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Entry version 40 (11 Dec 2019)
Sequence version 2 (29 Oct 2014)
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Protein
Submitted name:

Dynein heavy chain 8, axonemal

Gene

DNAH8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dynein heavy chain 8, axonemalImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124721.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2952 DNAH8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000124721

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A075B6F3

PeptideAtlas

More...
PeptideAtlasi
A0A075B6F3

PRoteomics IDEntifications database

More...
PRIDEi
A0A075B6F3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124721 Expressed in 32 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A075B6F3 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A075B6F3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2058 – 2202AAAInterPro annotationAdd BLAST145
Domaini2339 – 2492AAAInterPro annotationAdd BLAST154
Domaini2665 – 2813AAAInterPro annotationAdd BLAST149

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 55DisorderedSequence analysisAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3291 – 3311Sequence analysisAdd BLAST21
Coiled coili3333 – 3364Sequence analysisAdd BLAST32
Coiled coili3518 – 3559Sequence analysisAdd BLAST42
Coiled coili3811 – 3845Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 38PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158992

KEGG Orthology (KO)

More...
KOi
K10408

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALSWKPI

Database of Orthologous Groups

More...
OrthoDBi
6295at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676 PTHR10676, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A075B6F3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKDAEDGAP SEGAEAPPST EEAAPPRSEE EEAPRPPTVE APAEDGFSPS
60 70 80 90 100
AEDAVSSVVD YRDLIPSEEG IVLPDDHEAD LNRVRQRLAP RPVQSVISEV
110 120 130 140 150
LSLPSSRRSS RYRRSMSGLP NLQETLKERQ ARFREARESR RLKIDPSYKY
160 170 180 190 200
IFEILAENLG LDIVTVEELI LDCPSLEAFT NFFAKDGCKT LKFLYQEGDV
210 220 230 240 250
PGIECGRTIA GATKGAKMMK LYIDNAAPDK LKGLCIFFVR CRNDVAINVK
260 270 280 290 300
TIQEEALFTV LDASKGLLNG IRDMLANIFL PAVLATNNWG ALNQSKQGES
310 320 330 340 350
EKHIFTETIN RYLSFLDGAR ISIEGTVKLK TIDNVNFSKL HTFEEVTAAA
360 370 380 390 400
SNSETVHQLE EVLMVWYKQI EQVLIESEQM RKEAGDSGPL TELEHWKRMS
410 420 430 440 450
AKFNYIIEQI KGPSCKAVIN VLNVAHSKLL KNWRDLDARI TDTANESKDN
460 470 480 490 500
VRYLYTLEKV CQPLYNHDLV SMAHGIQNLI NAIRMIHGVS RYYNTSERMT
510 520 530 540 550
SLFIKVTNQM VTACKAYITD GGLNHVWDQE TPVVLKKIQD CIFLFKEYQA
560 570 580 590 600
SFHKTRKLIS ESSGEKSFEV SEMYIFGKFE AFCKRLEKIT EMITVVQTYS
610 620 630 640 650
TLSNSTIEGI DIMAIKFRNI YQGVKKKQYD ILDPRRTEFD TDFLDFMTKI
660 670 680 690 700
NGLEVQIQAF MNSSFGKILS SQQALQLLQR FQKLNIPCLG LEINHTIERI
710 720 730 740 750
LQYYVAELDA TKKLYHSQKD DPPLARNMPP IAGKILWVRQ LYRRISEPIN
760 770 780 790 800
YFFKNSDILS SPDGKAVIRQ YNKISYVLVE FEVVYHTAWI REISQLHYAL
810 820 830 840 850
QATLFVRHPE TGKLLVNFDP KILEVVRETK CMIKMKLDVP EQAKRLLKLE
860 870 880 890 900
SKLKADKLYL QGLLQYYDEL CQEVPSVFVN LMTPKMKKVE SVLRQGLTVL
910 920 930 940 950
TWSSLTLESF FQEVELVLDM FNQLLKKISD LCEMHIDTVL KEIAKTVLIS
960 970 980 990 1000
LPESGATKVE DMLTLNETYT KEWADILNHK SKHVEEAVRE LISIFEQIYE
1010 1020 1030 1040 1050
VKYTGKVGKQ SEQRKHVVFG SETGEGENND YEANIVNEFD THDKEDEFKK
1060 1070 1080 1090 1100
ECKEVFAFFS HQLLDSLQKA TRLSLDTMKR RIFVASLYGR KQSEDIISFI
1110 1120 1130 1140 1150
KSEVHLAIPN VVMIPSLDDI QQAINRMIQL TLEVSRGVAH WGQQQIRPIK
1160 1170 1180 1190 1200
SVIPSPTTTD VTHQNTGKLL KKEERSFEEA IPARKLKNFY PGVAEHKDIS
1210 1220 1230 1240 1250
KLVLLLSSSV NSLRKAAHEA LQDFQKYKTL WTEDRDVKVK EFLANNPSLT
1260 1270 1280 1290 1300
EIRSEILHYA TFEQEIDELK PIIVVGALEL HTEPMKLALS IEAKAWKMLL
1310 1320 1330 1340 1350
CRYLNEEYKK KMSYMIAFIN EYLKKLSRPI RDLDDVRFAM EALSCIRDNE
1360 1370 1380 1390 1400
IQMDMTLGPI EEAYAILNRF EVEVTKEESE AVDTLRYSFN KLQSKAVSVQ
1410 1420 1430 1440 1450
EDLVQVQPKF KSNLLESVEV FREDVINFAE AYELEGPMVP NIPPQEASNR
1460 1470 1480 1490 1500
LQIFQASFDD LWRKFVTYSS GEQLFGLPVT DYEVLHKTRK ELNLLQKLYG
1510 1520 1530 1540 1550
LYDTVMSSIS GYYEILWGDV DIEKINAELL EFQNRCRKLP KGLKDWQAFL
1560 1570 1580 1590 1600
DLKKRIDDFS ESCPLLEMMT NKAMKQRHWD RISELTGTPF DVESDSFCLR
1610 1620 1630 1640 1650
NIMEAPLLKH KDDIEDICIS AIKEKDIEAK LTQVIENWTN QNLSFAAFKG
1660 1670 1680 1690 1700
KGELLLKGTE SGEIITLMED SLMVLGSLLS NRYNAPFKKN IQNWVYKLST
1710 1720 1730 1740 1750
SSDIIEEWLV VQNLWVYLEA VFVGGDIAKQ LPQEAKRFQN IDKSWIKIMQ
1760 1770 1780 1790 1800
RAHENPNVIN CCVGDETMGQ LLPHLHEQLE VCQKSLTGYL EKKRLLFPRF
1810 1820 1830 1840 1850
FFVSDPVLLE ILGQASDSHT IQPHLPAVSD NINEVTFHAK DYDRIMAVIS
1860 1870 1880 1890 1900
REGEKIVLDN SVMAKGPVEI WLLDLLKMQM SSLHNIIRSA FYQISDSGFQ
1910 1920 1930 1940 1950
LLPFLSHFPA QVGLLGIQML WTHDSEEALR NAKDDRKIMQ VTNQKFLDIL
1960 1970 1980 1990 2000
NTLISQTTHD LSKFDRVKFE TLITIHVHQR DIFDDLVKMH IKSPTDFEWL
2010 2020 2030 2040 2050
KQSRFYFKED LDQTVVSITD VDFIYQNEFL GCTDRLVITP LTDRCYITLA
2060 2070 2080 2090 2100
QALGMNMGGA PAGPAGTGKT ETTKDMGRCL GKYVVVFNCS DQMDFRGLGR
2110 2120 2130 2140 2150
IFKGLAQSGS WGCFDEFNRI ELPVLSVAAQ QIYIVLTARK ERKKQFIFSD
2160 2170 2180 2190 2200
GDCVDLNPEF GIFLTMNPGY AGRQELPENL KIQFRTVAMM VPDRQIIMRV
2210 2220 2230 2240 2250
KLASCGFLEN VILAQKFYVL YKLCEEQLTK QVHYDFGLRN ILSVLRTLGS
2260 2270 2280 2290 2300
QKRARPEDSE LSIVMRGLRD MNLSKLVDED EPLFLSLIND LFPGLQLDSN
2310 2320 2330 2340 2350
TYAELQNAVA HQVQIEGLIN HPPWNLKLVQ LYETSLVRHG LMTLGPSGSG
2360 2370 2380 2390 2400
KTTVITILMK AQTECGRPHR EMRMNPKAIT APQMFGRLDT ATNDWTDGIF
2410 2420 2430 2440 2450
STLWRKTLKA KKGENIFLIL DGPVDAIWIE NLNSVLDDNK TLTLANGDRI
2460 2470 2480 2490 2500
PMAPSCKLLF EVHNIENASP ATVSRMGMVY ISSSALSWRP ILQAWLKKRT
2510 2520 2530 2540 2550
AQEAAVFLTL YEKVFEDTYT YMKLNLNPKM QLLECNYIVQ SLNLLEGLIP
2560 2570 2580 2590 2600
SKEEGGVSCV EHLHKLFVFG LMWSLGALLE LESREKLEAF LRQHESKLDL
2610 2620 2630 2640 2650
PEIPKGSNQT MYEFYVTDYG DWEHWNKKLQ PYYYPTDSIP EYSSILVPNV
2660 2670 2680 2690 2700
DNIRTNFLID TIAKQHKAVL LTGEQGTAKT VMVKAYLKKY DPEVQLSKSL
2710 2720 2730 2740 2750
NFSSATEPMM FQRTIESYVD KRIGSTYGPP GGRKMTVFID DINMPVINEW
2760 2770 2780 2790 2800
GDQITNEIVR QMMEMEGMYS LDKPGDFTTI VDVQLIAAMI HPGGGRNDIP
2810 2820 2830 2840 2850
QRLKRQFTVF NCTLPSNASI DKIFGIIGCG YFDPCRSFKP QICEMIVNLV
2860 2870 2880 2890 2900
SVGRVLWQWT KVKMLPTPSK FHYIFNLRDL SRIWQGMLTI KAEECASIPT
2910 2920 2930 2940 2950
LLSLFKHECS RVIADRFITP EDEQWFNAHL TRAVEENIGS DAASCILPEP
2960 2970 2980 2990 3000
YFVDFLREMP EPTGDEPEDS VFEVPKIYEL MPSFDFLAEK LQFYQRQFNE
3010 3020 3030 3040 3050
IIRGTSLDLV FFKDAMTHLI KISRIIRTSC GNALLVGVGG SGKQSLSRLA
3060 3070 3080 3090 3100
SFIAGYQIFQ ITLTRSYNVT NLTDDLKALY KVAGADGKGI TFIFTDSEIK
3110 3120 3130 3140 3150
DEAFLEYLNN LLSSGEISNL FARDEMDEIT QGLISVMKRE LPRHPPTFDN
3160 3170 3180 3190 3200
LYEYFISRSR KNLHVVLCFS PVGEKFRARS LKFPGLISGC TMDWFSRWPR
3210 3220 3230 3240 3250
EALIAVASYF LSDYNIVCSS EIKRQVVETM GLFHDMVSES CESYFQRYRR
3260 3270 3280 3290 3300
RAHVTPKSYL SFINGYKNIY AEKVKFINEQ AERMNIGLDK LMEASESVAK
3310 3320 3330 3340 3350
LSQDLAVKEK ELAVASIKAD EVLAEVTVSA QASAKIKNEV QEVKDKAQKI
3360 3370 3380 3390 3400
VDEIDSEKVK AESKLEAAKP ALEEAEAALN TIKPNDIATV RKLAKPPHLI
3410 3420 3430 3440 3450
MRIMDCVLLL FQKKIDPVTM DPEKSCCKPS WGESLKLMSA TGFLWSLQQF
3460 3470 3480 3490 3500
PKDTINEETV ELLQPYFNMD DYTFESAKKV CGNVAGLLSW TLAMAIFYGI
3510 3520 3530 3540 3550
NREVLPLKAN LAKQEGRLAV ANAELGKAQA LLDEKQAELD KVQAKFDAAM
3560 3570 3580 3590 3600
NEKMDLLNDA DTCRKKMQAA STLIDGLSGE KIRWTQQSKE FKAQINRLVG
3610 3620 3630 3640 3650
DILLCTGFLS YLGPFNQIFR NYLLKDQWEM ELRARKIPFT ENLNLISMLV
3660 3670 3680 3690 3700
DPPTIGEWGL QGLPGDDLSI QNGIIVTKAT RYPLLIDPQT QGKTWIKSKE
3710 3720 3730 3740 3750
KENDLQVTSL NHKYFRTHLE DSLSLGRPLL IEDIHEELDP ALDNVLEKNF
3760 3770 3780 3790 3800
IKSGTTFKVK VGDKECDIMD TFKLYITTKL PNPAFTPEIN AKTSVIDFTV
3810 3820 3830 3840 3850
TMKGLENQLL RRVILTEKQE LEAERVKLLE DVTFNKRKMK ELEDNLLYKL
3860 3870 3880 3890 3900
SATKGSLVDD ESLIGVLRTT KQTAAEVSEK LHVAAETEIK INAAQEEFRP
3910 3920 3930 3940 3950
AATRGSILYF LITEMSMVNI MYQTSLAQFL KLFDQSMARS EKSPLPQKRI
3960 3970 3980 3990 4000
TNIIEYLTYE VFTYSVRGLY ENHKFLFVLL MTLKIDLQRG TVKHREFQAL
4010 4020 4030 4040 4050
IKGGAALDLK ACPPKPYRWI LDMTWLNLVE LSKLPQFAEI MNQISRNEKG
4060 4070 4080 4090 4100
WKSWFDKDAP EEEIIPDGYN DSLDTCHKLL LIRSWCPDRT VFQARKYIAD
4110 4120 4130 4140 4150
SLEEKYTEPV ILNLEKTWEE SDTRTPLICF LSMGSDPTNQ IDALAKKLKL
4160 4170 4180 4190 4200
ECRTISMGQG QEVHARKLIQ MSMQQGGWVL LQNCHLGLEF MEELLETLIT
4210 4220 4230 4240 4250
TEASDDSFRV WITTEPHDRF PITLLQTSLK FTNEPPQGVR AGLKRTFAGI
4260 4270 4280 4290 4300
NQDLLDISNL PMWKPMLYTV AFLHSTVQER RKFGPLGWNI PYEFNSADFS
4310 4320 4330 4340 4350
ASVQFIQNHL DECDIKKGVS WNTVRYMIGE VQYGGRVTDD FDKRLLNCFA
4360 4370 4380 4390 4400
RVWFSEKMFE PSFCFYTGYK IPLCKTLDQY FEYIQSLPSL DNPEVFGLHP
4410 4420 4430 4440 4450
NADITYQSNT ASAVLETITN IQPKESGGGV GETREAIVYR LSEDMLSKLP
4460 4470 4480 4490 4500
PDYIPHEVKS RLIKMGHLNS MNIFLRQEID RMQRVISILR SSLSDLKLAI
4510 4520 4530 4540 4550
EGTIIMSENL RDALDNMYDA RIPQLWKRVS WDSSTLGFWF TELLERNAQF
4560 4570 4580 4590 4600
STWIFEGRPN VFWMTGFFNP QGFLTAMRQE VTRAHKGWAL DTVTIHNEVL
4610 4620 4630 4640 4650
RQTKEEITSP PGEGVYIYGL YMDGAAWDRR NGKLMESTPK VLFTQLPVLH
4660 4670 4680 4690 4700
IFAINSTAPK DPKLYVCPIY KKPRRTDLTF ITVVYLRTVL SPDHWILRGV

ALLCDIK
Length:4,707
Mass (Da):538,594
Last modified:October 29, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i822532AAA6AECA17
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96JB1DYH8_HUMAN
Dynein heavy chain 8, axonemal
DNAH8
4,490Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7V4H0Y7V4_HUMAN
Dynein heavy chain 8, axonemal
DNAH8
4,188Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLZ4H3BLZ4_HUMAN
Dynein heavy chain 8, axonemal
DNAH8
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IU65Q8IU65_HUMAN
Axonemal dynein heavy chain 8 isofo...
DNAH8
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL034345 Genomic DNA No translation available.
AL035555 Genomic DNA No translation available.
AL035690 Genomic DNA No translation available.
AL353700 Genomic DNA No translation available.
AL391415 Genomic DNA No translation available.
KF458149 Genomic DNA No translation available.
KF458154 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_001193856.1, NM_001206927.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000327475; ENSP00000333363; ENSG00000124721

Database of genes from NCBI RefSeq genomes

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GeneIDi
1769

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1769

UCSC genome browser

More...
UCSCi
uc021yzh.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034345 Genomic DNA No translation available.
AL035555 Genomic DNA No translation available.
AL035690 Genomic DNA No translation available.
AL353700 Genomic DNA No translation available.
AL391415 Genomic DNA No translation available.
KF458149 Genomic DNA No translation available.
KF458154 Genomic DNA No translation available.
RefSeqiNP_001193856.1, NM_001206927.1

3D structure databases

SMRiA0A075B6F3
ModBaseiSearch...

Proteomic databases

jPOSTiA0A075B6F3
PeptideAtlasiA0A075B6F3
PRIDEiA0A075B6F3

Genome annotation databases

EnsembliENST00000327475; ENSP00000333363; ENSG00000124721
GeneIDi1769
KEGGihsa:1769
UCSCiuc021yzh.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1769
EuPathDBiHostDB:ENSG00000124721.17
HGNCiHGNC:2952 DNAH8
OpenTargetsiENSG00000124721

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00940000158992
KOiK10408
OMAiALSWKPI
OrthoDBi6295at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DNAH8 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1769

Gene expression databases

BgeeiENSG00000124721 Expressed in 32 organ(s), highest expression level in testis
ExpressionAtlasiA0A075B6F3 baseline and differential

Family and domain databases

Gene3Di1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 3 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A075B6F3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A075B6F3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 29, 2014
Last modified: December 11, 2019
This is version 40 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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