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Entry version 21 (10 Feb 2021)
Sequence version 1 (01 Oct 2014)
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Protein

DUF4549 domain-containing protein

Gene

T265_02675

Organism
Opisthorchis viverrini
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DUF4549 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:T265_02675Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOpisthorchis viverriniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6198 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesTrematodaDigeneaOpisthorchiidaOpisthorchiataOpisthorchiidaeOpisthorchis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000054324 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 139DUF4549InterPro annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni268 – 289DisorderedSequence analysisAdd BLAST22
Regioni312 – 373DisorderedSequence analysisAdd BLAST62
Regioni1734 – 1809DisorderedSequence analysisAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2081 – 2101Sequence analysisAdd BLAST21
Coiled coili2114 – 2141Sequence analysisAdd BLAST28
Coiled coili2180 – 2200Sequence analysisAdd BLAST21
Coiled coili2283 – 2328Sequence analysisAdd BLAST46
Coiled coili2368 – 2392Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi269 – 283PolarSequence analysisAdd BLAST15
Compositional biasi312 – 335PolarSequence analysisAdd BLAST24
Compositional biasi1746 – 1809PolarSequence analysisAdd BLAST64

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
54096at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040401, CCDC162
IPR029376, DUF4549

The PANTHER Classification System

More...
PANTHERi
PTHR33331, PTHR33331, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15082, DUF4549, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A074ZYC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEDEDVLKT QEDGLRSDIL ELRAQIEENE LIHGIPSKGM SSVYIPKDPD
60 70 80 90 100
YFRRERKLIL QRTLQVLEPK PITLQAELMM QELDACSQRE FTEKTLPILL
110 120 130 140 150
HQYFIDRIHQ IVLLKHGYLL RWKRYCSSTA AVETIQSEYL NRLEYLTNEY
160 170 180 190 200
LDASSRAHRL ASTREGILAN SDNGVEDVTV EDYQIYLRYH LSQLQSLSYA
210 220 230 240 250
NQLLNKQYPY ILCEDVTNVA PRGGSEAGGT EAATVNLTKT QGAVEREMSA
260 270 280 290 300
HSMSADEGEA LIAEETETLR SGQRASSEKG ESGVPPSQPV EAGVILDELK
310 320 330 340 350
ALEQAHAVNE SMFDETNTAT TARSLPPSTK KKSFQRKSLT NVEDSDDPLQ
360 370 380 390 400
GRGSEIASAP HPQSHFRFSE QAPQPPAMMH AAVVGANAPL QPTKANLDLA
410 420 430 440 450
SSGGGIVTND KVAAPPLHSN DLETLRPHLV YFCHAYGIQM NIQAIRSSAD
460 470 480 490 500
EMELFAVINR KFRQIFSRQE EMLTFKTYDS AKSASERWGL DSWVRAVRKP
510 520 530 540 550
SNWLPYVKLR PRRHEYLVKL TMELRSGTVV DDLLKASANF LKMKSPEKVQ
560 570 580 590 600
DSLRHHAMLV QHPPIVHSAS VVSHRQGQST AEIFKKIYNN SDVFGKASAD
610 620 630 640 650
TDEPGKRQDD YDFTQAMQML GLDDATNAKD DPSSVQGAYL SYLHLRHLKL
660 670 680 690 700
RDVMRTCISV LNYFRSIERT LTINDQGLSM NSRGGVERTS PPNHRVGTEA
710 720 730 740 750
QGHKGGGNTI DGHGYLFNSP QEFKIKETEF MQFAEVDNHD DFYFHEEGRI
760 770 780 790 800
HVRDQVGFWI VYDAALEDFN KLEQDLLLLA TAFIQRDRQS RMSSNTKKKG
810 820 830 840 850
VNQEAQSSDL DIARYAHRDV DRFGVLYDIW INECAFQQAK QKLMDVYMEV
860 870 880 890 900
YGHIISRDSR RRLAQIMTNL MYQRPRLDLN ESYFVLAYRY ECAILRQRTE
910 920 930 940 950
IMRCILNHQI LNQREYLKKI HVEKPEFGLP PPLLERFPIA VHSDETLLTP
960 970 980 990 1000
VYLLEFHPSL SCAPSLAAAM DQSVQQLYEL FTPNHPMQEI VLEKRFYDFL
1010 1020 1030 1040 1050
RYEVETLKPL GGSYTAQLQR DLFSSYFVED AIQMCELSNQ HLAAIQNRNS
1060 1070 1080 1090 1100
RGDKKTRQMY LLNELGRLLD LVTLRHRLID CMWECEVLSK IYLTVAHEMG
1110 1120 1130 1140 1150
FDDFHLFIRP LQFEAAKYKE GADDLRPPIY ITAVQDDDSM LDKFLPSALP
1160 1170 1180 1190 1200
LAIHELDETH VGKFSFRGKV TIMEMLETRG VENMLTILKV QTAHKNALTA
1210 1220 1230 1240 1250
SVMLAYNARP SFYTMHAPKT KTGILRPSNT GANLISYTGL SGTQVGPTPL
1260 1270 1280 1290 1300
ALERSKHQLN ADYHPEAFFS IQLEKSPSRD RTQNAFIKRT QGGGIASSKS
1310 1320 1330 1340 1350
SVESEKMKRE FISQFCMDFG QRTQHISLRA QIISTYSSIL TILEKVPTVT
1360 1370 1380 1390 1400
EDFFVIGYAF EKKNPEDDLD VQVTDPRTLR TRPRRVLSTD GTKLYNFWFI
1410 1420 1430 1440 1450
PHFIEVLFIF RHLDDLSCTK ALQRMARLAC VLHDILHYLI AYARLGISSA
1460 1470 1480 1490 1500
KITPEQRQQV IAGSQKHGGQ QWRTATRGAL PTAAEVAANI AGTTSAETFV
1510 1520 1530 1540 1550
AQLSSAGTIP SMNMALSSPA LSVTPLDLSV HGRSLVVDQI IATELREIQY
1560 1570 1580 1590 1600
QINRLPDPTD PEQVIQMLDL RRDVMFLQFD VCMRTILRET FLAAGNVEAY
1610 1620 1630 1640 1650
KEVVENSHFP LSELSDVQRP CLNAIEMNVP EPLEARDDQA KALFPWRSLM
1660 1670 1680 1690 1700
NRCGPFLLFC FGPSTIEYNI HLCMAGLKPV DRPTVHGELL AMNLCLEDVL
1710 1720 1730 1740 1750
DVGDIPEAKA GEPMPIQQAE NMHCMLGKRT RDRRREIPPP NAASPTGTGG
1760 1770 1780 1790 1800
PASTPGSVAG TTNPANATGT SINTMNITHS SETQGQKSST HGGAGGTGPL
1810 1820 1830 1840 1850
TTTPDKTPKL STLDSPVAAY TLLKKFLILW KRVELLKYAW GRRRLGVESI
1860 1870 1880 1890 1900
NNPNLFKTFC SIYKREKLYP LIRSLAIQYR QPDMYALGPL DATDIIVMPK
1910 1920 1930 1940 1950
GIPEMVVRQR QLLKLIEAFE FYMIADLRKL LLRQTDLVIK ERNREEGNLP
1960 1970 1980 1990 2000
LELWKRPLLK LIEAFEFYMI ADLRKLLLRQ TDLVIKERNR EEGNLPLELW
2010 2020 2030 2040 2050
KRPAMKETLS VKRPGLADEF LVELMSHLEQ NARNDTYIIT KDKLNEVLQT
2060 2070 2080 2090 2100
VAISVMRTQR ESYENYSMYY ENLLKNQHSL LYAKEREIET LKETLRQNEL
2110 2120 2130 2140 2150
ETNVTVQFQM SEQAHNLLLE VTALRAKIAE LEDINLKTEA KVRNRVRREF
2160 2170 2180 2190 2200
SVAMRKLFGL SFEQKSRIDQ YRDHLHAITL QRIAEVREEA SAEMARIKER
2210 2220 2230 2240 2250
SGARASAEDE LAERNLRLSR EVNTLHQRNI GLQQMMSRLR VMAHWQQTTL
2260 2270 2280 2290 2300
RCAFEKQISG VEEQRNQSKS QVTRLGILSE QRVRMLNEEM SKLRDHLSNT
2310 2320 2330 2340 2350
EKHLNDMRKA LDKEMSDKVE KRHAAERKAA TDKQMAMVKQ MHIDQLMAEI
2360 2370 2380 2390 2400
AEKNATLEKM GSLLDASAKS KKQEADKSVR EVDLLRKQLR EERKLKKSAI
2410 2420 2430 2440 2450
HKVDDLMSQL YEFETAYSSG QNRPGVNLPT VAPKGEATAG GARKLSAEIQ
2460 2470 2480 2490 2500
RPYEDLVAKK SGPYTSKHYL RFRQETTRVP QLRERLAQQI LRNGSGQTHM
2510
HFLRTHDYSE TE
Length:2,512
Mass (Da):286,286
Last modified:October 1, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9529B450EB589B4D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KL596652 Genomic DNA Translation: KER30997.1

NCBI Reference Sequences

More...
RefSeqi
XP_009165241.1, XM_009166977.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20316863

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ovi:T265_02675

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KL596652 Genomic DNA Translation: KER30997.1
RefSeqiXP_009165241.1, XM_009166977.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi20316863
KEGGiovi:T265_02675

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
20316863

Phylogenomic databases

OrthoDBi54096at2759

Family and domain databases

InterProiView protein in InterPro
IPR040401, CCDC162
IPR029376, DUF4549
PANTHERiPTHR33331, PTHR33331, 3 hits
PfamiView protein in Pfam
PF15082, DUF4549, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A074ZYC6_9TREM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A074ZYC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: February 10, 2021
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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