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UniProtKB - A0A075ABK5 (A0A075ABK5_9TREM)

Entry version 27 (02 Dec 2020)
Sequence version 1 (01 Oct 2014)
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Protein

Protein MCM10 homolog

Gene

T265_14289

Organism
Opisthorchis viverrini
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA replicationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MCM10 homologARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:T265_14289Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOpisthorchis viverriniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6198 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Trematoda › Digenea › Opisthorchiida › Opisthorchiata › Opisthorchiidae › Opisthorchis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000054324 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini531 – 917Mcm10InterPro annotationAdd BLAST387

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 46DisorderedSequence analysisAdd BLAST20
Regioni53 – 93DisorderedSequence analysisAdd BLAST41
Regioni229 – 262DisorderedSequence analysisAdd BLAST34
Regioni465 – 516DisorderedSequence analysisAdd BLAST52
Regioni545 – 565DisorderedSequence analysisAdd BLAST21
Regioni598 – 623DisorderedSequence analysisAdd BLAST26
Regioni697 – 770DisorderedSequence analysisAdd BLAST74

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili790 – 810Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 42PolyampholyteSequence analysisAdd BLAST16
Compositional biasi73 – 93PolarSequence analysisAdd BLAST21
Compositional biasi247 – 261PolarSequence analysisAdd BLAST15
Compositional biasi598 – 622PolarSequence analysisAdd BLAST25
Compositional biasi719 – 752PolarSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MCM10 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		758449at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040184, Mcm10
IPR015411, Rep_factor_Mcm10_C
IPR015408, Znf_Mcm10/DnaG

The PANTHER Classification System

More...PANTHERi		PTHR13454, PTHR13454, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09332, Mcm10, 1 hit
PF09329, zf-primase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01280, Mcm10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A075ABK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPNPLSDKR KRRPVFVQLT EDEIQNFLAR SDGEKDSSGS DWDDVGETDM 
        60         70         80         90        100
ATFFASLSEK QTSPKRRKLS PRVSECTSTS KDPCPSQSLQ TEARQNKGVL 
       110        120        130        140        150
QDVGIDALFN ASVSKAEGNT EVPELDVHDL FGSSSSDSDA DGDILDGCDD 
       160        170        180        190        200
EQDVSLSECG ARIQKSLSVA RRKQKEAEIE QQVERAIVQT SVDACQTPST 
       210        220        230        240        250
SLSGSKGPIS VSASLAACAA RRQKALSDLN NAQLRTDRRR SSLPDNHPPV 
       260        270        280        290        300
TPHNSEKKSV VSSAPDYWLA VPTKLRVYRS KVSSELWANR TSDRQVYGLL 
       310        320        330        340        350
QFIQHQRSQV TLSMPSSKRQ SSTDSLVVVG VIGSKTPPRR SKNDRIYSIW 
       360        370        380        390        400
HLSDLDQVGP GSHIGCVKLF LFGDAHEKLW KEPDGSVVAI LGPRLMSDPS 
       410        420        430        440        450
TSFNDKDVGI TPPSPQHVMV LGQSPDYGIC AALNKSGQSC FHVINKSVCR 
       460        470        480        490        500
YCDLHVKKAY YEASSSRPGF FDSSHPALKK RPTNRYKGDR PPVNEPGVYS 
       510        520        530        540        550
LPTSKMFNPV SPSRSESRVK LTVAKLSAAG YTVDSSVGLA TQQHRVDGAG 
       560        570        580        590        600
DPSRPPPSQP LSSPERKLVK ALHRPTAGSM NLLRHLERST QLLEVKNTSV 
       610        620        630        640        650
NSRSQDPGTS CSMETQSHSH VCRPSADPKV GFTFSDFFAA RSKKQAVKLT 
       660        670        680        690        700
NDLRPGDFID LGPVSTSQTP MSPILSGARL RASQLVKAKG GLKAMEARAK 
       710        720        730        740        750
QRSEVSIKAS LGEQSADRHR PSPLSQILDN NSLGSSAAKP VSSSNPPSLD 
       760        770        780        790        800
AHPNGTENEP PEMSAAAARK NRLAELAKKV REGSSHTGLI AEAEINSEQA 
       810        820        830        840        850
RMAVLEKRDE FEQKLTGKTE EQCTYVCCKT CNYRAWKLSD DCRKSNHSVV 
       860        870        880        890        900
YLKGLKRYFK CKNCLKRTVT FERYPTVACK NCGESLFEKT GIIRERKGPL 
       910 
LPGEKLLPRG IEEKFLS
Length:917
Mass (Da):100,436
Last modified:October 1, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i092432FFA3B4D30D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KL596789 Genomic DNA Translation: KER25034.1

NCBI Reference Sequences

More...RefSeqi		XP_009171230.1, XM_009172966.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		20328455

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ovi:T265_14289

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KL596789 Genomic DNA Translation: KER25034.1
RefSeqiXP_009171230.1, XM_009172966.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi20328455
KEGGiovi:T265_14289

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		20328455

Phylogenomic databases

OrthoDBi758449at2759

Family and domain databases

InterProiView protein in InterPro
IPR040184, Mcm10
IPR015411, Rep_factor_Mcm10_C
IPR015408, Znf_Mcm10/DnaG
PANTHERiPTHR13454, PTHR13454, 1 hit
PfamiView protein in Pfam
PF09332, Mcm10, 1 hit
PF09329, zf-primase, 1 hit
SMARTiView protein in SMART
SM01280, Mcm10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A075ABK5_9TREM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A075ABK5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: December 2, 2020
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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