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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Gluconobacter oxydans DSM 3504
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processCoenzyme A biosynthesisUniRule annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00241;UER00356

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotationImported
ORF Names:GLS_c20740Imported
OrganismiGluconobacter oxydans DSM 3504Imported
Taxonomic identifieri1288313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
Proteomesi
  • UP000031656 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation

Phylogenomic databases

KOiK00859

Family and domain databases

CDDicd02022 DPCK, 1 hit
HAMAPiMF_00376 Dephospho_CoA_kinase, 1 hit
InterProiView protein in InterPro
IPR001977 Depp_CoAkinase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01121 CoaE, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00152 TIGR00152, 1 hit
PROSITEiView protein in PROSITE
PS51219 DPCK, 1 hit

Sequencei

Sequence statusi: Complete.

A0A067Z7U3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIIGLTGGM AAGKSTVAAL FRREGVPVFD ADACVRALQG EWGKALPLIG
60 70 80 90 100
QAFPGTVAEG RLDRAVLREA VRGRPEALKR LEAIMHPLVR AERERFLKQC
110 120 130 140 150
RARHEPFCVL DIPLLMEIGE DRRCDVVVVA EAPMGTRLSR IRQRGRSGGR
160 170 180 190 200
MSVADAKGLL ARQMSDHERR RRADIVIRTG LSRGQAVRQV HALLHRLREA

S
Length:201
Mass (Da):22,297
Last modified:October 1, 2014 - v1
Checksum:iB9B43E5A26F17383
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP004373 Genomic DNA Translation: AHK71945.1
RefSeqiWP_041112179.1, NZ_CP004373.1

Genome annotation databases

EnsemblBacteriaiAHK71945; AHK71945; GLS_c20740
KEGGigoy:GLS_c20740

Similar proteinsi

Entry informationi

Entry nameiA0A067Z7U3_GLUOY
AccessioniPrimary (citable) accession number: A0A067Z7U3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: September 27, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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