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Protein
Submitted name:

Desmuslin, isoform CRA_a

Gene

SYNM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Desmuslin, isoform CRA_aImported
Submitted name:
SyneminImported
Gene namesi
Name:SYNMImported
Synonyms:DMNImported
ORF Names:hCG_28262Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000182253.14
HGNCiHGNC:24466 SYNM

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filamentPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182253

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A075B7B1
PRIDEiA0A075B7B1

Expressioni

Gene expression databases

BgeeiENSG00000182253
ExpressionAtlasiA0A075B7B1 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 322IF rodInterPro annotationAdd BLAST312

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 49Sequence analysisAdd BLAST35
Coiled coili78 – 108Sequence analysisAdd BLAST31
Coiled coili120 – 140Sequence analysisAdd BLAST21
Coiled coili192 – 261Sequence analysisAdd BLAST70

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IH92 Eukaryota
ENOG4111GBF LUCA
GeneTreeiENSGT00730000110953

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR030634 SYNM
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF194 PTHR23239:SF194, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A075B7B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSWRLQTGP EKAELQELNA RLYDYVCRVR ELERENLLLE EELRGRRGRE
60 70 80 90 100
GLWAEGQARC AEEARSLRQQ LDELSWATAL AEGERDALRR ELRELQRLDA
110 120 130 140 150
EERAARGRLD AELGAQQREL QEALGARAAL EALLGRLQAE RRGLDAAHER
160 170 180 190 200
DVRELRARAA SLTMHFRARA TGPAAPPPRL REVHDSYALL VAESWRETVQ
210 220 230 240 250
LYEDEVRELE EALRRGQESR LQAEEETRLC AQEAEALRRE ALGLEQLRAR
260 270 280 290 300
LEDALLRMRE EYGIQAEERQ RVIDCLEDEK ATLTLAMADW LRDYQDLLQV
310 320 330 340 350
KTGLSLEVAT YRALLEGESN PEIVIWAEHV ENMPSEFRNK SYHYTDSLLQ
360 370 380 390 400
RENERNLFSR QKAPLASFNH SSALYSNLSG HRGSQTGTSI GGDARRGFLG
410 420 430 440 450
SGYSSSATTQ QENSYGKAVS SQTNVRTFSP TYGLLRNTEA QVKTFPDRPK
460 470 480 490 500
AGDTREVPVY IGEDSTIARE SYRDRRDKVA AGASESTRSN ERTVILGKKT
510 520 530 540 550
EVKATREQER NRPETIRTKP EEKMFDSKEK ASEERNLRWE ELTKLDKEAR
560 570 580 590 600
QRESQQMKEK AKEKDSPKEK SVREREVPIS LEVSQDRRAE VSPKGLQTPV
610 620 630 640 650
KDAGGGTGRE AEARELRFRL GTSDATGSLQ GDSMTETVAE NIVTSILKQF
660 670 680 690 700
TQSPETEASA DSFPDTKVTY VDRKELPGER KTKTEIVVES KLTEDVDVSD
710 720 730 740 750
EAGLDYLLSK DIKEVGLKGK SAEQMIGDII NLGLKGREGR AKVVNVEIVE
760 770 780 790 800
EPVSYVSGEK PEEFSVPFKV EEVEDVSPGP WGLVKEEEGY GESDVTFSVN
810 820 830 840 850
QHRRTKQPQE NTTHVEEVTE AGDSEGEQSY FVSTPDEHPG GHDRDDGSVY
860 870 880 890 900
GQIHIEEEST IRYSWQDEIV QGTRRRTQKD GAVGEKVVKP LDVPAPSLEG
910 920 930 940 950
DLGSTHWKEQ ARSGEFHAEP TVIEKEIKIP HEFHTSMKGI SSKEPRQQLV
960 970 980 990 1000
EVIGQLEETL PERMREELSA LTREGQGGPG SVSVDVKKVQ GAGGSSVTLV
1010 1020 1030 1040 1050
AEVNVSQTVD ADRLDLEELS KDEASEMEKA VESVVRESLS RQRSPAPGSP
1060 1070 1080 1090 1100
DEEGGAEAPA AGIRFRRWAT RELYIPSGES EVAGGASHSS GQRTPQGPVS
1110 1120 1130 1140 1150
ATVEVSSPTG FAQSQVLEDV SQAARHIKLG PSEVWRTERM SYEGPTAEVV
1160 1170 1180 1190 1200
EMDVSNVEAI RSRTQEAGAL GVSDRGSWRD ADSRNDQAVG VSFKASAGEG
1210 1220 1230 1240 1250
DQAHREQGKE QAMFDKKVQL QRMVDQRSVI SDEKKVALLY LDNEEEENDG

HWF
Length:1,253
Mass (Da):140,163
Last modified:October 1, 2014 - v1
Checksum:i47884E2C13E5060B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC036108 Genomic DNA No translation available.
AC223423 Genomic DNA No translation available.
CH471101 Genomic DNA Translation: EAX02230.1
RefSeqiNP_056101.5, NM_015286.5
UniGeneiHs.207106

Genome annotation databases

EnsembliENST00000594047; ENSP00000472953; ENSG00000182253
GeneIDi23336
UCSCiuc032cru.2 human

Similar proteinsi

Entry informationi

Entry nameiA0A075B7B1_HUMAN
AccessioniPrimary (citable) accession number: A0A075B7B1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: July 18, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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