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UniProtKB - A0A075A0G4 (A0A075A0G4_9TREM)

Entry version 36 (10 Feb 2021)
Sequence version 1 (01 Oct 2014)
Previous versions | rss
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Protein

Non-specific serine/threonine protein kinase

Gene

T265_02097

Organism
Opisthorchis viverrini
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationARBA annotation, Transferase
Biological processDNA damage, DNA repairARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:T265_02097Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOpisthorchis viverriniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6198 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Trematoda › Digenea › Opisthorchiida › Opisthorchiata › Opisthorchiidae › Opisthorchis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000054324 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1191 – 1893FATInterPro annotationAdd BLAST703
Domaini2036 – 2379PI3K/PI4KInterPro annotationAdd BLAST344
Domaini2347 – 2379FATCInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1151 – 1173DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1153 – 1173PolarSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.ARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		80538at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR012993, UME

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A075A0G4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGWRHCKKW RLVDVSGVRA VIFLPDCPIE RLCGPALKLV CSLIAWSCHT 
        60         70         80         90        100
NTLPVDELTK LFLPFTSLHS NSGAHILFWM HPILLGLESD RQNDYCLRIA 
       110        120        130        140        150
CEFMRELLRN LRGVALPKHT AQLLSHLSAK IVCCLAVCSG SPSVYCEHNR 
       160        170        180        190        200
CTGGSSHLTM KDPSALAIPS CYSLAEQIEL IDLMLEERNV EGASEAVVDL 
       210        220        230        240        250
VTHLSYHMRW DLVDAVHVHS LLTLVHSNLP HFTPAIVGKI FFNITSQLSK 
       260        270        280        290        300
ADLTAWLGVH NSVMPVLSAV ARQGPSSALT HVGIDEYRIM QYGAFALCLA 
       310        320        330        340        350
KHYTRILAVQ PNPAILCELT ERRTSNEGCP STVSSNSLVE ALVNVLAALC 
       360        370        380        390        400
RLGLVHQYTH ALYGAVYFHI ENVLGAVRMK PVHVLRLARD RLAQVVADHV 
       410        420        430        440        450
DQPVKQLIDC LSRLFQLNKA DIFKELISPL FIALVLRGNQ ESHVQIRQLV 
       460        470        480        490        500
AEVPYIRAGQ DYVNKLIQLC VLPDALVHIF TKTSKDEQEV HFAFLESHLG 
       510        520        530        540        550
MPIERIARLN DVSRLMHQFV LRLYPYRVGA SLGLRWIASR VLALRDSQST 
       560        570        580        590        600
STALVHVKGP ASADFLGHYV CGILAFFDTT LLDDDTMLEH RWIALRSLVV 
       610        620        630        640        650
FIQLLGSTHV TRMRAKFMAT LKICLRYKTA PFAKVVIKAW RSFIRTLEIE 
       660        670        680        690        700
AVCELLPDLG ATLVGLLPCG SGQVMDLFNY LFLEKREEIG DRLSCMFFIP 
       710        720        730        740        750
RVPMLLTYQE ILDDLCSWRS FDSSDSTTLP ESFLRRGLCA WLSALTHSSR 
       760        770        780        790        800
SVRRLALTSE LGDADAVAGH PTVARLWNMS SLVKDLSSAL PAADGNHDRD 
       810        820        830        840        850
SASEPAIPIN RLDSLETPGQ VIRSNSLLLG DLISALLEGL TRDIDERMRL 
       860        870        880        890        900
LYAQWLGNLG AIDPGRICLS MCVTSSMTGS TQMTHVNDPS FSFFMLCELA 
       910        920        930        940        950
KIYLRAASPK QLDSTALAIQ ELLKLFRIPE GGKPTGAGLS SAEVADTTNK 
       960        970        980        990       1000
VTEDVAAMPF VSGTDLWKLF PDHLCDLFAP LTTSRYAVEA FTDWSTIRSP 
      1010       1020       1030       1040       1050
LITSCTDDLS FESWIRLWAG SLCANIRSPH TSDLFQFCEP VVKTDAGFAR 
      1060       1070       1080       1090       1100
LALEHASLQI LLENNQDGID QIRSEILTVL TEVDSAMDSG TSDPSSLNDV 
      1110       1120       1130       1140       1150
LLTTTMSEMR SCDQGCRDAT HWQPWFPLAA QTVFGLLDHL GRWYREQEKA 
      1160       1170       1180       1190       1200
LRPQKQTTLS TNNSSKSTSK TVSTEAVKRV GDFLQTIPHL LQAKASLKCG 
      1210       1220       1230       1240       1250
GLARALLHWE LAYDEDELAN KSAFNTGAAL MNSLSDRFMP GPGSKDLNQR 
      1260       1270       1280       1290       1300
TSRNSLVLGS TGLAAIAGLL DTYTLLRDTD GLAGVLAVSQ LAPVAQALSW 
      1310       1320       1330       1340       1350
AKSNSSDEMH IPFTHSERFS ALRALELENE EQLDMAAAAY EHNLASSELE 
      1360       1370       1380       1390       1400
SSHLRSDSTS ASVDSTELRR LMLYGGLFRC ELSDPARLHG LVERAGGLIS 
      1410       1420       1430       1440       1450
RADANCPGIS VHHSARWRQR LNAYRAEAAW RLCDWGTLQE TTNLDPQGSS 
      1460       1470       1480       1490       1500
WSVDLGRLFL AINNKDSTEF SCMLSKLRLN QMNELSAAAL EGPGGYARAY 
      1510       1520       1530       1540       1550
ETIARLSSLS DVELLSSLGE RLRLVLSGDS VRNGASALAY RKSDGDIQTQ 
      1560       1570       1580       1590       1600
VESVLTLLDT RLKICQPTFH TLEPCLALHH TSLHLLWMEL RSLAVASPND 
      1610       1620       1630       1640       1650
QLIATLLDRV RLALGQNWLQ RAKLTRKSGQ FMAAYTCVLR AEAFGIPQAL 
      1660       1670       1680       1690       1700
IERAKLLWQT DKREAAQACL DKGIPELYGT FPSEPHSSVT SITKNPLISK 
      1710       1720       1730       1740       1750
KSLQEAMLLR ARYCEETNRF DFEATQRMYE EVCTLNEGCE EAHFRLARYV 
      1760       1770       1780       1790       1800
DQACSLATVA KQHDTLLKAA LTHYGLALSY GSQFIYQSMP RLLSLWLDYG 
      1810       1820       1830       1840       1850
SDCARHTGAP VSTKSNESRV PTDQRTFQEV QEIMLQNIQK IPPYQYYTAL 
      1860       1870       1880       1890       1900
GQILSRICHE VPTIVTTLLD LVVRIFEAYP LQTIWFLMPL NDSSVRQRRD 
      1910       1920       1930       1940       1950
RCQQVFSAVK SRQPALIKFI TDSITLCNHL RTICGLFMSA DRRELRSFSL 
      1960       1970       1980       1990       2000
HQFQRPLARL IENSDFSRIL IPIHRQLVPN LLPARASYEQ VKEHWPFGPG 
      2010       2020       2030       2040       2050
PDQLVFLAHL DDTVEILGSQ TRPKKMTWIG SDGRRYIIVA KPNDDLRKDS 
      2060       2070       2080       2090       2100
RLMELNGMIN KFLVKNPGTR RRALHIRTYA VIPLSEKGGL IEWVSNTEPF 
      2110       2120       2130       2140       2150
RAIITRLYTE SGRPINWAAM SRLYGTLLFV SFLFILSVKR DKYLNKWLPM 
      2160       2170       2180       2190       2200
FPLVFHRWFL DTFPNPSAWY SARESYARTC AVMSMVGYVL GLGDRHTENI 
      2210       2220       2230       2240       2250
LFDSTTGSVV HVDFSCVFNN GLTLPWPERV PFRLTRNMVR ALGPTGFEGI 
      2260       2270       2280       2290       2300
FRRCAEAVMR LLRHEIDPLL AVFRPLYFDA LVEQGGNTRG SVTGTEASGK 
      2310       2320       2330       2340       2350
IRRAAQDHAV STDLADRVAQ VAAEKLTNME DRLHGKITEH DGFSQILPIS 
      2360       2370 
VEGQVDVLIK EATDVDRLCQ MYKGWMPFL
Length:2,379
Mass (Da):265,901
Last modified:October 1, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i957F10D6064104B0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KL596642 Genomic DNA Translation: KER31732.1

NCBI Reference Sequences

More...RefSeqi		XP_009164520.1, XM_009166256.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		20316285

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ovi:T265_02097

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KL596642 Genomic DNA Translation: KER31732.1
RefSeqiXP_009164520.1, XM_009166256.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi20316285
KEGGiovi:T265_02097

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		20316285

Phylogenomic databases

OrthoDBi80538at2759

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR012993, UME
PfamiView protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit
SMARTiView protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A075A0G4_9TREM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A075A0G4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: February 10, 2021
This is version 36 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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