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Protein

General transcription factor IIH subunit 4

Gene

T265_06756

Organism
Opisthorchis viverrini
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4UniRule annotation
Gene namesi
ORF Names:T265_06756Imported
OrganismiOpisthorchis viverriniImported
Taxonomic identifieri6198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaOpisthorchiidaOpisthorchiataOpisthorchiidaeOpisthorchis
Proteomesi
  • UP000054324 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A074ZFD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYWLPAFDR YLVIIGCLIQ DFDKSELAFC RTGRISSLSI QCAVHTTVFH
60 70 80 90 100
FLMNEPKAAS IFEYIRNVDI LLLDELFSHP PTCLVIFREL PELAKHFVAR
110 120 130 140 150
LLFVEQPIPK SIVSGWVEKG SQALLQDACR ALSDLRIWHS VDGNVARGAW
160 170 180 190 200
CLSKKYQESL RISLFGGGKS LLGDLGSTTV DKYSKDVGFL ETYAAERWDS
210 220 230 240 250
LLHFMVGSES SEVGSVVQDV LLLSNLMKGG TPDTPVGITK HGFHFLLMSR
260 270 280 290 300
PDQVRLFLLH YFDYLKETKK NLVAALQFVF QLSFLSPEKS YPVDALTAPQ
310 320 330 340 350
QEVLQQMREL GLAYQRKRTA PRFYVTPLAT VLSGSRCHRP AMSSGSVLNA
360 370 380 390 400
IPTGVSHLDG TDSVQPTASS TSDVGYILLE TNFRLYAYTD SPLRTALLSL
410 420 430 440 450
FSKIRARFPN LVVADITRDS VREALIRGIT ADQIISFLTT NAHPDMLREP
460 470 480 490 500
PILPPTLVDQ IRLWELERDR FVFQEGCLYE QFSKSADFEM VRDFAKSIGV
510 520 530 540
LLWENPERRL MVVSKAGHED TNLSRIADEL NVHDIMGNMC LTPCYGL
Length:547
Mass (Da):61,613
Last modified:October 1, 2014 - v1
Checksum:iBD4776ADE7BE160A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KL596763 Genomic DNA Translation: KER25903.1
RefSeqiXP_009170365.1, XM_009172101.1

Genome annotation databases

GeneIDi20320935
KEGGiovi:T265_06756

Similar proteinsi

Entry informationi

Entry nameiA0A074ZFD8_9TREM
AccessioniPrimary (citable) accession number: A0A074ZFD8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: February 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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