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Entry version 63 (12 Aug 2020)
Sequence version 1 (01 Oct 2014)
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Protein

Ketol-acid reductoisomerase (NADP(+))

Gene

ilvC

Organism
Pseudomonas aeruginosa
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.UniRule annotationARBA annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.UniRule annotationARBA annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (HV87_02540), Acetolactate synthase (ilvI_1), Acetolactate synthase (GNQ20_08965), Acetolactate synthase, Acetolactate synthase (F7R07_26020), Acetolactate synthase (ilvN), Acetolactate synthase (ilvI), Acetolactate synthase (HV87_02545), Acetolactate synthase (ilvI), Acetolactate synthase (GGB98_29715), Acetolactate synthase (ilvB), Acetolactate synthase (ilvI), Acetolactate synthase (ilvH), Acetolactate synthase (ilvH), Acetolactate synthase (ilvI)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC), Ketol-acid reductoisomerase (NADP(+)) (ilvC), Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD_2), Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD_2), Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE), Branched-chain-amino-acid aminotransferase (HV87_18265), Branched-chain-amino-acid aminotransferase (ilvE), Branched-chain-amino-acid aminotransferase (ilvE), Branched-chain-amino-acid aminotransferase (ilvE), Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-valine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-valine from pyruvate.UniRule annotationARBA annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (HV87_02540), Acetolactate synthase (ilvI_1), Acetolactate synthase (GNQ20_08965), Acetolactate synthase, Acetolactate synthase (F7R07_26020), Acetolactate synthase (ilvN), Acetolactate synthase (ilvI), Acetolactate synthase (HV87_02545), Acetolactate synthase (ilvI), Acetolactate synthase (GGB98_29715), Acetolactate synthase (ilvB), Acetolactate synthase (ilvI), Acetolactate synthase (ilvH), Acetolactate synthase (ilvH), Acetolactate synthase (ilvI)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC), Ketol-acid reductoisomerase (NADP(+)) (ilvC), Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD_2), Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD_2), Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE), Branched-chain-amino-acid aminotransferase (HV87_18265), Branched-chain-amino-acid aminotransferase (ilvE), Branched-chain-amino-acid aminotransferase (ilvE), Branched-chain-amino-acid aminotransferase (ilvE), Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei47NADPUniRule annotation1
Binding sitei50NADPUniRule annotation1
Binding sitei52NADPUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei107UniRule annotation1
Binding sitei133NADP; via amide nitrogenUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi190Magnesium 1UniRule annotation1
Metal bindingi190Magnesium 2UniRule annotation1
Metal bindingi194Magnesium 1UniRule annotation1
Metal bindingi226Magnesium 2UniRule annotation1
Metal bindingi230Magnesium 2UniRule annotation1
Binding sitei251SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi24 – 27NADPUniRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomeraseImported, OxidoreductaseUniRule annotationImportedARBA annotation
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotationARBA annotation
LigandMagnesiumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation, NADPUniRule annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00047;UER00056
UPA00049;UER00060

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ketol-acid reductoisomerase (NADP(+))UniRule annotation (EC:1.1.1.86UniRule annotation)
Short name:
KARIUniRule annotation
Alternative name(s):
Acetohydroxy-acid isomeroreductaseUniRule annotation
Short name:
AHIRUniRule annotation
Alpha-keto-beta-hydroxylacyl reductoisomeraseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ilvCUniRule annotationImported
ORF Names:ALP65_01965Imported, C0044_31630Imported, CAZ10_37785Imported, CGU42_13100Imported, DT376_05415Imported, DY930_25275Imported, DZ962_28685Imported, E4V10_19695Imported, ECC04_028305Imported, EQH76_00020Imported, F3H14_32180Imported, F7O90_32660Imported, F7O93_22040Imported, F7O98_31700Imported, FC629_27610Imported, FDK04_26780Imported, GNQ48_21525Imported, IPC116_08995Imported, IPC1323_05260Imported, IPC1481_02820Imported, IPC1509_27700Imported, IPC36_08645Imported, IPC584_25930Imported, IPC669_03710Imported, NCTC10662_02214Imported, NCTC12934_01302Imported, NCTC12951_07001Imported, NCTC13437_05720Imported, NCTC13619_00475Imported, NCTC13621_03891Imported, PaeAG1_05728Imported, PAMH19_2403Imported, RW109_RW109_06280Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000043988 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000297623 Componenti: Unassembled WGS sequence
  • UP000253594 Componenti: Unassembled WGS sequence
  • UP000421245 Componenti: Unassembled WGS sequence
  • UP000272646 Componenti: Unassembled WGS sequence
  • UP000426765 Componenti: Unassembled WGS sequence
  • UP000270834 Componenti: Unassembled WGS sequence
  • UP000258262 Componenti: Unassembled WGS sequence
  • UP000194857 Componenti: Unassembled WGS sequence
  • UP000297361 Componenti: Unassembled WGS sequence
  • UP000446777 Componenti: Unassembled WGS sequence
  • UP000344659 Componenti: Unassembled WGS sequence
  • UP000297560 Componenti: Unassembled WGS sequence
  • UP000233777 Componenti: Chromosome mainomosome
  • UP000409361 Componenti: Unassembled WGS sequence
  • UP000247072 Componenti: Unassembled WGS sequence
  • UP000351144 Componenti: Chromosome
  • UP000278438 Componenti: Unassembled WGS sequence
  • UP000341211 Componenti: Unassembled WGS sequence
  • UP000354661 Componenti: Unassembled WGS sequence
  • UP000297232 Componenti: Unassembled WGS sequence
  • UP000372148 Componenti: Unassembled WGS sequence
  • UP000322750 Componenti: Unassembled WGS sequence
  • UP000424265 Componenti: Chromosome
  • UP000408447 Componenti: Unassembled WGS sequence
  • UP000433532 Componenti: Unassembled WGS sequence
  • UP000297845 Componenti: Unassembled WGS sequence
  • UP000297494 Componenti: Unassembled WGS sequence
  • UP000297376 Componenti: Unassembled WGS sequence
  • UP000285404 Componenti: Unassembled WGS sequence
  • UP000422128 Componenti: Chromosome
  • UP000287066 Componenti: Unassembled WGS sequence
  • UP000216659 Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
287.DR97_2036

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 181KARI N-terminal RossmannInterPro annotationAdd BLAST181
Domaini182 – 327KARI C-terminal knottedInterPro annotationAdd BLAST146

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ketol-acid reductoisomerase family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0059, Bacteria

KEGG Orthology (KO)

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KOi
K00053

Database of Orthologous Groups

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OrthoDBi
188901at2

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00435, IlvC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008927, 6-PGluconate_DH-like_C_sf
IPR013023, KARI
IPR000506, KARI_C
IPR013116, KARI_N
IPR014359, KARI_prok
IPR036291, NAD(P)-bd_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21371, PTHR21371, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01450, IlvC, 1 hit
PF07991, IlvN, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000116, IlvC_gammaproteo, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48179, SSF48179, 1 hit
SSF51735, SSF51735, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00465, ilvC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51851, KARI_C, 1 hit
PS51850, KARI_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A072ZK07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVFYDKDCD LSIIQGKKVA IIGYGSQGHA HACNLKDSGV DVTVGLRSGS
60 70 80 90 100
ATVAKAEAHG LKVADVKTAV AAADVVMILT PDEFQGRLYK EEIEPNLKKG
110 120 130 140 150
ATLAFAHGFS IHYNQVVPRA DLDVIMIAPK APGHTVRSEF VKGGGIPDLI
160 170 180 190 200
AIYQDASGNA KNVALSYACG VGGGRTGIIE TTFKDETETD LFGEQAVLCG
210 220 230 240 250
GCVELVKAGF ETLVEAGYAP EMAYFECLHE LKLIVDLMYE GGIANMNYSI
260 270 280 290 300
SNNAEYGEYV TGPEVINAES RAAMRNALKR IQDGEYAKMF ITEGAANYPS
310 320 330
MTAYRRNNAA HPIEQIGEKL RAMMPWIAAN KIVDKSKN
Length:338
Mass (Da):36,425
Last modified:October 1, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93CF5F7DA9F61B0A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CDAZ01000009 Genomic DNA Translation: CEI11577.1
VWQL01000050 Genomic DNA Translation: KAA5587547.1
VZIM01000167 Genomic DNA Translation: KAB0718746.1
VZIP01000233 Genomic DNA Translation: KAB0742593.1
VZIW01000150 Genomic DNA Translation: KAB0758458.1
WOAD01000020 Genomic DNA Translation: MUI37594.1
NFFZ01000057 Genomic DNA Translation: OTI53836.1
NMRQ01000024 Genomic DNA Translation: OZO16713.1
QHLU01002578 Genomic DNA Translation: PXB87997.1
CP045739 Genomic DNA Translation: QGH93887.1
CP039988 Genomic DNA Translation: QGP99363.1
CP039990 Genomic DNA Translation: QGQ06020.1
QORE01000110 Genomic DNA Translation: RCI75863.1
QVBL01000057 Genomic DNA Translation: RFJ66517.1
RBSQ01000254 Genomic DNA Translation: RMS61944.1
NSVB01000001 Genomic DNA Translation: RPY79693.1
RXTB01000132 Genomic DNA Translation: RTR69305.1
SBJW01000001 Genomic DNA Translation: RWY32364.1
LT969520 Genomic DNA Translation: SOV32133.1
RWMJ01000016 Genomic DNA Translation: TEE15286.1
RWNG01000002 Genomic DNA Translation: TEF48050.1
RWOM01000002 Genomic DNA Translation: TEH37266.1
RWQO01000008 Genomic DNA Translation: TEK60152.1
RWTJ01000003 Genomic DNA Translation: TEO97015.1
RWUZ01000003 Genomic DNA Translation: TER54549.1
SRHR01000028 Genomic DNA Translation: TGA87653.1
RHMD02000002 Genomic DNA Translation: TGB23113.1
CAADJI010000001 Genomic DNA Translation: VFS85571.1
CAADJO010000001 Genomic DNA Translation: VFT09547.1
CAADJP010000009 Genomic DNA Translation: VFT28880.1
CAADJQ010000024 Genomic DNA Translation: VFT52625.1
CAADJS010000003 Genomic DNA Translation: VFT61129.1
CABEEH010000129 Genomic DNA Translation: VTQ27498.1

NCBI Reference Sequences

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RefSeqi
WP_003095066.1, NZ_WYAF01000006.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CEI11577; CEI11577; PAMH19_2403
CRN59059; CRN59059; PAERUG_P32_London_17_VIM_2_10_11_00026
CRR21664; CRR21664; PAERUG_E15_London_28_01_14_08350
KSG98255; KSG98255; AO964_32525

Database of genes from NCBI RefSeq genomes

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GeneIDi
45712683

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
paeb:NCGM1900_5422

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|287.1477.peg.6233

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CDAZ01000009 Genomic DNA Translation: CEI11577.1
VWQL01000050 Genomic DNA Translation: KAA5587547.1
VZIM01000167 Genomic DNA Translation: KAB0718746.1
VZIP01000233 Genomic DNA Translation: KAB0742593.1
VZIW01000150 Genomic DNA Translation: KAB0758458.1
WOAD01000020 Genomic DNA Translation: MUI37594.1
NFFZ01000057 Genomic DNA Translation: OTI53836.1
NMRQ01000024 Genomic DNA Translation: OZO16713.1
QHLU01002578 Genomic DNA Translation: PXB87997.1
CP045739 Genomic DNA Translation: QGH93887.1
CP039988 Genomic DNA Translation: QGP99363.1
CP039990 Genomic DNA Translation: QGQ06020.1
QORE01000110 Genomic DNA Translation: RCI75863.1
QVBL01000057 Genomic DNA Translation: RFJ66517.1
RBSQ01000254 Genomic DNA Translation: RMS61944.1
NSVB01000001 Genomic DNA Translation: RPY79693.1
RXTB01000132 Genomic DNA Translation: RTR69305.1
SBJW01000001 Genomic DNA Translation: RWY32364.1
LT969520 Genomic DNA Translation: SOV32133.1
RWMJ01000016 Genomic DNA Translation: TEE15286.1
RWNG01000002 Genomic DNA Translation: TEF48050.1
RWOM01000002 Genomic DNA Translation: TEH37266.1
RWQO01000008 Genomic DNA Translation: TEK60152.1
RWTJ01000003 Genomic DNA Translation: TEO97015.1
RWUZ01000003 Genomic DNA Translation: TER54549.1
SRHR01000028 Genomic DNA Translation: TGA87653.1
RHMD02000002 Genomic DNA Translation: TGB23113.1
CAADJI010000001 Genomic DNA Translation: VFS85571.1
CAADJO010000001 Genomic DNA Translation: VFT09547.1
CAADJP010000009 Genomic DNA Translation: VFT28880.1
CAADJQ010000024 Genomic DNA Translation: VFT52625.1
CAADJS010000003 Genomic DNA Translation: VFT61129.1
CABEEH010000129 Genomic DNA Translation: VTQ27498.1
RefSeqiWP_003095066.1, NZ_WYAF01000006.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

STRINGi287.DR97_2036

Genome annotation databases

EnsemblBacteriaiCEI11577; CEI11577; PAMH19_2403
CRN59059; CRN59059; PAERUG_P32_London_17_VIM_2_10_11_00026
CRR21664; CRR21664; PAERUG_E15_London_28_01_14_08350
KSG98255; KSG98255; AO964_32525
GeneIDi45712683
KEGGipaeb:NCGM1900_5422
PATRICifig|287.1477.peg.6233

Phylogenomic databases

eggNOGiCOG0059, Bacteria
KOiK00053
OrthoDBi188901at2

Enzyme and pathway databases

UniPathwayiUPA00047;UER00056
UPA00049;UER00060

Family and domain databases

HAMAPiMF_00435, IlvC, 1 hit
InterProiView protein in InterPro
IPR008927, 6-PGluconate_DH-like_C_sf
IPR013023, KARI
IPR000506, KARI_C
IPR013116, KARI_N
IPR014359, KARI_prok
IPR036291, NAD(P)-bd_dom_sf
PANTHERiPTHR21371, PTHR21371, 1 hit
PfamiView protein in Pfam
PF01450, IlvC, 1 hit
PF07991, IlvN, 1 hit
PIRSFiPIRSF000116, IlvC_gammaproteo, 2 hits
SUPFAMiSSF48179, SSF48179, 1 hit
SSF51735, SSF51735, 1 hit
TIGRFAMsiTIGR00465, ilvC, 1 hit
PROSITEiView protein in PROSITE
PS51851, KARI_C, 1 hit
PS51850, KARI_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A072ZK07_PSEAI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A072ZK07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: August 12, 2020
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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