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Protein
Submitted name:

SLIT-ROBO Rho GTPase-activating protein 2

Gene

SRGAP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
SLIT-ROBO Rho GTPase-activating protein 2Imported
Gene namesi
Name:SRGAP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000266028.7
HGNCiHGNC:19751 SRGAP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000266028

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A075B7E6

Expressioni

Gene expression databases

BgeeiENSG00000266028 Expressed in 200 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiA0A075B7E6 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 62Rho-GAPInterPro annotationAdd BLAST62
Domaini111 – 170SH3InterPro annotationAdd BLAST60

Keywords - Domaini

SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3565 Eukaryota
ENOG410XS44 LUCA
GeneTreeiENSGT00760000118863

Family and domain databases

CDDicd11955 SH3_srGAP1-3, 1 hit
Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035648 srGAP1/2/3_SH3
IPR030252 srGAP2
PANTHERiPTHR14166:SF6 PTHR14166:SF6, 1 hit
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A075B7E6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XLFAFLNHLS QFSEENMMDP YNLAICFGPS LMSVPEGHDQ VSCQAHVNEL
60 70 80 90 100
IKTIIIQHEN IFPSPRELEG PVYSRGGSME DYCDSPHGET TSVEDSTQDV
110 120 130 140 150
TAEHHTSDDE CEPIEAIAKF DYVGRTAREL SFKKGASLLL YQRASDDWWE
160 170 180 190 200
GRHNGIDGLI PHQYIVVQDT EDGVVERSSP KSEIEVISEP PEEKVTARAG
210 220
ASCPSGGHVA DIYLANINNF HCGC
Length:224
Mass (Da):24,809
Last modified:October 1, 2014 - v1
Checksum:i1D64DBEBD71ECEAD
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O75044SRGP2_HUMAN
SLIT-ROBO Rho GTPase-activating pro...
SRGAP2 ARHGAP34, FNBP2, KIAA0456, SRGAP2A
1,071Annotation score:
B7ZM87B7ZM87_HUMAN
SLIT-ROBO Rho GTPase-activating pro...
SRGAP2
1,070Annotation score:
A0A075B7E9A0A075B7E9_HUMAN
SLIT-ROBO Rho GTPase-activating pro...
SRGAP2
294Annotation score:
Q5VZB4Q5VZB4_HUMAN
SLIT-ROBO Rho GTPase-activating pro...
SRGAP2 RP11-421E17.2-002
450Annotation score:
A0A075B7B5A0A075B7B5_HUMAN
SLIT-ROBO Rho GTPase-activating pro...
SRGAP2
789Annotation score:
E9PDX4E9PDX4_HUMAN
SLIT-ROBO Rho GTPase-activating pro...
SRGAP2
305Annotation score:
A0A075B743A0A075B743_HUMAN
SLIT-ROBO Rho GTPase-activating pro...
SRGAP2
118Annotation score:
A0A075B7C8A0A075B7C8_HUMAN
SLIT-ROBO Rho GTPase-activating pro...
SRGAP2
86Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244023 Genomic DNA No translation available.
AC244034 Genomic DNA No translation available.
AC244035 Genomic DNA No translation available.
AC244158 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000604925; ENSP00000474699; ENSG00000266028
UCSCiuc057owr.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244023 Genomic DNA No translation available.
AC244034 Genomic DNA No translation available.
AC244035 Genomic DNA No translation available.
AC244158 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A075B7E6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000604925; ENSP00000474699; ENSG00000266028
UCSCiuc057owr.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000266028.7
HGNCiHGNC:19751 SRGAP2
OpenTargetsiENSG00000266028
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3565 Eukaryota
ENOG410XS44 LUCA
GeneTreeiENSGT00760000118863

Miscellaneous databases

ChiTaRSiSRGAP2 human

Gene expression databases

BgeeiENSG00000266028 Expressed in 200 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiA0A075B7E6 baseline and differential

Family and domain databases

CDDicd11955 SH3_srGAP1-3, 1 hit
Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035648 srGAP1/2/3_SH3
IPR030252 srGAP2
PANTHERiPTHR14166:SF6 PTHR14166:SF6, 1 hit
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A075B7E6_HUMAN
AccessioniPrimary (citable) accession number: A0A075B7E6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: September 12, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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