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Entry version 23 (07 Apr 2021)
Sequence version 1 (01 Oct 2014)
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Protein

Mediator of RNA polymerase II transcription subunit 14

Gene

T265_06436

Organism
Opisthorchis viverrini
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 14UniRule annotation
Alternative name(s):
Mediator complex subunit 14UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:T265_06436Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOpisthorchis viverriniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6198 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesTrematodaDigeneaOpisthorchiidaOpisthorchiataOpisthorchiidaeOpisthorchis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000054324 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex.

UniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 14 family.UniRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
323359at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013947, Mediator_Med14

The PANTHER Classification System

More...
PANTHERi
PTHR12809, PTHR12809, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08638, Med14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A074ZKM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENSTLFGKR WFGIRNTRPN QRNFWCWTHS SMEVPVTQPK TRFLTASLRI
60 70 80 90 100
RRHQPTRAMV LRQRLCLKLA NAVRALQIRA FTSSVTLQSE LIQLPRYVKR
110 120 130 140 150
STTSSASPWI VSGVFSDCTS TSMTLHFVGA KCIQIKGRNS SVVKPQFPWF
160 170 180 190 200
EPNLSISTLG SGSLTISQPP YFLQVATEQE QVVPRPRPDA VPLSVLIEFI
210 220 230 240 250
CQKIYTDLMR LVDLLPSKTD LEKKIEIATF FSRTRHLIIR LEALIKWSNN
260 270 280 290 300
ASKVDKCEKI SNFLEEQSFF LINTANTLSR LLRETLVGAR LPPFAVLLAI
310 320 330 340 350
DIFTNRTYTR LPKSIKNCTG ATETVGNREL SQALLDLNRV IQNRLSLTQI
360 370 380 390 400
PRQFKIIKIV NGRVHFVVPN EFHVTLTLMS EAVDFPWRIL DLRFLTKDPV
410 420 430 440 450
TNYQSLLHPL QLQFIQTQVQ SRLLYRQFDK RPPLIHLYDM LHSFSISLQL
460 470 480 490 500
DVLHEQAQRA RAKRPSDQLV IEAYRPGHSM VLSYWHTLSR NQFQAQLCLD
510 520 530 540 550
GKLQPTAYLL SIHADPVDPQ RPLCVSHRPE LPETQSHRIG TILQGNHLSI
560 570 580 590 600
EKLLARTIIT RAEHILQDIR QQLMIFSPGP VQLSDAPLCL HLPLLWPCSP
610 620 630 640 650
QEFLQFRVDP TQGTVCATCP FLLTSEVDAM LLGWSAHSQV TTVSGASSDG
660 670 680 690 700
YSRFTVLSAL VSLENALNRP STRRVCPVSS NPQSSVGDQS LVVAQSRGLR
710 720 730 740 750
ALAHTEARWR SIICQSLEHL RICIGLVRLI RTARTHRPFW QPARRSLPLI
760 770 780 790 800
LSPVQAKLAR DSSSFWATLI RLQQSSMWPI VFVQLFPNDE YYLTCEVVSK
810 820 830 840 850
PLGVDYRYHL MVCTAVADNS VISVDADGLL ISCANSNVSA PALYPTSTGL
860 870 880 890 900
FLQVTHLVPI ETGSVWFHNP SASIGLLKSC ADKARENALK KRSSRVAELL
910 920 930 940 950
NRIKTRSVQS VESSAHPVES TTENTQPVVP ALSKLVGMLE ENILSTCFAL
960 970 980 990 1000
ELSRAGVIHD GVQYDCNGCL SAIRIRSLPS SPPPWQPPGV IPLSDFVHDI
1010 1020 1030 1040 1050
VLRPYFDPFT HRRSWQLDLL FTGLVPTRAR RIITDRPRRD AQQSGSLHQL
1060 1070 1080 1090 1100
RHQTAEWFVT KLEDYAIVVE NVIAEWDSLC VMHALSYHVV NNPELHLPRF
1110 1120 1130 1140 1150
VSLQSHFNLK TLSLVYNTYY MVEISFRPEQ GFAIALGFTP NFSPKNATSS
1160 1170 1180 1190 1200
DVTVSLTELP KDVDSNPHVV IRQHLEELLN ATKSVTSLAR ALVHTLPFVR
1210 1220 1230 1240 1250
AVEPLRDRTL STNGLKPAIH ANAVRPVRGM VLIALSAHDL VLIYRASLSL
1260 1270 1280 1290 1300
RIVLSRQRPT LTNNFVSDTV PGREETVQLL DAYRQLAEHS STPYRGVTPW
1310 1320 1330 1340 1350
GDTLLNGLVP LPAFSNFLKA LQEAYQMDIE ADAWSGLTVS QLAQLVRPPR
1360 1370 1380 1390 1400
AAAKLLMSSD GRNRTARNPS NNQRANIPGL LSPLESYLAS SLLFHACLSA
1410 1420 1430 1440 1450
IHSLDVPIAP LSELVSGSDI ADQNLTADVV QTGSFEAHWP LPALTTHVCL
1460 1470 1480 1490 1500
LPQRTGVDVA CWRLSLRLSS FQSSNTGPTD CWPQETLNLI EEFFNARVCA
1510 1520 1530 1540 1550
PPFQPSAVAS FFRLLTLPPR AFRSIVRLLP FDLHPPTHAA VHIRLGLVGL
1560 1570 1580 1590 1600
GTGKRPASSQ SGGRATTVAS SPMDTSAALG GVELFPGLPG VIVRPPRITL
1610 1620 1630 1640 1650
QLLVSRTQRP QLSKFPAPPM AQLIPICYDW DANRVVILPG TSGATTSGSS
1660 1670 1680 1690 1700
QPGRADSAPN LYQILREADV EANSNMMASN SGESALVQLA LLVTQTAAAA
1710 1720
STTYASTAGA TVGSVKPVYG ST
Length:1,722
Mass (Da):191,383
Last modified:October 1, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59332591DFEB3106
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KL596751 Genomic DNA Translation: KER26322.1

NCBI Reference Sequences

More...
RefSeqi
XP_009169958.1, XM_009171694.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20320615

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ovi:T265_06436

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KL596751 Genomic DNA Translation: KER26322.1
RefSeqiXP_009169958.1, XM_009171694.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi20320615
KEGGiovi:T265_06436

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
20320615

Phylogenomic databases

OrthoDBi323359at2759

Family and domain databases

InterProiView protein in InterPro
IPR013947, Mediator_Med14
PANTHERiPTHR12809, PTHR12809, 1 hit
PfamiView protein in Pfam
PF08638, Med14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A074ZKM0_9TREM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A074ZKM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: April 7, 2021
This is version 23 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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