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UniProtKB - A0A074ZKM0 (A0A074ZKM0_9TREM)

Entry version 22 (02 Dec 2020)
Sequence version 1 (01 Oct 2014)
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Protein

Mediator of RNA polymerase II transcription subunit 14

Gene

T265_06436

Organism
Opisthorchis viverrini
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 14UniRule annotation
Alternative name(s):
Mediator complex subunit 14UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:T265_06436Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOpisthorchis viverriniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6198 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Trematoda › Digenea › Opisthorchiida › Opisthorchiata › Opisthorchiidae › Opisthorchis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000054324 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex.

UniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 14 family.UniRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		323359at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013947, Mediator_Med14

The PANTHER Classification System

More...PANTHERi		PTHR12809, PTHR12809, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08638, Med14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A074ZKM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENSTLFGKR WFGIRNTRPN QRNFWCWTHS SMEVPVTQPK TRFLTASLRI 
        60         70         80         90        100
RRHQPTRAMV LRQRLCLKLA NAVRALQIRA FTSSVTLQSE LIQLPRYVKR 
       110        120        130        140        150
STTSSASPWI VSGVFSDCTS TSMTLHFVGA KCIQIKGRNS SVVKPQFPWF 
       160        170        180        190        200
EPNLSISTLG SGSLTISQPP YFLQVATEQE QVVPRPRPDA VPLSVLIEFI 
       210        220        230        240        250
CQKIYTDLMR LVDLLPSKTD LEKKIEIATF FSRTRHLIIR LEALIKWSNN 
       260        270        280        290        300
ASKVDKCEKI SNFLEEQSFF LINTANTLSR LLRETLVGAR LPPFAVLLAI 
       310        320        330        340        350
DIFTNRTYTR LPKSIKNCTG ATETVGNREL SQALLDLNRV IQNRLSLTQI 
       360        370        380        390        400
PRQFKIIKIV NGRVHFVVPN EFHVTLTLMS EAVDFPWRIL DLRFLTKDPV 
       410        420        430        440        450
TNYQSLLHPL QLQFIQTQVQ SRLLYRQFDK RPPLIHLYDM LHSFSISLQL 
       460        470        480        490        500
DVLHEQAQRA RAKRPSDQLV IEAYRPGHSM VLSYWHTLSR NQFQAQLCLD 
       510        520        530        540        550
GKLQPTAYLL SIHADPVDPQ RPLCVSHRPE LPETQSHRIG TILQGNHLSI 
       560        570        580        590        600
EKLLARTIIT RAEHILQDIR QQLMIFSPGP VQLSDAPLCL HLPLLWPCSP 
       610        620        630        640        650
QEFLQFRVDP TQGTVCATCP FLLTSEVDAM LLGWSAHSQV TTVSGASSDG 
       660        670        680        690        700
YSRFTVLSAL VSLENALNRP STRRVCPVSS NPQSSVGDQS LVVAQSRGLR 
       710        720        730        740        750
ALAHTEARWR SIICQSLEHL RICIGLVRLI RTARTHRPFW QPARRSLPLI 
       760        770        780        790        800
LSPVQAKLAR DSSSFWATLI RLQQSSMWPI VFVQLFPNDE YYLTCEVVSK 
       810        820        830        840        850
PLGVDYRYHL MVCTAVADNS VISVDADGLL ISCANSNVSA PALYPTSTGL 
       860        870        880        890        900
FLQVTHLVPI ETGSVWFHNP SASIGLLKSC ADKARENALK KRSSRVAELL 
       910        920        930        940        950
NRIKTRSVQS VESSAHPVES TTENTQPVVP ALSKLVGMLE ENILSTCFAL 
       960        970        980        990       1000
ELSRAGVIHD GVQYDCNGCL SAIRIRSLPS SPPPWQPPGV IPLSDFVHDI 
      1010       1020       1030       1040       1050
VLRPYFDPFT HRRSWQLDLL FTGLVPTRAR RIITDRPRRD AQQSGSLHQL 
      1060       1070       1080       1090       1100
RHQTAEWFVT KLEDYAIVVE NVIAEWDSLC VMHALSYHVV NNPELHLPRF 
      1110       1120       1130       1140       1150
VSLQSHFNLK TLSLVYNTYY MVEISFRPEQ GFAIALGFTP NFSPKNATSS 
      1160       1170       1180       1190       1200
DVTVSLTELP KDVDSNPHVV IRQHLEELLN ATKSVTSLAR ALVHTLPFVR 
      1210       1220       1230       1240       1250
AVEPLRDRTL STNGLKPAIH ANAVRPVRGM VLIALSAHDL VLIYRASLSL 
      1260       1270       1280       1290       1300
RIVLSRQRPT LTNNFVSDTV PGREETVQLL DAYRQLAEHS STPYRGVTPW 
      1310       1320       1330       1340       1350
GDTLLNGLVP LPAFSNFLKA LQEAYQMDIE ADAWSGLTVS QLAQLVRPPR 
      1360       1370       1380       1390       1400
AAAKLLMSSD GRNRTARNPS NNQRANIPGL LSPLESYLAS SLLFHACLSA 
      1410       1420       1430       1440       1450
IHSLDVPIAP LSELVSGSDI ADQNLTADVV QTGSFEAHWP LPALTTHVCL 
      1460       1470       1480       1490       1500
LPQRTGVDVA CWRLSLRLSS FQSSNTGPTD CWPQETLNLI EEFFNARVCA 
      1510       1520       1530       1540       1550
PPFQPSAVAS FFRLLTLPPR AFRSIVRLLP FDLHPPTHAA VHIRLGLVGL 
      1560       1570       1580       1590       1600
GTGKRPASSQ SGGRATTVAS SPMDTSAALG GVELFPGLPG VIVRPPRITL 
      1610       1620       1630       1640       1650
QLLVSRTQRP QLSKFPAPPM AQLIPICYDW DANRVVILPG TSGATTSGSS 
      1660       1670       1680       1690       1700
QPGRADSAPN LYQILREADV EANSNMMASN SGESALVQLA LLVTQTAAAA 
      1710       1720 
STTYASTAGA TVGSVKPVYG ST
Length:1,722
Mass (Da):191,383
Last modified:October 1, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59332591DFEB3106
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KL596751 Genomic DNA Translation: KER26322.1

NCBI Reference Sequences

More...RefSeqi		XP_009169958.1, XM_009171694.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		20320615

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ovi:T265_06436

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KL596751 Genomic DNA Translation: KER26322.1
RefSeqiXP_009169958.1, XM_009171694.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi20320615
KEGGiovi:T265_06436

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		20320615

Phylogenomic databases

OrthoDBi323359at2759

Family and domain databases

InterProiView protein in InterPro
IPR013947, Mediator_Med14
PANTHERiPTHR12809, PTHR12809, 1 hit
PfamiView protein in Pfam
PF08638, Med14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A074ZKM0_9TREM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A074ZKM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: December 2, 2020
This is version 22 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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