 Genomic DNA Translation: AHH82375.1
KF691441 Genomic DNA Translation: AHH82376.1
KF691446 Genomic DNA Translation: AHH82381.1
KF691503 Genomic DNA Translation: AHH82438.1
KF691504 Genomic DNA Translation: AHH82439.1
KF691505 Genomic DNA Translation: AHH82440.1
KF691506 Genomic DNA Translation: AHH82441.1
KF691507 Genomic DNA Translation: AHH82442.1
KF691508 Genomic DNA Translation: AHH82443.1
KF691556 Genomic DNA Translation: AHH82491.1
KF691557 Genomic DNA Translation: AHH82492.1
KF691558 Genomic DNA Translation: AHH82493.1
KF691559 Genomic DNA Translation: AHH82494.1
KF691560 Genomic DNA Translation: AHH82495.1
KF691561 Genomic DNA Translation: AHH82496.1
KF691562 Genomic DNA Translation: AHH82497.1
KF691563 Genomic DNA Translation: AHH82498.1
KF691564 Genomic DNA Translation: AHH82499.1
KF691565 Genomic DNA Translation: AHH82500.1
KF691566 Genomic DNA Translation: AHH82501.1
KF691567 Genomic DNA Translation: AHH82502.1
KF691568 Genomic DNA Translation: AHH82503.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF691154 Genomic DNA Translation: AHH82089.1
KF691155 Genomic DNA Translation: AHH82090.1
KF691156 Genomic DNA Translation: AHH82091.1
KF691160 Genomic DNA Translation: AHH82095.1
KF691161 Genomic DNA Translation: AHH82096.1
KF691163 Genomic DNA Translation: AHH82098.1
KF691164 Genomic DNA Translation: AHH82099.1
KF691165 Genomic DNA Translation: AHH82100.1
KF691173 Genomic DNA Translation: AHH82108.1
KF691174 Genomic DNA Translation: AHH82109.1
KF691175 Genomic DNA Translation: AHH82110.1
KF691176 Genomic DNA Translation: AHH82111.1
KF691177 Genomic DNA Translation: AHH82112.1
KF691178 Genomic DNA Translation: AHH82113.1
KF691179 Genomic DNA Translation: AHH82114.1
KF691180 Genomic DNA Translation: AHH82115.1
KF691181 Genomic DNA Translation: AHH82116.1
KF691182 Genomic DNA Translation: AHH82117.1
KF691184 Genomic DNA Translation: AHH82119.1
KF691185 Genomic DNA Translation: AHH82120.1
KF691186 Genomic DNA Translation: AHH82121.1
KF691190 Genomic DNA Translation: AHH82125.1
KF691191 Genomic DNA Translation: AHH82126.1
KF691192 Genomic DNA Translation: AHH82127.1
KF691193 Genomic DNA Translation: AHH82128.1
KF691195 Genomic DNA Translation: AHH82130.1
KF691196 Genomic DNA Translation: AHH82131.1
KF691197 Genomic DNA Translation: AHH82132.1
KF691198 Genomic DNA Translation: AHH82133.1
KF691205 Genomic DNA Translation: AHH82140.1
KF691206 Genomic DNA Translation: AHH82141.1
KF691207 Genomic DNA Translation: AHH82142.1
KF691219 Genomic DNA Translation: AHH82154.1
KF691220 Genomic DNA Translation: AHH82155.1
KF691221 Genomic DNA Translation: AHH82156.1
KF691222 Genomic DNA Translation: AHH82157.1
KF691223 Genomic DNA Translation: AHH82158.1
KF691227 Genomic DNA Translation: AHH82162.1
KF691228 Genomic DNA Translation: AHH82163.1
KF691229 Genomic DNA Translation: AHH82164.1
KF691230 Genomic DNA Translation: AHH82165.1
KF691231 Genomic DNA Translation: AHH82166.1
KF691232 Genomic DNA Translation: AHH82167.1
KF691237 Genomic DNA Translation: AHH82172.1
KF691239 Genomic DNA Translation: AHH82174.1
KF691240 Genomic DNA Translation: AHH82175.1
KF691241 Genomic DNA Translation: AHH82176.1
KF691242 Genomic DNA Translation: AHH82177.1
KF691243 Genomic DNA Translation: AHH82178.1
KF691244 Genomic DNA Translation: AHH82179.1
KF691250 Genomic DNA Translation: AHH82185.1
KF691251 Genomic DNA Translation: AHH82186.1
KF691252 Genomic DNA Translation: AHH82187.1
KF691253 Genomic DNA Translation: AHH82188.1
KF691254 Genomic DNA Translation: AHH82189.1
KF691255 Genomic DNA Translation: AHH82190.1
KF691256 Genomic DNA Translation: AHH82191.1
KF691258 Genomic DNA Translation: AHH82193.1
KF691259 Genomic DNA Translation: AHH82194.1
KF691260 Genomic DNA Translation: AHH82195.1
KF691261 Genomic DNA Translation: AHH82196.1
KF691262 Genomic DNA Translation: AHH82197.1
KF691263 Genomic DNA Translation: AHH82198.1
KF691264 Genomic DNA Translation: AHH82199.1
KF691266 Genomic DNA Translation: AHH82201.1
KF691267 Genomic DNA Translation: AHH82202.1
KF691278 Genomic DNA Translation: AHH82213.1
KF691279 Genomic DNA Translation: AHH82214.1
KF691280 Genomic DNA Translation: AHH82215.1
KF691281 Genomic DNA Translation: AHH82216.1
KF691282 Genomic DNA Translation: AHH82217.1
KF691283 Genomic DNA Translation: AHH82218.1
KF691284 Genomic DNA Translation: AHH82219.1
KF691285 Genomic DNA Translation: AHH82220.1
KF691286 Genomic DNA Translation: AHH82221.1
KF691291 Genomic DNA Translation: AHH82226.1
KF691292 Genomic DNA Translation: AHH82227.1
KF691293 Genomic DNA Translation: AHH82228.1
KF691294 Genomic DNA Translation: AHH82229.1
KF691295 Genomic DNA Translation: AHH82230.1
KF691296 Genomic DNA Translation: AHH82231.1
KF691297 Genomic DNA Translation: AHH82232.1
KF691303 Genomic DNA Translation: AHH82238.1
KF691304 Genomic DNA Translation: AHH82239.1
KF691305 Genomic DNA Translation: AHH82240.1
KF691306 Genomic DNA Translation: AHH82241.1
KF691307 Genomic DNA Translation: AHH82242.1
KF691308 Genomic DNA Translation: AHH82243.1
KF691309 Genomic DNA Translation: AHH82244.1
KF691310 Genomic DNA Translation: AHH82245.1
KF691311 Genomic DNA Translation: AHH82246.1
KF691312 Genomic DNA Translation: AHH82247.1
KF691313 Genomic DNA Translation: AHH82248.1
KF691314 Genomic DNA Translation: AHH82249.1
KF691315 Genomic DNA Translation: AHH82250.1
KF691324 Genomic DNA Translation: AHH82259.1
KF691325 Genomic DNA Translation: AHH82260.1
KF691326 Genomic DNA Translation: AHH82261.1
KF691327 Genomic DNA Translation: AHH82262.1
KF691328 Genomic DNA Translation: AHH82263.1
KF691329 Genomic DNA Translation: AHH82264.1
KF691330 Genomic DNA Translation: AHH82265.1
KF691331 Genomic DNA Translation: AHH82266.1
KF691332 Genomic DNA Translation: AHH82267.1
KF691347 Genomic DNA Translation: AHH82282.1
KF691349 Genomic DNA Translation: AHH82284.1
KF691351 Genomic DNA Translation: AHH82286.1
KF691352 Genomic DNA Translation: AHH82287.1
KF691353 Genomic DNA Translation: AHH82288.1
KF691354 Genomic DNA Translation: AHH82289.1
KF691355 Genomic DNA Translation: AHH82290.1
KF691356 Genomic DNA Translation: AHH82291.1
KF691362 Genomic DNA Translation: AHH82297.1
KF691363 Genomic DNA Translation: AHH82298.1
KF691364 Genomic DNA Translation: AHH82299.1
KF691365 Genomic DNA Translation: AHH82300.1
KF691366 Genomic DNA Translation: AHH82301.1
KF691376 Genomic DNA Translation: AHH82311.1
KF691377 Genomic DNA Translation: AHH82312.1
KF691378 Genomic DNA Translation: AHH82313.1
KF691379 Genomic DNA Translation: AHH82314.1
KF691380 Genomic DNA Translation: AHH82315.1
KF691381 Genomic DNA Translation: AHH82316.1
KF691382 Genomic DNA Translation: AHH82317.1
KF691383 Genomic DNA Translation: AHH82318.1
KF691439 Genomic DNA Translation: AHH82374.1
KF691440 Genomic DNA Translation: AHH82375.1
KF691441 Genomic DNA Translation: AHH82376.1
KF691446 Genomic DNA Translation: AHH82381.1
KF691503 Genomic DNA Translation: AHH82438.1
KF691504 Genomic DNA Translation: AHH82439.1
KF691505 Genomic DNA Translation: AHH82440.1
KF691506 Genomic DNA Translation: AHH82441.1
KF691507 Genomic DNA Translation: AHH82442.1
KF691508 Genomic DNA Translation: AHH82443.1
KF691556 Genomic DNA Translation: AHH82491.1
KF691557 Genomic DNA Translation: AHH82492.1
KF691558 Genomic DNA Translation: AHH82493.1
KF691559 Genomic DNA Translation: AHH82494.1
KF691560 Genomic DNA Translation: AHH82495.1
KF691561 Genomic DNA Translation: AHH82496.1
KF691562 Genomic DNA Translation: AHH82497.1
KF691563 Genomic DNA Translation: AHH82498.1
KF691564 Genomic DNA Translation: AHH82499.1
KF691565 Genomic DNA Translation: AHH82500.1
KF691566 Genomic DNA Translation: AHH82501.1
KF691567 Genomic DNA Translation: AHH82502.1
KF691568 Genomic DNA Translation: AHH82503.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00705

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A075D7P7_ARTSF
AccessioniPrimary (citable) accession number: A0A075D7P7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: May 23, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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