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Entry version 61 (12 Aug 2020)
Sequence version 1 (01 Oct 2014)
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Protein

Iron-sulfur cluster insertion protein ErpA

Gene

erpA

Organism
Pseudomonas aeruginosa
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for insertion of 4Fe-4S clusters for at least IspG.UniRule annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

iron-sulfur clusterUniRule annotationNote: Binds 1 iron-sulfur cluster per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi44Iron-sulfurUniRule annotation1
Metal bindingi108Iron-sulfurUniRule annotation1
Metal bindingi110Iron-sulfurUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandIron, Iron-sulfurUniRule annotationARBA annotation, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Iron-sulfur cluster insertion protein ErpAUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:erpAUniRule annotationImported
ORF Names:ALP65_03605Imported, C0044_04770Imported, CAZ10_19370Imported, CGU42_16040Imported, CSB93_1953Imported, DY930_23400Imported, DY940_04435Imported, DZ962_09515Imported, E4V10_20180Imported, ECC04_011285Imported, EQH76_07750Imported, F3H14_34075Imported, F7O90_27785Imported, F7O93_13115Imported, F7O98_06345Imported, FC629_03530Imported, FDK04_03795Imported, GNQ48_28950Imported, IPC116_16360Imported, IPC1323_10945Imported, IPC1481_12865Imported, IPC1509_08495Imported, IPC36_16820Imported, IPC584_28595Imported, IPC669_27705Imported, NCTC10662_00381Imported, NCTC12924_03188Imported, NCTC12934_05395Imported, NCTC12951_02864Imported, NCTC13437_03859Imported, NCTC13619_01750Imported, NCTC13621_06439Imported, NCTC13628_01586Imported, PaeAG1_00732Imported, PAMH19_0703Imported, RW109_RW109_01314Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000043988 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000297623 Componenti: Unassembled WGS sequence
  • UP000421245 Componenti: Unassembled WGS sequence
  • UP000348842 Componenti: Unassembled WGS sequence
  • UP000272646 Componenti: Unassembled WGS sequence
  • UP000426765 Componenti: Unassembled WGS sequence
  • UP000270834 Componenti: Unassembled WGS sequence
  • UP000258262 Componenti: Unassembled WGS sequence
  • UP000194857 Componenti: Unassembled WGS sequence
  • UP000297361 Componenti: Unassembled WGS sequence
  • UP000446777 Componenti: Unassembled WGS sequence
  • UP000344659 Componenti: Unassembled WGS sequence
  • UP000297560 Componenti: Unassembled WGS sequence
  • UP000276985 Componenti: Unassembled WGS sequence
  • UP000233777 Componenti: Chromosome mainomosome
  • UP000409361 Componenti: Unassembled WGS sequence
  • UP000247072 Componenti: Unassembled WGS sequence
  • UP000238390 Componenti: Chromosome
  • UP000351144 Componenti: Chromosome
  • UP000356665 Componenti: Unassembled WGS sequence
  • UP000278438 Componenti: Unassembled WGS sequence
  • UP000354661 Componenti: Unassembled WGS sequence
  • UP000341211 Componenti: Unassembled WGS sequence
  • UP000297232 Componenti: Unassembled WGS sequence
  • UP000372148 Componenti: Unassembled WGS sequence
  • UP000322750 Componenti: Unassembled WGS sequence
  • UP000424265 Componenti: Chromosome
  • UP000408447 Componenti: Unassembled WGS sequence
  • UP000433532 Componenti: Unassembled WGS sequence
  • UP000297845 Componenti: Unassembled WGS sequence
  • UP000297494 Componenti: Unassembled WGS sequence
  • UP000297376 Componenti: Unassembled WGS sequence
  • UP000285404 Componenti: Unassembled WGS sequence
  • UP000422128 Componenti: Chromosome
  • UP000287066 Componenti: Unassembled WGS sequence
  • UP000216659 Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
287.DR97_3618

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 111Fe-S_biosynInterPro annotationAdd BLAST100

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HesB/IscA family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0316, Bacteria

KEGG Orthology (KO)

More...
KOi
K15724

Database of Orthologous Groups

More...
OrthoDBi
1891602at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.300.12, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01380, Fe_S_insert_ErpA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000361, FeS_biogenesis
IPR016092, FeS_cluster_insertion
IPR017870, FeS_cluster_insertion_CS
IPR023063, FeS_cluster_insertion_RrpA
IPR035903, HesB-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01521, Fe-S_biosyn, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF89360, SSF89360, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00049, TIGR00049, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01152, HESB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A071KZB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIETFTPTP LLFTPGAANK VKTLIDEEGN PRLKLRVFVT GGGCSGFQYG
60 70 80 90 100
FTFDEDIADD DTVIERDGVG LVVDPMSFQY LAGSEVDYQE GLEGSRFVIK
110
NPNAATTCGC GQSFSI
Length:116
Mass (Da):12,484
Last modified:October 1, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF478C4EA6CA446F1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP027169 Genomic DNA Translation: AVK06244.1
CDAZ01000003 Genomic DNA Translation: CEI00843.1
VWQL01000071 Genomic DNA Translation: KAA5587094.1
VZIM01000097 Genomic DNA Translation: KAB0723788.1
VZIP01000102 Genomic DNA Translation: KAB0748423.1
VZIW01000009 Genomic DNA Translation: KAB0769615.1
WOAD01000040 Genomic DNA Translation: MUI39038.1
NFFZ01000009 Genomic DNA Translation: OTI60445.1
NMRQ01000025 Genomic DNA Translation: OZO16673.1
QHLU01000342 Genomic DNA Translation: PXC02758.1
CP045739 Genomic DNA Translation: QGH88964.1
CP039988 Genomic DNA Translation: QGP94840.1
CP039990 Genomic DNA Translation: QGQ01695.1
QVBL01000008 Genomic DNA Translation: RFJ74550.1
RBSQ01001205 Genomic DNA Translation: RMS46734.1
NSVB01000018 Genomic DNA Translation: RPY66347.1
RXTB01000123 Genomic DNA Translation: RTR70390.1
RXTL01000005 Genomic DNA Translation: RTS52057.1
SBJW01000004 Genomic DNA Translation: RWY28680.1
LT969520 Genomic DNA Translation: SOV27239.1
RWMJ01000002 Genomic DNA Translation: TEE29558.1
RWNG01000007 Genomic DNA Translation: TEF45161.1
RWOM01000003 Genomic DNA Translation: TEH36615.1
RWQO01000012 Genomic DNA Translation: TEK57712.1
RWTJ01000006 Genomic DNA Translation: TEO92925.1
RWUZ01000006 Genomic DNA Translation: TER51288.1
SRHR01000030 Genomic DNA Translation: TGA87360.1
RHMD02000001 Genomic DNA Translation: TGB27004.1
CAADJI010000001 Genomic DNA Translation: VFS74926.1
CAADJO010000002 Genomic DNA Translation: VFT14931.1
CAADJQ010000008 Genomic DNA Translation: VFT15400.1
CAADJR010000001 Genomic DNA Translation: VFT24133.1
CAADJS010000002 Genomic DNA Translation: VFT41511.1
CAADJP010000012 Genomic DNA Translation: VFT53663.1
CABDUZ010000001 Genomic DNA Translation: VTL99748.1
CABEEH010000468 Genomic DNA Translation: VTQ44210.1

NCBI Reference Sequences

More...
RefSeqi
WP_003085254.1, NZ_WYAF01000005.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CEI00843; CEI00843; PAMH19_0703
CRO61891; CRO61891; PAERUG_P32_London_17_VIM_2_10_11_02666
CRQ89263; CRQ89263; PAERUG_E15_London_28_01_14_06681
KSC87558; KSC87558; AO896_19140
KSH09251; KSH09251; AO964_16255

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
45708479

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
paeb:NCGM1900_0665

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|287.1477.peg.3112

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP027169 Genomic DNA Translation: AVK06244.1
CDAZ01000003 Genomic DNA Translation: CEI00843.1
VWQL01000071 Genomic DNA Translation: KAA5587094.1
VZIM01000097 Genomic DNA Translation: KAB0723788.1
VZIP01000102 Genomic DNA Translation: KAB0748423.1
VZIW01000009 Genomic DNA Translation: KAB0769615.1
WOAD01000040 Genomic DNA Translation: MUI39038.1
NFFZ01000009 Genomic DNA Translation: OTI60445.1
NMRQ01000025 Genomic DNA Translation: OZO16673.1
QHLU01000342 Genomic DNA Translation: PXC02758.1
CP045739 Genomic DNA Translation: QGH88964.1
CP039988 Genomic DNA Translation: QGP94840.1
CP039990 Genomic DNA Translation: QGQ01695.1
QVBL01000008 Genomic DNA Translation: RFJ74550.1
RBSQ01001205 Genomic DNA Translation: RMS46734.1
NSVB01000018 Genomic DNA Translation: RPY66347.1
RXTB01000123 Genomic DNA Translation: RTR70390.1
RXTL01000005 Genomic DNA Translation: RTS52057.1
SBJW01000004 Genomic DNA Translation: RWY28680.1
LT969520 Genomic DNA Translation: SOV27239.1
RWMJ01000002 Genomic DNA Translation: TEE29558.1
RWNG01000007 Genomic DNA Translation: TEF45161.1
RWOM01000003 Genomic DNA Translation: TEH36615.1
RWQO01000012 Genomic DNA Translation: TEK57712.1
RWTJ01000006 Genomic DNA Translation: TEO92925.1
RWUZ01000006 Genomic DNA Translation: TER51288.1
SRHR01000030 Genomic DNA Translation: TGA87360.1
RHMD02000001 Genomic DNA Translation: TGB27004.1
CAADJI010000001 Genomic DNA Translation: VFS74926.1
CAADJO010000002 Genomic DNA Translation: VFT14931.1
CAADJQ010000008 Genomic DNA Translation: VFT15400.1
CAADJR010000001 Genomic DNA Translation: VFT24133.1
CAADJS010000002 Genomic DNA Translation: VFT41511.1
CAADJP010000012 Genomic DNA Translation: VFT53663.1
CABDUZ010000001 Genomic DNA Translation: VTL99748.1
CABEEH010000468 Genomic DNA Translation: VTQ44210.1
RefSeqiWP_003085254.1, NZ_WYAF01000005.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi287.DR97_3618

Genome annotation databases

EnsemblBacteriaiCEI00843; CEI00843; PAMH19_0703
CRO61891; CRO61891; PAERUG_P32_London_17_VIM_2_10_11_02666
CRQ89263; CRQ89263; PAERUG_E15_London_28_01_14_06681
KSC87558; KSC87558; AO896_19140
KSH09251; KSH09251; AO964_16255
GeneIDi45708479
KEGGipaeb:NCGM1900_0665
PATRICifig|287.1477.peg.3112

Phylogenomic databases

eggNOGiCOG0316, Bacteria
KOiK15724
OrthoDBi1891602at2

Family and domain databases

Gene3Di2.60.300.12, 1 hit
HAMAPiMF_01380, Fe_S_insert_ErpA, 1 hit
InterProiView protein in InterPro
IPR000361, FeS_biogenesis
IPR016092, FeS_cluster_insertion
IPR017870, FeS_cluster_insertion_CS
IPR023063, FeS_cluster_insertion_RrpA
IPR035903, HesB-like_dom_sf
PfamiView protein in Pfam
PF01521, Fe-S_biosyn, 1 hit
SUPFAMiSSF89360, SSF89360, 1 hit
TIGRFAMsiTIGR00049, TIGR00049, 1 hit
PROSITEiView protein in PROSITE
PS01152, HESB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A071KZB2_PSEAI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A071KZB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: August 12, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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