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Protein

Phospholipid-transporting ATPase

Gene

ATP11C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
Name:ATP11CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000101974.14
HGNCiHGNC:13554 ATP11C

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei290 – 313HelicalUniRule annotationAdd BLAST24
Transmembranei344 – 363HelicalUniRule annotationAdd BLAST20
Transmembranei903 – 923HelicalUniRule annotationAdd BLAST21
Transmembranei953 – 975HelicalUniRule annotationAdd BLAST23
Transmembranei987 – 1009HelicalUniRule annotationAdd BLAST23
Transmembranei1021 – 1044HelicalUniRule annotationAdd BLAST24
Transmembranei1064 – 1084HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101974

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A067XG54

Expressioni

Gene expression databases

BgeeiENSG00000101974 Expressed in 198 organ(s), highest expression level in female gonad
ExpressionAtlasiA0A067XG54 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A067XG54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 91PhoLip_ATPase_NInterPro annotationAdd BLAST55
Domaini839 – 1087PhoLip_ATPase_CInterPro annotationAdd BLAST249

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili608 – 632Sequence analysisAdd BLAST25
Coiled coili705 – 725Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0206 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00910000144008

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030363 ATP11C
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF38 PTHR24092:SF38, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A067XG54-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRRSLNRFC AGEEKRVGTR TVFVGNHPVS ETEAYIAQRF CDNRIVSSKY
60 70 80 90 100
TLWNFLPKNL FEQFRRIANF YFLIIFLVQV TVDTPTSPVT SGLPLFFVIT
110 120 130 140 150
VTAIKQGYED CLRHRADNEV NKSTVYIIEN AKRVRKESEK IKVGDVVEVQ
160 170 180 190 200
ADETFPCDLI LLSSCTTDGT CYVTTASLDG ESNCKTHYAV RDTIALCTAE
210 220 230 240 250
SIDTLRAAIE CEQPQPDLYK FVGRINIYSN SLEAVARSLG PENLLLKGAT
260 270 280 290 300
LKNTEKIYGV AVYTGMETKM ALNYQGKSQK RSAVEKSINA FLIVYLFILL
310 320 330 340 350
TKAAVCTTLK YVWQSTPYND EPWYNQKTQK ERETLKVLKM FTDFLSFMVL
360 370 380 390 400
FNFIIPVSMY VTVEMQKFLG SFFISWDKDF YDEEINEGAL VNTSDLNEEL
410 420 430 440 450
GQVDYVFTDK TGTLTENSME FIECCIDGHK YKGVTQEVDG LSQTDGTLTY
460 470 480 490 500
FDKVDKNREE LFLRALCLCH TVEIKTNDAV DGATESAELT YISSSPDEIA
510 520 530 540 550
LVKGAKRYGF TFLGNRNGYM RVENQRKEIE EYELLHTLNF DAVRRRMSVI
560 570 580 590 600
VKTQEGDILL FCKGADSAVF PRVQNHEIEL TKVHVERNAM DGYRTLCVAF
610 620 630 640 650
KEIAPDDYER INRQLIEAKM ALQDREEKME KVFDDIETNM NLIGATAVED
660 670 680 690 700
KLQDQAAETI EALHAAGLKV WVLTGDKMET AKSTCYACRL FQTNTELLEL
710 720 730 740 750
TTKTIEESER KEDRLHELLI EYRKKLLHEF PKSTRSFKKA WTEHQEYGLI
760 770 780 790 800
IDGSTLSLIL NSSQDSSSNN YKSIFLQICM KCTAVLCCRM APLQKAQIVR
810 820 830 840 850
MVKNLKGSPI TLSIGDGAND VSMILESHVG IGKEGRQAAR NSDYSVPKFK
860 870 880 890 900
HLKKLLLAHG HLYYVRIAHL VQYFFYKNLC FILPQFLYQF FCGFSQQPLY
910 920 930 940 950
DAAYLTMYNI CFTSLPILAY SLLEQHINID TLTSDPRLYM KISGNAMLQL
960 970 980 990 1000
GPFLYWTFLA AFEGTVFFFG TYFLFQTASL EENGKVYGNW TFGTIVFTVL
1010 1020 1030 1040 1050
VFTVTLKLAL DTRFWTWINH FVIWGSLAFY VFFSFFWGGI IWPFLKQQRM
1060 1070 1080 1090 1100
YFVFAQMLSS VSTWLAIILL IFISLFPEIL LIVLKNVRRR SARNPNLELP
1110
MLLSYKHTDS GYS
Length:1,113
Mass (Da):127,681
Last modified:September 3, 2014 - v1
Checksum:iD4DC3D1ED1DFEF81
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NB49AT11C_HUMAN
Phospholipid-transporting ATPase IG
ATP11C ATPIG, ATPIQ
1,132Annotation score:
H7C0E8H7C0E8_HUMAN
Phospholipid-transporting ATPase IG
ATP11C
202Annotation score:
H7C113H7C113_HUMAN
Phospholipid-transporting ATPase IG
ATP11C
165Annotation score:
A0A067XG57A0A067XG57_HUMAN
Phospholipid-transporting ATPase IG
ATP11C
172Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161777 Genomic DNA No translation available.
AL356785 Genomic DNA No translation available.
AL590077 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000370557; ENSP00000359588; ENSG00000101974
UCSCiuc065bjm.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161777 Genomic DNA No translation available.
AL356785 Genomic DNA No translation available.
AL590077 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A067XG54
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A067XG54

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370557; ENSP00000359588; ENSG00000101974
UCSCiuc065bjm.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000101974.14
HGNCiHGNC:13554 ATP11C
OpenTargetsiENSG00000101974
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0206 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00910000144008

Miscellaneous databases

ChiTaRSiATP11C human

Gene expression databases

BgeeiENSG00000101974 Expressed in 198 organ(s), highest expression level in female gonad
ExpressionAtlasiA0A067XG54 baseline and differential

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030363 ATP11C
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF38 PTHR24092:SF38, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A067XG54_HUMAN
AccessioniPrimary (citable) accession number: A0A067XG54
Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: September 12, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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